{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O08641","secondaryAccessions":["Q6P7V3","Q6PDR3"],"uniProtkbId":"SH3Y1_MOUSE","entryAudit":{"firstPublicDate":"2008-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1997-07-01","entryVersion":159,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"SH3 domain-containing YSC84-like protein 1"}}},"genes":[{"geneName":{"value":"Sh3yl1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12615363"}],"value":"Interacts with SH3D19"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O08641","intActId":"EBI-2024519"},"interactantTwo":{"uniProtKBAccession":"Q91X43","geneName":"Sh3d19","intActId":"EBI-2024543"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["O08641-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["O08641-2"],"sequenceIds":["VSP_034336"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["O08641-3"],"sequenceIds":["VSP_034337"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10771491"}],"value":"Expressed in skin, kidney, stomach, small intestine and colon. Highly expressed in the anagen hair follicle. In hair, it is expressed predominantly in the hair bulb, the hair shaft, inner root sheath, and outer root sheath in the lower half of the follicle"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10771491"}],"value":"In skin, expression follows hair-growth cycle, increasing significantly during mid and late anagen phases, and decreases during catagen, telogen and early anagen phases"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SH3YL1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"SH3 domain-containing YSC84-like protein 1","featureId":"PRO_0000341561"},{"type":"Domain","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"SH3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00192"}]},{"type":"Region","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Alternative sequence","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_034336","alternativeSequence":{"originalSequence":"AHVIAKAKGLAVLSVIKAGFLVTARGGSGIVLARLPDGK","alternativeSequences":["E"]}},{"type":"Alternative sequence","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_034337","alternativeSequence":{"originalSequence":"AKELPPKPSSRPQPAHPPVQLNAGSQGNRNEYKLYPELSSYHEKTGNLNQPIEVTALYSFEGQQPGDLNFQAGDRIIVISKTDSNFDWWEGKLRGQTGIFPANYVTMN","alternativeSequences":["VLWPGFTSLSVNMRGSVLAQL"]}},{"type":"Sequence conflict","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"in Ref. 3; AAH61488","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0728","category":"Domain","name":"SH3 domain"}],"references":[{"referenceNumber":1,"citation":{"id":"10771491","citationType":"journal article","authors":["Aoki N.","Ito K.","Ito M."],"citationCrossReferences":[{"database":"PubMed","id":"10771491"},{"database":"DOI","id":"10.1046/j.1523-1747.2000.00971.x"}],"title":"A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle.","publicationDate":"2000","journal":"J. Invest. Dermatol.","firstPage":"1050","lastPage":"1056","volume":"114"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"129","type":"STRAIN"},{"value":"FVB/N","type":"STRAIN"},{"value":"Mammary tumor","type":"TISSUE"},{"value":"Olfactory epithelium","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"12615363","citationType":"journal article","authors":["Shimomura Y.","Aoki N.","Ito K.","Ito M."],"citationCrossReferences":[{"database":"PubMed","id":"12615363"},{"database":"DOI","id":"10.1016/s0923-1811(02)00140-8"}],"title":"Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles.","publicationDate":"2003","journal":"J. Dermatol. Sci.","firstPage":"43","lastPage":"51","volume":"31"},"referencePositions":["INTERACTION WITH SH3D19"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D85926","properties":[{"key":"ProteinId","value":"BAA19679.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK141199","properties":[{"key":"ProteinId","value":"BAE24582.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC010296","properties":[{"key":"ProteinId","value":"AAH10296.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC058557","properties":[{"key":"ProteinId","value":"AAH58557.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC061488","properties":[{"key":"ProteinId","value":"AAH61488.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC110043","properties":[{"key":"ProteinId","value":"AAI10044.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS25859.1","properties":[{"key":"Description","value":"-"}],"isoformId":"O08641-1"},{"database":"CCDS","id":"CCDS79110.1","properties":[{"key":"Description","value":"-"}],"isoformId":"O08641-2"},{"database":"RefSeq","id":"NP_001276409.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001289480.1"}],"isoformId":"O08641-2"},{"database":"RefSeq","id":"NP_038737.1","properties":[{"key":"NucleotideSequenceId","value":"NM_013709.5"}],"isoformId":"O08641-1"},{"database":"AlphaFoldDB","id":"O08641","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O08641","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O08641","properties":[{"key":"Number of interactors","value":"18"}]},{"database":"IntAct","id":"O08641","properties":[{"key":"Interactions","value":"2"}]},{"database":"STRING","id":"10090.ENSMUSP00000020997","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O08641","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000020997","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O08641","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"257146","properties":[{"key":"Description","value":"-"}],"isoformId":"O08641-1"},{"database":"ProteomicsDB","id":"257147","properties":[{"key":"Description","value":"-"}],"isoformId":"O08641-2"},{"database":"ProteomicsDB","id":"257148","properties":[{"key":"Description","value":"-"}],"isoformId":"O08641-3"},{"database":"Antibodypedia","id":"49866","properties":[{"key":"antibodies","value":"37 antibodies from 14 providers"}]},{"database":"DNASU","id":"24057","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000020997.15","properties":[{"key":"ProteinId","value":"ENSMUSP00000020997.9"},{"key":"GeneId","value":"ENSMUSG00000020669.16"}],"isoformId":"O08641-1"},{"database":"Ensembl","id":"ENSMUST00000110880.3","properties":[{"key":"ProteinId","value":"ENSMUSP00000106504.3"},{"key":"GeneId","value":"ENSMUSG00000020669.16"}],"isoformId":"O08641-2"},{"database":"GeneID","id":"24057","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:24057","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007ngz.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"O08641-1"},{"database":"UCSC","id":"uc011ylg.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"O08641-2"},{"database":"AGR","id":"MGI:1346118","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"26751","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1346118","properties":[{"key":"GeneName","value":"Sh3yl1"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000020669","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1843","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00510000048137","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_015320_2_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O08641","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"SNCKARN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"35017at9989","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"O08641","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"24057","properties":[{"key":"hits","value":"3 hits in 76 CRISPR screens"}]},{"database":"PRO","id":"PR:O08641","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"RNAct","id":"O08641","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000020669","properties":[{"key":"ExpressionPatterns","value":"Expressed in seminal vesicle and 230 other cell types or tissues"}]},{"database":"GO","id":"GO:0032587","properties":[{"key":"GoTerm","value":"C:ruffle membrane"},{"key":"GoEvidenceType","value":"ISO:MGI"}]},{"database":"GO","id":"GO:0019902","properties":[{"key":"GoTerm","value":"F:phosphatase binding"},{"key":"GoEvidenceType","value":"ISO:MGI"}],"evidences":[{"evidenceCode":"ECO:0000266","source":"PubMed","id":"21624956"}]},{"database":"GO","id":"GO:0035091","properties":[{"key":"GoTerm","value":"F:phosphatidylinositol binding"},{"key":"GoEvidenceType","value":"ISO:MGI"}]},{"database":"GO","id":"GO:0006661","properties":[{"key":"GoTerm","value":"P:phosphatidylinositol biosynthetic process"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21624956"}]},{"database":"GO","id":"GO:1900027","properties":[{"key":"GoTerm","value":"P:regulation of ruffle assembly"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21624956"}]},{"database":"CDD","id":"cd11841","properties":[{"key":"EntryName","value":"SH3_SH3YL1_like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd11525","properties":[{"key":"EntryName","value":"SYLF_SH3YL1_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.30.40:FF:000100","properties":[{"key":"EntryName","value":"SH3 domain-containing YSC84-like protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.30.40","properties":[{"key":"EntryName","value":"SH3 Domains"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036028","properties":[{"key":"EntryName","value":"SH3-like_dom_sf"}]},{"database":"InterPro","id":"IPR001452","properties":[{"key":"EntryName","value":"SH3_domain"}]},{"database":"InterPro","id":"IPR051702","properties":[{"key":"EntryName","value":"SH3_domain_YSC84-like"}]},{"database":"InterPro","id":"IPR035511","properties":[{"key":"EntryName","value":"SH3YL1_SH3"}]},{"database":"InterPro","id":"IPR033643","properties":[{"key":"EntryName","value":"SYLF_SH3YL1-like"}]},{"database":"InterPro","id":"IPR007461","properties":[{"key":"EntryName","value":"Ysc84_actin-binding"}]},{"database":"PANTHER","id":"PTHR15629:SF2","properties":[{"key":"EntryName","value":"SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15629","properties":[{"key":"EntryName","value":"SH3YL1 PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14604","properties":[{"key":"EntryName","value":"SH3_9"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04366","properties":[{"key":"EntryName","value":"Ysc84"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00452","properties":[{"key":"EntryName","value":"SH3DOMAIN"}]},{"database":"SMART","id":"SM00326","properties":[{"key":"EntryName","value":"SH3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50044","properties":[{"key":"EntryName","value":"SH3-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50002","properties":[{"key":"EntryName","value":"SH3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNNPIPSNLKSEAKKAAKILREFTEITSRNGPDKIIPAHVIAKAKGLAVLSVIKAGFLVTARGGSGIVLARLPDGKWSAPSAIGIAGLGGGFEIGIEVSDLVIILNYDRAVEAFAKGGNLTLGGNFTVAVGPLGRNLEGNVSLRSSAAVFTYCKSRGLFAGISLEGSCLIERKETNRKFYCQDIRAYDILFGDVPQPAQAEDLYEILNSFTEKYETEGQRINLKKVAREQRKAKELPPKPSSRPQPAHPPVQLNAGSQGNRNEYKLYPELSSYHEKTGNLNQPIEVTALYSFEGQQPGDLNFQAGDRIIVISKTDSNFDWWEGKLRGQTGIFPANYVTMN","length":340,"molWeight":37028,"crc64":"3FE12C0A8530C74E","md5":"93EB1CDD1817639E6B048B3AEEB239D6"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"INTERACTION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":1,"Compositional bias":2,"Alternative sequence":2,"Sequence conflict":1},"uniParcId":"UPI00000279C1"}}