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May also recruit sec1 to prime SNARE complex assembly and trigger vesicle fusion with the cell membrane (PubMed:41144523). Binds phosphatidylserine and phosphatidylinositol-4,5-bisphosphate (PIP2) (PubMed:30044717). Required for endocytic site selection during cytokinesis, to ensure proper dynamics of cell-wall enzymes (PubMed:30044717)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41144523"}],"value":"Interacts with rga7; the interaction is direct and leads to tethering of glucanase-containing exocytic vesicles along the cleavage furrow (PubMed:41144523). Interacts with rng10; to promote tethering of glucanase-containing exocytic vesicles along the cleavage furrow (PubMed:41144523). Interacts with sec1; during formation of the secondary septum (PubMed:41144523)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30044717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41144523"}],"value":"Localizes to the plasma membrane at cell tips during interphase and at the division site from anaphase"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30044717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41144523"}],"value":"Cell tip","id":"SL-0456"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30044717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41144523"}],"value":"Cell membrane","id":"SL-0039"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30044717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41144523"}],"value":"Cleavage furrow","id":"SL-0467"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30044717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41144523"}],"value":"Defective cytokinesis resulting in cell lysis (PubMed:30044717). Uneven distribution of glucan synthases and glucanases involved in secondary septum formation at the septum plane resulting in irregular distribution of cell-wall material in the septum (PubMed:30044717, PubMed:41144523). Abnormal secondary septum morphology (PubMed:30044717, PubMed:41144523)"}],"commentType":"DISRUPTION PHENOTYPE"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1237,"modifier":"EXACT"}},"description":"Exocytic regulator ync13","featureId":"PRO_0000116677"},{"type":"Domain","location":{"start":{"value":591,"modifier":"EXACT"},"end":{"value":712,"modifier":"EXACT"}},"description":"MHD1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00587"}]},{"type":"Domain","location":{"start":{"value":786,"modifier":"EXACT"},"end":{"value":906,"modifier":"EXACT"}},"description":"C2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00041"}]},{"type":"Domain","location":{"start":{"value":1014,"modifier":"EXACT"},"end":{"value":1130,"modifier":"EXACT"}},"description":"MHD2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00588"}]}],"keywords":[{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0132","category":"Biological process","name":"Cell division"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0268","category":"Biological process","name":"Exocytosis"},{"id":"KW-0446","category":"Ligand","name":"Lipid-binding"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11859360","citationType":"journal article","authors":["Wood V.","Gwilliam R.","Rajandream M.A.","Lyne M.H.","Lyne R.","Stewart A.","Sgouros J.G.","Peat N.","Hayles J.","Baker S.G.","Basham D.","Bowman S.","Brooks K.","Brown D.","Brown S.","Chillingworth T.","Churcher C.M.","Collins M.","Connor R.","Cronin A.","Davis P.","Feltwell T.","Fraser A.","Gentles S.","Goble A.","Hamlin N.","Harris D.E.","Hidalgo J.","Hodgson G.","Holroyd S.","Hornsby T.","Howarth S.","Huckle E.J.","Hunt S.","Jagels K.","James K.D.","Jones L.","Jones M.","Leather S.","McDonald S.","McLean J.","Mooney P.","Moule S.","Mungall K.L.","Murphy L.D.","Niblett D.","Odell C.","Oliver K.","O'Neil S.","Pearson D.","Quail M.A.","Rabbinowitsch E.","Rutherford K.M.","Rutter S.","Saunders D.","Seeger K.","Sharp S.","Skelton J.","Simmonds M.N.","Squares R.","Squares S.","Stevens K.","Taylor K.","Taylor R.G.","Tivey A.","Walsh S.V.","Warren T.","Whitehead S.","Woodward J.R.","Volckaert G.","Aert R.","Robben J.","Grymonprez B.","Weltjens I.","Vanstreels E.","Rieger M.","Schaefer M.","Mueller-Auer S.","Gabel C.","Fuchs M.","Duesterhoeft A.","Fritzc C.","Holzer E.","Moestl D.","Hilbert H.","Borzym K.","Langer I.","Beck A.","Lehrach H.","Reinhardt R.","Pohl T.M.","Eger P.","Zimmermann W.","Wedler H.","Wambutt R.","Purnelle B.","Goffeau A.","Cadieu E.","Dreano S.","Gloux S.","Lelaure V.","Mottier S.","Galibert F.","Aves S.J.","Xiang Z.","Hunt C.","Moore K.","Hurst S.M.","Lucas M.","Rochet M.","Gaillardin C.","Tallada V.A.","Garzon A.","Thode G.","Daga R.R.","Cruzado L.","Jimenez J.","Sanchez M.","del Rey F.","Benito J.","Dominguez A.","Revuelta J.L.","Moreno S.","Armstrong J.","Forsburg S.L.","Cerutti L.","Lowe T.","McCombie W.R.","Paulsen I.","Potashkin J.","Shpakovski G.V.","Ussery D.","Barrell B.G.","Nurse P."],"citationCrossReferences":[{"database":"PubMed","id":"11859360"},{"database":"DOI","id":"10.1038/nature724"}],"title":"The genome sequence of Schizosaccharomyces pombe.","publicationDate":"2002","journal":"Nature","firstPage":"871","lastPage":"880","volume":"415"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"972 / ATCC 24843","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"30044717","citationType":"journal article","authors":["Zhu Y.H.","Hyun J.","Pan Y.Z.","Hopper J.E.","Rizo J.","Wu J.Q."],"citationCrossReferences":[{"database":"PubMed","id":"30044717"},{"database":"DOI","id":"10.1091/mbc.e18-04-0225"}],"title":"Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.","publicationDate":"2018","journal":"Mol. 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