{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O07672","uniProtkbId":"FTSA_ENTHR","entryAudit":{"firstPublicDate":"1998-07-15","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"1997-07-01","entryVersion":72,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Enterococcus hirae","taxonId":1354,"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Lactobacillales","Enterococcaceae","Enterococcus"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02033"}],"value":"Cell division protein FtsA"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02033"}],"value":"ftsA"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02033"}],"value":"Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02033"}],"value":"Self-interacts. Interacts with FtsZ"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02033"}],"value":"Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02033"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02033"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02033"}],"value":"Cytoplasmic side","id":"SL-9910"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02033"}],"value":"Belongs to the FtsA/MreB family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":442,"modifier":"EXACT"}},"description":"Cell division protein FtsA","featureId":"PRO_0000062739"},{"type":"Region","location":{"start":{"value":401,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0132","category":"Biological process","name":"Cell division"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"}],"references":[{"referenceNumber":1,"citation":{"id":"10520745","citationType":"journal article","authors":["Duez C.","Thamm I.","Sapunaric F.","Coyette J.","Ghuysen J.-M."],"citationCrossReferences":[{"database":"PubMed","id":"10520745"},{"database":"DOI","id":"10.3109/10425179809072190"}],"title":"The division and cell wall gene cluster of Enterococcus hirae S185.","publicationDate":"1998","journal":"DNA Seq.","firstPage":"149","lastPage":"161","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"S185","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Y13922","properties":[{"key":"ProteinId","value":"CAA74237.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_088775049.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP072891.1"}]},{"database":"AlphaFoldDB","id":"O07672","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O07672","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"1354.A6P53_03415","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"1354-A6P53_03415","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0032153","properties":[{"key":"GoTerm","value":"C:cell division site"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009898","properties":[{"key":"GoTerm","value":"C:cytoplasmic side of plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0043093","properties":[{"key":"GoTerm","value":"P:FtsZ-dependent cytokinesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd24048","properties":[{"key":"EntryName","value":"ASKHA_NBD_FtsA"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"HAMAP","id":"MF_02033","properties":[{"key":"EntryName","value":"FtsA"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR020823","properties":[{"key":"EntryName","value":"Cell_div_FtsA"}]},{"database":"InterPro","id":"IPR050696","properties":[{"key":"EntryName","value":"FtsA/MreB"}]},{"database":"InterPro","id":"IPR021873","properties":[{"key":"EntryName","value":"FtsA_C"}]},{"database":"InterPro","id":"IPR003494","properties":[{"key":"EntryName","value":"SHS2_FtsA"}]},{"database":"NCBIfam","id":"TIGR01174","properties":[{"key":"EntryName","value":"ftsA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR32432:SF4","properties":[{"key":"EntryName","value":"CELL DIVISION PROTEIN FTSA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR32432","properties":[{"key":"EntryName","value":"CELL DIVISION PROTEIN FTSA-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14450","properties":[{"key":"EntryName","value":"FtsA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11983","properties":[{"key":"EntryName","value":"FtsA_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02491","properties":[{"key":"EntryName","value":"SHS2_FTSA"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF003101","properties":[{"key":"EntryName","value":"FtsA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00842","properties":[{"key":"EntryName","value":"FtsA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MAKTGMYVGLDIGTTSVKVVVAEYIDSQMNIIGVGNAKSEGINRGIIVDIDKTVQAIQRAVRQAEEKAGIQIKGVSVGLPANLLEVENCQGMIAVNGDSKEITDEDVRNVASAALVRSIPPERQIVSILPQDFTVDGFEGIKDPRGMIGVRLEMYGLLFTGPKTIVHNIRKCVENAGLVVNELVITPLALTETILSDGEKDFGTIVIDMGGGQTTTAVMHDKQLKFTSLDQEGGEFVTKDISIVLNTSFNNAEALKINYGDAYPERTSANEEFPVDVIGQSEPVKVDERYLSEVISARMEQIFNKAKEALDQIEALELPGGIVLTGGAASLPGVVDLAQEIFGVNVKLYVPNQMGLRNPVFTNVISIVDYSANLSEVYQLAKIAVTGETVVAHHTTVEQEVTSYDNDSYDAPEETVYDEPEQKKSDEDVTTKIKGFFSKIFD","length":442,"molWeight":47955,"crc64":"5F199A9F4AC5034C","md5":"5D678E2DEBBBBB569ECFE3518C536CC0"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI000012ACAE"}}