{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O14980","secondaryAccessions":["A6NL14","A8K1K5","D6W5E2","Q63HP8","Q68CP3","Q99433"],"uniProtkbId":"XPO1_HUMAN","entryAudit":{"firstPublicDate":"2005-06-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1998-01-01","entryVersion":229,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Exportin-1"},"shortNames":[{"value":"Exp1"}]},"alternativeNames":[{"fullName":{"value":"Chromosome region maintenance 1 protein homolog"}}]},"genes":[{"geneName":{"value":"XPO1"},"synonyms":[{"value":"CRM1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574332"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20921223"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9311922"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9323133"}],"value":"Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9837918"}],"value":"(Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P5F9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10209022"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10358091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11425870"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11571268"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11932251"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12724356"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12808100"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15507209"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16103875"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16302269"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18316374"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20826784"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20921223"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22022502"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22084111"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22275354"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22500989"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22730302"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23164465"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28325843"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9049309"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9323133"}],"value":"Found in a U snRNA export complex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA (By similarity). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUP42, NUP88, NUP214, RANBP3 and TERT. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at 'Lys-129'. Interacts with DTNBP1 and SERTAD2; the interactions translocate DTNBP1 and SERTAD2 out of the nucleus. Interacts with ATF2. Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with CPEB3 (PubMed:22730302). Interacts with HAX1 (PubMed:23164465). Interacts with BOK; translocates to the cytoplasm (PubMed:16302269). Interacts with HSP90AB1 (PubMed:22022502). Interacts with LRPPRC; interacts with LRPPRC alone and also when LRPPRC is in complex with EIF4E and with EIF4E sensitivity element (4ESE)-containing mRNAs to form an EIF4E-dependent mRNA export complex (PubMed:28325843)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12134013"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15632073"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9837918"}],"value":"(Microbial infection) Interacts with HIV-1 Rev"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"}],"value":"(Microbial infection) Interacts with HTLV-1 Rex"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11119609"}],"value":"(Microbial infection) Interacts with influenza A nucleoprotein"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10400785"}],"value":"(Microbial infection) Interacts with Epstein-Barr virus protein BMLF1"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20147401"}],"value":"(Microbial infection) Part of a tetrameric complex composed of CRM1, importin alpha/beta dimer and the Venezuelan equine encephalitis virus (VEEV) capsid; this complex blocks the receptor-mediated transport through the nuclear pore"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21637748"}],"value":"(Microbial infection) Interacts with SARS-CoV virus protein ORF9b; this interaction mediates protein ORF9b export out of the nucleus"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O14980","intActId":"EBI-355867"},"interactantTwo":{"uniProtKBAccession":"O15392","geneName":"BIRC5","intActId":"EBI-518823"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14980","intActId":"EBI-355867"},"interactantTwo":{"uniProtKBAccession":"Q08211","geneName":"DHX9","intActId":"EBI-352022"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14980","intActId":"EBI-355867"},"interactantTwo":{"uniProtKBAccession":"P04626","geneName":"ERBB2","intActId":"EBI-641062"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14980","intActId":"EBI-355867"},"interactantTwo":{"uniProtKBAccession":"P42704","geneName":"LRPPRC","intActId":"EBI-1050853"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14980","intActId":"EBI-355867"},"interactantTwo":{"uniProtKBAccession":"P22736","geneName":"NR4A1","intActId":"EBI-721550"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14980","intActId":"EBI-355867"},"interactantTwo":{"uniProtKBAccession":"P35232","geneName":"PHB1","intActId":"EBI-354213"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14980","intActId":"EBI-355867"},"interactantTwo":{"uniProtKBAccession":"P61925","geneName":"PKIA","intActId":"EBI-2682139"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14980","intActId":"EBI-355867"},"interactantTwo":{"uniProtKBAccession":"P18754","geneName":"RCC1","intActId":"EBI-992720"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14980","intActId":"EBI-355867"},"interactantTwo":{"uniProtKBAccession":"O95149","geneName":"SNUPN","intActId":"EBI-714033"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14980","intActId":"EBI-355867"},"interactantTwo":{"uniProtKBAccession":"P04637","geneName":"TP53","intActId":"EBI-366083"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14980","intActId":"EBI-355867"},"interactantTwo":{"uniProtKBAccession":"P63104","geneName":"YWHAZ","intActId":"EBI-347088"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14980","intActId":"EBI-355867"},"interactantTwo":{"uniProtKBAccession":"P04618","geneName":"rev","intActId":"EBI-6164309"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O14980","intActId":"EBI-355867"},"interactantTwo":{"uniProtKBAccession":"Q9WMX2","intActId":"EBI-710918"},"numberOfExperiments":3,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm"}]},"subcellularLocations":[{"location":{"value":"Cytoplasm","id":"SL-0086"}},{"location":{"value":"Nucleus, nucleoplasm","id":"SL-0190"}},{"location":{"value":"Nucleus, Cajal body","id":"SL-0031"}},{"location":{"value":"Nucleus, nucleolus","id":"SL-0188"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9049309"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9368044"}],"value":"Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the exportin family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/44168/XPO1","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1071,"modifier":"EXACT"}},"description":"Exportin-1","featureId":"PRO_0000204705"},{"type":"Domain","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Importin N-terminal","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00115"}]},{"type":"Repeat","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"HEAT 1"},{"type":"Repeat","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"HEAT 2"},{"type":"Repeat","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":"HEAT 3"},{"type":"Repeat","location":{"start":{"value":515,"modifier":"EXACT"},"end":{"value":553,"modifier":"EXACT"}},"description":"HEAT 4"},{"type":"Repeat","location":{"start":{"value":560,"modifier":"EXACT"},"end":{"value":597,"modifier":"EXACT"}},"description":"HEAT 5"},{"type":"Repeat","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":639,"modifier":"EXACT"}},"description":"HEAT 6"},{"type":"Repeat","location":{"start":{"value":775,"modifier":"EXACT"},"end":{"value":813,"modifier":"EXACT"}},"description":"HEAT 7"},{"type":"Repeat","location":{"start":{"value":885,"modifier":"EXACT"},"end":{"value":916,"modifier":"EXACT"}},"description":"HEAT 8"},{"type":"Repeat","location":{"start":{"value":917,"modifier":"EXACT"},"end":{"value":954,"modifier":"EXACT"}},"description":"HEAT 9"},{"type":"Repeat","location":{"start":{"value":1002,"modifier":"EXACT"},"end":{"value":1039,"modifier":"EXACT"}},"description":"HEAT 10"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":679,"modifier":"EXACT"}},"description":"Necessary for HTLV-1 Rex-mediated mRNA export"},{"type":"Region","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"Interaction with Ran and nuclear export complex formation"},{"type":"Region","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"Interaction with RANBP3"},{"type":"Region","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"Necessary for HTLV-1 Rex multimerization"},{"type":"Region","location":{"start":{"value":800,"modifier":"EXACT"},"end":{"value":820,"modifier":"EXACT"}},"description":"Interaction with HIV-1 Rev"},{"type":"Modified residue","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":446,"modifier":"EXACT"},"end":{"value":446,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":448,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80U96"}]},{"type":"Modified residue","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80U96"}]},{"type":"Modified residue","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80U96"}]},{"type":"Modified residue","location":{"start":{"value":693,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1031,"modifier":"EXACT"},"end":{"value":1031,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Mutagenesis","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"Does not abolish Rex-mediated mRNA export.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"Does not abolish Rex-mediated mRNA export.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"Does not abolish Rex-mediated mRNA export.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Mutagenesis","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"Does not abolish Rex-mediated mRNA export.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Does not abolish Rex-mediated mRNA export.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"Does not abolish Rex-mediated mRNA export.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Mutagenesis","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"Strongly abolishes interaction with Rex and RANBP3, abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3; when associated with S-414. Abolishes Rex multimerization; when associated with S-414.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Mutagenesis","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Does not abolish interaction with Rex and RANBP3, and Rex-mediated mRNA export.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"Strongly abolishes interaction with Rex and RANBP3, abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3; when associated with T-411. Abolishes Rex multimerization; when associated with T-411.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":428,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"Abolishes Ran binding activity in absence of cargo and abolishes partially Ran binding activity in presence of cargo.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"}],"alternativeSequence":{"originalSequence":"EEVLVVENDQGEVVREFMKD","alternativeSequences":["QQVLVVQNNQGQVVRQFMKN"]}},{"type":"Mutagenesis","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":446,"modifier":"EXACT"}},"description":"Partially restores Ran binding activity in presence of cargo.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"}],"alternativeSequence":{"originalSequence":"VLVVENDQGEVVREFMK","alternativeSequences":["DEDEENDQGEDEEEDDD"]}},{"type":"Mutagenesis","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"Abolishes Ran binding activity both in absence or presence of cargo.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"}],"alternativeSequence":{"originalSequence":"VLVV","alternativeSequences":["DEDE"]}},{"type":"Mutagenesis","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"Does not abolish Ran binding activity and nuclear export complex formation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":474,"modifier":"EXACT"}},"description":"Strongly abolishes interaction with Rex and RANBP3, abolishes Rex-mediated mRNA export.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["I"]}},{"type":"Mutagenesis","location":{"start":{"value":481,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"Strongly abolishes interaction with Rex and RANBP3, abolishes Rex-mediated mRNA export.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":513,"modifier":"EXACT"},"end":{"value":513,"modifier":"EXACT"}},"description":"Abolishes Ran binding activity and nuclear export complex formation. Abolishes Ran binding activity and nuclear export complex formation; when associated with A-553 and A-554.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":525,"modifier":"EXACT"},"end":{"value":525,"modifier":"EXACT"}},"description":"Enhances Ran binding activity and does not abolish nuclear export complex formation. Does not abolish Ran binding activity and partially abolish nuclear export complex formation; when associated with A-561. Does not abolish Ran binding activity and partially abolish nuclear export complex formation; when associated with A-568 and A-572.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":550,"modifier":"EXACT"},"end":{"value":550,"modifier":"EXACT"}},"description":"Enhances Ran binding activity and does not abolish nuclear export complex formation; when associated with A-553 and A-590.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":553,"modifier":"EXACT"},"end":{"value":553,"modifier":"EXACT"}},"description":"Enhances Ran binding activity and does not abolish nuclear export complex formation; when associated with A-550 and A-590. Abolishes Ran binding activity and nuclear export complex formation; when associated with A-513 and A-554.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":554,"modifier":"EXACT"},"end":{"value":554,"modifier":"EXACT"}},"description":"Partially abolishes Ran binding activity and does not abolish nuclear export complex formation. Abolishes Ran binding activity and nuclear export complex formation; when associated with A-561. Abolishes Ran binding activity and nuclear export complex formation; when associated with A-553 and A-513.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":561,"modifier":"EXACT"},"end":{"value":561,"modifier":"EXACT"}},"description":"Abolishes Ran binding activity and nuclear export complex formation. Abolishes Ran binding activity and nuclear export complex formation; when associated with A-554. Does not abolish Ran binding activity and partially abolish nuclear export complex formation; when associated with A-525.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":568,"modifier":"EXACT"},"end":{"value":568,"modifier":"EXACT"}},"description":"Does not abolish Ran binding activity and partially abolish nuclear export complex formation; when associated with A-525 and A-572.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":572,"modifier":"EXACT"},"end":{"value":572,"modifier":"EXACT"}},"description":"Does not abolish Ran binding activity and partially abolish nuclear export complex formation; when associated with A-525 and A-568.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":583,"modifier":"EXACT"},"end":{"value":583,"modifier":"EXACT"}},"description":"Enhances Ran binding activity; when associated with A-590.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":590,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"Enhances Ran binding activity and does not abolish nuclear export complex formation. Enhances Ran binding activity and does not abolish nuclear export complex formation; when associated with A-583. Enhances Ran binding activity and does not abolish nuclear export complex formation; when associated with A-550 and A-553.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":406,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"in Ref. 4; CAH56174","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":953,"modifier":"EXACT"},"end":{"value":953,"modifier":"EXACT"}},"description":"in Ref. 4; CAH18695","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":989,"modifier":"EXACT"},"end":{"value":989,"modifier":"EXACT"}},"description":"in Ref. 4; CAH56174","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["I"]}},{"type":"Helix","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Beta strand","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Beta strand","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TVO"}]},{"type":"Helix","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Turn","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Turn","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Beta strand","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5DIS"}]},{"type":"Helix","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Turn","location":{"start":{"value":410,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":426,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Beta strand","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":434,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Beta strand","location":{"start":{"value":436,"modifier":"EXACT"},"end":{"value":438,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Beta strand","location":{"start":{"value":440,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":449,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":469,"modifier":"EXACT"},"end":{"value":484,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Beta strand","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":488,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GB8"}]},{"type":"Helix","location":{"start":{"value":491,"modifier":"EXACT"},"end":{"value":503,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Turn","location":{"start":{"value":504,"modifier":"EXACT"},"end":{"value":506,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":510,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":534,"modifier":"EXACT"},"end":{"value":549,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":552,"modifier":"EXACT"},"end":{"value":557,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":559,"modifier":"EXACT"},"end":{"value":572,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":580,"modifier":"EXACT"},"end":{"value":595,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":596,"modifier":"EXACT"},"end":{"value":599,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Beta strand","location":{"start":{"value":605,"modifier":"EXACT"},"end":{"value":608,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GB8"}]},{"type":"Helix","location":{"start":{"value":610,"modifier":"EXACT"},"end":{"value":615,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":618,"modifier":"EXACT"},"end":{"value":621,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":627,"modifier":"EXACT"},"end":{"value":642,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":647,"modifier":"EXACT"},"end":{"value":657,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":659,"modifier":"EXACT"},"end":{"value":674,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":676,"modifier":"EXACT"},"end":{"value":680,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":682,"modifier":"EXACT"},"end":{"value":702,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":704,"modifier":"EXACT"},"end":{"value":706,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7B51"}]},{"type":"Helix","location":{"start":{"value":711,"modifier":"EXACT"},"end":{"value":713,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":714,"modifier":"EXACT"},"end":{"value":735,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":738,"modifier":"EXACT"},"end":{"value":741,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":743,"modifier":"EXACT"},"end":{"value":763,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":769,"modifier":"EXACT"},"end":{"value":775,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":777,"modifier":"EXACT"},"end":{"value":789,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":793,"modifier":"EXACT"},"end":{"value":795,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":799,"modifier":"EXACT"},"end":{"value":811,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":812,"modifier":"EXACT"},"end":{"value":818,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":819,"modifier":"EXACT"},"end":{"value":834,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Turn","location":{"start":{"value":837,"modifier":"EXACT"},"end":{"value":839,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":842,"modifier":"EXACT"},"end":{"value":858,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":862,"modifier":"EXACT"},"end":{"value":865,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":868,"modifier":"EXACT"},"end":{"value":881,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Beta strand","location":{"start":{"value":884,"modifier":"EXACT"},"end":{"value":886,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GB8"}]},{"type":"Helix","location":{"start":{"value":887,"modifier":"EXACT"},"end":{"value":906,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":908,"modifier":"EXACT"},"end":{"value":914,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":915,"modifier":"EXACT"},"end":{"value":919,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":920,"modifier":"EXACT"},"end":{"value":931,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Beta strand","location":{"start":{"value":932,"modifier":"EXACT"},"end":{"value":934,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":936,"modifier":"EXACT"},"end":{"value":938,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TVO"}]},{"type":"Helix","location":{"start":{"value":939,"modifier":"EXACT"},"end":{"value":954,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Beta strand","location":{"start":{"value":961,"modifier":"EXACT"},"end":{"value":963,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5DIS"}]},{"type":"Beta strand","location":{"start":{"value":964,"modifier":"EXACT"},"end":{"value":966,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":970,"modifier":"EXACT"},"end":{"value":985,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":991,"modifier":"EXACT"},"end":{"value":1003,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Turn","location":{"start":{"value":1004,"modifier":"EXACT"},"end":{"value":1006,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Helix","location":{"start":{"value":1008,"modifier":"EXACT"},"end":{"value":1023,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Turn","location":{"start":{"value":1024,"modifier":"EXACT"},"end":{"value":1026,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W9C"}]},{"type":"Turn","location":{"start":{"value":1028,"modifier":"EXACT"},"end":{"value":1030,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GB8"}]},{"type":"Turn","location":{"start":{"value":1031,"modifier":"EXACT"},"end":{"value":1033,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9B62"}]},{"type":"Helix","location":{"start":{"value":1035,"modifier":"EXACT"},"end":{"value":1047,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5DIS"}]},{"type":"Helix","location":{"start":{"value":1053,"modifier":"EXACT"},"end":{"value":1055,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GB8"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0509","category":"Biological process","name":"mRNA transport"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"9049309","citationType":"journal article","authors":["Fornerod M.","van Deursen J.M.","van Baal S.","Reynolds A.","Davis D.","Murti K.G.","Fransen J.","Grosveld G."],"citationCrossReferences":[{"database":"PubMed","id":"9049309"},{"database":"DOI","id":"10.1093/emboj/16.4.807"}],"title":"The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88.","publicationDate":"1997","journal":"EMBO J.","firstPage":"807","lastPage":"816","volume":"16"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","PROTEIN SEQUENCE OF 757-765","INTERACTION WITH NUP88 AND NUP214","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"9368044","citationType":"journal article","authors":["Kudo N.","Kohchbin S.","Nishi K.","Kitano K.","Yanagida M.","Yoshida M.","Horinouchi S."],"citationCrossReferences":[{"database":"PubMed","id":"9368044"},{"database":"DOI","id":"10.1074/jbc.272.47.29742"}],"title":"Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"29742","lastPage":"29751","volume":"272"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Chronic myeloid leukemia cell","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Hippocampus","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"CI-590RJT58FU1V","citationType":"submission","authors":["Bienvenut W.V."],"publicationDate":"JUN-2005","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 45-54; 63-88; 105-112; 130-139; 159-190; 246-253; 296-305; 407-415; 424-442; 459-474; 480-492; 516-531; 538-553; 675-686; 701-722; 797-810; 873-883; 996-1012 AND 1017-1038","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"B-cell lymphoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"9323133","citationType":"journal article","authors":["Fornerod M.","Ohno M.","Yoshida M.","Mattaj I.W."],"citationCrossReferences":[{"database":"PubMed","id":"9323133"},{"database":"DOI","id":"10.1016/s0092-8674(00)80371-2"}],"title":"CRM1 is an export receptor for leucine-rich nuclear export signals.","publicationDate":"1997","journal":"Cell","firstPage":"1051","lastPage":"1060","volume":"90"},"referencePositions":["FUNCTION IN PROTEIN NUCLEAR EXPORT","IDENTIFICATION IN A NUCLEAR EXPORT COMPLEX WITH RAN"]},{"referenceNumber":10,"citation":{"id":"9311922","citationType":"journal article","authors":["Ossareh-Nazari B.","Bachelerie F.","Dargemont C."],"citationCrossReferences":[{"database":"PubMed","id":"9311922"},{"database":"DOI","id":"10.1126/science.278.5335.141"}],"title":"Evidence for a role of CRM1 in signal-mediated nuclear protein export.","publicationDate":"1997","journal":"Science","firstPage":"141","lastPage":"144","volume":"278"},"referencePositions":["FUNCTION IN PROTEIN NUCLEAR EXPORT"]},{"referenceNumber":11,"citation":{"id":"9837918","citationType":"journal article","authors":["Askjaer P.","Jensen T.H.","Nilsson J.","Englmeier L.","Kjems J."],"citationCrossReferences":[{"database":"PubMed","id":"9837918"},{"database":"DOI","id":"10.1074/jbc.273.50.33414"}],"title":"The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP.","publicationDate":"1998","journal":"J. Biol. Chem.","firstPage":"33414","lastPage":"33422","volume":"273"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH HIV-1 REV (MICROBIAL INFECTION)"]},{"referenceNumber":12,"citation":{"id":"10209022","citationType":"journal article","authors":["Paraskeva E.","Izaurralde E.","Bischoff F.R.","Huber J.","Kutay U.","Hartmann E.","Luehrmann R.","Goerlich D."],"citationCrossReferences":[{"database":"PubMed","id":"10209022"},{"database":"DOI","id":"10.1083/jcb.145.2.255"}],"title":"CRM1-mediated recycling of snurportin 1 to the cytoplasm.","publicationDate":"1999","journal":"J. Cell Biol.","firstPage":"255","lastPage":"264","volume":"145"},"referencePositions":["IDENTIFICATION IN A NUCLEAR EXPORT RECEPTOR COMPLEX","INTERACTION WITH IPO7; KPNB1 AND SNUPN","IDENTIFICATION IN A TRIMERIC EXPORT COMPLEX WITH RAN AND SNUPN"]},{"referenceNumber":13,"citation":{"id":"10400785","citationType":"journal article","authors":["Boyle S.M.","Ruvolo V.","Gupta A.K.","Swaminathan S."],"citationCrossReferences":[{"database":"PubMed","id":"10400785"},{"database":"DOI","id":"10.1128/jvi.73.8.6872-6881.1999"}],"title":"Association with the cellular export receptor CRM 1 mediates function and intracellular localization of Epstein-Barr virus SM protein, a regulator of gene expression.","publicationDate":"1999","journal":"J. Virol.","firstPage":"6872","lastPage":"6881","volume":"73"},"referencePositions":["INTERACTION WITH EBV BMLF1 (MICROBIAL INFECTION)"]},{"referenceNumber":14,"citation":{"id":"10430904","citationType":"journal article","authors":["Kudo N.","Matsumori N.","Taoka H.","Fujiwara D.","Schreiner E.P.","Wolff B.","Yoshida M.","Horinouchi S."],"citationCrossReferences":[{"database":"PubMed","id":"10430904"},{"database":"DOI","id":"10.1073/pnas.96.16.9112"}],"title":"Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region.","publicationDate":"1999","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"9112","lastPage":"9117","volume":"96"},"referencePositions":["INACTIVATION BY LMB"]},{"referenceNumber":15,"citation":{"id":"10358091","citationType":"journal article","authors":["Farjot G.","Sergeant A.","Mikaelian I."],"citationCrossReferences":[{"database":"PubMed","id":"10358091"},{"database":"DOI","id":"10.1074/jbc.274.24.17309"}],"title":"A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"17309","lastPage":"17317","volume":"274"},"referencePositions":["INTERACTION WITH NUP42"]},{"referenceNumber":16,"citation":{"id":"11571268","citationType":"journal article","authors":["Englmeier L.","Fornerod M.","Bischoff F.R.","Petosa C.","Mattaj I.W.","Kutay U."],"citationCrossReferences":[{"database":"PubMed","id":"11571268"},{"database":"DOI","id":"10.1093/embo-reports/kve200"}],"title":"RanBP3 influences interactions between CRM1 and its nuclear protein export substrates.","publicationDate":"2001","journal":"EMBO Rep.","firstPage":"926","lastPage":"932","volume":"2"},"referencePositions":["IDENTIFICATION IN A NUCLEAR EXPORT COMPLEX WITH RANBP3 AND RAN","INTERACTION WITH RANBP3"]},{"referenceNumber":17,"citation":{"id":"11119609","citationType":"journal article","authors":["Elton D.","Simpson-Holley M.","Archer K.","Medcalf L.","Hallam R.","McCauley J.","Digard P."],"citationCrossReferences":[{"database":"PubMed","id":"11119609"},{"database":"DOI","id":"10.1128/jvi.75.1.408-419.2001"}],"title":"Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway.","publicationDate":"2001","journal":"J. Virol.","firstPage":"408","lastPage":"419","volume":"75"},"referencePositions":["INTERACTION WITH INFLUENZA A NUCLEOPROTEIN (MICROBIAL INFECTION)"]},{"referenceNumber":18,"citation":{"id":"11425870","citationType":"journal article","authors":["Lindsay M.E.","Holaska J.M.","Welch K.","Paschal B.M.","Macara I.G."],"citationCrossReferences":[{"database":"PubMed","id":"11425870"},{"database":"DOI","id":"10.1083/jcb.153.7.1391"}],"title":"Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export.","publicationDate":"2001","journal":"J. Cell Biol.","firstPage":"1391","lastPage":"1402","volume":"153"},"referencePositions":["IDENTIFICATION IN A NUCLEAR EXPORT COMPLEX WITH RANBP3 AND RAN","INTERACTION WITH RANBP3"]},{"referenceNumber":19,"citation":{"id":"11932251","citationType":"journal article","authors":["Nemergut M.E.","Lindsay M.E.","Brownawell A.M.","Macara I.G."],"citationCrossReferences":[{"database":"PubMed","id":"11932251"},{"database":"DOI","id":"10.1074/jbc.c100620200"}],"title":"Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"17385","lastPage":"17388","volume":"277"},"referencePositions":["INTERACTION WITH RANBP3"]},{"referenceNumber":20,"citation":{"id":"12134013","citationType":"journal article","authors":["Hakata Y.","Yamada M.","Mabuchi N.","Shida H."],"citationCrossReferences":[{"database":"PubMed","id":"12134013"},{"database":"DOI","id":"10.1128/jvi.76.16.8079-8089.2002"}],"title":"The carboxy-terminal region of the human immunodeficiency virus type 1 protein Rev has multiple roles in mediating CRM1-related Rev functions.","publicationDate":"2002","journal":"J. Virol.","firstPage":"8079","lastPage":"8089","volume":"76"},"referencePositions":["INTERACTION WITH HIV-1 REV (MICROBIAL INFECTION)"]},{"referenceNumber":21,"citation":{"id":"12724356","citationType":"journal article","authors":["Thomas F.","Kutay U."],"citationCrossReferences":[{"database":"PubMed","id":"12724356"},{"database":"DOI","id":"10.1242/jcs.00464"}],"title":"Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway.","publicationDate":"2003","journal":"J. Cell Sci.","firstPage":"2409","lastPage":"2419","volume":"116"},"referencePositions":["IDENTIFICATION IN A 60S RIBOSOMAL SUBUNIT COMPLEX WITH RAN AND NMD3","INTERACTION WITH NMD3"]},{"referenceNumber":22,"citation":{"id":"12808100","citationType":"journal article","authors":["Haendeler J.","Hoffmann J.","Brandes R.P.","Zeiher A.M.","Dimmeler S."],"citationCrossReferences":[{"database":"PubMed","id":"12808100"},{"database":"DOI","id":"10.1128/mcb.23.13.4598-4610.2003"}],"title":"Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.","publicationDate":"2003","journal":"Mol. Cell. Biol.","firstPage":"4598","lastPage":"4610","volume":"23"},"referencePositions":["INTERACTION WITH TERT"]},{"referenceNumber":23,"citation":{"id":"14612415","citationType":"journal article","authors":["Hakata Y.","Yamada M.","Shida H."],"citationCrossReferences":[{"database":"PubMed","id":"14612415"},{"database":"DOI","id":"10.1128/mcb.23.23.8751-8761.2003"}],"title":"A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein.","publicationDate":"2003","journal":"Mol. Cell. Biol.","firstPage":"8751","lastPage":"8761","volume":"23"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","IDENTIFICATION IN A COMPLEX WITH HTLV-1 REX; RANBP3 AND RAN","INTERACTION WITH HTLV-1 REX (MICROBIAL INFECTION) AND RANBP3","MUTAGENESIS OF SER-191; VAL-284; ASP-334; ILE-337; THR-346; VAL-402; PRO-411; MET-412; PHE-414; ARG-474 AND HIS-481"]},{"referenceNumber":24,"citation":{"id":"15507209","citationType":"journal article","authors":["Yedavalli V.S.","Neuveut C.","Chi Y.-H.","Kleiman L.","Jeang K.-T."],"citationCrossReferences":[{"database":"PubMed","id":"15507209"},{"database":"DOI","id":"10.1016/j.cell.2004.09.029"}],"title":"Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function.","publicationDate":"2004","journal":"Cell","firstPage":"381","lastPage":"392","volume":"119"},"referencePositions":["INTERACTION WITH DDX3X"]},{"referenceNumber":25,"citation":{"id":"15574332","citationType":"journal article","authors":["Boulon S.","Verheggen C.","Jady B.E.","Girard C.","Pescia C.","Paul C.","Ospina J.K.","Kiss T.","Matera A.G.","Bordonne R.","Bertrand E."],"citationCrossReferences":[{"database":"PubMed","id":"15574332"},{"database":"DOI","id":"10.1016/j.molcel.2004.11.013"}],"title":"PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli.","publicationDate":"2004","journal":"Mol. Cell","firstPage":"777","lastPage":"787","volume":"16"},"referencePositions":["FUNCTION IN U3 SNORNA TRANSPORT","SUBCELLULAR LOCATION","RNA-BINDING"]},{"referenceNumber":26,"citation":{"id":"15632073","citationType":"journal article","authors":["Daelemans D.","Costes S.V.","Lockett S.","Pavlakis G.N."],"citationCrossReferences":[{"database":"PubMed","id":"15632073"},{"database":"DOI","id":"10.1128/mcb.25.2.728-739.2005"}],"title":"Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo.","publicationDate":"2005","journal":"Mol. Cell. Biol.","firstPage":"728","lastPage":"739","volume":"25"},"referencePositions":["INTERACTION WITH HIV-1 REV (MICROBIAL INFECTION)","SUBCELLULAR LOCATION"]},{"referenceNumber":27,"citation":{"id":"16103875","citationType":"journal article","authors":["Bi X.","Jones T.","Abbasi F.","Lee H.","Stultz B.","Hursh D.A.","Mortin M.A."],"citationCrossReferences":[{"database":"PubMed","id":"16103875"},{"database":"DOI","id":"10.1038/sj.onc.1208962"}],"title":"Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells.","publicationDate":"2005","journal":"Oncogene","firstPage":"8229","lastPage":"8239","volume":"24"},"referencePositions":["INTERACTION WITH NEMF"]},{"referenceNumber":28,"citation":{"id":"16302269","citationType":"journal article","authors":["Bartholomeusz G.","Wu Y.","Ali Seyed M.","Xia W.","Kwong K.Y.","Hortobagyi G.","Hung M.C."],"citationCrossReferences":[{"database":"PubMed","id":"16302269"},{"database":"DOI","id":"10.1002/mc.20156"}],"title":"Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis.","publicationDate":"2006","journal":"Mol. Carcinog.","firstPage":"73","lastPage":"83","volume":"45"},"referencePositions":["INTERACTION WITH BOK"]},{"referenceNumber":29,"citation":{"id":"16964243","citationType":"journal article","authors":["Beausoleil S.A.","Villen J.","Gerber S.A.","Rush J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"16964243"},{"database":"DOI","id":"10.1038/nbt1240"}],"title":"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.","publicationDate":"2006","journal":"Nat. Biotechnol.","firstPage":"1285","lastPage":"1292","volume":"24"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":30,"citation":{"id":"18316374","citationType":"journal article","authors":["Cheong J.K.","Gunaratnam L.","Hsu S.I."],"citationCrossReferences":[{"database":"PubMed","id":"18316374"},{"database":"DOI","id":"10.1074/jbc.m708365200"}],"title":"CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"11661","lastPage":"11676","volume":"283"},"referencePositions":["INTERACTION WITH SERTAD2"]},{"referenceNumber":31,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":32,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":33,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-446 AND LYS-693","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":34,"citation":{"id":"20826784","citationType":"journal article","authors":["Wang H.","Holloway M.P.","Ma L.","Cooper Z.A.","Riolo M.","Samkari A.","Elenitoba-Johnson K.S.","Chin Y.E.","Altura R.A."],"citationCrossReferences":[{"database":"PubMed","id":"20826784"},{"database":"DOI","id":"10.1074/jbc.m110.152777"}],"title":"Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"36129","lastPage":"36137","volume":"285"},"referencePositions":["INTERACTION WITH BIRC5/SURVIVIN"]},{"referenceNumber":35,"citation":{"id":"20147401","citationType":"journal article","authors":["Atasheva S.","Fish A.","Fornerod M.","Frolova E.I."],"citationCrossReferences":[{"database":"PubMed","id":"20147401"},{"database":"DOI","id":"10.1128/jvi.02554-09"}],"title":"Venezuelan equine encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin alpha/beta that obstructs nuclear pore complex function.","publicationDate":"2010","journal":"J. Virol.","firstPage":"4158","lastPage":"4171","volume":"84"},"referencePositions":["IDENTIFICATION IN COMPLEX WITH CRM1 AND VENEZUELAN EQUINE ENCEPHALITIS VIRUS CAPSID PROTEIN (MICROBIAL INFECTION)"]},{"referenceNumber":36,"citation":{"id":"20921223","citationType":"journal article","authors":["Fei E.","Ma X.","Zhu C.","Xue T.","Yan J.","Xu Y.","Zhou J.","Wang G."],"citationCrossReferences":[{"database":"PubMed","id":"20921223"},{"database":"DOI","id":"10.1074/jbc.m110.107912"}],"title":"Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"38630","lastPage":"38640","volume":"285"},"referencePositions":["INTERACTION WITH DTNBP1","FUNCTION"]},{"referenceNumber":37,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":38,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":39,"citation":{"id":"22022502","citationType":"journal article","authors":["Echeverria P.C.","Bernthaler A.","Dupuis P.","Mayer B.","Picard D."],"citationCrossReferences":[{"database":"PubMed","id":"22022502"},{"database":"DOI","id":"10.1371/journal.pone.0026044"}],"title":"An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine.","publicationDate":"2011","journal":"PLoS ONE","firstPage":"E26044","lastPage":"E26044","volume":"6"},"referencePositions":["INTERACTION WITH HSP90AB1"]},{"referenceNumber":40,"citation":{"id":"21637748","citationType":"journal article","authors":["Sharma K.","Aakerstroem S.","Sharma A.K.","Chow V.T.","Teow S.","Abrenica B.","Booth S.A.","Booth T.F.","Mirazimi A.","Lal S.K."],"citationCrossReferences":[{"database":"PubMed","id":"21637748"},{"database":"DOI","id":"10.1371/journal.pone.0019436"}],"title":"SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.","publicationDate":"2011","journal":"PLoS ONE","firstPage":"e19436","lastPage":"e19436","volume":"6"},"referencePositions":["INTERACTION WITH SARS-COV VIRUS PROTEIN ORF9B (MICROBIAL INFECTION)"]},{"referenceNumber":41,"citation":{"id":"22500989","citationType":"journal article","authors":["Wu F.","Wang S.","Xing J.","Li M.","Zheng C."],"citationCrossReferences":[{"database":"PubMed","id":"22500989"},{"database":"DOI","id":"10.1016/j.febslet.2012.02.053"}],"title":"Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A).","publicationDate":"2012","journal":"FEBS Lett.","firstPage":"1079","lastPage":"1085","volume":"586"},"referencePositions":["INTERACTION WITH DCAF8"]},{"referenceNumber":42,"citation":{"id":"22084111","citationType":"journal article","authors":["Krapivinsky G.","Krapivinsky L.","Stotz S.C.","Manasian Y.","Clapham D.E."],"citationCrossReferences":[{"database":"PubMed","id":"22084111"},{"database":"DOI","id":"10.1073/pnas.1117231108"}],"title":"POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.","publicationDate":"2011","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"19234","lastPage":"19239","volume":"108"},"referencePositions":["INTERACTION WITH SLC35G1 AND STIM1"]},{"referenceNumber":43,"citation":{"id":"22275354","citationType":"journal article","authors":["Hsu C.C.","Hu C.D."],"citationCrossReferences":[{"database":"PubMed","id":"22275354"},{"database":"DOI","id":"10.1074/jbc.m111.294272"}],"title":"Critical role of N-terminal end-localized nuclear export signal in regulation of activating transcription factor 2 (ATF2) subcellular localization and transcriptional activity.","publicationDate":"2012","journal":"J. Biol. Chem.","firstPage":"8621","lastPage":"8632","volume":"287"},"referencePositions":["INTERACTION WITH ATF2"]},{"referenceNumber":44,"citation":{"id":"22730302","citationType":"journal article","authors":["Chao H.W.","Lai Y.T.","Lu Y.L.","Lin C.L.","Mai W.","Huang Y.S."],"citationCrossReferences":[{"database":"PubMed","id":"22730302"},{"database":"DOI","id":"10.1093/nar/gks598"}],"title":"NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3.","publicationDate":"2012","journal":"Nucleic Acids Res.","firstPage":"8484","lastPage":"8498","volume":"40"},"referencePositions":["INTERACTION WITH CPEB3"]},{"referenceNumber":45,"citation":{"id":"23164465","citationType":"journal article","authors":["Grzybowska E.A.","Zayat V.","Konopinski R.","Trebinska A.","Szwarc M.","Sarnowska E.","Macech E.","Korczynski J.","Knapp A.","Siedlecki J.A."],"citationCrossReferences":[{"database":"PubMed","id":"23164465"},{"database":"DOI","id":"10.1111/febs.12066"}],"title":"HAX-1 is a nucleocytoplasmic shuttling protein with a possible role in mRNA processing.","publicationDate":"2013","journal":"FEBS J.","firstPage":"256","lastPage":"272","volume":"280"},"referencePositions":["INTERACTION WITH HAX1"]},{"referenceNumber":46,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391 AND SER-1031","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":47,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":48,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":49,"citation":{"id":"28325843","citationType":"journal article","authors":["Volpon L.","Culjkovic-Kraljacic B.","Sohn H.S.","Blanchet-Cohen A.","Osborne M.J.","Borden K.L.B."],"citationCrossReferences":[{"database":"PubMed","id":"28325843"},{"database":"DOI","id":"10.1261/rna.060137.116"}],"title":"A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.","publicationDate":"2017","journal":"RNA","firstPage":"927","lastPage":"937","volume":"23"},"referencePositions":["INTERACTION WITH LRPPRC"]},{"referenceNumber":50,"citation":{"id":"15574331","citationType":"journal article","authors":["Petosa C.","Schoehn G.","Askjaer P.","Bauer U.","Moulin M.","Steuerwald U.","Soler-Lopez M.","Baudin F.","Mattaj I.W.","Mueller C.W."],"citationCrossReferences":[{"database":"PubMed","id":"15574331"},{"database":"DOI","id":"10.1016/j.molcel.2004.11.018"}],"title":"Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex.","publicationDate":"2004","journal":"Mol. Cell","firstPage":"761","lastPage":"775","volume":"16"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 707-1027","ELECTRON MICROSCOPY (22 ANGSTROMS)","IDENTIFICATION IN A NUCLEAR EXPORT COMPLEX WITH RAN","MUTAGENESIS OF 428-GLU--ASP-447; 430-VAL--LYS-446; 430-VAL--VAL-433; TYR-454; GLU-513; LEU-525; GLN-550; ARG-553; PHE-554; PHE-561; LYS-568; PHE-572; MET-583 AND LYS-590"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Y08614","properties":[{"key":"ProteinId","value":"CAA69905.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D89729","properties":[{"key":"ProteinId","value":"BAA23415.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK289920","properties":[{"key":"ProteinId","value":"BAF82609.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BX647758","properties":[{"key":"ProteinId","value":"CAH56174.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR749840","properties":[{"key":"ProteinId","value":"CAH18695.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC016727","properties":[{"key":"ProteinId","value":"AAY14949.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471053","properties":[{"key":"ProteinId","value":"EAW99993.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471053","properties":[{"key":"ProteinId","value":"EAW99994.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC032847","properties":[{"key":"ProteinId","value":"AAH32847.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS33205.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_003391.1","properties":[{"key":"NucleotideSequenceId","value":"NM_003400.4"}]},{"database":"RefSeq","id":"XP_006712157.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006712094.4"}]},{"database":"RefSeq","id":"XP_011531399.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011533097.2"}]},{"database":"RefSeq","id":"XP_024308893.1","properties":[{"key":"NucleotideSequenceId","value":"XM_024453125.2"}]},{"database":"RefSeq","id":"XP_047301714.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047445758.1"}]},{"database":"RefSeq","id":"XP_047301715.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047445759.1"}]},{"database":"RefSeq","id":"XP_047301716.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047445760.1"}]},{"database":"RefSeq","id":"XP_054199748.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054343773.1"}]},{"database":"RefSeq","id":"XP_054199749.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054343774.1"}]},{"database":"RefSeq","id":"XP_054199750.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054343775.1"}]},{"database":"RefSeq","id":"XP_054199751.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054343776.1"}]},{"database":"RefSeq","id":"XP_054199752.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054343777.1"}]},{"database":"RefSeq","id":"XP_054199753.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054343778.1"}]},{"database":"PDB","id":"1W9C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B=707-1027"}]},{"database":"PDB","id":"2L1L","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=504-630"}]},{"database":"PDB","id":"3GB8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=1-1071"}]},{"database":"PDB","id":"4BSM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"4.50 A"},{"key":"Chains","value":"A=1-1032"}]},{"database":"PDB","id":"4BSN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"4.10 A"},{"key":"Chains","value":"A=1-1032"}]},{"database":"PDB","id":"5DIS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"A=5-1048"}]},{"database":"PDB","id":"6TVO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=1-1036"}]},{"database":"PDB","id":"7B51","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.58 A"},{"key":"Chains","value":"A=1-1036"}]},{"database":"PDB","id":"8URJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.25 A"},{"key":"Chains","value":"A/C=1-1056"}]},{"database":"PDB","id":"9B62","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=1-1071"}]},{"database":"PDB","id":"9HFL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.62 A"},{"key":"Chains","value":"A=1-1071"}]},{"database":"PDB","id":"9OG9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.93 A"},{"key":"Chains","value":"A=1-1071"}]},{"database":"PDB","id":"9OGA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.37 A"},{"key":"Chains","value":"A=1-1071"}]},{"database":"PDB","id":"9OGB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.25 A"},{"key":"Chains","value":"A=1-1071"}]},{"database":"PDB","id":"9OGC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.37 A"},{"key":"Chains","value":"A=1-1071"}]},{"database":"PDB","id":"9OGD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.49 A"},{"key":"Chains","value":"A=1-1071"}]},{"database":"PDB","id":"9OGE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.28 A"},{"key":"Chains","value":"A=1-1071"}]},{"database":"PDB","id":"9OGF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.21 A"},{"key":"Chains","value":"A=1-1071"}]},{"database":"PDBsum","id":"1W9C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2L1L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3GB8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4BSM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4BSN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5DIS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TVO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B51","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8URJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9B62","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HFL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OG9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OGA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OGB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OGC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OGD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OGE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OGF","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42494","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44235","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44236","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44237","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44238","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44239","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44240","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44241","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44242","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44243","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52115","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-6231","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70458","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70459","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70460","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70461","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70462","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70463","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70464","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"113348","properties":[{"key":"Interactions","value":"1588"}]},{"database":"CORUM","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-33678N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O14980","properties":[{"key":"Number of interactors","value":"5071"}]},{"database":"IntAct","id":"O14980","properties":[{"key":"Interactions","value":"238"}]},{"database":"MINT","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-XPO1","properties":[{"key":"Evidences","value":"13 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000384863","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL5661","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB16153","properties":[{"key":"GenericName","value":"Eltanexor"}]},{"database":"DrugBank","id":"DB21067","properties":[{"key":"GenericName","value":"Felezonexor"}]},{"database":"DrugBank","id":"DB11942","properties":[{"key":"GenericName","value":"Selinexor"}]},{"database":"DrugCentral","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"3014","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.I.1.1.3","properties":[{"key":"FamilyName","value":"the nuclear pore complex (npc) family"}]},{"database":"GlyGen","id":"O14980","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (2 sites)"}]},{"database":"iPTMnet","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"XPO1","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000384863","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"48356","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"4124","properties":[{"key":"antibodies","value":"372 antibodies from 38 providers"}]},{"database":"DNASU","id":"7514","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000401558.7","properties":[{"key":"ProteinId","value":"ENSP00000384863.2"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000404992.6","properties":[{"key":"ProteinId","value":"ENSP00000385942.2"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000406957.5","properties":[{"key":"ProteinId","value":"ENSP00000385559.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000676553.1","properties":[{"key":"ProteinId","value":"ENSP00000504247.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000676667.1","properties":[{"key":"ProteinId","value":"ENSP00000503809.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000677150.1","properties":[{"key":"ProteinId","value":"ENSP00000503167.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000677239.1","properties":[{"key":"ProteinId","value":"ENSP00000504087.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000677417.1","properties":[{"key":"ProteinId","value":"ENSP00000503572.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000677813.1","properties":[{"key":"ProteinId","value":"ENSP00000504543.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000677814.1","properties":[{"key":"ProteinId","value":"ENSP00000504848.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000677928.1","properties":[{"key":"ProteinId","value":"ENSP00000504198.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000677933.1","properties":[{"key":"ProteinId","value":"ENSP00000503482.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000678182.1","properties":[{"key":"ProteinId","value":"ENSP00000504594.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000678790.1","properties":[{"key":"ProteinId","value":"ENSP00000503419.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000852809.1","properties":[{"key":"ProteinId","value":"ENSP00000522868.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000852810.1","properties":[{"key":"ProteinId","value":"ENSP00000522869.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000852812.1","properties":[{"key":"ProteinId","value":"ENSP00000522871.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000852815.1","properties":[{"key":"ProteinId","value":"ENSP00000522874.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000852816.1","properties":[{"key":"ProteinId","value":"ENSP00000522875.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000852819.1","properties":[{"key":"ProteinId","value":"ENSP00000522878.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000852821.1","properties":[{"key":"ProteinId","value":"ENSP00000522880.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000933475.1","properties":[{"key":"ProteinId","value":"ENSP00000603534.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000933477.1","properties":[{"key":"ProteinId","value":"ENSP00000603536.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000933478.1","properties":[{"key":"ProteinId","value":"ENSP00000603537.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000933482.1","properties":[{"key":"ProteinId","value":"ENSP00000603541.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000933485.1","properties":[{"key":"ProteinId","value":"ENSP00000603544.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000933486.1","properties":[{"key":"ProteinId","value":"ENSP00000603545.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000945827.1","properties":[{"key":"ProteinId","value":"ENSP00000615886.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000945828.1","properties":[{"key":"ProteinId","value":"ENSP00000615887.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000945831.1","properties":[{"key":"ProteinId","value":"ENSP00000615890.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000945832.1","properties":[{"key":"ProteinId","value":"ENSP00000615891.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"Ensembl","id":"ENST00000945834.1","properties":[{"key":"ProteinId","value":"ENSP00000615893.1"},{"key":"GeneId","value":"ENSG00000082898.20"}]},{"database":"GeneID","id":"7514","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:7514","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000401558.7","properties":[{"key":"ProteinId","value":"ENSP00000384863.2"},{"key":"RefSeqNucleotideId","value":"NM_003400.4"},{"key":"RefSeqProteinId","value":"NP_003391.1"}]},{"database":"UCSC","id":"uc002sbj.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:12825","properties":[{"key":"Description","value":"-"}]},{"database":"CIViC","id":"7514","properties":[{"key":"Number of evidences","value":"1 evidence item across 2 molecular profiles"}]},{"database":"ClinPGx","id":"PA37418","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"7514","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"7514","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"XPO1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:12825","properties":[{"key":"GeneName","value":"XPO1"}]},{"database":"HPA","id":"ENSG00000082898","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"XPO1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"602559","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000082898","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"261349","properties":[{"key":"Disease","value":"2p15p16.1 microdeletion syndrome"}]},{"database":"Orphanet","id":"528084","properties":[{"key":"Disease","value":"Non-specific syndromic intellectual disability"}]},{"database":"Orphanet","id":"98838","properties":[{"key":"Disease","value":"Primary mediastinal large B-cell lymphoma"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000082898","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2020","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000153408","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_011906_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WAFKHNN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"27218at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"O14980","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-141444","properties":[{"key":"PathwayName","value":"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"}]},{"database":"Reactome","id":"R-HSA-165054","properties":[{"key":"PathwayName","value":"Rev-mediated nuclear export of HIV RNA"}]},{"database":"Reactome","id":"R-HSA-168333","properties":[{"key":"PathwayName","value":"NEP/NS2 Interacts with the Cellular Export Machinery"}]},{"database":"Reactome","id":"R-HSA-2173788","properties":[{"key":"PathwayName","value":"Downregulation of TGF-beta receptor signaling"}]},{"database":"Reactome","id":"R-HSA-2467813","properties":[{"key":"PathwayName","value":"Separation of Sister Chromatids"}]},{"database":"Reactome","id":"R-HSA-2500257","properties":[{"key":"PathwayName","value":"Resolution of Sister Chromatid Cohesion"}]},{"database":"Reactome","id":"R-HSA-3769402","properties":[{"key":"PathwayName","value":"Deactivation of the beta-catenin transactivating complex"}]},{"database":"Reactome","id":"R-HSA-450520","properties":[{"key":"PathwayName","value":"HuR (ELAVL1) binds and stabilizes mRNA"}]},{"database":"Reactome","id":"R-HSA-5663220","properties":[{"key":"PathwayName","value":"RHO GTPases Activate Formins"}]},{"database":"Reactome","id":"R-HSA-5687128","properties":[{"key":"PathwayName","value":"MAPK6/MAPK4 signaling"}]},{"database":"Reactome","id":"R-HSA-68877","properties":[{"key":"PathwayName","value":"Mitotic Prometaphase"}]},{"database":"Reactome","id":"R-HSA-69273","properties":[{"key":"PathwayName","value":"Cyclin A/B1/B2 associated events during G2/M transition"}]},{"database":"Reactome","id":"R-HSA-9634638","properties":[{"key":"PathwayName","value":"Estrogen-dependent nuclear events downstream of ESR-membrane signaling"}]},{"database":"Reactome","id":"R-HSA-9648025","properties":[{"key":"PathwayName","value":"EML4 and NUDC in mitotic spindle formation"}]},{"database":"Reactome","id":"R-HSA-9707616","properties":[{"key":"PathwayName","value":"Heme signaling"}]},{"database":"Reactome","id":"R-HSA-9768919","properties":[{"key":"PathwayName","value":"NPAS4 regulates expression of target genes"}]},{"database":"Reactome","id":"R-HSA-9828806","properties":[{"key":"PathwayName","value":"Maturation of hRSV A proteins"}]},{"database":"Reactome","id":"R-HSA-9856649","properties":[{"key":"PathwayName","value":"Transcriptional and post-translational regulation of MITF-M expression and activity"}]},{"database":"Reactome","id":"R-HSA-9918432","properties":[{"key":"PathwayName","value":"Maturation of DENV proteins"}]},{"database":"SignaLink","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000082898","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"7514","properties":[{"key":"hits","value":"740 hits in 1180 CRISPR screens"}]},{"database":"CD-CODE","id":"6F24707C","properties":[{"key":"EntryName","value":"Cajal body"}]},{"database":"CD-CODE","id":"804901D1","properties":[{"key":"EntryName","value":"Nuclear speckle"}]},{"database":"CD-CODE","id":"8C2F96ED","properties":[{"key":"EntryName","value":"Centrosome"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"CD-CODE","id":"B5B9A610","properties":[{"key":"EntryName","value":"PML body"}]},{"database":"CD-CODE","id":"BC3C46DC","properties":[{"key":"EntryName","value":"Synthetic Condensate 000257"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"XPO1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"O14980","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"XPO1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"7514","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"O14980","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:O14980","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"O14980","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000082898","properties":[{"key":"ExpressionPatterns","value":"Expressed in tibia and 214 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"O14980","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005642","properties":[{"key":"GoTerm","value":"C:annulate lamellae"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12210765"}]},{"database":"GO","id":"GO:0015030","properties":[{"key":"GoTerm","value":"C:Cajal body"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23782956"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0000776","properties":[{"key":"GoTerm","value":"C:kinetochore"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17363900"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0005635","properties":[{"key":"GoTerm","value":"C:nuclear envelope"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9368044"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23782956"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10557333"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29666234"}]},{"database":"GO","id":"GO:1990904","properties":[{"key":"GoTerm","value":"C:ribonucleoprotein complex"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18809582"}]},{"database":"GO","id":"GO:0140297","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005049","properties":[{"key":"GoTerm","value":"F:nuclear export signal receptor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29666234"}]},{"database":"GO","id":"GO:0019904","properties":[{"key":"GoTerm","value":"F:protein domain specific binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031267","properties":[{"key":"GoTerm","value":"F:small GTPase binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:1902075","properties":[{"key":"GoTerm","value":"P:cellular response to salt"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071401","properties":[{"key":"GoTerm","value":"P:cellular response to triglyceride"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006406","properties":[{"key":"GoTerm","value":"P:mRNA export from nucleus"},{"key":"GoEvidenceType","value":"ISS:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"31340148"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006913","properties":[{"key":"GoTerm","value":"P:nucleocytoplasmic transport"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11000203"}]},{"database":"GO","id":"GO:0006611","properties":[{"key":"GoTerm","value":"P:protein export from nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29666234"}]},{"database":"GO","id":"GO:0032434","properties":[{"key":"GoTerm","value":"P:regulation of proteasomal ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29666234"}]},{"database":"GO","id":"GO:0009410","properties":[{"key":"GoTerm","value":"P:response to xenobiotic stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0000055","properties":[{"key":"GoTerm","value":"P:ribosomal large subunit export from nucleus"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12773398"}]},{"database":"GO","id":"GO:0000056","properties":[{"key":"GoTerm","value":"P:ribosomal small subunit export from nucleus"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12773398"}]},{"database":"GO","id":"GO:0000054","properties":[{"key":"GoTerm","value":"P:ribosomal subunit export from nucleus"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12724356"}]},{"database":"GO","id":"GO:0042254","properties":[{"key":"GoTerm","value":"P:ribosome biogenesis"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12724356"}]},{"database":"FunFam","id":"1.25.10.10:FF:001255","properties":[{"key":"EntryName","value":"Exportin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.10.10","properties":[{"key":"EntryName","value":"Leucine-rich Repeat Variant"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00357","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR011989","properties":[{"key":"EntryName","value":"ARM-like"}]},{"database":"InterPro","id":"IPR016024","properties":[{"key":"EntryName","value":"ARM-type_fold"}]},{"database":"InterPro","id":"IPR041123","properties":[{"key":"EntryName","value":"CRM1_repeat"}]},{"database":"InterPro","id":"IPR041235","properties":[{"key":"EntryName","value":"Exp1_repeat_2"}]},{"database":"InterPro","id":"IPR013598","properties":[{"key":"EntryName","value":"Exportin-1/Importin-b-like"}]},{"database":"InterPro","id":"IPR001494","properties":[{"key":"EntryName","value":"Importin-beta_N"}]},{"database":"InterPro","id":"IPR045065","properties":[{"key":"EntryName","value":"XPO1/5"}]},{"database":"InterPro","id":"IPR014877","properties":[{"key":"EntryName","value":"XPO1_C_dom"}]},{"database":"InterPro","id":"IPR040485","properties":[{"key":"EntryName","value":"XPO1_repeat_3"}]},{"database":"PANTHER","id":"PTHR11223","properties":[{"key":"EntryName","value":"EXPORTIN 1/5"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11223:SF2","properties":[{"key":"EntryName","value":"EXPORTIN-1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08767","properties":[{"key":"EntryName","value":"CRM1_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18777","properties":[{"key":"EntryName","value":"CRM1_repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18784","properties":[{"key":"EntryName","value":"CRM1_repeat_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18787","properties":[{"key":"EntryName","value":"CRM1_repeat_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03810","properties":[{"key":"EntryName","value":"IBN_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08389","properties":[{"key":"EntryName","value":"Xpo1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01102","properties":[{"key":"EntryName","value":"CRM1_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00913","properties":[{"key":"EntryName","value":"IBN_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48371","properties":[{"key":"EntryName","value":"ARM repeat"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50166","properties":[{"key":"EntryName","value":"IMPORTIN_B_NT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFDFSSGQITQVKSKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFVTLFTLTMMQLKQMLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHDQLIEKRLNLRETLMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDVPPRRQLYLPMLFKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTERIMTEKLHNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFLAIPPTQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKISTSLNPGNPVNNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDTSDLFLEEREIALRQADEEKHKRQMSVPGIFNPHEIPEEMCD","length":1071,"molWeight":123386,"crc64":"FDB00C065DA2FB1D","md5":"80D49CC2DA16D3A554D304B757DB5D87"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":7,"INTERACTION":13,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"MISCELLANEOUS":1,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Domain":1,"Repeat":10,"Region":5,"Modified residue":7,"Mutagenesis":25,"Sequence conflict":3,"Helix":72,"Beta strand":12,"Turn":9},"uniParcId":"UPI0000001C23"}}