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Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination (PubMed:21980433, PubMed:25505247, PubMed:31182716, PubMed:34857742, PubMed:37816714). The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2 (PubMed:21980433, PubMed:25505247, PubMed:34857742). The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR (PubMed:11781573)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37816714"}],"value":"Substrate-binding is prevented by the covalent inhibitor MN551 that cross-links with Cys-111 (PubMed:37816714). Also inhibited by a MN551 derivative, MN714, which contains a pivaloyloxymethyl that allows cell permeability (PubMed:37816714)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11781573"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21980433"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25505247"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31182716"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34857742"}],"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16675548"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21980433"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23401859"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23897481"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25505247"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31182716"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34857742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37816714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9727029"}],"value":"Substrate-recognition component of the ECS(SOCS2) complex, composed of SOCS2, CUL5, ELOB, ELOC and RNF7/RBX2 (PubMed:16675548, PubMed:21980433, PubMed:23897481, PubMed:25505247, PubMed:31182716, PubMed:34857742, PubMed:37816714). 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