{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O15047","secondaryAccessions":["A0A804HLA6","A6NP62","Q6PIF3","Q8TAJ6"],"uniProtkbId":"SET1A_HUMAN","entryAudit":{"firstPublicDate":"2005-06-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-06-21","entryVersion":209,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Histone-lysine N-methyltransferase SETD1A"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25561738"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29937342"}],"value":"2.1.1.364"}]},"alternativeNames":[{"fullName":{"value":"Lysine N-methyltransferase 2F"}},{"fullName":{"value":"SET domain-containing protein 1A"},"shortNames":[{"value":"hSET1A"}]},{"fullName":{"value":"Set1/Ash2 histone methyltransferase complex subunit SET1"}}]},"genes":[{"geneName":{"value":"SETD1A"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAA20797.2"}],"value":"KIAA0339"},{"value":"KMT2F"},{"value":"SET1"},{"value":"SET1A"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"E9PYH6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12670868"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25561738"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29937342"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31197650"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32346159"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38003223"}],"value":"Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60264"},{"database":"Rhea","id":"RHEA-COMP:15543"},{"database":"Rhea","id":"RHEA-COMP:15547"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:61929"}],"ecNumber":"2.1.1.364","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25561738"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29937342"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60265"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25561738"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29937342"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60268"},{"database":"Rhea","id":"RHEA-COMP:15540"},{"database":"Rhea","id":"RHEA-COMP:15543"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:61929"},{"database":"ChEBI","id":"CHEBI:61976"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25561738"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60269"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25561738"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60272"},{"database":"Rhea","id":"RHEA-COMP:15537"},{"database":"Rhea","id":"RHEA-COMP:15540"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:61961"},{"database":"ChEBI","id":"CHEBI:61976"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25561738"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60273"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25561738"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"E9PYH6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12670868"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16253997"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17355966"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17998332"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18838538"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22266653"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22665483"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22843687"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23178126"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23508102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25561738"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29937342"}],"value":"Component of the SET1A/COMPASS complex composed of the catalytic subunit SETD1A, WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 homotrimer (PubMed:16253997, PubMed:17355966, PubMed:17998332, PubMed:18838538, PubMed:22266653, PubMed:22665483, PubMed:23508102). Forms a core complex with the evolutionary conserved subcomplex WRAD composed of WDR5, RBBP5, ASH2L/ASH2 and DPY30 subunits; WRAD differentially stimulates the methyltransferase activity (PubMed:22266653, PubMed:22665483, PubMed:23508102, PubMed:25561738). Interacts with BOD1L1 (via COMPASS-Shg1 domain) at replication forks (PubMed:29937342). Interacts with HCFC1 (PubMed:12670868). Interacts with ASH2/ASH2L (PubMed:17998332). Interacts with CXXC1/CFP1 (PubMed:17998332). Interacts with RBBP5 (PubMed:17998332). Interacts (via N-terminal region) with WDR82; the interaction is direct (PubMed:17998332, PubMed:37030068). Interacts (via the RRM domain) with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) only in the presence of WDR82 (PubMed:17998332). Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad. Interacts with ZNF335 (PubMed:23178126). Interacts with SUPT6H (PubMed:22843687). Interacts with NAP1L1 (By similarity). Interacts (via WIN motif) with WDR5 (PubMed:17998332, PubMed:22266653, PubMed:22665483)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O15047","intActId":"EBI-540779"},"interactantTwo":{"uniProtKBAccession":"Q9UBL3-3","geneName":"ASH2L","intActId":"EBI-16130425"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15047","intActId":"EBI-540779"},"interactantTwo":{"uniProtKBAccession":"P51610","geneName":"HCFC1","intActId":"EBI-396176"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15047","intActId":"EBI-540779"},"interactantTwo":{"uniProtKBAccession":"Q15291","geneName":"RBBP5","intActId":"EBI-592823"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15047","intActId":"EBI-540779"},"interactantTwo":{"uniProtKBAccession":"Q02248","geneName":"Ctnnb1","intActId":"EBI-397872"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17355966"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38003223"}],"value":"Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes (PubMed:17355966). 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