{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O15021","secondaryAccessions":["A6NL49","B5ME48","E7EWQ5","J3QT34","Q05EE6","Q6ZN07","Q8N4X4","Q96LY3"],"uniProtkbId":"MAST4_HUMAN","entryAudit":{"firstPublicDate":"2006-10-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-03-28","entryVersion":193,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Microtubule-associated serine/threonine-protein kinase 4"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}],"value":"2.7.11.1"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:19037"}],"value":"MAST4"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9205841"}],"value":"KIAA0303"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1"}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1"}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000250"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["O15021-5"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["O15021-2"],"sequenceIds":["VSP_020888"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["O15021-4"],"sequenceIds":["VSP_035852","VSP_035853"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["O15021-3"],"sequenceIds":["VSP_023109"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["O15021-6"],"sequenceIds":["VSP_059373","VSP_059374"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17086981"}],"value":"Highly expressed in most normal human tissues, with an exception of in testis, small intestine, colon and peripheral blood leukocyte"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AK131421","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":2623,"modifier":"EXACT"}},"description":"Microtubule-associated serine/threonine-protein kinase 4","featureId":"PRO_0000252256"},{"type":"Domain","location":{"start":{"value":570,"modifier":"EXACT"},"end":{"value":843,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}]},{"type":"Domain","location":{"start":{"value":844,"modifier":"EXACT"},"end":{"value":916,"modifier":"EXACT"}},"description":"AGC-kinase C-terminal","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00618"}]},{"type":"Domain","location":{"start":{"value":1141,"modifier":"EXACT"},"end":{"value":1229,"modifier":"EXACT"}},"description":"PDZ","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00143"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":536,"modifier":"EXACT"},"end":{"value":560,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":921,"modifier":"EXACT"},"end":{"value":1082,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1107,"modifier":"EXACT"},"end":{"value":1143,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1227,"modifier":"EXACT"},"end":{"value":1262,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1289,"modifier":"EXACT"},"end":{"value":1527,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1540,"modifier":"EXACT"},"end":{"value":1561,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1609,"modifier":"EXACT"},"end":{"value":1671,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1714,"modifier":"EXACT"},"end":{"value":1741,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1764,"modifier":"EXACT"},"end":{"value":1795,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1809,"modifier":"EXACT"},"end":{"value":1864,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1876,"modifier":"EXACT"},"end":{"value":2386,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2398,"modifier":"EXACT"},"end":{"value":2623,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":558,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":935,"modifier":"EXACT"},"end":{"value":964,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1019,"modifier":"EXACT"},"end":{"value":1036,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1049,"modifier":"EXACT"},"end":{"value":1062,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1069,"modifier":"EXACT"},"end":{"value":1078,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1107,"modifier":"EXACT"},"end":{"value":1139,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1241,"modifier":"EXACT"},"end":{"value":1256,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1290,"modifier":"EXACT"},"end":{"value":1343,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1444,"modifier":"EXACT"},"end":{"value":1460,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1540,"modifier":"EXACT"},"end":{"value":1552,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1625,"modifier":"EXACT"},"end":{"value":1638,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1662,"modifier":"EXACT"},"end":{"value":1671,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1780,"modifier":"EXACT"},"end":{"value":1792,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1821,"modifier":"EXACT"},"end":{"value":1832,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1844,"modifier":"EXACT"},"end":{"value":1864,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1914,"modifier":"EXACT"},"end":{"value":1923,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1924,"modifier":"EXACT"},"end":{"value":1934,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1963,"modifier":"EXACT"},"end":{"value":1975,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1982,"modifier":"EXACT"},"end":{"value":1997,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2006,"modifier":"EXACT"},"end":{"value":2015,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2043,"modifier":"EXACT"},"end":{"value":2055,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2068,"modifier":"EXACT"},"end":{"value":2083,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2114,"modifier":"EXACT"},"end":{"value":2126,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2365,"modifier":"EXACT"},"end":{"value":2375,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2441,"modifier":"EXACT"},"end":{"value":2451,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2475,"modifier":"EXACT"},"end":{"value":2488,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2599,"modifier":"EXACT"},"end":{"value":2614,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":693,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}]},{"type":"Binding site","location":{"start":{"value":576,"modifier":"EXACT"},"end":{"value":584,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":599,"modifier":"EXACT"},"end":{"value":599,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Modified residue","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q811L6"}]},{"type":"Modified residue","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q811L6"}]},{"type":"Modified residue","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":914,"modifier":"EXACT"},"end":{"value":914,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1292,"modifier":"EXACT"},"end":{"value":1292,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q811L6"}]},{"type":"Modified residue","location":{"start":{"value":1370,"modifier":"EXACT"},"end":{"value":1370,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":1384,"modifier":"EXACT"},"end":{"value":1384,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1397,"modifier":"EXACT"},"end":{"value":1397,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q811L6"}]},{"type":"Modified residue","location":{"start":{"value":1419,"modifier":"EXACT"},"end":{"value":1419,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1467,"modifier":"EXACT"},"end":{"value":1467,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1523,"modifier":"EXACT"},"end":{"value":1523,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1779,"modifier":"EXACT"},"end":{"value":1779,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":1822,"modifier":"EXACT"},"end":{"value":1822,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1909,"modifier":"EXACT"},"end":{"value":1909,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":2442,"modifier":"EXACT"},"end":{"value":2442,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":2520,"modifier":"EXACT"},"end":{"value":2520,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":2552,"modifier":"EXACT"},"end":{"value":2552,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_020888","alternativeSequence":{"originalSequence":"MGEKVSEAPEPVPRGCSGHGSRTPASALVAASSPGASSAESSSGSETLSEEGEPGGFSREHQPPPPPPLGGTLGARAPAAWAPASVLLERGVLALPPPLPGGAVPPAPRGSSASQEEQDEELDHILSPPPMPFRKCSNPDVASGPGKSLKYKRQLSEDGRQLRRGSLGGALTGRYLLPNPVAGQAWPASAETSNLVRMRSQALGQSAPSLTASLKELSLPRRGSF","alternativeSequences":["MDMSDPNFWTVLSNFTLPHLRSGNRLRRTQS"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17086981"}],"featureId":"VSP_023109","alternativeSequence":{"originalSequence":"MGEKVSEAPEPVPRGCSGHGSRTPASALVAASSPGASSAESSSGSETLSEEGEPGGFSREHQPPPPPPLGGTLGARAPAAWAPASVLLERGVLALPPPLPGGAVPPAPRGSSASQEEQDEELDHILSPPPMPFRKCSNPDVASGPGKSLKYKRQLSEDGRQLRRGSLGGALTGRYLLPNPVAGQAWPASAETSNLVRMRSQALGQSAPSLTASLKELSLPRRGSF","alternativeSequences":["MDESSILRRRGLQKELSLPRRGSLIDSQKWNCLVKR"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_059373","alternativeSequence":{"originalSequence":"MGEKVSEAPEPVPRGCSGHGSRTPASALVAASSPGASSAESSSGSETLSEEGEPGGFSREHQPPPPPPLGGTLGARAPAAWAPASVLLERGVLALPPPLPGGAVPPAPRGSSASQEEQDEELDHILSPPPMPFRKCSNPDVASGPGKSLKYKRQLSEDGRQLRRGSLGGALTGRYLLPNPVAGQAWPASAETSNLVRMRSQALGQSAPSLTASLKELSLPRRGSF","alternativeSequences":["MKAQRERLQIPGLTLDLTPRSLSPTPSSPGSPCSPLLAFHFWS"]}},{"type":"Alternative sequence","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_035852","alternativeSequence":{"originalSequence":"FCRTSNRKSLIGNGQSPALPRPHSPL","alternativeSequences":["LIDSQKWNCLVKRPVCPNAGRTSPLG"]}},{"type":"Alternative sequence","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":2623,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_035853","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_059374","alternativeSequence":{"originalSequence":"R","alternativeSequences":["RRND"]}},{"type":"Natural variant","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"in dbSNP:rs6867856","featureCrossReferences":[{"database":"dbSNP","id":"rs6867856"}],"featureId":"VAR_059768","alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":920,"modifier":"EXACT"},"end":{"value":920,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_040787","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":1954,"modifier":"EXACT"},"end":{"value":1954,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_040788","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":2198,"modifier":"EXACT"},"end":{"value":2198,"modifier":"EXACT"}},"description":"in dbSNP:rs752429440","featureCrossReferences":[{"database":"dbSNP","id":"rs752429440"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_040789","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":2290,"modifier":"EXACT"},"end":{"value":2290,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_040790","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":2467,"modifier":"EXACT"},"end":{"value":2467,"modifier":"EXACT"}},"description":"in a lung squamous cell carcinoma sample; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_040791","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":350,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"in Ref. 4; AK131421","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":662,"modifier":"EXACT"},"end":{"value":662,"modifier":"EXACT"}},"description":"in Ref. 4; AK131421","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":674,"modifier":"EXACT"},"end":{"value":678,"modifier":"EXACT"}},"description":"in Ref. 4; BAB71532","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"FAETV","alternativeSequences":["YIVKL"]}},{"type":"Sequence conflict","location":{"start":{"value":1624,"modifier":"EXACT"},"end":{"value":1624,"modifier":"EXACT"}},"description":"in Ref. 1; AAW52510 and 5; BAA20762","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":1799,"modifier":"EXACT"},"end":{"value":1799,"modifier":"EXACT"}},"description":"in Ref. 1; AAW52510 and 5; BAA20762","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Beta strand","location":{"start":{"value":1142,"modifier":"EXACT"},"end":{"value":1145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2W7R"}]},{"type":"Beta strand","location":{"start":{"value":1153,"modifier":"EXACT"},"end":{"value":1161,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2W7R"}]},{"type":"Beta strand","location":{"start":{"value":1168,"modifier":"EXACT"},"end":{"value":1177,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2W7R"}]},{"type":"Helix","location":{"start":{"value":1182,"modifier":"EXACT"},"end":{"value":1186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2W7R"}]},{"type":"Beta strand","location":{"start":{"value":1193,"modifier":"EXACT"},"end":{"value":1197,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2W7R"}]},{"type":"Helix","location":{"start":{"value":1207,"modifier":"EXACT"},"end":{"value":1215,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2W7R"}]},{"type":"Turn","location":{"start":{"value":1216,"modifier":"EXACT"},"end":{"value":1219,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2W7R"}]},{"type":"Beta strand","location":{"start":{"value":1220,"modifier":"EXACT"},"end":{"value":1226,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2W7R"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"17086981","citationType":"journal article","authors":["Sun L.","Gu S.","Li X.","Sun Y.","Zheng D.","Yu K.","Ji C.","Tang R.","Xie Y.","Mao Y."],"citationCrossReferences":[{"database":"PubMed","id":"17086981"},{"database":"DOI","id":"10.1134/s0026893306050062"}],"title":"Identification of a novel human MAST4 gene, a new member of the microtubule associated serine-threonine kinase family.","publicationDate":"2006","journal":"Mol. Biol. (Mosk.)","firstPage":"808","lastPage":"815","volume":"40"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)","TISSUE SPECIFICITY"]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.-F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1074 (ISOFORM 5)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-678 (ISOFORM 2)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Thymus","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"9205841","citationType":"journal article","authors":["Nagase T.","Ishikawa K.","Nakajima D.","Ohira M.","Seki N.","Miyajima N.","Tanaka A.","Kotani H.","Nomura N.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"9205841"},{"database":"DOI","id":"10.1093/dnares/4.2.141"}],"title":"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.","publicationDate":"1997","journal":"DNA Res.","firstPage":"141","lastPage":"150","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 487-2623 (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":7,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270; SER-914; SER-1370; SER-1384; SER-1419; SER-1467; SER-1523; SER-1779; SER-1822; SER-1909; SER-2442; SER-2520 AND SER-2552","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1370; SER-1779 AND SER-2520","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"CI-EOAA37899DP6C","citationType":"submission","authoringGroup":["Structural genomics consortium (SGC)"],"title":"Structure of the Pdz domain of human Microtubule Associated Serine-Threonine Kinase 4.","publicationDate":"MAY-2009","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 1140-1231"]},{"referenceNumber":10,"citation":{"id":"17344846","citationType":"journal article","authors":["Greenman C.","Stephens P.","Smith R.","Dalgliesh G.L.","Hunter C.","Bignell G.","Davies H.","Teague J.","Butler A.","Stevens C.","Edkins S.","O'Meara S.","Vastrik I.","Schmidt E.E.","Avis T.","Barthorpe S.","Bhamra G.","Buck G.","Choudhury B.","Clements J.","Cole J.","Dicks E.","Forbes S.","Gray K.","Halliday K.","Harrison R.","Hills K.","Hinton J.","Jenkinson A.","Jones D.","Menzies A.","Mironenko T.","Perry J.","Raine K.","Richardson D.","Shepherd R.","Small A.","Tofts C.","Varian J.","Webb T.","West S.","Widaa S.","Yates A.","Cahill D.P.","Louis D.N.","Goldstraw P.","Nicholson A.G.","Brasseur F.","Looijenga L.","Weber B.L.","Chiew Y.-E.","DeFazio A.","Greaves M.F.","Green A.R.","Campbell P.","Birney E.","Easton D.F.","Chenevix-Trench G.","Tan M.-H.","Khoo S.K.","Teh B.T.","Yuen S.T.","Leung S.Y.","Wooster R.","Futreal P.A.","Stratton M.R."],"citationCrossReferences":[{"database":"PubMed","id":"17344846"},{"database":"DOI","id":"10.1038/nature05610"}],"title":"Patterns of somatic mutation in human cancer genomes.","publicationDate":"2007","journal":"Nature","firstPage":"153","lastPage":"158","volume":"446"},"referencePositions":["VARIANTS [LARGE SCALE ANALYSIS] ARG-920; TRP-1954; LEU-2198; CYS-2290 AND ASP-2467"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY830839","properties":[{"key":"ProteinId","value":"AAW52510.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC008872","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC008920","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC016634","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC034208","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC044799","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC092349","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC092373","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113365","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KC877001","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KC877010","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC033215","properties":[{"key":"ProteinId","value":"AAH33215.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK057601","properties":[{"key":"ProteinId","value":"BAB71532.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK131421","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB002301","properties":[{"key":"ProteinId","value":"BAA20762.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS47224.1","properties":[{"key":"Description","value":"-"}],"isoformId":"O15021-4"},{"database":"CCDS","id":"CCDS47225.1","properties":[{"key":"Description","value":"-"}],"isoformId":"O15021-3"},{"database":"CCDS","id":"CCDS54861.1","properties":[{"key":"Description","value":"-"}],"isoformId":"O15021-5"},{"database":"CCDS","id":"CCDS75254.1","properties":[{"key":"Description","value":"-"}],"isoformId":"O15021-2"},{"database":"RefSeq","id":"NP_001158136.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001164664.2"}],"isoformId":"O15021-5"},{"database":"RefSeq","id":"NP_001277155.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001290226.2"}]},{"database":"RefSeq","id":"NP_001277157.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001290228.2"}]},{"database":"RefSeq","id":"NP_001284580.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001297651.2"}],"isoformId":"O15021-2"},{"database":"RefSeq","id":"NP_055998.1","properties":[{"key":"NucleotideSequenceId","value":"NM_015183.3"}],"isoformId":"O15021-3"},{"database":"RefSeq","id":"NP_942123.1","properties":[{"key":"NucleotideSequenceId","value":"NM_198828.3"}],"isoformId":"O15021-4"},{"database":"RefSeq","id":"XP_006714669.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006714606.4"}],"isoformId":"O15021-2"},{"database":"PDB","id":"2W7R","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B=1140-1231"}]},{"database":"PDBsum","id":"2W7R","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"131980","properties":[{"key":"Interactions","value":"31"}]},{"database":"FunCoup","id":"O15021","properties":[{"key":"Number of interactors","value":"815"}]},{"database":"IntAct","id":"O15021","properties":[{"key":"Interactions","value":"40"}]},{"database":"MINT","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"MUSIC2-C5240-MAST4","properties":[{"key":"Evidences","value":"Osteosarcoma (U2OS) cell map - Regulation of gene expression and cell cycle progression (16 proteins)"}]},{"database":"STRING","id":"9606.ENSP00000385727","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2417351","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"O15021","properties":[{"key":"glycosylation","value":"8 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"MAST4","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000385727","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"18893","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"48378","properties":[{"key":"Description","value":"-"}],"isoformId":"O15021-5"},{"database":"ProteomicsDB","id":"48380","properties":[{"key":"Description","value":"-"}],"isoformId":"O15021-2"},{"database":"ProteomicsDB","id":"48381","properties":[{"key":"Description","value":"-"}],"isoformId":"O15021-3"},{"database":"ProteomicsDB","id":"48382","properties":[{"key":"Description","value":"-"}],"isoformId":"O15021-4"},{"database":"Pumba","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"627","properties":[{"key":"antibodies","value":"106 antibodies from 24 providers"}]},{"database":"DNASU","id":"375449","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000261569.11","properties":[{"key":"ProteinId","value":"ENSP00000261569.7"},{"key":"GeneId","value":"ENSG00000069020.19"}],"isoformId":"O15021-2"},{"database":"Ensembl","id":"ENST00000403625.7","properties":[{"key":"ProteinId","value":"ENSP00000385727.1"},{"key":"GeneId","value":"ENSG00000069020.19"}],"isoformId":"O15021-5"},{"database":"Ensembl","id":"ENST00000403666.5","properties":[{"key":"ProteinId","value":"ENSP00000384313.1"},{"key":"GeneId","value":"ENSG00000069020.19"}],"isoformId":"O15021-3"},{"database":"Ensembl","id":"ENST00000405643.5","properties":[{"key":"ProteinId","value":"ENSP00000384099.1"},{"key":"GeneId","value":"ENSG00000069020.19"}],"isoformId":"O15021-6"},{"database":"Ensembl","id":"ENST00000406374.5","properties":[{"key":"ProteinId","value":"ENSP00000385088.1"},{"key":"GeneId","value":"ENSG00000069020.19"}],"isoformId":"O15021-4"},{"database":"GeneID","id":"375449","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:375449","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000403625.7","properties":[{"key":"ProteinId","value":"ENSP00000385727.1"},{"key":"RefSeqNucleotideId","value":"NM_001164664.2"},{"key":"RefSeqProteinId","value":"NP_001158136.1"}]},{"database":"UCSC","id":"uc003jur.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"O15021-5"},{"database":"AGR","id":"HGNC:19037","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134920494","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"375449","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"375449","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"MAST4","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:19037","properties":[{"key":"GeneName","value":"MAST4"}]},{"database":"HPA","id":"ENSG00000069020","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"618002","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000069020","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000069020","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0606","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000156399","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"LERLGTX","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10070999at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"O15021","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000069020","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"375449","properties":[{"key":"hits","value":"20 hits in 1180 CRISPR screens"}]},{"database":"ChiTaRS","id":"MAST4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"O15021","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"375449","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"O15021","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:O15021","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"O15021","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000069020","properties":[{"key":"ExpressionPatterns","value":"Expressed in cervix squamous epithelium and 213 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"O15021","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0015630","properties":[{"key":"GoTerm","value":"C:microtubule cytoskeleton"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000287","properties":[{"key":"GoTerm","value":"F:magnesium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0106310","properties":[{"key":"GoTerm","value":"F:protein serine kinase activity"},{"key":"GoEvidenceType","value":"IEA:RHEA"}]},{"database":"GO","id":"GO:0004674","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007010","properties":[{"key":"GoTerm","value":"P:cytoskeleton organization"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0032502","properties":[{"key":"GoTerm","value":"P:developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0035556","properties":[{"key":"GoTerm","value":"P:intracellular signal transduction"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd23076","properties":[{"key":"EntryName","value":"PDZ_MAST4"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05609","properties":[{"key":"EntryName","value":"STKc_MAST"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.200.20:FF:001045","properties":[{"key":"EntryName","value":"Microtubule-associated serine/threonine kinase 1a"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000012","properties":[{"key":"EntryName","value":"microtubule-associated serine/threonine-protein kinase 2 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1480.20:FF:000001","properties":[{"key":"EntryName","value":"microtubule-associated serine/threonine-protein kinase 4 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.42.10:FF:000008","properties":[{"key":"EntryName","value":"microtubule-associated serine/threonine-protein kinase 4 isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.42.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1480.20","properties":[{"key":"EntryName","value":"MAST3 pre-PK domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000961","properties":[{"key":"EntryName","value":"AGC-kinase_C"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR037711","properties":[{"key":"EntryName","value":"MAST"}]},{"database":"InterPro","id":"IPR015022","properties":[{"key":"EntryName","value":"MAST_pre-PK_dom"}]},{"database":"InterPro","id":"IPR023142","properties":[{"key":"EntryName","value":"MAST_pre-PK_dom_sf"}]},{"database":"InterPro","id":"IPR001478","properties":[{"key":"EntryName","value":"PDZ"}]},{"database":"InterPro","id":"IPR041489","properties":[{"key":"EntryName","value":"PDZ_6"}]},{"database":"InterPro","id":"IPR036034","properties":[{"key":"EntryName","value":"PDZ_sf"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR008271","properties":[{"key":"EntryName","value":"Ser/Thr_kinase_AS"}]},{"database":"InterPro","id":"IPR050236","properties":[{"key":"EntryName","value":"Ser_Thr_kinase_AGC"}]},{"database":"PANTHER","id":"PTHR24356:SF224","properties":[{"key":"EntryName","value":"MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24356","properties":[{"key":"EntryName","value":"SERINE/THREONINE-PROTEIN KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08926","properties":[{"key":"EntryName","value":"DUF1908"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17820","properties":[{"key":"EntryName","value":"PDZ_6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00069","properties":[{"key":"EntryName","value":"Pkinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00228","properties":[{"key":"EntryName","value":"PDZ"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00220","properties":[{"key":"EntryName","value":"S_TKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF140482","properties":[{"key":"EntryName","value":"MAST3 pre-PK domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50156","properties":[{"key":"EntryName","value":"PDZ domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51285","properties":[{"key":"EntryName","value":"AGC_KINASE_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50106","properties":[{"key":"EntryName","value":"PDZ"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00108","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ST"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGEKVSEAPEPVPRGCSGHGSRTPASALVAASSPGASSAESSSGSETLSEEGEPGGFSREHQPPPPPPLGGTLGARAPAAWAPASVLLERGVLALPPPLPGGAVPPAPRGSSASQEEQDEELDHILSPPPMPFRKCSNPDVASGPGKSLKYKRQLSEDGRQLRRGSLGGALTGRYLLPNPVAGQAWPASAETSNLVRMRSQALGQSAPSLTASLKELSLPRRGSFCRTSNRKSLIGNGQSPALPRPHSPLSAHAGNSPQDSPRNFSPSASAHFSFARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPYQPTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRSLSPGRSPACCDHEIIMMNHVYKERFPKATAQMEERLKEIITSYSPDNVLPLADGVLSFTHHQIIELARDCLDKSHQGLITSRYFLELQHKLDKLLQEAHDRSESGELAFIKQLVRKILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGIKTDIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQKAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSHRFSKVFSSIDRITQNSAEEKEDSVDKTKSTTLPSTETLSWSSEYSEMQQLSTSNSSDTESNRHKLSSGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPPEECAQEEPEVTTPASTISSSTLSVGSFSEHLDQINGRSECVDSTDNSSKPSSEPASHMARQRLESTEKKKISGKVTKSLSASALSLMIPGDMFAVSPLGSPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQPIVIHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGLKAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKSRMVRRSKKSKKKESLERRRSLFKKLAKQPSPLLHTSRSFSCLNRSLSSGESLPGSPTHSLSPRSPTPSYRSTPDFPSGTNSSQSSSPSSSAPNSPAGSGHIRPSTLHGLAPKLGGQRYRSGRRKSAGNIPLSPLARTPSPTPQPTSPQRSPSPLLGHSLGNSKIAQAFPSKMHSPPTIVRHIVRPKSAEPPRSPLLKRVQSEEKLSPSYGSDKKHLCSRKHSLEVTQEEVQREQSQREAPLQSLDENVCDVPPLSRARPVEQGCLKRPVSRKVGRQESVDDLDRDKLKAKVVVKKADGFPEKQESHQKSHGPGSDLENFALFKLEEREKKVYPKAVERSSTFENKASMQEAPPLGSLLKDALHKQASVRASEGAMSDGRVPAEHRQGGGDFRRAPAPGTLQDGLCHSLDRGISGKGEGTEKSSQAKELLRCEKLDSKLANIDYLRKKMSLEDKEDNLCPVLKPKMTAGSHECLPGNPVRPTGGQQEPPPASESRAFVSSTHAAQMSAVSFVPLKALTGRVDSGTEKPGLVAPESPVRKSPSEYKLEGRSVSCLKPIEGTLDIALLSGPQASKTELPSPESAQSPSPSGDVRASVPPVLPSSSGKKNDTTSARELSPSSLKMNKSYLLEPWFLPPSRGLQNSPAVSLPDPEFKRDRKGPHPTARSPGTVMESNPQQREGSSPKHQDHTTDPKLLTCLGQNLHSPDLARPRCPLPPEASPSREKPGLRESSERGPPTARSERSAARADTCREPSMELCFPETAKTSDNSKNLLSVGRTHPDFYTQTQAMEKAWAPGGKTNHKDGPGEARPPPRDNSSLHSAGIPCEKELGKVRRGVEPKPEALLARRSLQPPGIESEKSEKLSSFPSLQKDGAKEPERKEQPLQRHPSSIPPPPLTAKDLSSPAARQHCSSPSHASGREPGAKPSTAEPSSSPQDPPKPVAAHSESSSHKPRPGPDPGPPKTKHPDRSLSSQKPSVGATKGKEPATQSLGGSSREGKGHSKSGPDVFPATPGSQNKASDGIGQGEGGPSVPLHTDRAPLDAKPQPTSGGRPLEVLEKPVHLPRPGHPGPSEPADQKLSAVGEKQTLSPKHPKPSTVKDCPTLCKQTDNRQTDKSPSQPAANTDRRAEGKKCTEALYAPAEGDKLEAGLSFVHSENRLKGAERPAAGVGKGFPEARGKGPGPQKPPTEADKPNGMKRSPSATGQSSFRSTALPEKSLSCSSSFPETRAGVREASAASSDTSSAKAAGGMLELPAPSNRDHRKAQPAGEGRTHMTKSDSLPSFRVSTLPLESHHPDPNTMGGASHRDRALSVTATVGETKGKDPAPAQPPPARKQNVGRDVTKPSPAPNTDRPISLSNEKDFVVRQRRGKESLRSSPHKKAL","length":2623,"molWeight":284097,"crc64":"983747097AC218E7","md5":"9D21F5BF4D5D60D4CD1C40B6E61A6D8F"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":2,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":5,"TISSUE SPECIFICITY":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":3,"Region":16,"Compositional bias":33,"Active site":1,"Binding site":2,"Modified residue":17,"Alternative sequence":6,"Natural variant":6,"Sequence conflict":5,"Beta strand":5,"Helix":2,"Turn":1},"uniParcId":"UPI000173A2B0"}}