{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O06342","uniProtkbId":"Y3479_MYCTU","entryAudit":{"firstPublicDate":"2015-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-04-01","entryVersion":128,"sequenceVersion":4},"annotationScore":2.0,"organism":{"scientificName":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","taxonId":83332,"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Mycobacteriales","Mycobacteriaceae","Mycobacterium","Mycobacterium tuberculosis complex"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized membrane protein Rv3479"}}},"genes":[{"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"CCP46301.1"}],"value":"Rv3479"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CCP46301.1","note":"Truncated N-terminus."}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1082,"modifier":"EXACT"}},"description":"Uncharacterized membrane protein Rv3479","featureId":"PRO_0000432522"},{"type":"Transmembrane","location":{"start":{"value":959,"modifier":"EXACT"},"end":{"value":979,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":982,"modifier":"EXACT"},"end":{"value":1002,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1012,"modifier":"EXACT"},"end":{"value":1032,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1057,"modifier":"EXACT"},"end":{"value":1077,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"PNPLA","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"GXSXG","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"DGA/G","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01161"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"9634230","citationType":"journal article","authors":["Cole S.T.","Brosch R.","Parkhill J.","Garnier T.","Churcher C.M.","Harris D.E.","Gordon S.V.","Eiglmeier K.","Gas S.","Barry C.E. III","Tekaia F.","Badcock K.","Basham D.","Brown D.","Chillingworth T.","Connor R.","Davies R.M.","Devlin K.","Feltwell T.","Gentles S.","Hamlin N.","Holroyd S.","Hornsby T.","Jagels K.","Krogh A.","McLean J.","Moule S.","Murphy L.D.","Oliver S.","Osborne J.","Quail M.A.","Rajandream M.A.","Rogers J.","Rutter S.","Seeger K.","Skelton S.","Squares S.","Squares R.","Sulston J.E.","Taylor K.","Whitehead S.","Barrell B.G."],"citationCrossReferences":[{"database":"PubMed","id":"9634230"},{"database":"DOI","id":"10.1038/31159"}],"title":"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.","publicationDate":"1998","journal":"Nature","firstPage":"537","lastPage":"544","volume":"393"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 25618 / H37Rv","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"21969609","citationType":"journal article","authors":["Kelkar D.S.","Kumar D.","Kumar P.","Balakrishnan L.","Muthusamy B.","Yadav A.K.","Shrivastava P.","Marimuthu A.","Anand S.","Sundaram H.","Kingsbury R.","Harsha H.C.","Nair B.","Prasad T.S.","Chauhan D.S.","Katoch K.","Katoch V.M.","Kumar P.","Chaerkady R.","Ramachandran S.","Dash D.","Pandey A."],"citationCrossReferences":[{"database":"PubMed","id":"21969609"},{"database":"DOI","id":"10.1074/mcp.m111.011445"}],"title":"Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.","publicationDate":"2011","journal":"Mol. Cell. Proteomics","firstPage":"M111.011627","lastPage":"M111.011627","volume":"10"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"ATCC 25618 / H37Rv","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL123456","properties":[{"key":"ProteinId","value":"CCP46301.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_217996.2","properties":[{"key":"NucleotideSequenceId","value":"NC_000962.3"}]},{"database":"RefSeq","id":"WP_010886170.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000962.3"}]},{"database":"AlphaFoldDB","id":"O06342","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"83332.Rv3479","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"83332-Rv3479","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"888478","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"888478","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mtu:Rv3479","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|83332.12.peg.3885","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"TubercuList","id":"Rv3479","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG1752","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"InParanoid","id":"O06342","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8728704at2","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001584","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"HDA:MTBBASE"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"15952732"}]},{"database":"GO","id":"GO:0006629","properties":[{"key":"GoTerm","value":"P:lipid metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.1090.10","properties":[{"key":"EntryName","value":"Cytosolic phospholipase A2 catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR024282","properties":[{"key":"EntryName","value":"DUF3376"}]},{"database":"InterPro","id":"IPR019894","properties":[{"key":"EntryName","value":"Patatin-related_protein"}]},{"database":"InterPro","id":"IPR002641","properties":[{"key":"EntryName","value":"PNPLA_dom"}]},{"database":"NCBIfam","id":"TIGR03607","properties":[{"key":"EntryName","value":"patatin-like protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11856","properties":[{"key":"EntryName","value":"DUF3376"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01734","properties":[{"key":"EntryName","value":"Patatin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51635","properties":[{"key":"EntryName","value":"PNPLA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MFPAAVGVLWQSGLRDPTPPGGPHGIEGLSLAFEKPSPVTALTQELRFATTMTGGVSLAIWMAGVTREINLLAQASQWRRLGGTFPTNSQLTNESAASLRLYAQLIDLLDMVVDVDILSGTSAGGINAALLASSRVTGSDLGGIRDLWLDLGALTELLRDPRDKKTPSLLYGDERIFAALAKRLPKLATGPFPPTTFPEAARTPSTTLYITTTLLAGETSRFTDSFGTLVQDVDLRGLFTFTETDLARPDTAPALALAARSSASFPLAFEPSFLPFTKGTAKKGEVPARPAMAPFTSLTRPHWVSDGGLLDNRPIGVLFKRIFDRPARRPVRRVLLFVVPSSGPAPDPMHEPPPDNVDEPLGLIDGLLKGLAAVTTQSIAADLRAIRAHQDCMEARTDAKLRLAELAATLRNGTRLLTPSLLTDYRTREATKQAQTLTSALLRRLSTCPPESGPATESLPKSWSAELTVGGDADKVCRQQITATILLSWSQPTAQPLPQSPAELARFGQPAYDLAKGCALTVIRAAFQLARSDADIAALAEVTEAIHRAWRPTASSDLSVLVRTMCSRPAIRQGSLENAADQLAADYLQQSTVPGDAWERLGAALVNAYPTLTQLAASASADSGAPTDSLLARDHVAAGQLETYLSYLGTYPGRADDSRDAPTMAWKLFDLATTQRAMLPADAEIEQGLELVQVSADTRSLLAPDWQTAQQKLTGMRLHHFGAFYKRSWRANDWMWGRLDGAGWLVHVLLDPRRVRWIVGERADTNGPQSGAQWFLGKLKELGAPDFPSPGYPLPAVGGGPAQHLTEDMLLDELGFLDDPAKPLPASIPWTALWLSQAWQQRVLEEELDGLANTVLDPQPGKLPDWSPTSSRTWATKVLAAHPGDAKYALLNENPIAGETFASDKGSPLMAHTVAKAAATAAGAAGSVRQLPSVLKPPLITLRTLTLSGYRVVSLTKGIARSTIIAGALLLVLGVAAAIQSVTVFGVTGLIAAGTGGLLVVLGTWQVSGRLLFALLSFSVVGAVLALATPVVREWLFGTQQQPGWVGTHAYWLGAQWWHPLVVVGLIALVAIMIAAATPGRR","length":1082,"molWeight":115605,"crc64":"96EBB31106D2AFA2","md5":"08574BF06E29D25BBAFE27293826FC80"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Transmembrane":4,"Domain":1,"Motif":2,"Active site":2},"uniParcId":"UPI0003179DB6"}}