{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O09000","secondaryAccessions":["Q9CRD5"],"uniProtkbId":"NCOA3_MOUSE","entryAudit":{"firstPublicDate":"2002-09-19","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1998-08-01","entryVersion":210,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Nuclear receptor coactivator 3"},"shortNames":[{"value":"NCoA-3"}],"ecNumbers":[{"value":"2.3.1.48"}]},"alternativeNames":[{"fullName":{"value":"Amplified in breast cancer-1 protein homolog"},"shortNames":[{"value":"AIB-1"}]},{"fullName":{"value":"CBP-interacting protein"},"shortNames":[{"value":"p/CIP"},{"value":"pCIP"}]},{"fullName":{"value":"Receptor-associated coactivator 3"},"shortNames":[{"value":"RAC-3"}]},{"fullName":{"value":"Steroid receptor coactivator protein 3"},"shortNames":[{"value":"SRC-3"}]},{"fullName":{"value":"Thyroid hormone receptor activator molecule 1"},"shortNames":[{"value":"ACTR"},{"value":"TRAM-1"}]}]},"genes":[{"geneName":{"value":"Ncoa3"},"synonyms":[{"value":"Aib1"},{"value":"Pcip"},{"value":"Rac3"},{"value":"Tram1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10823921"}],"value":"Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, probably via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45948"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:10731"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:61930"}],"ecNumber":"2.3.1.48"}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors (By similarity)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Y6Q9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10381882"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12709428"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23019124"}],"value":"Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the histone acetyltransferase protein CREBBP (By similarity). Found in a complex containing NCOA3, AR and MAK (By similarity). Interacts with ATAD2; the interaction is enhanced by estradiol (By similarity). Interacts with CARM1 (PubMed:10381882). Interacts with CASP8AP2 (By similarity). Interacts with ESR (By similarity). Interacts with ESRRB; mediates the interaction between ESRRB and RNA polymerase II complexes and allows NCOA3 corecruitment to ESRRB, KLF4, NANOG, and SOX2 enhancer regions to trigger ESRRB-dependent gene activation involved in self-renewal and pluripotency (PubMed:23019124). Interacts with NFKB1 (By similarity). Interacts with NPAS2 (By similarity). Interacts with NR3C1 (By similarity). Interacts with NR4A1/Nur77 (By similarity). Interacts with NR4A3 (PubMed:12709428). Interacts with PCAF (By similarity). Interacts with PPARA (By similarity). Interacts with PSMB9 (By similarity). Interacts with RARA (By similarity). Interacts with RXRA (By similarity). Interacts with THRA (By similarity). Interacts with VDR (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00981"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10823921"}],"value":"Not expressed in all steroid sensitive tissues. Highly expressed in the female reproductive system, in both oocyte and smooth muscle cells of the oviduct, but not expressed in the uterine endometrium. Highly expressed in mammary glands. Expressed moderately in smooth muscle cells of both blood vessels and intestines, and weakly expressed in hepatocytes. In brain, highly expressed in neurons of the hippocampus, and in mitral cell and granule layers of the olfactory bulb. Expressed moderately in the internal layer of cerebellum. Not expressed in the spinal cord, cardiac muscle, skeletal muscle, thymus and pancreas"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain) (By similarity)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11701890"}],"value":"Methylated by CARM1"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Y6Q9"}],"value":"Phosphorylated by IKK complex (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10823921"}],"value":"Defects result in diverse phenotype of postnatal growth retardation, such as dwarfism, delayed puberty, abnormal reproductive function and mammary gland growth retardation"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SRC/p160 nuclear receptor coactivator family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Y6Q9"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":1398,"modifier":"EXACT"}},"description":"Nuclear receptor coactivator 3","featureId":"PRO_0000094407"},{"type":"Domain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"bHLH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00981"}]},{"type":"Domain","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00140"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":512,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":611,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":668,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":697,"modifier":"EXACT"},"end":{"value":724,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":748,"modifier":"EXACT"},"end":{"value":788,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":839,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":891,"modifier":"EXACT"},"end":{"value":1054,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":949,"modifier":"EXACT"},"end":{"value":1113,"modifier":"EXACT"}},"description":"Interaction with CREBBP","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":1104,"modifier":"EXACT"},"end":{"value":1278,"modifier":"EXACT"}},"description":"Acetyltransferase"},{"type":"Region","location":{"start":{"value":1296,"modifier":"EXACT"},"end":{"value":1323,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":678,"modifier":"EXACT"},"end":{"value":682,"modifier":"EXACT"}},"description":"LXXLL motif 1"},{"type":"Motif","location":{"start":{"value":730,"modifier":"EXACT"},"end":{"value":734,"modifier":"EXACT"}},"description":"LXXLL motif 2"},{"type":"Motif","location":{"start":{"value":1041,"modifier":"EXACT"},"end":{"value":1045,"modifier":"EXACT"}},"description":"LXXLL motif 3"},{"type":"Compositional bias","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":428,"modifier":"EXACT"},"end":{"value":438,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":439,"modifier":"EXACT"},"end":{"value":460,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":503,"modifier":"EXACT"},"end":{"value":512,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":543,"modifier":"EXACT"},"end":{"value":561,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":572,"modifier":"EXACT"},"end":{"value":584,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":585,"modifier":"EXACT"},"end":{"value":595,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":642,"modifier":"EXACT"},"end":{"value":664,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":701,"modifier":"EXACT"},"end":{"value":719,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":750,"modifier":"EXACT"},"end":{"value":770,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":771,"modifier":"EXACT"},"end":{"value":781,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":965,"modifier":"EXACT"},"end":{"value":987,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1300,"modifier":"EXACT"},"end":{"value":1317,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Y6Q9"}]},{"type":"Modified residue","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19144319"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":544,"modifier":"EXACT"},"end":{"value":544,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19144319"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":562,"modifier":"EXACT"},"end":{"value":562,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":609,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23806337"}]},{"type":"Modified residue","location":{"start":{"value":612,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23806337"}]},{"type":"Modified residue","location":{"start":{"value":613,"modifier":"EXACT"},"end":{"value":613,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23806337"}]},{"type":"Modified residue","location":{"start":{"value":680,"modifier":"EXACT"},"end":{"value":680,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Y6Q9"}]},{"type":"Modified residue","location":{"start":{"value":687,"modifier":"EXACT"},"end":{"value":687,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Y6Q9"}]},{"type":"Modified residue","location":{"start":{"value":720,"modifier":"EXACT"},"end":{"value":720,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19144319"}]},{"type":"Modified residue","location":{"start":{"value":847,"modifier":"EXACT"},"end":{"value":847,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19144319"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":850,"modifier":"EXACT"},"end":{"value":850,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19144319"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1040,"modifier":"EXACT"},"end":{"value":1040,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Y6Q9"}]},{"type":"Modified residue","location":{"start":{"value":1178,"modifier":"EXACT"},"end":{"value":1178,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":1184,"modifier":"EXACT"},"end":{"value":1184,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":1195,"modifier":"EXACT"},"end":{"value":1195,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":1304,"modifier":"EXACT"},"end":{"value":1304,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Y6Q9"}]}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"9192892","citationType":"journal article","authors":["Torchia J.","Rose D.W.","Inostroza J.","Kamei Y.","Westin S.","Glass C.K.","Rosenfeld M.G."],"citationCrossReferences":[{"database":"PubMed","id":"9192892"},{"database":"DOI","id":"10.1038/42652"}],"title":"The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.","publicationDate":"1997","journal":"Nature","firstPage":"677","lastPage":"684","volume":"387"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","INTERACTION WITH CREBBP; ESR AND RARA"]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1360-1398"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Embryonic stem cell","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"10823921","citationType":"journal article","authors":["Xu J.","Liao L.","Ning G.","Yoshida-Komiya H.","Deng C.","O'Malley B.W."],"citationCrossReferences":[{"database":"PubMed","id":"10823921"},{"database":"DOI","id":"10.1073/pnas.120166297"}],"title":"The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development.","publicationDate":"2000","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"6379","lastPage":"6384","volume":"97"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY","DISRUPTION PHENOTYPE"]},{"referenceNumber":4,"citation":{"id":"10381882","citationType":"journal article","authors":["Chen D.","Ma H.","Hong H.","Koh S.S.","Huang S.-M.","Schurter B.T.","Aswad D.W.","Stallcup M.R."],"citationCrossReferences":[{"database":"PubMed","id":"10381882"},{"database":"DOI","id":"10.1126/science.284.5423.2174"}],"title":"Regulation of transcription by a protein methyltransferase.","publicationDate":"1999","journal":"Science","firstPage":"2174","lastPage":"2177","volume":"284"},"referencePositions":["INTERACTION WITH CARM1"]},{"referenceNumber":5,"citation":{"id":"11701890","citationType":"journal article","authors":["Xu W.","Chen H.","Du K.","Asahara H.","Tini M.","Emerson B.M.","Montminy M.","Evans R.M."],"citationCrossReferences":[{"database":"PubMed","id":"11701890"},{"database":"DOI","id":"10.1126/science.1065961"}],"title":"A transcriptional switch mediated by cofactor methylation.","publicationDate":"2001","journal":"Science","firstPage":"2507","lastPage":"2511","volume":"294"},"referencePositions":["METHYLATION BY CARM1"]},{"referenceNumber":6,"citation":{"id":"12709428","citationType":"journal article","authors":["Wansa K.D.","Harris J.M.","Yan G.","Ordentlich P.","Muscat G.E."],"citationCrossReferences":[{"database":"PubMed","id":"12709428"},{"database":"DOI","id":"10.1074/jbc.m300088200"}],"title":"The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"24776","lastPage":"24790","volume":"278"},"referencePositions":["INTERACTION WITH NR4A3"]},{"referenceNumber":7,"citation":{"id":"19144319","citationType":"journal article","authors":["Trost M.","English L.","Lemieux S.","Courcelles M.","Desjardins M.","Thibault P."],"citationCrossReferences":[{"database":"PubMed","id":"19144319"},{"database":"DOI","id":"10.1016/j.immuni.2008.11.006"}],"title":"The phagosomal proteome in interferon-gamma-activated macrophages.","publicationDate":"2009","journal":"Immunity","firstPage":"143","lastPage":"154","volume":"30"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215; SER-544; SER-720; SER-847 AND SER-850","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":8,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215; SER-544; SER-562; SER-847 AND SER-850","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brown adipose tissue","type":"TISSUE"},{"value":"Heart","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Liver","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Pancreas","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"23019124","citationType":"journal article","authors":["Percharde M.","Lavial F.","Ng J.H.","Kumar V.","Tomaz R.A.","Martin N.","Yeo J.C.","Gil J.","Prabhakar S.","Ng H.H.","Parker M.G.","Azuara V."],"citationCrossReferences":[{"database":"PubMed","id":"23019124"},{"database":"DOI","id":"10.1101/gad.195545.112"}],"title":"Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming.","publicationDate":"2012","journal":"Genes Dev.","firstPage":"2286","lastPage":"2298","volume":"26"},"referencePositions":["INTERACTION WITH ESRRB"]},{"referenceNumber":10,"citation":{"id":"23806337","citationType":"journal article","authors":["Park J.","Chen Y.","Tishkoff D.X.","Peng C.","Tan M.","Dai L.","Xie Z.","Zhang Y.","Zwaans B.M.","Skinner M.E.","Lombard D.B.","Zhao Y."],"citationCrossReferences":[{"database":"PubMed","id":"23806337"},{"database":"DOI","id":"10.1016/j.molcel.2013.06.001"}],"title":"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.","publicationDate":"2013","journal":"Mol. Cell","firstPage":"919","lastPage":"930","volume":"50"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-609; LYS-612 AND LYS-613","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Embryonic fibroblast","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"24129315","citationType":"journal article","authors":["Guo A.","Gu H.","Zhou J.","Mulhern D.","Wang Y.","Lee K.A.","Yang V.","Aguiar M.","Kornhauser J.","Jia X.","Ren J.","Beausoleil S.A.","Silva J.C.","Vemulapalli V.","Bedford M.T.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"24129315"},{"database":"DOI","id":"10.1074/mcp.o113.027870"}],"title":"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.","publicationDate":"2014","journal":"Mol. Cell. Proteomics","firstPage":"372","lastPage":"387","volume":"13"},"referencePositions":["METHYLATION [LARGE SCALE ANALYSIS] AT ARG-1178; ARG-1184 AND ARG-1195","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Embryo","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF000581","properties":[{"key":"ProteinId","value":"AAC05020.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK021229","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"O09000","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-44921N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O09000","properties":[{"key":"Number of interactors","value":"2395"}]},{"database":"IntAct","id":"O09000","properties":[{"key":"Interactions","value":"16"}]},{"database":"MINT","id":"O09000","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"10090.ENSMUSP00000085416","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"O09000","properties":[{"key":"glycosylation","value":"6 sites, 1 O-linked glycan (5 sites)"}]},{"database":"iPTMnet","id":"O09000","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O09000","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"O09000","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"O09000","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000085416","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O09000","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"287454","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"O09000","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"MGI:1276535","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1276535","properties":[{"key":"GeneName","value":"Ncoa3"}]},{"database":"eggNOG","id":"KOG3561","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"O09000","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-5687128","properties":[{"key":"PathwayName","value":"MAPK6/MAPK4 signaling"}]},{"database":"Reactome","id":"R-MMU-9018519","properties":[{"key":"PathwayName","value":"Estrogen-dependent gene expression"}]},{"database":"PRO","id":"PR:O09000","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"RNAct","id":"O09000","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11555636"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0090575","properties":[{"key":"GoTerm","value":"C:RNA polymerase II transcription regulator complex"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22977234"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16109736"}]},{"database":"GO","id":"GO:0097718","properties":[{"key":"GoTerm","value":"F:disordered domain specific binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0001228","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription activator activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22977234"}]},{"database":"GO","id":"GO:0004402","properties":[{"key":"GoTerm","value":"F:histone acetyltransferase activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0050681","properties":[{"key":"GoTerm","value":"F:nuclear androgen receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0030331","properties":[{"key":"GoTerm","value":"F:nuclear estrogen receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0016922","properties":[{"key":"GoTerm","value":"F:nuclear receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0042975","properties":[{"key":"GoTerm","value":"F:peroxisome proliferator activated receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0046983","properties":[{"key":"GoTerm","value":"F:protein dimerization activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0044877","properties":[{"key":"GoTerm","value":"F:protein-containing complex binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000993","properties":[{"key":"GoTerm","value":"F:RNA polymerase II complex binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23019124"}]},{"database":"GO","id":"GO:0000977","properties":[{"key":"GoTerm","value":"F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0003713","properties":[{"key":"GoTerm","value":"F:transcription coactivator activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27601327"}]},{"database":"GO","id":"GO:0043697","properties":[{"key":"GoTerm","value":"P:cell dedifferentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23019124"}]},{"database":"GO","id":"GO:0071392","properties":[{"key":"GoTerm","value":"P:cellular response to estradiol stimulus"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0032870","properties":[{"key":"GoTerm","value":"P:cellular response to hormone stimulus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0060713","properties":[{"key":"GoTerm","value":"P:labyrinthine layer morphogenesis"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"20685850"}]},{"database":"GO","id":"GO:0060744","properties":[{"key":"GoTerm","value":"P:mammary gland branching involved in thelarche"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11015591"}]},{"database":"GO","id":"GO:0035264","properties":[{"key":"GoTerm","value":"P:multicellular organism growth"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10823921"}]},{"database":"GO","id":"GO:0043066","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:2000737","properties":[{"key":"GoTerm","value":"P:negative regulation of stem cell differentiation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22977234"}]},{"database":"GO","id":"GO:0071630","properties":[{"key":"GoTerm","value":"P:nuclear protein quality control by the ubiquitin-proteasome system"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0030307","properties":[{"key":"GoTerm","value":"P:positive regulation of cell growth"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22977234"}]},{"database":"GO","id":"GO:0033145","properties":[{"key":"GoTerm","value":"P:positive regulation of intracellular steroid hormone receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0045618","properties":[{"key":"GoTerm","value":"P:positive regulation of keratinocyte differentiation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:1902459","properties":[{"key":"GoTerm","value":"P:positive regulation of stem cell population maintenance"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23019124"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:2000035","properties":[{"key":"GoTerm","value":"P:regulation of stem cell division"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23019124"}]},{"database":"GO","id":"GO:2000036","properties":[{"key":"GoTerm","value":"P:regulation of stem cell population maintenance"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22977234"}]},{"database":"GO","id":"GO:0072091","properties":[{"key":"GoTerm","value":"P:regulation of stem cell proliferation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22977234"}]},{"database":"GO","id":"GO:0048384","properties":[{"key":"GoTerm","value":"P:retinoic acid receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0070561","properties":[{"key":"GoTerm","value":"P:vitamin D receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000008","properties":[{"key":"EntryName","value":"Nuclear receptor coactivator"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.280.10:FF:000008","properties":[{"key":"EntryName","value":"Nuclear receptor coactivator"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000341","properties":[{"key":"EntryName","value":"Nuclear receptor coactivator 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.140.410","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.280.10","properties":[{"key":"EntryName","value":"Helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR011598","properties":[{"key":"EntryName","value":"bHLH_dom"}]},{"database":"InterPro","id":"IPR056193","properties":[{"key":"EntryName","value":"bHLH_NCOA1-3"}]},{"database":"InterPro","id":"IPR036638","properties":[{"key":"EntryName","value":"HLH_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR010011","properties":[{"key":"EntryName","value":"NCO_DUF1518"}]},{"database":"InterPro","id":"IPR032565","properties":[{"key":"EntryName","value":"NCOA2/3_DUF4927"}]},{"database":"InterPro","id":"IPR009110","properties":[{"key":"EntryName","value":"Nuc_rcpt_coact"}]},{"database":"InterPro","id":"IPR014920","properties":[{"key":"EntryName","value":"Nuc_rcpt_coact_Ncoa-typ"}]},{"database":"InterPro","id":"IPR037077","properties":[{"key":"EntryName","value":"Nuc_rcpt_coact_Ncoa_int_sf"}]},{"database":"InterPro","id":"IPR017426","properties":[{"key":"EntryName","value":"Nuclear_rcpt_coactivator"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"InterPro","id":"IPR013767","properties":[{"key":"EntryName","value":"PAS_fold"}]},{"database":"InterPro","id":"IPR014935","properties":[{"key":"EntryName","value":"SRC/p160_LXXLL"}]},{"database":"PANTHER","id":"PTHR10684","properties":[{"key":"EntryName","value":"NUCLEAR RECEPTOR COACTIVATOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10684:SF3","properties":[{"key":"EntryName","value":"NUCLEAR RECEPTOR COACTIVATOR 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23172","properties":[{"key":"EntryName","value":"bHLH_NCOA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07469","properties":[{"key":"EntryName","value":"DUF1518"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16279","properties":[{"key":"EntryName","value":"DUF4927"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16665","properties":[{"key":"EntryName","value":"NCOA_u2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08815","properties":[{"key":"EntryName","value":"Nuc_rec_co-act"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00989","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14598","properties":[{"key":"EntryName","value":"PAS_11"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08832","properties":[{"key":"EntryName","value":"SRC-1"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF038181","properties":[{"key":"EntryName","value":"Nuclear_receptor_coactivator"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01151","properties":[{"key":"EntryName","value":"DUF1518"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00353","properties":[{"key":"EntryName","value":"HLH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00091","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47459","properties":[{"key":"EntryName","value":"HLH, helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF69125","properties":[{"key":"EntryName","value":"Nuclear receptor coactivator interlocking domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50888","properties":[{"key":"EntryName","value":"BHLH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSGLGESSLDPLAAESRKRKLPCDAPGQGLVYSGEKWRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISSDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYSILHEPRRKDFLNTYQNPQLMEFLGLMRTRDKKAPYILIVRMLMKTHDILEDVNASPETRQRYETMQCFALSQPRAMLEEGEDLQCCMICVARRVTAPFPSSPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYVHGHAETPVYRFSLADGTIVSAQTKSKLFRNPVTNDRHGFISTHFLQREQNGYRPNPIPQDKGIRPPAAGCGVSMSPNQNVQMMGSRTYGVPDPSNTGQMGGARYGASSSVASLTPGQSLQSPSSYQNSSYGLSMSSPPHGSPGLGPNQQNIMISPRNRGSPKMASHQFSPAAGAHSPMGPSGNTGSHSFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNISQPSKVSGQDSKSPLGLYCEQNPVESSVCQSNSRDPQVKKESKESSGEVSETPRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDPNCKDSSVSVTSPSGVSSSTSGTVSSTSNVHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSTASCGEGTTRQEQLSPKKKENNALLRYLLDRDDPSDVLAKELQPQADSGDSKLSQCSCSTNPSSGQEKDPKIKTETNDEVSGDLDNLDAILGDLTSSDFYNNPTNGGHPGAKQQMFAGPSSLGLRSPQPVQSVRPPYNRAVSLDSPVSVGSGPPVKNVSAFPGLPKQPILAGNPRMMDSQENYGANMGPNRNVPVNPTSSPGDWGLANSRASRMEPLASSPLGRTGADYSATLPRPAMGGSVPTLPLRSNRLPGARPSLQQQQQQQQQQQQQQQQQQQQQQQMLQMRTGEIPMGMGVNPYSPAVQSNQPGSWPEGMLSMEQGPHGSQNRPLLRNSLDDLLGPPSNAEGQSDERALLDQLHTFLSNTDATGLEEIDRALGIPELVNQGQALESKQDVFQGQEAAVMMDQKAALYGQTYPAQGPPLQGGFNLQGQSPSFNSMMGQISQQGSFPLQGMHPRAGLVRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALEMKMENPAGTAVMRPMMPQAFFNAQMAAQQKRELMSHHLQQQRMAMMMSQPQPQAFSPPPNVTASPSMDGVLAGSAMPQAPPQQFPYPANYGMGQPPEPAFGRGSSPPSAMMSSRMGPSQNAMVQHPQPTPMYQPSDMKGWPSGNLARNGSFPQQQFAPQGNPAAYNMVHMNSSGGHLGQMAMTPMPMSGMPMGPDQKYC","length":1398,"molWeight":151574,"crc64":"EF44E92735816C24","md5":"3F3238D410F45B51D05C9C74867CEF04"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"ACTIVITY REGULATION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DOMAIN":1,"PTM":3,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Domain":2,"Region":11,"Motif":3,"Compositional bias":13,"Modified residue":17},"uniParcId":"UPI00000278CB"}}