{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O14786","secondaryAccessions":["B0LPG9","O60461","Q5T7F1","Q5T7F2","Q5T7F3","Q86T59","Q96I90","Q96IH5"],"uniProtkbId":"NRP1_HUMAN","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-09-23","entryVersion":243,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Neuropilin-1"}},"alternativeNames":[{"fullName":{"value":"Vascular endothelial cell growth factor 165 receptor"}}],"cdAntigenNames":[{"value":"CD304"}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:8004"}],"value":"NRP1"},"synonyms":[{"value":"NRP"},{"value":"VEGF165R"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97333"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10688880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19805273"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30623799"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9288753"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9529250"}],"value":"Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed:10688880, PubMed:9288753, PubMed:9529250). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed:19805273). It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed:10688880, PubMed:19805273, PubMed:9288753, PubMed:9529250). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33082293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33082294"}],"value":"(Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10748121"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26503042"}],"value":"Binds VEGF-165 and may inhibit its binding to cells (PubMed:10748121, PubMed:26503042). May induce apoptosis by sequestering VEGF-165 (PubMed:10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97333"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10520995"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17989695"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19805273"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26503042"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30623799"}],"value":"Homodimer, and heterodimer with NRP2 (PubMed:17989695). Interacts with FER (By similarity). Interacts with PLXNB1 (PubMed:10520995). Interacts with VEGFA (PubMed:19805273, PubMed:26503042). Interacts with ABCB8/MITOSUR in mitochondria (PubMed:30623799)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33082294"}],"value":"(Microbial infection) Interacts with SARS coronavirus-2/SARS-CoV-2 spike protein S1 (via the CendR motif RRAR)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O14786","intActId":"EBI-1187100"},"interactantTwo":{"uniProtKBAccession":"P21333","geneName":"FLNA","intActId":"EBI-350432"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14786","intActId":"EBI-1187100"},"interactantTwo":{"uniProtKBAccession":"P08648","geneName":"ITGA5","intActId":"EBI-1382311"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14786","intActId":"EBI-1187100"},"interactantTwo":{"uniProtKBAccession":"P35968","geneName":"KDR","intActId":"EBI-1005487"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14786","intActId":"EBI-1187100"},"interactantTwo":{"uniProtKBAccession":"P15692","geneName":"VEGFA","intActId":"EBI-1026643"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14786","intActId":"EBI-1187100"},"interactantTwo":{"uniProtKBAccession":"P15692-4","geneName":"VEGFA","intActId":"EBI-1026691"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14786","intActId":"EBI-1187100"},"interactantTwo":{"uniProtKBAccession":"P0DTC2","geneName":"S","intActId":"EBI-25474821"},"numberOfExperiments":9,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O14786-2","intActId":"EBI-6285281"},"interactantTwo":{"uniProtKBAccession":"P15692-4","geneName":"VEGFA","intActId":"EBI-1026691"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 2","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10688880"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"30623799"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30623799"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30623799"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34742300"}],"value":"(Microbial infection) Proteolytically cleaved at the cell membrane upon H.pylori infection"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34742300"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"Membrane-bound"}],"isoformIds":["O14786-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10688880"}],"value":"Soluble"},{"value":"SNRP1"}],"isoformIds":["O14786-2"],"sequenceIds":["VSP_004339","VSP_004340"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["O14786-3"],"sequenceIds":["VSP_053498","VSP_004339","VSP_004340"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10688880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33082293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36213313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9529250"}],"value":"The expression of isoforms 1 and 2 does not seem to overlap. Expressed in olfactory epithelium (at protein level) (PubMed:33082293). Expressed in fibroblasts (at protein level) (PubMed:36213313). Expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain (PubMed:10688880, PubMed:9529250). Expressed in the central nervous system, including olfactory related regions such as the olfactory tubercles and paraolfactory gyri (PubMed:33082293)"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10688880"}],"value":"The expression of isoforms 1 and 2 does not seem to overlap. Found in liver hepatocytes, kidney distal and proximal tubules"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19805273"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33082294"}],"value":"The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding. F5/8 domains mediate the recognition and binding to R/KXXR/K CendR motifs (PubMed:19805273, PubMed:33082294)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34742300"}],"value":"(Microbial infection) Proteolytically cleaved at the cell membrane upon H.pylori infection"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the neuropilin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10688880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9529250"}]},{"type":"Chain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":923,"modifier":"EXACT"}},"description":"Neuropilin-1","featureId":"PRO_0000021859"},{"type":"Topological domain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":856,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":857,"modifier":"EXACT"},"end":{"value":879,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":880,"modifier":"EXACT"},"end":{"value":923,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"CUB 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00059"}]},{"type":"Domain","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"CUB 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00059"}]},{"type":"Domain","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":424,"modifier":"EXACT"}},"description":"F5/8 type C 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00081"}]},{"type":"Domain","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":583,"modifier":"EXACT"}},"description":"F5/8 type C 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00081"}]},{"type":"Domain","location":{"start":{"value":645,"modifier":"EXACT"},"end":{"value":811,"modifier":"EXACT"}},"description":"MAM","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00128"}]},{"type":"Region","location":{"start":{"value":820,"modifier":"EXACT"},"end":{"value":845,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17989695"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2QQM"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17989695"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2QQM"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17989695"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2QQM"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Modified residue","location":{"start":{"value":894,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97333"}]},{"type":"Glycosylation","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16335952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17989695"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17989695"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":522,"modifier":"EXACT"},"end":{"value":522,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":612,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"O-linked (Xyl...) (chondroitin sulfate) serine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16763549"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":612,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"O-linked (Xyl...) (heparan sulfate) serine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16763549"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":829,"modifier":"EXACT"},"end":{"value":829,"modifier":"EXACT"}},"description":"O-linked (Xyl...) (chondroitin sulfate) serine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36213313"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":842,"modifier":"EXACT"},"end":{"value":842,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17989695"}]},{"type":"Disulfide bond","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17989695"}]},{"type":"Disulfide bond","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17989695"}]},{"type":"Disulfide bond","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17989695"}]},{"type":"Disulfide bond","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":424,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17989695"}]},{"type":"Disulfide bond","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":583,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17989695"}]},{"type":"Alternative sequence","location":{"start":{"value":587,"modifier":"EXACT"},"end":{"value":621,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_053498","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":642,"modifier":"EXACT"},"end":{"value":644,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10688880"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"featureId":"VSP_004339","alternativeSequence":{"originalSequence":"EFP","alternativeSequences":["GIK"]}},{"type":"Alternative sequence","location":{"start":{"value":645,"modifier":"EXACT"},"end":{"value":923,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10688880"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"featureId":"VSP_004340","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"in dbSNP:rs7079053","featureCrossReferences":[{"database":"dbSNP","id":"rs7079053"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10688880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17974005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9288753"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9529250"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.8"}],"featureId":"VAR_046536","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":561,"modifier":"EXACT"},"end":{"value":561,"modifier":"EXACT"}},"description":"in dbSNP:rs2228637","featureCrossReferences":[{"database":"dbSNP","id":"rs2228637"}],"featureId":"VAR_046537","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":733,"modifier":"EXACT"},"end":{"value":733,"modifier":"EXACT"}},"description":"in dbSNP:rs2228638","featureCrossReferences":[{"database":"dbSNP","id":"rs2228638"}],"featureId":"VAR_056957","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"in Ref. 1; AAC51759","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"in Ref. 5; CAD91133","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":749,"modifier":"EXACT"},"end":{"value":749,"modifier":"EXACT"}},"description":"in Ref. 2; AAC12921","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":855,"modifier":"EXACT"},"end":{"value":855,"modifier":"EXACT"}},"description":"in Ref. 1; AAC51759","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}},{"type":"Beta strand","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Beta strand","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Turn","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Helix","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Beta strand","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Helix","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Beta strand","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Beta strand","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Turn","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Beta strand","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Beta strand","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Beta strand","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Beta strand","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Helix","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Turn","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RN5"}]},{"type":"Turn","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FMC"}]},{"type":"Beta strand","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PFE"}]},{"type":"Helix","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FMC"}]},{"type":"Beta strand","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FMC"}]},{"type":"Helix","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FMC"}]},{"type":"Helix","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FMC"}]},{"type":"Beta strand","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKK"}]},{"type":"Beta strand","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FMC"}]},{"type":"Turn","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FMC"}]},{"type":"Beta strand","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FMC"}]},{"type":"Beta strand","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KEX"}]},{"type":"Beta strand","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C7G"}]},{"type":"Beta strand","location":{"start":{"value":385,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FMC"}]},{"type":"Beta strand","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FMC"}]},{"type":"Beta strand","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":424,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FMC"}]},{"type":"Helix","location":{"start":{"value":426,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Helix","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Beta strand","location":{"start":{"value":437,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Helix","location":{"start":{"value":442,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Beta strand","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Turn","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":453,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQI"}]},{"type":"Helix","location":{"start":{"value":459,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Turn","location":{"start":{"value":464,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QQM"}]},{"type":"Beta strand","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":469,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8C5G"}]},{"type":"Beta strand","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Beta strand","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":501,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Beta strand","location":{"start":{"value":503,"modifier":"EXACT"},"end":{"value":505,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Beta strand","location":{"start":{"value":508,"modifier":"EXACT"},"end":{"value":510,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Beta strand","location":{"start":{"value":512,"modifier":"EXACT"},"end":{"value":525,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Beta strand","location":{"start":{"value":535,"modifier":"EXACT"},"end":{"value":537,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Beta strand","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":541,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8C5G"}]},{"type":"Beta strand","location":{"start":{"value":544,"modifier":"EXACT"},"end":{"value":547,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Beta strand","location":{"start":{"value":550,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Beta strand","location":{"start":{"value":573,"modifier":"EXACT"},"end":{"value":584,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EOU"}]},{"type":"Helix","location":{"start":{"value":643,"modifier":"EXACT"},"end":{"value":646,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Beta strand","location":{"start":{"value":667,"modifier":"EXACT"},"end":{"value":671,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Beta strand","location":{"start":{"value":674,"modifier":"EXACT"},"end":{"value":677,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Beta strand","location":{"start":{"value":680,"modifier":"EXACT"},"end":{"value":682,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Turn","location":{"start":{"value":686,"modifier":"EXACT"},"end":{"value":689,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Beta strand","location":{"start":{"value":690,"modifier":"EXACT"},"end":{"value":696,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Helix","location":{"start":{"value":699,"modifier":"EXACT"},"end":{"value":701,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Beta strand","location":{"start":{"value":705,"modifier":"EXACT"},"end":{"value":713,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Beta strand","location":{"start":{"value":720,"modifier":"EXACT"},"end":{"value":728,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Beta strand","location":{"start":{"value":733,"modifier":"EXACT"},"end":{"value":742,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Beta strand","location":{"start":{"value":744,"modifier":"EXACT"},"end":{"value":746,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Beta strand","location":{"start":{"value":749,"modifier":"EXACT"},"end":{"value":757,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Beta strand","location":{"start":{"value":761,"modifier":"EXACT"},"end":{"value":770,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Beta strand","location":{"start":{"value":777,"modifier":"EXACT"},"end":{"value":785,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Beta strand","location":{"start":{"value":792,"modifier":"EXACT"},"end":{"value":800,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Turn","location":{"start":{"value":806,"modifier":"EXACT"},"end":{"value":808,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]},{"type":"Beta strand","location":{"start":{"value":809,"modifier":"EXACT"},"end":{"value":811,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L73"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0037","category":"Biological process","name":"Angiogenesis"},{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0357","category":"PTM","name":"Heparan sulfate"},{"id":"KW-0358","category":"Molecular function","name":"Heparin-binding"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"9288753","citationType":"journal article","authors":["He Z.","Tessier-Lavigne M."],"citationCrossReferences":[{"database":"PubMed","id":"9288753"},{"database":"DOI","id":"10.1016/s0092-8674(00)80534-6"}],"title":"Neuropilin is a receptor for the axonal chemorepellent semaphorin III.","publicationDate":"1997","journal":"Cell","firstPage":"739","lastPage":"751","volume":"90"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","FUNCTION","VARIANT ALA-179"]},{"referenceNumber":2,"citation":{"id":"9529250","citationType":"journal article","authors":["Soker S.","Takashima S.","Miao H.-Q.","Neufeld G.","Klagsbrun M."],"citationCrossReferences":[{"database":"PubMed","id":"9529250"},{"database":"DOI","id":"10.1016/s0092-8674(00)81402-6"}],"title":"Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.","publicationDate":"1998","journal":"Cell","firstPage":"735","lastPage":"745","volume":"92"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","FUNCTION","PROTEIN SEQUENCE OF 22-39","VARIANT ALA-179","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Mammary gland","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"10688880","citationType":"journal article","authors":["Gagnon M.L.","Bielenberg D.R.","Gechtman Z.","Miao H.-Q.","Takashima S.","Soker S.","Klagsbrun M."],"citationCrossReferences":[{"database":"PubMed","id":"10688880"},{"database":"DOI","id":"10.1073/pnas.040337597"}],"title":"Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: in vivo expression and antitumor activity.","publicationDate":"2000","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"2573","lastPage":"2578","volume":"97"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)","FUNCTION","PROTEIN SEQUENCE OF 22-31","VARIANT ALA-179","TISSUE SPECIFICITY","SUBCELLULAR LOCATION (ISOFORM 2)"],"referenceComments":[{"value":"Prostatic adenocarcinoma","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"CI-4IUTJLP3044AK","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)","VARIANT ALA-179"]},{"referenceNumber":5,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)","VARIANT ALA-179"],"referenceComments":[{"value":"Skeletal muscle","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"CI-845191F0NVKT5","citationType":"submission","authoringGroup":["SeattleSNPs variation discovery resource"],"publicationDate":"DEC-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT ALA-179"]},{"referenceNumber":7,"citation":{"id":"15164054","citationType":"journal article","authors":["Deloukas P.","Earthrowl M.E.","Grafham D.V.","Rubenfield M.","French L.","Steward C.A.","Sims S.K.","Jones M.C.","Searle S.","Scott C.","Howe K.","Hunt S.E.","Andrews T.D.","Gilbert J.G.R.","Swarbreck D.","Ashurst J.L.","Taylor A.","Battles J.","Bird C.P.","Ainscough R.","Almeida J.P.","Ashwell R.I.S.","Ambrose K.D.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Bates K.","Beasley H.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Cahill P.","Camire D.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Corby N.","Coulson A.","Dhami P.","Dutta I.","Dunn M.","Faulkner L.","Frankish A.","Frankland J.A.","Garner P.","Garnett J.","Gribble S.","Griffiths C.","Grocock R.","Gustafson E.","Hammond S.","Harley J.L.","Hart E.","Heath P.D.","Ho T.P.","Hopkins B.","Horne J.","Howden P.J.","Huckle E.","Hynds C.","Johnson C.","Johnson D.","Kana A.","Kay M.","Kimberley A.M.","Kershaw J.K.","Kokkinaki M.","Laird G.K.","Lawlor S.","Lee H.M.","Leongamornlert D.A.","Laird G.","Lloyd C.","Lloyd D.M.","Loveland J.","Lovell J.","McLaren S.","McLay K.E.","McMurray A.","Mashreghi-Mohammadi M.","Matthews L.","Milne S.","Nickerson T.","Nguyen M.","Overton-Larty E.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.","Rice C.M.","Rogosin A.","Ross M.T.","Sarafidou T.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Standring L.","Sycamore N.","Tester J.","Thorpe A.","Torcasso W.","Tracey A.","Tromans A.","Tsolas J.","Wall M.","Walsh J.","Wang H.","Weinstock K.","West A.P.","Willey D.L.","Whitehead S.L.","Wilming L.","Wray P.W.","Young L.","Chen Y.","Lovering R.C.","Moschonas N.K.","Siebert R.","Fechtel K.","Bentley D.","Durbin R.M.","Hubbard T.","Doucette-Stamm L.","Beck S.","Smith D.R.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"15164054"},{"database":"DOI","id":"10.1038/nature02462"}],"title":"The DNA sequence and comparative analysis of human chromosome 10.","publicationDate":"2004","journal":"Nature","firstPage":"375","lastPage":"381","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]","VARIANT ALA-179"]},{"referenceNumber":9,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)","VARIANT ALA-179"],"referenceComments":[{"value":"Kidney","type":"TISSUE"},{"value":"Muscle","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"10520995","citationType":"journal article","authors":["Tamagnone L.","Artigiani S.","Chen H.","He Z.","Ming G.-L.","Song H.-L.","Chedotal A.","Winberg M.L.","Goodman C.S.","Poo M.-M.","Tessier-Lavigne M.","Comoglio P.M."],"citationCrossReferences":[{"database":"PubMed","id":"10520995"},{"database":"DOI","id":"10.1016/s0092-8674(00)80063-x"}],"title":"Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates.","publicationDate":"1999","journal":"Cell","firstPage":"71","lastPage":"80","volume":"99"},"referencePositions":["INTERACTION WITH PLXNB1"]},{"referenceNumber":11,"citation":{"id":"10748121","citationType":"journal article","authors":["Gluzman-Poltorak Z.","Cohen T.","Herzog Y.","Neufeld G."],"citationCrossReferences":[{"database":"PubMed","id":"10748121"},{"database":"DOI","id":"10.1074/jbc.m909259199"}],"title":"Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"18040","lastPage":"18045","volume":"275"},"referencePositions":["FUNCTION"]},{"referenceNumber":12,"citation":{"id":"16335952","citationType":"journal article","authors":["Liu T.","Qian W.-J.","Gritsenko M.A.","Camp D.G. II","Monroe M.E.","Moore R.J.","Smith R.D."],"citationCrossReferences":[{"database":"PubMed","id":"16335952"},{"database":"DOI","id":"10.1021/pr0502065"}],"title":"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.","publicationDate":"2005","journal":"J. Proteome Res.","firstPage":"2070","lastPage":"2080","volume":"4"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-150"],"referenceComments":[{"value":"Plasma","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"16763549","citationType":"journal article","authors":["Shintani Y.","Takashima S.","Asano Y.","Kato H.","Liao Y.","Yamazaki S.","Tsukamoto O.","Seguchi O.","Yamamoto H.","Fukushima T.","Sugahara K.","Kitakaze M.","Hori M."],"citationCrossReferences":[{"database":"PubMed","id":"16763549"},{"database":"DOI","id":"10.1038/sj.emboj.7601188"}],"title":"Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling.","publicationDate":"2006","journal":"EMBO J.","firstPage":"3045","lastPage":"3055","volume":"25"},"referencePositions":["GLYCOSYLATION AT SER-612"]},{"referenceNumber":14,"citation":{"id":"19159218","citationType":"journal article","authors":["Chen R.","Jiang X.","Sun D.","Han G.","Wang F.","Ye M.","Wang L.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"19159218"},{"database":"DOI","id":"10.1021/pr8008012"}],"title":"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.","publicationDate":"2009","journal":"J. Proteome Res.","firstPage":"651","lastPage":"661","volume":"8"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-150; ASN-261 AND ASN-522"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"19805273","citationType":"journal article","authors":["Teesalu T.","Sugahara K.N.","Kotamraju V.R.","Ruoslahti E."],"citationCrossReferences":[{"database":"PubMed","id":"19805273"},{"database":"DOI","id":"10.1073/pnas.0908201106"}],"title":"C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration.","publicationDate":"2009","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"16157","lastPage":"16162","volume":"106"},"referencePositions":["FUNCTION","INTERACTION WITH VEGF-A165","DOMAIN"]},{"referenceNumber":16,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"26503042","citationType":"journal article","authors":["He W.","Bai G.","Zhou H.","Wei N.","White N.M.","Lauer J.","Liu H.","Shi Y.","Dumitru C.D.","Lettieri K.","Shubayev V.","Jordanova A.","Guergueltcheva V.","Griffin P.R.","Burgess R.W.","Pfaff S.L.","Yang X.L."],"citationCrossReferences":[{"database":"PubMed","id":"26503042"},{"database":"DOI","id":"10.1038/nature15510"}],"title":"CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.","publicationDate":"2015","journal":"Nature","firstPage":"710","lastPage":"714","volume":"526"},"referencePositions":["INTERACTION WITH VEGFA"]},{"referenceNumber":18,"citation":{"id":"26789244","citationType":"journal article","authors":["He W.","Bai G.","Zhou H.","Wei N.","White N.M.","Lauer J.","Liu H.","Shi Y.","Dan Dumitru C.","Lettieri K.","Shubayev V.","Jordanova A.","Guergueltcheva V.","Griffin P.R.","Burgess R.W.","Pfaff S.L.","Yang X.L."],"citationCrossReferences":[{"database":"PubMed","id":"26789244"},{"database":"DOI","id":"10.1038/nature16499"}],"title":"Corrigendum: CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.","publicationDate":"2016","journal":"Nature","firstPage":"402","lastPage":"402","volume":"532"},"referencePositions":["ERRATUM OF PUBMED:26503042"]},{"referenceNumber":19,"citation":{"id":"30623799","citationType":"journal article","authors":["Issitt T.","Bosseboeuf E.","De Winter N.","Dufton N.","Gestri G.","Senatore V.","Chikh A.","Randi A.M.","Raimondi C."],"citationCrossReferences":[{"database":"PubMed","id":"30623799"},{"database":"DOI","id":"10.1016/j.isci.2018.12.005"}],"title":"Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative Stress.","publicationDate":"2019","journal":"IScience","firstPage":"205","lastPage":"223","volume":"11"},"referencePositions":["FUNCTION","SUBUNIT","SUBCELLULAR LOCATION"]},{"referenceNumber":20,"citation":{"id":"33000221","citationType":"journal article","authors":["Davies J.","Randeva H.S.","Chatha K.","Hall M.","Spandidos D.A.","Karteris E.","Kyrou I."],"citationCrossReferences":[{"database":"PubMed","id":"33000221"},{"database":"DOI","id":"10.3892/mmr.2020.11510"}],"title":"Neuropilin-1 as a new potential SARS-CoV-2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID-19.","publicationDate":"2020","journal":"Mol. Med. Report.","firstPage":"4221","lastPage":"4226","volume":"22"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH SARS-COV-2 SPIKE GLYCOPROTEIN (MICROBIAL INFECTION)"]},{"referenceNumber":21,"citation":{"id":"33082293","citationType":"journal article","authors":["Cantuti-Castelvetri L.","Ojha R.","Pedro L.D.","Djannatian M.","Franz J.","Kuivanen S.","van der Meer F.","Kallio K.","Kaya T.","Anastasina M.","Smura T.","Levanov L.","Szirovicza L.","Tobi A.","Kallio-Kokko H.","Oesterlund P.","Joensuu M.","Meunier F.A.","Butcher S.J.","Winkler M.S.","Mollenhauer B.","Helenius A.","Gokce O.","Teesalu T.","Hepojoki J.","Vapalahti O.","Stadelmann C.","Balistreri G.","Simons M."],"citationCrossReferences":[{"database":"PubMed","id":"33082293"},{"database":"DOI","id":"10.1126/science.abd2985"}],"title":"Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.","publicationDate":"2020","journal":"Science","firstPage":"856","lastPage":"860","volume":"370"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":22,"citation":{"id":"34742300","citationType":"journal article","authors":["Bernegger S.","Vidmar R.","Fonovic M.","Posselt G.","Turk B.","Wessler S."],"citationCrossReferences":[{"database":"PubMed","id":"34742300"},{"database":"DOI","id":"10.1186/s12964-021-00788-x"}],"title":"Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells.","publicationDate":"2021","journal":"Cell Commun. Signal.","firstPage":"108","lastPage":"108","volume":"19"},"referencePositions":["SUBCELLULAR LOCATION (MICROBIAL INFECTION)","PROTEOLYTIC CLEAVAGE (MICROBIAL INFECTION)"]},{"referenceNumber":23,"citation":{"id":"36213313","citationType":"journal article","authors":["Ramarajan M.G.","Saraswat M.","Budhraja R.","Garapati K.","Raymond K.","Pandey A."],"citationCrossReferences":[{"database":"PubMed","id":"36213313"},{"database":"DOI","id":"10.1007/s42485-022-00092-3"}],"title":"Mass spectrometric analysis of chondroitin sulfate-linked peptides.","publicationDate":"2022","journal":"J. Proteins Proteom.","firstPage":"187","lastPage":"203","volume":"13"},"referencePositions":["TISSUE SPECIFICITY","GLYCOSYLATION AT SER-829"]},{"referenceNumber":24,"citation":{"id":"12517344","citationType":"journal article","authors":["Lee C.C.","Kreusch A.","McMullan D.","Ng K.","Spraggon G."],"citationCrossReferences":[{"database":"PubMed","id":"12517344"},{"database":"DOI","id":"10.1016/s0969-2126(02)00941-3"}],"title":"Crystal structure of the human neuropilin-1 b1 domain.","publicationDate":"2003","journal":"Structure","firstPage":"99","lastPage":"108","volume":"11"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 273-427"]},{"referenceNumber":25,"citation":{"id":"17989695","citationType":"journal article","authors":["Appleton B.A.","Wu P.","Maloney J.","Yin J.","Liang W.C.","Stawicki S.","Mortara K.","Bowman K.K.","Elliott J.M.","Desmarais W.","Bazan J.F.","Bagri A.","Tessier-Lavigne M.","Koch A.W.","Wu Y.","Watts R.J.","Wiesmann C."],"citationCrossReferences":[{"database":"PubMed","id":"17989695"},{"database":"DOI","id":"10.1038/sj.emboj.7601906"}],"title":"Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.","publicationDate":"2007","journal":"EMBO J.","firstPage":"4902","lastPage":"4912","volume":"26"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 141-586 ALONE AND IN COMPLEX WITH ANTIBODY","GLYCOSYLATION AT ASN-150 AND ASN-261","SUBUNIT","CALCIUM-BINDING SITES","HEPARIN-BINDING","DISULFIDE BONDS"]},{"referenceNumber":26,"citation":{"id":"33082294","citationType":"journal article","authors":["Daly J.L.","Simonetti B.","Klein K.","Chen K.E.","Williamson M.K.","Anton-Plagaro C.","Shoemark D.K.","Simon-Gracia L.","Bauer M.","Hollandi R.","Greber U.F.","Horvath P.","Sessions R.B.","Helenius A.","Hiscox J.A.","Teesalu T.","Matthews D.A.","Davidson A.D.","Collins B.M.","Cullen P.J.","Yamauchi Y."],"citationCrossReferences":[{"database":"PubMed","id":"33082294"},{"database":"DOI","id":"10.1126/science.abd3072"}],"title":"Neuropilin-1 is a host factor for SARS-CoV-2 infection.","publicationDate":"2020","journal":"Science","firstPage":"861","lastPage":"865","volume":"370"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.36 ANGSTROMS) OF 273-427 IN COMPLEX WITH SARS-COV-2 SPIKE PROTEIN S1","FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH SARS-COV-2 SPIKE PROTEIN S1 (MICROBIAL INFECTION)"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7JJC"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF018956","properties":[{"key":"ProteinId","value":"AAC51759.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF016050","properties":[{"key":"ProteinId","value":"AAC12921.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF145712","properties":[{"key":"ProteinId","value":"AAF44344.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT006995","properties":[{"key":"ProteinId","value":"AAP35641.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BX510902","properties":[{"key":"ProteinId","value":"CAD91133.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EU332859","properties":[{"key":"ProteinId","value":"ABY87548.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL353600","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL121748","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471072","properties":[{"key":"ProteinId","value":"EAW85942.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471072","properties":[{"key":"ProteinId","value":"EAW85944.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC007533","properties":[{"key":"ProteinId","value":"AAH07533.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC007737","properties":[{"key":"ProteinId","value":"AAH07737.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS31179.1","properties":[{"key":"Description","value":"-"}],"isoformId":"O14786-3"},{"database":"CCDS","id":"CCDS31180.1","properties":[{"key":"Description","value":"-"}],"isoformId":"O14786-2"},{"database":"CCDS","id":"CCDS7177.1","properties":[{"key":"Description","value":"-"}],"isoformId":"O14786-1"},{"database":"RefSeq","id":"NP_001019799.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001024628.3"}],"isoformId":"O14786-2"},{"database":"RefSeq","id":"NP_001019800.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001024629.3"}],"isoformId":"O14786-3"},{"database":"RefSeq","id":"NP_001316997.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001330068.2"}]},{"database":"RefSeq","id":"NP_003864.5","properties":[{"key":"NucleotideSequenceId","value":"NM_003873.7"}],"isoformId":"O14786-1"},{"database":"PDB","id":"1KEX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=273-427"}]},{"database":"PDB","id":"2QQI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=273-586"}]},{"database":"PDB","id":"2QQM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=141-586"}]},{"database":"PDB","id":"2QQN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=273-427"}]},{"database":"PDB","id":"3I97","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A/B=273-427"}]},{"database":"PDB","id":"4DEQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.65 A"},{"key":"Chains","value":"A/B=274-429"}]},{"database":"PDB","id":"4RN5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.73 A"},{"key":"Chains","value":"A=273-427"}]},{"database":"PDB","id":"5C7G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A=273-427"}]},{"database":"PDB","id":"5IJR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.52 A"},{"key":"Chains","value":"A/B=273-427"}]},{"database":"PDB","id":"5IYY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B=273-427"}]},{"database":"PDB","id":"5J1X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/D=273-427"}]},{"database":"PDB","id":"5JGI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.38 A"},{"key":"Chains","value":"A/B=273-427"}]},{"database":"PDB","id":"5JGQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B=273-427"}]},{"database":"PDB","id":"5JHK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=273-427"}]},{"database":"PDB","id":"5L73","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.24 A"},{"key":"Chains","value":"A/B=628-813"}]},{"database":"PDB","id":"6FMC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"0.90 A"},{"key":"Chains","value":"A=273-427"}]},{"database":"PDB","id":"6FMF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.81 A"},{"key":"Chains","value":"A=273-427"}]},{"database":"PDB","id":"6TKK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.06 A"},{"key":"Chains","value":"A=273-427"}]},{"database":"PDB","id":"7JJC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.36 A"},{"key":"Chains","value":"A/B/C/D=273-427"}]},{"database":"PDB","id":"7O1N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.56 A"},{"key":"Chains","value":"A=273-427"}]},{"database":"PDB","id":"7P5U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"AAA/BBB=273-427"}]},{"database":"PDB","id":"8C5G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B=271-586"}]},{"database":"PDB","id":"8PFE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.35 A"},{"key":"Chains","value":"A/C=273-427"}]},{"database":"PDB","id":"9EOU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A=273-586"}]},{"database":"PDB","id":"9F6B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.57 A"},{"key":"Chains","value":"A/B=273-427"}]},{"database":"PDBsum","id":"1KEX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2QQI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2QQM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2QQN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3I97","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4DEQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4RN5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5C7G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5IJR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5IYY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5J1X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JGI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JGQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JHK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5L73","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6FMC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6FMF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TKK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JJC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7O1N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7P5U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8C5G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PFE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EOU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9F6B","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"114356","properties":[{"key":"Interactions","value":"334"}]},{"database":"CORUM","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-5743N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O14786","properties":[{"key":"Number of interactors","value":"904"}]},{"database":"IntAct","id":"O14786","properties":[{"key":"Interactions","value":"81"}]},{"database":"MINT","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-NRP1","properties":[{"key":"Evidences","value":"16 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000265371","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL5174","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB04895","properties":[{"key":"GenericName","value":"Pegaptanib"}]},{"database":"GuidetoPHARMACOLOGY","id":"2998","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"8.A.47.1.5","properties":[{"key":"FamilyName","value":"the neuropilin and tolloid-like (neto) family"}]},{"database":"GlyConnect","id":"O14786","properties":[{"key":"glycosylation","value":"7 N-Linked glycans (4 sites)"}]},{"database":"GlyCosmos","id":"O14786","properties":[{"key":"glycosylation","value":"11 sites, 10 glycans"}]},{"database":"GlyGen","id":"O14786","properties":[{"key":"glycosylation","value":"17 sites, 54 N-linked glycans (4 sites), 5 O-linked glycans (8 sites)"}]},{"database":"iPTMnet","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"NRP1","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000265371","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"48233","properties":[{"key":"Description","value":"-"}],"isoformId":"O14786-1"},{"database":"ProteomicsDB","id":"48234","properties":[{"key":"Description","value":"-"}],"isoformId":"O14786-2"},{"database":"ProteomicsDB","id":"64659","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"O14786","properties":[{"key":"antibodies","value":"26 sequenced antibodies"}]},{"database":"Antibodypedia","id":"3859","properties":[{"key":"antibodies","value":"956 antibodies from 45 providers"}]},{"database":"DNASU","id":"8829","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000265371.8","properties":[{"key":"ProteinId","value":"ENSP00000265371.3"},{"key":"GeneId","value":"ENSG00000099250.19"}],"isoformId":"O14786-1"},{"database":"Ensembl","id":"ENST00000374821.9","properties":[{"key":"ProteinId","value":"ENSP00000363954.5"},{"key":"GeneId","value":"ENSG00000099250.19"}],"isoformId":"O14786-3"},{"database":"Ensembl","id":"ENST00000374822.8","properties":[{"key":"ProteinId","value":"ENSP00000363955.4"},{"key":"GeneId","value":"ENSG00000099250.19"}],"isoformId":"O14786-2"},{"database":"Ensembl","id":"ENST00000374867.7","properties":[{"key":"ProteinId","value":"ENSP00000364001.2"},{"key":"GeneId","value":"ENSG00000099250.19"}],"isoformId":"O14786-1"},{"database":"GeneID","id":"8829","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:8829","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000374867.7","properties":[{"key":"ProteinId","value":"ENSP00000364001.2"},{"key":"RefSeqNucleotideId","value":"NM_003873.7"},{"key":"RefSeqProteinId","value":"NP_003864.5"}]},{"database":"UCSC","id":"uc001iwx.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"O14786-1"},{"database":"AGR","id":"HGNC:8004","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA31783","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"8829","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"8829","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"NRP1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:8004","properties":[{"key":"GeneName","value":"NRP1"}]},{"database":"HPA","id":"ENSG00000099250","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"NRP1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"602069","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000099250","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000099250","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QUEH","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157169","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_015228_6_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QEDCTKP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6155811at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"O14786","properties":[{"key":"Number of GO annotations","value":"15 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-194306","properties":[{"key":"PathwayName","value":"Neuropilin interactions with VEGF and VEGFR"}]},{"database":"Reactome","id":"R-HSA-376176","properties":[{"key":"PathwayName","value":"Signaling by ROBO receptors"}]},{"database":"Reactome","id":"R-HSA-399954","properties":[{"key":"PathwayName","value":"Sema3A PAK dependent Axon repulsion"}]},{"database":"Reactome","id":"R-HSA-399955","properties":[{"key":"PathwayName","value":"SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"}]},{"database":"Reactome","id":"R-HSA-399956","properties":[{"key":"PathwayName","value":"CRMPs in Sema3A signaling"}]},{"database":"Reactome","id":"R-HSA-445144","properties":[{"key":"PathwayName","value":"Signal transduction by L1"}]},{"database":"Reactome","id":"R-HSA-447041","properties":[{"key":"PathwayName","value":"CHL1 interactions"}]},{"database":"Reactome","id":"R-HSA-9694614","properties":[{"key":"PathwayName","value":"Attachment and Entry"}]},{"database":"SignaLink","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000099250","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"8829","properties":[{"key":"hits","value":"19 hits in 1158 CRISPR screens"}]},{"database":"ChiTaRS","id":"NRP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"O14786","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Neuropilin_1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"8829","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"O14786","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:O14786","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"RNAct","id":"O14786","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000099250","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"O14786","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30623799"}]},{"database":"GO","id":"GO:0031410","properties":[{"key":"GoTerm","value":"C:cytoplasmic vesicle"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"21245381"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21245381"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"23639442"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34742300"}]},{"database":"GO","id":"GO:0005925","properties":[{"key":"GoTerm","value":"C:focal adhesion"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24863063"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005883","properties":[{"key":"GoTerm","value":"C:neurofilament"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043005","properties":[{"key":"GoTerm","value":"C:neuron projection"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"22683681"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21245381"}]},{"database":"GO","id":"GO:0045211","properties":[{"key":"GoTerm","value":"C:postsynaptic membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0002116","properties":[{"key":"GoTerm","value":"C:semaphorin receptor complex"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19909241"}]},{"database":"GO","id":"GO:0043235","properties":[{"key":"GoTerm","value":"C:signaling receptor complex"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"21245381"}]},{"database":"GO","id":"GO:0097443","properties":[{"key":"GoTerm","value":"C:sorting endosome"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"23639442"}]},{"database":"GO","id":"GO:0015026","properties":[{"key":"GoTerm","value":"F:coreceptor activity"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"21245381"}]},{"database":"GO","id":"GO:0019955","properties":[{"key":"GoTerm","value":"F:cytokine binding"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19909241"}]},{"database":"GO","id":"GO:0019838","properties":[{"key":"GoTerm","value":"F:growth factor binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"9529250"}]},{"database":"GO","id":"GO:0005096","properties":[{"key":"GoTerm","value":"F:GTPase activator activity"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26051942"}]},{"database":"GO","id":"GO:0019901","properties":[{"key":"GoTerm","value":"F:protein kinase binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0017154","properties":[{"key":"GoTerm","value":"F:semaphorin receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0038085","properties":[{"key":"GoTerm","value":"F:vascular endothelial growth factor binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"24401374"}]},{"database":"GO","id":"GO:0005021","properties":[{"key":"GoTerm","value":"F:vascular endothelial growth factor receptor activity"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0001525","properties":[{"key":"GoTerm","value":"P:angiogenesis"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23639442"}]},{"database":"GO","id":"GO:0060978","properties":[{"key":"GoTerm","value":"P:angiogenesis involved in coronary vascular morphogenesis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"24401374"}]},{"database":"GO","id":"GO:0009887","properties":[{"key":"GoTerm","value":"P:animal organ morphogenesis"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9529250"}]},{"database":"GO","id":"GO:0048844","properties":[{"key":"GoTerm","value":"P:artery morphogenesis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"23639442"},{"evidenceCode":"ECO:0000250","source":"PubMed","id":"24401374"}]},{"database":"GO","id":"GO:0048846","properties":[{"key":"GoTerm","value":"P:axon extension involved in axon guidance"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0007411","properties":[{"key":"GoTerm","value":"P:axon guidance"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0060385","properties":[{"key":"GoTerm","value":"P:axonogenesis involved in innervation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0150020","properties":[{"key":"GoTerm","value":"P:basal dendrite arborization"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"22683681"}]},{"database":"GO","id":"GO:0150018","properties":[{"key":"GoTerm","value":"P:basal dendrite development"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"22683681"}]},{"database":"GO","id":"GO:0001569","properties":[{"key":"GoTerm","value":"P:branching involved in blood vessel morphogenesis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"24401374"}]},{"database":"GO","id":"GO:0021785","properties":[{"key":"GoTerm","value":"P:branchiomotor neuron axon guidance"},{"key":"GoEvidenceType","value":"ISS:ParkinsonsUK-UCL"}]},{"database":"GO","id":"GO:0002042","properties":[{"key":"GoTerm","value":"P:cell migration involved in sprouting angiogenesis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0007267","properties":[{"key":"GoTerm","value":"P:cell-cell signaling"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9288753"}]},{"database":"GO","id":"GO:0035729","properties":[{"key":"GoTerm","value":"P:cellular response to hepatocyte growth factor stimulus"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21245381"}]},{"database":"GO","id":"GO:0035924","properties":[{"key":"GoTerm","value":"P:cellular response to vascular endothelial growth factor stimulus"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"24401374"}]},{"database":"GO","id":"GO:0071679","properties":[{"key":"GoTerm","value":"P:commissural neuron axon guidance"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0060982","properties":[{"key":"GoTerm","value":"P:coronary artery morphogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1904835","properties":[{"key":"GoTerm","value":"P:dorsal root ganglion morphogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0035767","properties":[{"key":"GoTerm","value":"P:endothelial cell chemotaxis"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21245381"}]},{"database":"GO","id":"GO:0097102","properties":[{"key":"GoTerm","value":"P:endothelial tip cell fate specification"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0021612","properties":[{"key":"GoTerm","value":"P:facial nerve structural organization"},{"key":"GoEvidenceType","value":"ISS:ParkinsonsUK-UCL"}]},{"database":"GO","id":"GO:1903375","properties":[{"key":"GoTerm","value":"P:facioacoustic ganglion development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0021828","properties":[{"key":"GoTerm","value":"P:gonadotrophin-releasing hormone neuronal migration to the hypothalamus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048012","properties":[{"key":"GoTerm","value":"P:hepatocyte growth factor receptor signaling pathway"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21245381"}]},{"database":"GO","id":"GO:0007229","properties":[{"key":"GoTerm","value":"P:integrin-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24863063"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26051942"}]},{"database":"GO","id":"GO:0008045","properties":[{"key":"GoTerm","value":"P:motor neuron axon guidance"},{"key":"GoEvidenceType","value":"ISS:ParkinsonsUK-UCL"}]},{"database":"GO","id":"GO:0097475","properties":[{"key":"GoTerm","value":"P:motor neuron migration"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:2001237","properties":[{"key":"GoTerm","value":"P:negative regulation of extrinsic apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043524","properties":[{"key":"GoTerm","value":"P:negative regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001755","properties":[{"key":"GoTerm","value":"P:neural crest cell migration"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:1901166","properties":[{"key":"GoTerm","value":"P:neural crest cell migration involved in autonomic nervous system development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0001764","properties":[{"key":"GoTerm","value":"P:neuron migration"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0038189","properties":[{"key":"GoTerm","value":"P:neuropilin signaling pathway"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24863063"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26051942"}]},{"database":"GO","id":"GO:1905040","properties":[{"key":"GoTerm","value":"P:otic placode development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003148","properties":[{"key":"GoTerm","value":"P:outflow tract septum morphogenesis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0048008","properties":[{"key":"GoTerm","value":"P:platelet-derived growth factor receptor signaling pathway"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21245381"}]},{"database":"GO","id":"GO:0050918","properties":[{"key":"GoTerm","value":"P:positive chemotaxis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0045766","properties":[{"key":"GoTerm","value":"P:positive regulation of angiogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048842","properties":[{"key":"GoTerm","value":"P:positive regulation of axon extension involved in axon guidance"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0090050","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration involved in sprouting angiogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0010595","properties":[{"key":"GoTerm","value":"P:positive regulation of endothelial cell migration"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24863063"}]},{"database":"GO","id":"GO:0001938","properties":[{"key":"GoTerm","value":"P:positive regulation of endothelial cell proliferation"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"21245381"}]},{"database":"GO","id":"GO:0070374","properties":[{"key":"GoTerm","value":"P:positive regulation of ERK1 and ERK2 cascade"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"23639442"}]},{"database":"GO","id":"GO:0051491","properties":[{"key":"GoTerm","value":"P:positive regulation of filopodium assembly"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26051942"}]},{"database":"GO","id":"GO:0051894","properties":[{"key":"GoTerm","value":"P:positive regulation of focal adhesion assembly"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24863063"}]},{"database":"GO","id":"GO:0042327","properties":[{"key":"GoTerm","value":"P:positive regulation of phosphorylation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0014911","properties":[{"key":"GoTerm","value":"P:positive regulation of smooth muscle cell migration"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"21245381"}]},{"database":"GO","id":"GO:0051496","properties":[{"key":"GoTerm","value":"P:positive regulation of stress fiber assembly"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26051942"}]},{"database":"GO","id":"GO:1900026","properties":[{"key":"GoTerm","value":"P:positive regulation of substrate adhesion-dependent cell spreading"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24863063"}]},{"database":"GO","id":"GO:0099173","properties":[{"key":"GoTerm","value":"P:postsynapse organization"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1902946","properties":[{"key":"GoTerm","value":"P:protein localization to early endosome"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"23639442"}]},{"database":"GO","id":"GO:0032489","properties":[{"key":"GoTerm","value":"P:regulation of Cdc42 protein signal transduction"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26051942"}]},{"database":"GO","id":"GO:0030947","properties":[{"key":"GoTerm","value":"P:regulation of vascular endothelial growth factor receptor signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0060627","properties":[{"key":"GoTerm","value":"P:regulation of vesicle-mediated transport"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"21245381"}]},{"database":"GO","id":"GO:0061441","properties":[{"key":"GoTerm","value":"P:renal artery morphogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009611","properties":[{"key":"GoTerm","value":"P:response to wounding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0061299","properties":[{"key":"GoTerm","value":"P:retina vasculature morphogenesis in camera-type eye"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"24401374"}]},{"database":"GO","id":"GO:0031290","properties":[{"key":"GoTerm","value":"P:retinal ganglion cell axon guidance"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0071526","properties":[{"key":"GoTerm","value":"P:semaphorin-plexin signaling pathway"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0097374","properties":[{"key":"GoTerm","value":"P:sensory neuron axon guidance"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9288753"}]},{"database":"GO","id":"GO:0002040","properties":[{"key":"GoTerm","value":"P:sprouting angiogenesis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"24401374"}]},{"database":"GO","id":"GO:0006930","properties":[{"key":"GoTerm","value":"P:substrate-dependent cell migration, cell extension"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24863063"}]},{"database":"GO","id":"GO:0046718","properties":[{"key":"GoTerm","value":"P:symbiont entry into host cell"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33000221"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33082294"}]},{"database":"GO","id":"GO:0061549","properties":[{"key":"GoTerm","value":"P:sympathetic ganglion development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0097490","properties":[{"key":"GoTerm","value":"P:sympathetic neuron projection extension"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0097491","properties":[{"key":"GoTerm","value":"P:sympathetic neuron projection guidance"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0061551","properties":[{"key":"GoTerm","value":"P:trigeminal ganglion development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0021637","properties":[{"key":"GoTerm","value":"P:trigeminal nerve structural organization"},{"key":"GoEvidenceType","value":"ISS:ParkinsonsUK-UCL"}]},{"database":"GO","id":"GO:0048010","properties":[{"key":"GoTerm","value":"P:vascular endothelial growth factor receptor signaling pathway"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21245381"}]},{"database":"GO","id":"GO:0001570","properties":[{"key":"GoTerm","value":"P:vasculogenesis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0038190","properties":[{"key":"GoTerm","value":"P:VEGF-activated neuropilin signaling pathway"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24863063"}]},{"database":"GO","id":"GO:0036486","properties":[{"key":"GoTerm","value":"P:ventral trunk neural crest cell migration"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0021649","properties":[{"key":"GoTerm","value":"P:vestibulocochlear nerve structural organization"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"CDD","id":"cd00041","properties":[{"key":"EntryName","value":"CUB"},{"key":"MatchStatus","value":"2"}]},{"database":"CDD","id":"cd00057","properties":[{"key":"EntryName","value":"FA58C"},{"key":"MatchStatus","value":"2"}]},{"database":"CDD","id":"cd06263","properties":[{"key":"EntryName","value":"MAM"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.120.260:FF:000002","properties":[{"key":"EntryName","value":"Coagulation factor VIII"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.120.200:FF:000043","properties":[{"key":"EntryName","value":"Neuropilin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.120.260:FF:000013","properties":[{"key":"EntryName","value":"Neuropilin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.120.290:FF:000003","properties":[{"key":"EntryName","value":"Neuropilin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.120.290:FF:000010","properties":[{"key":"EntryName","value":"Neuropilin"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.120.200","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.120.260","properties":[{"key":"EntryName","value":"Galactose-binding domain-like"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"2.60.120.290","properties":[{"key":"EntryName","value":"Spermadhesin, CUB domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR013320","properties":[{"key":"EntryName","value":"ConA-like_dom_sf"}]},{"database":"InterPro","id":"IPR000859","properties":[{"key":"EntryName","value":"CUB_dom"}]},{"database":"InterPro","id":"IPR000421","properties":[{"key":"EntryName","value":"FA58C"}]},{"database":"InterPro","id":"IPR008979","properties":[{"key":"EntryName","value":"Galactose-bd-like_sf"}]},{"database":"InterPro","id":"IPR000998","properties":[{"key":"EntryName","value":"MAM_dom"}]},{"database":"InterPro","id":"IPR014648","properties":[{"key":"EntryName","value":"Neuropilin"}]},{"database":"InterPro","id":"IPR022579","properties":[{"key":"EntryName","value":"Neuropilin_C"}]},{"database":"InterPro","id":"IPR050633","properties":[{"key":"EntryName","value":"Neuropilin_MCO_CoagFactor"}]},{"database":"InterPro","id":"IPR035914","properties":[{"key":"EntryName","value":"Sperma_CUB_dom_sf"}]},{"database":"PANTHER","id":"PTHR46806","properties":[{"key":"EntryName","value":"F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46806:SF4","properties":[{"key":"EntryName","value":"NEUROPILIN-1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00431","properties":[{"key":"EntryName","value":"CUB"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF11980","properties":[{"key":"EntryName","value":"DUF3481"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00754","properties":[{"key":"EntryName","value":"F5_F8_type_C"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00629","properties":[{"key":"EntryName","value":"MAM"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF036960","properties":[{"key":"EntryName","value":"Neuropilin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00020","properties":[{"key":"EntryName","value":"MAMDOMAIN"}]},{"database":"SMART","id":"SM00042","properties":[{"key":"EntryName","value":"CUB"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00231","properties":[{"key":"EntryName","value":"FA58C"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00137","properties":[{"key":"EntryName","value":"MAM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49899","properties":[{"key":"EntryName","value":"Concanavalin A-like lectins/glucanases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49785","properties":[{"key":"EntryName","value":"Galactose-binding domain-like"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF49854","properties":[{"key":"EntryName","value":"Spermadhesin, CUB domain"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS01180","properties":[{"key":"EntryName","value":"CUB"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS01285","properties":[{"key":"EntryName","value":"FA58C_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS01286","properties":[{"key":"EntryName","value":"FA58C_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50022","properties":[{"key":"EntryName","value":"FA58C_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00740","properties":[{"key":"EntryName","value":"MAM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50060","properties":[{"key":"EntryName","value":"MAM_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA","length":923,"molWeight":103134,"crc64":"1EAC2FA6C8FD6A0B","md5":"77BE6E1314C21F4B98B42504D4D3DA2C"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"SUBUNIT":2,"INTERACTION":7,"SUBCELLULAR LOCATION":3,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":2,"DOMAIN":1,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":5,"Region":1,"Binding site":3,"Modified residue":1,"Glycosylation":8,"Disulfide bond":6,"Alternative sequence":3,"Natural variant":3,"Sequence conflict":4,"Beta strand":45,"Turn":9,"Helix":12},"uniParcId":"UPI000013D60A"}}