{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O08653","uniProtkbId":"TEP1_RAT","entryAudit":{"firstPublicDate":"2004-05-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1997-07-01","entryVersion":159,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Rattus norvegicus","commonName":"Rat","taxonId":10116,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Rattus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Telomerase protein component 1"},"shortNames":[{"value":"rTLP1"}]},"alternativeNames":[{"fullName":{"value":"Telomerase-associated protein 1"},"shortNames":[{"value":"Telomerase protein 1"}]},{"fullName":{"value":"p230"}},{"fullName":{"value":"p240"}},{"fullName":{"value":"p80 telomerase homolog"}}]},"genes":[{"geneName":{"value":"Tep1"},"synonyms":[{"value":"Tlp1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97499"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q99973"}],"value":"Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (By similarity). Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction (By similarity). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97499"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q99973"}],"value":"Associated component of the telomerase holoenzyme complex (By similarity). Associates with MVP to form part of the vault particle (By similarity). The vault is a massive cage-like structure; it consists of a dimer of half-vaults, with each half-vault comprising 39 identical MVP subunits (By similarity). The two half-vaults assemble to form the complete vault, where minor vault components such as PARP4, TEP1 and vault RNAs (vRNAs) may bind to the interior (By similarity). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Chromosome, telomere","id":"SL-0276"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":2629,"modifier":"EXACT"}},"description":"Telomerase protein component 1","featureId":"PRO_0000050984"},{"type":"Repeat","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"TEP1 N-terminal 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00575"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"TEP1 N-terminal 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00575"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"TEP1 N-terminal 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00575"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"TEP1 N-terminal 4","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00575"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Domain","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":689,"modifier":"EXACT"}},"description":"TROVE","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00343"}]},{"type":"Domain","location":{"start":{"value":1175,"modifier":"EXACT"},"end":{"value":1582,"modifier":"EXACT"}},"description":"NACHT","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00136"}]},{"type":"Repeat","location":{"start":{"value":1424,"modifier":"EXACT"},"end":{"value":1461,"modifier":"EXACT"}},"description":"WD 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":1685,"modifier":"EXACT"},"end":{"value":1724,"modifier":"EXACT"}},"description":"WD 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":1727,"modifier":"EXACT"},"end":{"value":1765,"modifier":"EXACT"}},"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":1768,"modifier":"EXACT"},"end":{"value":1807,"modifier":"EXACT"}},"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":1809,"modifier":"EXACT"},"end":{"value":1848,"modifier":"EXACT"}},"description":"WD 5","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":1851,"modifier":"EXACT"},"end":{"value":1890,"modifier":"EXACT"}},"description":"WD 6","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":1893,"modifier":"EXACT"},"end":{"value":1934,"modifier":"EXACT"}},"description":"WD 7","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":1936,"modifier":"EXACT"},"end":{"value":1975,"modifier":"EXACT"}},"description":"WD 8","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":1978,"modifier":"EXACT"},"end":{"value":2016,"modifier":"EXACT"}},"description":"WD 9","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":2019,"modifier":"EXACT"},"end":{"value":2058,"modifier":"EXACT"}},"description":"WD 10","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":2070,"modifier":"EXACT"},"end":{"value":2109,"modifier":"EXACT"}},"description":"WD 11","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":2116,"modifier":"EXACT"},"end":{"value":2154,"modifier":"EXACT"}},"description":"WD 12","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":2157,"modifier":"EXACT"},"end":{"value":2194,"modifier":"EXACT"}},"description":"WD 13","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":2200,"modifier":"EXACT"},"end":{"value":2244,"modifier":"EXACT"}},"description":"WD 14","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":2247,"modifier":"EXACT"},"end":{"value":2285,"modifier":"EXACT"}},"description":"WD 15","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":2288,"modifier":"EXACT"},"end":{"value":2327,"modifier":"EXACT"}},"description":"WD 16","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":2329,"modifier":"EXACT"},"end":{"value":2365,"modifier":"EXACT"}},"description":"WD 17","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":2378,"modifier":"EXACT"},"end":{"value":2427,"modifier":"EXACT"}},"description":"WD 18","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":2470,"modifier":"EXACT"},"end":{"value":2510,"modifier":"EXACT"}},"description":"WD 19","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":2555,"modifier":"EXACT"},"end":{"value":2592,"modifier":"EXACT"}},"description":"WD 20","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Repeat","location":{"start":{"value":2594,"modifier":"EXACT"},"end":{"value":2628,"modifier":"EXACT"}},"description":"WD 21","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10864046"}]},{"type":"Region","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":416,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":401,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":1181,"modifier":"EXACT"},"end":{"value":1188,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00136"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0687","category":"Molecular function","name":"Ribonucleoprotein"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0779","category":"Cellular component","name":"Telomere"},{"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"9118230","citationType":"journal article","authors":["Nakayama J.","Saito M.","Nakamura H.","Matsuura A.","Ishikawa F."],"citationCrossReferences":[{"database":"PubMed","id":"9118230"},{"database":"DOI","id":"10.1016/s0092-8674(00)81933-9"}],"title":"TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family.","publicationDate":"1997","journal":"Cell","firstPage":"875","lastPage":"884","volume":"88"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX"],"referenceComments":[{"value":"Fischer 344","type":"STRAIN"},{"value":"Fibroblast","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"10551828","citationType":"journal article","authors":["Kickhoefer V.A.","Stephen A.G.","Harrington L.","Robinson M.O.","Rome L.H."],"citationCrossReferences":[{"database":"PubMed","id":"10551828"},{"database":"DOI","id":"10.1074/jbc.274.46.32712"}],"title":"Vaults and telomerase share a common subunit, TEP1.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"32712","lastPage":"32717","volume":"274"},"referencePositions":["IDENTIFICATION IN THE VAULTS RIBONUCLEOPROTEIN PARTICLE"]},{"referenceNumber":3,"citation":{"id":"10864046","citationType":"journal article","authors":["Kong L.B.","Siva A.C.","Kickhoefer V.A.","Rome L.H.","Stewart P.L."],"citationCrossReferences":[{"database":"PubMed","id":"10864046"},{"database":"DOI","id":"10.1017/s1355838200000157"}],"title":"RNA location and modeling of a WD40 repeat domain within the vault.","publicationDate":"2000","journal":"RNA","firstPage":"890","lastPage":"900","volume":"6"},"referencePositions":["ELECTRON CRYOMICROSCOPY (22 ANGSTROMS) OF VAULT COMPLEX AND TEP1 WD REPEATS MODELING"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U89282","properties":[{"key":"ProteinId","value":"AAB51690.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PIR","id":"T32735","properties":[{"key":"EntryName","value":"T32735"}]},{"database":"RefSeq","id":"NP_072113.1","properties":[{"key":"NucleotideSequenceId","value":"NM_022591.2"}]},{"database":"AlphaFoldDB","id":"O08653","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O08653","properties":[{"key":"Number of interactors","value":"255"}]},{"database":"STRING","id":"10116.ENSRNOP00000068552","properties":[{"key":"Description","value":"-"}]},{"database":"CarbonylDB","id":"O08653","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"O08653","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"O08653","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O08653","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10116-ENSRNOP00000068552","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"64523","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"rno:64523","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"RGD:3869","properties":[{"key":"OrganismName","value":"rat"}]},{"database":"AGR","id":"RGD:3869","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"7011","properties":[{"key":"Description","value":"-"}]},{"database":"RGD","id":"3869","properties":[{"key":"GeneName","value":"Tep1"}]},{"database":"eggNOG","id":"KOG3602","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"eggNOG","id":"KOG4155","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"O08653","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"41113at9989","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"O08653","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:O08653","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002494","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"GO","id":"GO:0000781","properties":[{"key":"GoTerm","value":"C:chromosome, telomeric region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0016363","properties":[{"key":"GoTerm","value":"C:nuclear matrix"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:1990904","properties":[{"key":"GoTerm","value":"C:ribonucleoprotein complex"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10864046"}]},{"database":"GO","id":"GO:0005697","properties":[{"key":"GoTerm","value":"C:telomerase holoenzyme complex"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9118230"}]},{"database":"GO","id":"GO:0019899","properties":[{"key":"GoTerm","value":"F:enzyme binding"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0002039","properties":[{"key":"GoTerm","value":"F:p53 binding"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0070034","properties":[{"key":"GoTerm","value":"F:telomerase RNA binding"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0006278","properties":[{"key":"GoTerm","value":"P:RNA-templated DNA biosynthetic process"},{"key":"GoEvidenceType","value":"IC:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"9118230"}]},{"database":"GO","id":"GO:0000722","properties":[{"key":"GoTerm","value":"P:telomere maintenance via recombination"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"CDD","id":"cd00200","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.370:FF:000002","properties":[{"key":"EntryName","value":"Telomerase associated protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:000636","properties":[{"key":"EntryName","value":"Telomerase protein component 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:000691","properties":[{"key":"EntryName","value":"Telomerase protein component 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:002153","properties":[{"key":"EntryName","value":"Telomerase protein component 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:002164","properties":[{"key":"EntryName","value":"Telomerase protein component 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:004068","properties":[{"key":"EntryName","value":"Telomerase protein component 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.370","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"6"}]},{"database":"InterPro","id":"IPR056829","properties":[{"key":"EntryName","value":"Beta-prop_TEP1_2nd"}]},{"database":"InterPro","id":"IPR056828","properties":[{"key":"EntryName","value":"Beta-prop_TEP1_C"}]},{"database":"InterPro","id":"IPR025139","properties":[{"key":"EntryName","value":"DUF4062"}]},{"database":"InterPro","id":"IPR045804","properties":[{"key":"EntryName","value":"DUF5920"}]},{"database":"InterPro","id":"IPR007111","properties":[{"key":"EntryName","value":"NACHT_NTPase"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR052652","properties":[{"key":"EntryName","value":"Telomerase_Complex_Comp"}]},{"database":"InterPro","id":"IPR008850","properties":[{"key":"EntryName","value":"TEP1_N"}]},{"database":"InterPro","id":"IPR008858","properties":[{"key":"EntryName","value":"TROVE_dom"}]},{"database":"InterPro","id":"IPR037214","properties":[{"key":"EntryName","value":"TROVE_dom_sf"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"PANTHER","id":"PTHR44791:SF1","properties":[{"key":"EntryName","value":"TELOMERASE PROTEIN COMPONENT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR44791","properties":[{"key":"EntryName","value":"TELOMERASE PROTEIN COMPONENT 1 TEP1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25047","properties":[{"key":"EntryName","value":"Beta-prop_TEP1_2nd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25048","properties":[{"key":"EntryName","value":"Beta-prop_TEP1_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13271","properties":[{"key":"EntryName","value":"DUF4062"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19334","properties":[{"key":"EntryName","value":"DUF5920"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05729","properties":[{"key":"EntryName","value":"NACHT"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05386","properties":[{"key":"EntryName","value":"TEP1_N"},{"key":"MatchStatus","value":"4"}]},{"database":"Pfam","id":"PF05731","properties":[{"key":"EntryName","value":"TROVE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"4"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"16"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF140864","properties":[{"key":"EntryName","value":"TROVE domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50837","properties":[{"key":"EntryName","value":"NACHT"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51226","properties":[{"key":"EntryName","value":"TEP1_N"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50988","properties":[{"key":"EntryName","value":"TROVE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"7"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MEKLCGYVPVHPDILSLKNRCLTMLSDIQPLEKIHGQRSVNPDILSLENRCLTLLPDLQPMEKIHGQRSVHPDILSSENRCLTLLPDLQSLEKLCGHMSSHPDVLSLENRCLATLPTVKRTVSSGPLLQCLHRSHTAQADLRDPNFRNCLFPEPPTIEAPCFLKELDLPTGPRALKSMSATARVQEVALGQRCVSEGKELQEEKESAEVPMPLYSLSLGGEEEEVVGAPVLKLTSGDSDSHPETTDQILQEKKMALLTLLCSAMASSVNVKDASDPTRASIHEVCSALAPLEPEFILKASLYARQQLNLRDIANIVLAVAALLPACRPHVRRYYSAIVHLPSDWIQVAEFYQSLAEGDEKKLVPLPACLRAAMTDKFAQFDEYQLAKYNPRKHRSKTRSRQPPRPQRTKPPFSESGKCFPKSVWPLKNEQISFEAAYNAVSEKKRLPRFTLKKLVEQLHIHEPAQHVQALLGYRYPSTLELFSRSHLPGPWDSSRAGQRMKLQRPETWERELSLRGNRASVWEELIDNGKLPFMAMLRNLCNLLRTGISAHHHELVLQRLQHEKSVIHSRQFPFRFLNAHDSLDRLEAQLRSKASPFPSNTTLMKRIMIRNSKKIKRPANPRYLCTLTQRQLRAAMAIPVMYEHLKREKLRLHKARQWTCDLELLERYRQALETAVNISVKHNLPPLPGRTLLVYLTDANANRLCPKSHLQGPPLNYVLLLIGMMMARAEQTTVWLCGTGTVKTPVLTADEGILKTAIKLQAQVQELEENDEWPLETFEKYLLSLAVRRTPIDRVILFGQRMDTELLNVAKQIIWQHVNSKCLFVSVLLRKMQYMSPNLNPNDVTLSGCTDGILKFIAEHGASRLLEHVGQLDKIFKIPPPPGKTKVSPLRPLEENNPGPFVPISQHGWRNIRLFISSTFRDMHGERDLLMRSVLPALQARAFPHRISLHAIDLRWGITEEETRRNRQLEVCLGEVENSQLFVGILGSRYGYTPPSYDLPDHPHFHWTQRYPSGRSVTEMEVMQFLNRGQRSEPSDQALIYFRDPGFLSSVPDVWKPDFISESEEAAHRVSELKRFLQEQKEVTCRRYSCEWGGVAAGRPYTGGLEEFGQLVLQDVWSVIQKRYLQPGAQLEQPGSISEEDLIQASFQQLKSPPSPARPRLLQDTVQQLMLPHGRLSLVIGQAGQGKTAFLASLVSALKVPDQPNVAPFVFFHFSAARPDQCLAFNLLRRLCTHLHQKLGEPSALPSTYRGLVWELQQKLLLKSAQWLQPGQTLVLIIDGADKLVDHNGQLISDWIPKSLPRRVHLVLSVSSDSGLGETLQQSQSAYVVALGSLVPSSRAQLVREELALYGKRLEESPFNNQMRLLLAKQGSSLPLYLHLVTDYLRLFTLYEQVSERLRTLPATLPLLLQHILSTLEQEHGHNVLPQALTALEVTHSGLTVDQLHAVLSTWLTLPKETKSWEEAVAASHSGNLYPLAPFAYLVQSLRSLLGEGPVERPGARLCLSDGPLRTAVKRRYGKRLGLEKTAHVLIAAHLWKMCDPDASGTFRSCPPEALKDLPYHLLQSGNHGLLAKFLTNLHVVAAYLEVGLVPDLLEAYELYASSKPEVNQKLPEADVAVFHNFLKQQASLLTQYPLLLLQQAASQPEESPVCCQAPLLTQRWHNQCILKWINKPQTLKGQQSLSLPISSSPTAVAFSPNGQRAAVGTAGGTIYLLNLRTWQEEKALVSGCDGISSFAFLSDTALFLTTFDGLLELWDLQHGCWVFQTKAHQYQITGCCLSPDRRLLATVCLGGYVKLWDTVQGQLAFQYTHPKSLNCITFHPEGQVVATGNWSGIVTFFQADGLKVTKELGGPGPSVRTLAFSAPGKVVALGRIDGTVELWAWQEGTRLAAFPAQCGGVSTVLFLHAGGRFLTAGEDGKAQLWSGFLGRPRGCLGSLYLSPALSVALNPDGDQVAVGYRGDGIKIYRISSGPQEAQCQELNVAVSALVWLSPSVLVSGAEDGSLHGWMLRRNSLQSLWLSSVCQKPVLGLAASQEFLASASEDFTVRLWPRQLLTQPHAVEELPCAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWDVKVAQAPLLIHTFSSCHRDWITGCTWTKDNILISCSSDGSVGLWNPEAGQQLGQFPGHQSAVSAVVAVEEHIVSVSRDGTLKVWDRQGVELTSIPAHSGPISQCAAALEPRPAGQPGSELMVVTVGLDGATKLWHPLLVCQIHTLQGHSGPVTAAAASEASGLLLTSDNSSVRLWQIPKEADDTCKPRSSAVITAVAWAPDGSLVVSGNEAGELTLWQKAQAVATARAPGRVSDLIWCSANAFFVLSANENVSEWQVELRKGSTCTNFRLYLKRVLQEDLGVLTGMALAPDGQSLILMKEDVELLQMKPGSTPSSICRRYAVHSSILCTSKDYGLFYLQQGNSGSLSILEQEESGKFEKTLDFNLNLNNPNGSPVSITQAEPESGSSLLCATSDGMLWNLSECTPEGEWVVDNIWQKKSRNPKSRTPGTDSSPGLFCMDSWVEPTHLKARQCKKIHLGSVTALHVLPGLLVTASEDRDVKLWERPSMQLLGLFRCEGPVSCLEPWMEPSSPLQLAVGDAQGNLYFLSWE","length":2629,"molWeight":291708,"crc64":"B90C3F72E5D4B6BE","md5":"0EFAB070CD0232DC2026160219A5AD9D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1,"Repeat":25,"Domain":2,"Region":1,"Compositional bias":1,"Binding site":1},"uniParcId":"UPI00000E6D37"}}