{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O06973","uniProtkbId":"YVCJ_BACSU","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1997-07-01","entryVersion":131,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Bacillus subtilis (strain 168)","taxonId":224308,"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Bacillaceae","Bacillus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00636"}],"value":"Nucleotide-binding protein YvcJ"}}},"genes":[{"geneName":{"value":"yvcJ"},"orderedLocusNames":[{"value":"BSU34770"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074378"}],"value":"Displays ATPase and GTPase activities. Can also hydrolyze pNPP. May affect the expression of competence via the phosphorylation of a cellular component"}],"commentType":"FUNCTION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074378"}],"value":"GTP is hydrolyzed with a 2-fold higher efficiency than ATP."}]}}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074378"}],"value":"Cells lacking this gene show a reduction in transformation efficiency and in fraction of cells that express competence"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00636"}],"value":"Belongs to the RapZ-like family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Nucleotide-binding protein YvcJ","featureId":"PRO_0000107689"},{"type":"Binding site","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00636"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00636"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}}],"keywords":[{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-83VLBI6EPOAAM","citationType":"submission","authors":["Denizot F."],"publicationDate":"APR-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"168","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9384377","citationType":"journal article","authors":["Kunst F.","Ogasawara N.","Moszer I.","Albertini A.M.","Alloni G.","Azevedo V.","Bertero M.G.","Bessieres P.","Bolotin A.","Borchert S.","Borriss R.","Boursier L.","Brans A.","Braun M.","Brignell S.C.","Bron S.","Brouillet S.","Bruschi C.V.","Caldwell B.","Capuano V.","Carter N.M.","Choi S.-K.","Codani J.-J.","Connerton I.F.","Cummings N.J.","Daniel R.A.","Denizot F.","Devine K.M.","Duesterhoeft A.","Ehrlich S.D.","Emmerson P.T.","Entian K.-D.","Errington J.","Fabret C.","Ferrari E.","Foulger D.","Fritz C.","Fujita M.","Fujita Y.","Fuma S.","Galizzi A.","Galleron N.","Ghim S.-Y.","Glaser P.","Goffeau A.","Golightly E.J.","Grandi G.","Guiseppi G.","Guy B.J.","Haga K.","Haiech J.","Harwood C.R.","Henaut A.","Hilbert H.","Holsappel S.","Hosono S.","Hullo M.-F.","Itaya M.","Jones L.-M.","Joris B.","Karamata D.","Kasahara Y.","Klaerr-Blanchard M.","Klein C.","Kobayashi Y.","Koetter P.","Koningstein G.","Krogh S.","Kumano M.","Kurita K.","Lapidus A.","Lardinois S.","Lauber J.","Lazarevic V.","Lee S.-M.","Levine A.","Liu H.","Masuda S.","Mauel C.","Medigue C.","Medina N.","Mellado R.P.","Mizuno M.","Moestl D.","Nakai S.","Noback M.","Noone D.","O'Reilly M.","Ogawa K.","Ogiwara A.","Oudega B.","Park S.-H.","Parro V.","Pohl T.M.","Portetelle D.","Porwollik S.","Prescott A.M.","Presecan E.","Pujic P.","Purnelle B.","Rapoport G.","Rey M.","Reynolds S.","Rieger M.","Rivolta C.","Rocha E.","Roche B.","Rose M.","Sadaie Y.","Sato T.","Scanlan E.","Schleich S.","Schroeter R.","Scoffone F.","Sekiguchi J.","Sekowska A.","Seror S.J.","Serror P.","Shin B.-S.","Soldo B.","Sorokin A.","Tacconi E.","Takagi T.","Takahashi H.","Takemaru K.","Takeuchi M.","Tamakoshi A.","Tanaka T.","Terpstra P.","Tognoni A.","Tosato V.","Uchiyama S.","Vandenbol M.","Vannier F.","Vassarotti A.","Viari A.","Wambutt R.","Wedler E.","Wedler H.","Weitzenegger T.","Winters P.","Wipat A.","Yamamoto H.","Yamane K.","Yasumoto K.","Yata K.","Yoshida K.","Yoshikawa H.-F.","Zumstein E.","Yoshikawa H.","Danchin A."],"citationCrossReferences":[{"database":"PubMed","id":"9384377"},{"database":"DOI","id":"10.1038/36786"}],"title":"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.","publicationDate":"1997","journal":"Nature","firstPage":"249","lastPage":"256","volume":"390"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"168","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"19074378","citationType":"journal article","authors":["Luciano J.","Foulquier E.","Fantino J.R.","Galinier A.","Pompeo F."],"citationCrossReferences":[{"database":"PubMed","id":"19074378"},{"database":"DOI","id":"10.1128/jb.01493-08"}],"title":"Characterization of YvcJ, a conserved P-loop-containing protein, and its implication in competence in Bacillus subtilis.","publicationDate":"2009","journal":"J. Bacteriol.","firstPage":"1556","lastPage":"1564","volume":"191"},"referencePositions":["FUNCTION","NTPASE ACTIVITY","KINETIC PARAMETERS","DISRUPTION PHENOTYPE"],"referenceComments":[{"value":"168","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z94043","properties":[{"key":"ProteinId","value":"CAB08057.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL009126","properties":[{"key":"ProteinId","value":"CAB15482.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"H70031","properties":[{"key":"EntryName","value":"H70031"}]},{"database":"RefSeq","id":"NP_391357.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000964.3"}]},{"database":"RefSeq","id":"WP_003243903.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000964.3"}]},{"database":"AlphaFoldDB","id":"O06973","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O06973","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O06973","properties":[{"key":"Number of interactors","value":"208"}]},{"database":"IntAct","id":"O06973","properties":[{"key":"Interactions","value":"2"}]},{"database":"STRING","id":"224308.BSU34770","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"O06973","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"224308-BSU34770","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"CAB15482","properties":[{"key":"ProteinId","value":"CAB15482"},{"key":"GeneId","value":"BSU_34770"}]},{"database":"GeneID","id":"936532","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"bsu:BSU34770","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|224308.179.peg.3765","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"eggNOG","id":"COG1660","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"InParanoid","id":"O06973","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9784461at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"O06973","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"BSUB:BSU34770-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001570","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"O06973","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0060090","properties":[{"key":"GoTerm","value":"F:molecular adaptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"HAMAP","id":"MF_00636","properties":[{"key":"EntryName","value":"RapZ_like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR005337","properties":[{"key":"EntryName","value":"RapZ-like"}]},{"database":"InterPro","id":"IPR053930","properties":[{"key":"EntryName","value":"RapZ-like_N"}]},{"database":"InterPro","id":"IPR053931","properties":[{"key":"EntryName","value":"RapZ_C"}]},{"database":"NCBIfam","id":"NF003828","properties":[{"key":"EntryName","value":"PRK05416.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30448","properties":[{"key":"EntryName","value":"RNASE ADAPTER PROTEIN RAPZ"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30448:SF0","properties":[{"key":"EntryName","value":"RNASE ADAPTER PROTEIN RAPZ"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22740","properties":[{"key":"EntryName","value":"PapZ_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03668","properties":[{"key":"EntryName","value":"RapZ-like_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF005052","properties":[{"key":"EntryName","value":"P-loopkin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSLLPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDSILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIVKHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSSYVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYFKKDYYTHVTHRDIEKRSRK","length":295,"molWeight":33851,"crc64":"4D717DCB4459F92A","md5":"19932D6400164A2253B97467BCF733AE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Binding site":2},"uniParcId":"UPI0000060ADE"}}