{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O14744","secondaryAccessions":["A8MTP3","A8MZ91","B4DX49","B4DY30","B5BU10","D3DS33","E2QRE7","Q6IBR1","Q9UKH1"],"uniProtkbId":"ANM5_HUMAN","entryAudit":{"firstPublicDate":"2003-06-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":218,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein arginine N-methyltransferase 5"},"shortNames":[{"value":"PRMT5"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19011621"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21081503"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23071334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33762328"}],"value":"2.1.1.320"}]},"alternativeNames":[{"fullName":{"value":"72 kDa ICln-binding protein"}},{"fullName":{"value":"Histone-arginine N-methyltransferase PRMT5"}},{"fullName":{"value":"Jak-binding protein 1"}},{"fullName":{"value":"Shk1 kinase-binding protein 1 homolog"},"shortNames":[{"value":"SKB1 homolog"},{"value":"SKB1Hs"}]}],"contains":[{"recommendedName":{"fullName":{"value":"Protein arginine N-methyltransferase 5, N-terminally processed"}}}]},"genes":[{"geneName":{"value":"PRMT5"},"synonyms":[{"value":"HRMT1L5"},{"value":"IBP72"},{"value":"JBP1"},{"value":"SKB1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8CIG8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10531356"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11152681"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11747828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12411503"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12718890"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15737618"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16428440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17709427"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19011621"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20159986"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20421892"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20810653"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21081503"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21258366"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21917714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22269951"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25092918"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25284789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26700805"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33762328"}],"value":"Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21081503, PubMed:21258366, PubMed:21917714, PubMed:22269951, PubMed:33762328). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:11747828, PubMed:12411503, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). May methylate the N-terminal region of MBD2 (PubMed:16428440). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10 (PubMed:20159986). Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21258366, PubMed:21917714). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity (PubMed:19011621). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). Acts as a negative regulator of cGAS-STING signaling by mediating methylation of CGAS, preventing DNA-binding ability of CGAS (PubMed:33762328)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48108"},{"database":"Rhea","id":"RHEA-COMP:10532"},{"database":"Rhea","id":"RHEA-COMP:11992"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29965"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:88221"}],"ecNumber":"2.1.1.320","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19011621"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21081503"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23071334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33762328"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48109"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33762328"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21917714"}],"value":"Activity is increased by EGF, HGF, FGF1 or FGF2 treatments, and slightly decreased by NGF treatment"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8CIG8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10531356"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10734105"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11152681"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12411503"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12718890"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15485929"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15737618"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16087681"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16428440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17184735"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17709427"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18404153"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18984161"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19011621"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20159986"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20810653"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21081503"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21258366"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21917714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22269951"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23071334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25092918"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25284789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26700805"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33376131"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9556550"}],"value":"Forms, at least, homodimers and homotetramers (PubMed:11152681). Component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A (PubMed:21081503, PubMed:23071334, PubMed:33376131). Found in a complex composed of PRMT5, WDR77 and RIOK1 (PubMed:21081503). RIOK1 and CLNS1A associate with PRMT5 in a mutually exclusive fashion, which allows the recruitment of distinct methylation substrates, such as nucleolin/NCL and Sm proteins, respectively (PubMed:21081503). Interacts with PRDM1 (By similarity). Identified in a complex composed of methylosome and PRMT1 and ERH (PubMed:25284789). Interacts with EGFR; methylates EGFR and stimulates EGFR-mediated ERK activation. Interacts with HOXA9. Interacts with SRGAP2. Found in a complex with COPRS, RUNX1 and CBFB. Interacts with CHTOP; the interaction symmetrically methylates CHTOP, but seems to require the presence of PRMT1 (PubMed:25284789). Interacts with EPB41L3; this modulates methylation of target proteins. Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4. Interacts with JAK2, SSTR1, SUPT5H, BRAF and with active RAF1. Interacts with LSM11, PRMT7 and SNRPD3 (PubMed:16087681, PubMed:17709427). Interacts with COPRS; promoting its recruitment on histone H4. Interacts with CLNS1A/pICln (PubMed:21081503, PubMed:9556550). Identified in a complex with CLNS1A/pICln and Sm proteins. Interacts with RPS10 (PubMed:20159986). Interacts with WDR77. Interacts with IWS1. Interacts with CRY1. Interacts with POLR2A (PubMed:26700805). Interacts with SMN1/SMN2 (PubMed:26700805). Interacts with LYAR; this interaction is direct (PubMed:25092918). Interacts with TTC5/STRAP; this interaction is DNA damage-dependent and promotes PRMT5 interaction with p53/TP53 (PubMed:19011621). Interacts with p53/TP53 in response to DNA damage; the interaction is TTC5/STRAP dependent (PubMed:19011621). Interacts with FAM47E; the interaction is direct, promotes PRMT5 localization to chromatin, and does not disrupt its association with WDR77 or STUB1 (PubMed:33376131). Interacts with TDRD6 (By similarity). Interacts with STUB1 (PubMed:33376131). Interacts with MBD2 (PubMed:16428440). Does not interact with MBD3 (PubMed:16428440)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P01019","geneName":"AGT","intActId":"EBI-751728"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q9NX04","geneName":"AIRIM","intActId":"EBI-8643161"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q8WUW1","geneName":"BRK1","intActId":"EBI-2837444"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q08289","geneName":"CACNB2","intActId":"EBI-2874501"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P78371","geneName":"CCT2","intActId":"EBI-357407"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q16543","geneName":"CDC37","intActId":"EBI-295634"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q8N8U2","geneName":"CDYL2","intActId":"EBI-8467076"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P54105","geneName":"CLNS1A","intActId":"EBI-724693"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P21964-2","geneName":"COMT","intActId":"EBI-10200977"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q9NQ92","geneName":"COPRS","intActId":"EBI-1642558"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q16526","geneName":"CRY1","intActId":"EBI-741297"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q9Y6K1","geneName":"DNMT3A","intActId":"EBI-923653"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q01094","geneName":"E2F1","intActId":"EBI-448924"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q08426","geneName":"EHHADH","intActId":"EBI-2339219"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P38919","geneName":"EIF4A3","intActId":"EBI-299104"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q14241","geneName":"ELOA","intActId":"EBI-742350"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"O15197-2","geneName":"EPHB6","intActId":"EBI-10182490"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q6ZV65","geneName":"FAM47E","intActId":"EBI-26583822"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P01100","geneName":"FOS","intActId":"EBI-852851"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"O95995","geneName":"GAS8","intActId":"EBI-1052570"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P62993","geneName":"GRB2","intActId":"EBI-401755"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q8TE85","geneName":"GRHL3","intActId":"EBI-8469396"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q9BX10","geneName":"GTPBP2","intActId":"EBI-6115579"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P62805","geneName":"H4C9","intActId":"EBI-302023"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P31269","geneName":"HOXA9","intActId":"EBI-742314"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q00613","geneName":"HSF1","intActId":"EBI-719620"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q63ZY3","geneName":"KANK2","intActId":"EBI-2556193"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P03952","geneName":"KLKB1","intActId":"EBI-10087153"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q8TBB1","geneName":"LNX1","intActId":"EBI-739832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P06858","geneName":"LPL","intActId":"EBI-715909"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q86UQ8-1","geneName":"NFE4","intActId":"EBI-15759783"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q96HA8","geneName":"NTAQ1","intActId":"EBI-741158"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q8WVJ2","geneName":"NUDCD2","intActId":"EBI-1052153"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P24928","geneName":"POLR2A","intActId":"EBI-295301"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"O14744","geneName":"PRMT5","intActId":"EBI-351098"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q86U06","geneName":"RBM23","intActId":"EBI-780319"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q9BRS2","geneName":"RIOK1","intActId":"EBI-7307838"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"O75044","geneName":"SRGAP2","intActId":"EBI-1051034"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q96RU7","geneName":"TRIB3","intActId":"EBI-492476"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P31930","geneName":"UQCRC1","intActId":"EBI-1052596"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P40337-2","geneName":"VHL","intActId":"EBI-12157263"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q9BQA1","geneName":"WDR77","intActId":"EBI-1237307"},"numberOfExperiments":17,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P63104","geneName":"YWHAZ","intActId":"EBI-347088"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q96E35","geneName":"ZMYND19","intActId":"EBI-746595"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"Q91XC0","geneName":"Ajuba","intActId":"EBI-1565930"},"numberOfExperiments":4,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O14744","intActId":"EBI-351098"},"interactantTwo":{"uniProtKBAccession":"P03418","geneName":"N","intActId":"EBI-6930799"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O14744-1","intActId":"EBI-26583938"},"interactantTwo":{"uniProtKBAccession":"Q6ZV65-2","geneName":"FAM47E","intActId":"EBI-26583549"},"numberOfExperiments":5,"organismDiffer":false}]},{"commentType":"SUBCELLULAR 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