{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"M9MSG8","secondaryAccessions":["H6X2P4"],"uniProtkbId":"PIEZO_DROME","entryAudit":{"firstPublicDate":"2015-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-06-26","entryVersion":73,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Drosophila melanogaster","commonName":"Fruit fly","taxonId":7227,"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000000803"}],"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Diptera","Brachycera","Muscomorpha","Ephydroidea","Drosophilidae","Drosophila","Sophophora"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Piezo-type mechanosensitive ion channel component"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"FlyBase","id":"FBgn0264953"}],"value":"Piezo"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"FlyBase","id":"FBgn0264953"}],"value":"CG18103"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22343891"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22343900"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32649914"}],"value":"Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:22343891, PubMed:22343900). Plays a major role in nociception (response to strong or painful touch) (PubMed:22343891). Required for maintaining the mechanosensitivity of tarsal bristle mechanosensors (PubMed:32649914). During their evalulation of potential egg-laying sites, females determine the softest substrate for their eggs first by making a coarse evaluation of substrate hardness using mechanosensitive channels nan and Piezo in the leg tarsal bristles, followed by a much finer assessment using nan, iav and Tmc mechanosensitive channels on the labellum (PubMed:32649914). Acts in the nompC- and nan-expressing neurons of the female leg tarsals, to sense the mild differences in egg-laying substrate stiffness (PubMed:32649914)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22343900"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22343891"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32649914"}],"value":"Viable and fertile, with no apparent coordination defects (PubMed:22343891). Flies have significant defects in detection of strong touch stimuli, however detection of gentle touch and temperature is unaffected (PubMed:22343891). Decreases firing frequencies of adult leg tarsal bristles (PubMed:32649914). In females, no effect on texture selection during egg-laying (PubMed:32649914). RNAi-mediated knockdown in NompC-expressing neurons, reduces the female's preference for softer egg-laying substrates (PubMed:32649914)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Piezo comes from the Greek 'piesi' meaning pressure"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the PIEZO (TC 1.A.75) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":2551,"modifier":"EXACT"}},"description":"Piezo-type mechanosensitive ion channel component","featureId":"PRO_0000432404"},{"type":"Transmembrane","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"Helical; Name=8","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":395,"modifier":"EXACT"},"end":{"value":415,"modifier":"EXACT"}},"description":"Helical; Name=9","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"Helical; Name=10","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"Helical; Name=11","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":516,"modifier":"EXACT"},"end":{"value":536,"modifier":"EXACT"}},"description":"Helical; Name=12","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":548,"modifier":"EXACT"},"end":{"value":568,"modifier":"EXACT"}},"description":"Helical; Name=13","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":588,"modifier":"EXACT"},"end":{"value":608,"modifier":"EXACT"}},"description":"Helical; Name=14","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":611,"modifier":"EXACT"},"end":{"value":631,"modifier":"EXACT"}},"description":"Helical; Name=15","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":639,"modifier":"EXACT"},"end":{"value":659,"modifier":"EXACT"}},"description":"Helical; Name=16","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":695,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Helical; Name=17","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":819,"modifier":"EXACT"},"end":{"value":839,"modifier":"EXACT"}},"description":"Helical; Name=18","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":857,"modifier":"EXACT"},"end":{"value":877,"modifier":"EXACT"}},"description":"Helical; Name=19","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":910,"modifier":"EXACT"},"end":{"value":930,"modifier":"EXACT"}},"description":"Helical; Name=20","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":973,"modifier":"EXACT"},"end":{"value":993,"modifier":"EXACT"}},"description":"Helical; Name=21","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":994,"modifier":"EXACT"},"end":{"value":1014,"modifier":"EXACT"}},"description":"Helical; Name=22","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1022,"modifier":"EXACT"},"end":{"value":1042,"modifier":"EXACT"}},"description":"Helical; Name=23","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1071,"modifier":"EXACT"},"end":{"value":1091,"modifier":"EXACT"}},"description":"Helical; Name=24","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1152,"modifier":"EXACT"},"end":{"value":1172,"modifier":"EXACT"}},"description":"Helical; Name=25","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1174,"modifier":"EXACT"},"end":{"value":1194,"modifier":"EXACT"}},"description":"Helical; Name=26","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1198,"modifier":"EXACT"},"end":{"value":1218,"modifier":"EXACT"}},"description":"Helical; Name=27","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1239,"modifier":"EXACT"},"end":{"value":1259,"modifier":"EXACT"}},"description":"Helical; Name=28","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1275,"modifier":"EXACT"},"end":{"value":1295,"modifier":"EXACT"}},"description":"Helical; Name=29","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1718,"modifier":"EXACT"},"end":{"value":1738,"modifier":"EXACT"}},"description":"Helical; Name=30","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1741,"modifier":"EXACT"},"end":{"value":1761,"modifier":"EXACT"}},"description":"Helical; Name=31","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1770,"modifier":"EXACT"},"end":{"value":1790,"modifier":"EXACT"}},"description":"Helical; Name=32","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1817,"modifier":"EXACT"},"end":{"value":1837,"modifier":"EXACT"}},"description":"Helical; Name=33","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1937,"modifier":"EXACT"},"end":{"value":1957,"modifier":"EXACT"}},"description":"Helical; Name=34","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1979,"modifier":"EXACT"},"end":{"value":1999,"modifier":"EXACT"}},"description":"Helical; Name=35","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":2008,"modifier":"EXACT"},"end":{"value":2028,"modifier":"EXACT"}},"description":"Helical; Name=36","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":2033,"modifier":"EXACT"},"end":{"value":2053,"modifier":"EXACT"}},"description":"Helical; Name=37","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":2075,"modifier":"EXACT"},"end":{"value":2095,"modifier":"EXACT"}},"description":"Helical; Name=38","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":2151,"modifier":"EXACT"},"end":{"value":2171,"modifier":"EXACT"}},"description":"Helical; Name=39","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":2431,"modifier":"EXACT"},"end":{"value":2451,"modifier":"EXACT"}},"description":"Helical; Name=40","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":731,"modifier":"EXACT"},"end":{"value":772,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1426,"modifier":"EXACT"},"end":{"value":1521,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1592,"modifier":"EXACT"},"end":{"value":1658,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1854,"modifier":"EXACT"},"end":{"value":1876,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2522,"modifier":"EXACT"},"end":{"value":2551,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":731,"modifier":"EXACT"},"end":{"value":741,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1430,"modifier":"EXACT"},"end":{"value":1448,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1466,"modifier":"EXACT"},"end":{"value":1477,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1497,"modifier":"EXACT"},"end":{"value":1511,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1621,"modifier":"EXACT"},"end":{"value":1634,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1644,"modifier":"EXACT"},"end":{"value":1658,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Sequence conflict","location":{"start":{"value":1640,"modifier":"EXACT"},"end":{"value":1642,"modifier":"EXACT"}},"description":"in Ref. 1; AFB77909","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":2326,"modifier":"EXACT"},"end":{"value":2326,"modifier":"EXACT"}},"description":"in Ref. 1; AFB77909","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0407","category":"Molecular function","name":"Ion channel"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0716","category":"Biological process","name":"Sensory transduction"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"22343900","citationType":"journal article","authors":["Coste B.","Xiao B.","Santos J.S.","Syeda R.","Grandl J.","Spencer K.S.","Kim S.E.","Schmidt M.","Mathur J.","Dubin A.E.","Montal M.","Patapoutian A."],"citationCrossReferences":[{"database":"PubMed","id":"22343900"},{"database":"DOI","id":"10.1038/nature10812"}],"title":"Piezo proteins are pore-forming subunits of mechanically activated channels.","publicationDate":"2012","journal":"Nature","firstPage":"176","lastPage":"181","volume":"483"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","FUNCTION","SUBCELLULAR LOCATION"],"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AFB77909.1"}]},{"referenceNumber":2,"citation":{"id":"10731132","citationType":"journal article","authors":["Adams M.D.","Celniker S.E.","Holt R.A.","Evans C.A.","Gocayne J.D.","Amanatides P.G.","Scherer S.E.","Li P.W.","Hoskins R.A.","Galle R.F.","George R.A.","Lewis S.E.","Richards S.","Ashburner M.","Henderson S.N.","Sutton G.G.","Wortman J.R.","Yandell M.D.","Zhang Q.","Chen L.X.","Brandon R.C.","Rogers Y.-H.C.","Blazej R.G.","Champe M.","Pfeiffer B.D.","Wan K.H.","Doyle C.","Baxter E.G.","Helt G.","Nelson C.R.","Miklos G.L.G.","Abril J.F.","Agbayani A.","An H.-J.","Andrews-Pfannkoch C.","Baldwin D.","Ballew R.M.","Basu A.","Baxendale J.","Bayraktaroglu L.","Beasley E.M.","Beeson K.Y.","Benos P.V.","Berman B.P.","Bhandari D.","Bolshakov S.","Borkova D.","Botchan M.R.","Bouck J.","Brokstein P.","Brottier P.","Burtis K.C.","Busam D.A.","Butler H.","Cadieu E.","Center A.","Chandra I.","Cherry J.M.","Cawley S.","Dahlke C.","Davenport L.B.","Davies P.","de Pablos B.","Delcher A.","Deng Z.","Mays A.D.","Dew I.","Dietz S.M.","Dodson K.","Doup L.E.","Downes M.","Dugan-Rocha S.","Dunkov B.C.","Dunn P.","Durbin K.J.","Evangelista C.C.","Ferraz C.","Ferriera S.","Fleischmann W.","Fosler C.","Gabrielian A.E.","Garg N.S.","Gelbart W.M.","Glasser K.","Glodek A.","Gong F.","Gorrell J.H.","Gu Z.","Guan P.","Harris M.","Harris N.L.","Harvey D.A.","Heiman T.J.","Hernandez J.R.","Houck J.","Hostin D.","Houston K.A.","Howland T.J.","Wei M.-H.","Ibegwam C.","Jalali M.","Kalush F.","Karpen G.H.","Ke Z.","Kennison J.A.","Ketchum K.A.","Kimmel B.E.","Kodira C.D.","Kraft C.L.","Kravitz S.","Kulp D.","Lai Z.","Lasko P.","Lei Y.","Levitsky A.A.","Li J.H.","Li Z.","Liang Y.","Lin X.","Liu X.","Mattei B.","McIntosh T.C.","McLeod M.P.","McPherson D.","Merkulov G.","Milshina N.V.","Mobarry C.","Morris J.","Moshrefi A.","Mount S.M.","Moy M.","Murphy B.","Murphy L.","Muzny D.M.","Nelson D.L.","Nelson D.R.","Nelson K.A.","Nixon K.","Nusskern D.R.","Pacleb J.M.","Palazzolo M.","Pittman G.S.","Pan S.","Pollard J.","Puri V.","Reese M.G.","Reinert K.","Remington K.","Saunders R.D.C.","Scheeler F.","Shen H.","Shue B.C.","Siden-Kiamos I.","Simpson M.","Skupski M.P.","Smith T.J.","Spier E.","Spradling A.C.","Stapleton M.","Strong R.","Sun E.","Svirskas R.","Tector C.","Turner R.","Venter E.","Wang A.H.","Wang X.","Wang Z.-Y.","Wassarman D.A.","Weinstock G.M.","Weissenbach J.","Williams S.M.","Woodage T.","Worley K.C.","Wu D.","Yang S.","Yao Q.A.","Ye J.","Yeh R.-F.","Zaveri J.S.","Zhan M.","Zhang G.","Zhao Q.","Zheng L.","Zheng X.H.","Zhong F.N.","Zhong W.","Zhou X.","Zhu S.C.","Zhu X.","Smith H.O.","Gibbs R.A.","Myers E.W.","Rubin G.M.","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"10731132"},{"database":"DOI","id":"10.1126/science.287.5461.2185"}],"title":"The genome sequence of Drosophila melanogaster.","publicationDate":"2000","journal":"Science","firstPage":"2185","lastPage":"2195","volume":"287"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"ADV36969.1"}]},{"referenceNumber":3,"citation":{"id":"12537572","citationType":"journal article","authors":["Misra S.","Crosby M.A.","Mungall C.J.","Matthews B.B.","Campbell K.S.","Hradecky P.","Huang Y.","Kaminker J.S.","Millburn G.H.","Prochnik S.E.","Smith C.D.","Tupy J.L.","Whitfield E.J.","Bayraktaroglu L.","Berman B.P.","Bettencourt B.R.","Celniker S.E.","de Grey A.D.N.J.","Drysdale R.A.","Harris N.L.","Richter J.","Russo S.","Schroeder A.J.","Shu S.Q.","Stapleton M.","Yamada C.","Ashburner M.","Gelbart W.M.","Rubin G.M.","Lewis S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12537572"},{"database":"DOI","id":"10.1186/gb-2002-3-12-research0083"}],"title":"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.","publicationDate":"2002","journal":"Genome Biol.","firstPage":"RESEARCH0083.1","lastPage":"RESEARCH0083.22","volume":"3"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000000803"}],"value":"Berkeley","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"ADV36969.1"},{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000000803"}]},{"referenceNumber":4,"citation":{"id":"22343891","citationType":"journal article","authors":["Kim S.E.","Coste B.","Chadha A.","Cook B.","Patapoutian A."],"citationCrossReferences":[{"database":"PubMed","id":"22343891"},{"database":"DOI","id":"10.1038/nature10801"}],"title":"The role of Drosophila Piezo in mechanical nociception.","publicationDate":"2012","journal":"Nature","firstPage":"209","lastPage":"212","volume":"483"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"],"evidences":[{"evidenceCode":"ECO:0000305"}]},{"referenceNumber":5,"citation":{"id":"32649914","citationType":"journal article","authors":["Zhang L.","Yu J.","Guo X.","Wei J.","Liu T.","Zhang W."],"citationCrossReferences":[{"database":"PubMed","id":"32649914"},{"database":"DOI","id":"10.1016/j.cub.2020.05.076"}],"title":"Parallel Mechanosensory Pathways Direct Oviposition Decision-Making in Drosophila.","publicationDate":"2020","journal":"Curr. Biol.","firstPage":"3075","lastPage":"3088","volume":"30"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ425255","properties":[{"key":"ProteinId","value":"AFB77909.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AE014134","properties":[{"key":"ProteinId","value":"ADV36969.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001188719.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001201790.2"}]},{"database":"AlphaFoldDB","id":"M9MSG8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"M9MSG8","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"M9MSG8","properties":[{"key":"Number of interactors","value":"355"}]},{"database":"STRING","id":"7227.FBpp0312565","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"7227-FBpp0312565","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"M9MSG8","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblMetazoa","id":"FBtr0335179","properties":[{"key":"ProteinId","value":"FBpp0307172"},{"key":"GeneId","value":"FBgn0264953"}]},{"database":"GeneID","id":"34112","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"dme:Dmel_CG44122","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"FB:FBgn0264953","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"34112","properties":[{"key":"Description","value":"-"}]},{"database":"FlyBase","id":"FBgn0264953","properties":[{"key":"GeneName","value":"Piezo"}]},{"database":"VEuPathDB","id":"VectorBase:FBgn0264953","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1893","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"M9MSG8","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"303066at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"34112","properties":[{"key":"hits","value":"0 hits in 3 CRISPR screens"}]},{"database":"GenomeRNAi","id":"34112","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:M9MSG8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000803","properties":[{"key":"Component","value":"Chromosome 2L"}]},{"database":"Bgee","id":"FBgn0264953","properties":[{"key":"ExpressionPatterns","value":"Expressed in nociceptive neuron in imaginal disc-derived wing and 223 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"M9MSG8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22343900"}]},{"database":"GO","id":"GO:0140135","properties":[{"key":"GoTerm","value":"F:mechanosensitive monoatomic cation channel activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0008381","properties":[{"key":"GoTerm","value":"F:mechanosensitive monoatomic ion channel activity"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22343900"}]},{"database":"GO","id":"GO:0071260","properties":[{"key":"GoTerm","value":"P:cellular response to mechanical stimulus"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22343891"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22343900"}]},{"database":"GO","id":"GO:0050982","properties":[{"key":"GoTerm","value":"P:detection of mechanical stimulus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0050965","properties":[{"key":"GoTerm","value":"P:detection of temperature stimulus involved in sensory perception of pain"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"36200757"}]},{"database":"GO","id":"GO:0007638","properties":[{"key":"GoTerm","value":"P:mechanosensory behavior"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22343891"}]},{"database":"GO","id":"GO:0098655","properties":[{"key":"GoTerm","value":"P:monoatomic cation transmembrane transport"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22343900"}]},{"database":"GO","id":"GO:0034220","properties":[{"key":"GoTerm","value":"P:monoatomic ion transmembrane transport"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"32649914"}]},{"database":"GO","id":"GO:0042391","properties":[{"key":"GoTerm","value":"P:regulation of membrane potential"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR027272","properties":[{"key":"EntryName","value":"Piezo"}]},{"database":"InterPro","id":"IPR031334","properties":[{"key":"EntryName","value":"Piezo_cap_dom"}]},{"database":"InterPro","id":"IPR056770","properties":[{"key":"EntryName","value":"Piezo_THU9_anchor"}]},{"database":"InterPro","id":"IPR056769","properties":[{"key":"EntryName","value":"Piezo_TM1-24"}]},{"database":"InterPro","id":"IPR031805","properties":[{"key":"EntryName","value":"Piezo_TM25-28"}]},{"database":"InterPro","id":"IPR056768","properties":[{"key":"EntryName","value":"THU_Piezo"}]},{"database":"PANTHER","id":"PTHR47049","properties":[{"key":"EntryName","value":"PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47049:SF2","properties":[{"key":"EntryName","value":"PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12166","properties":[{"key":"EntryName","value":"Piezo_cap"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24874","properties":[{"key":"EntryName","value":"Piezo_THU9_anchor"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24871","properties":[{"key":"EntryName","value":"Piezo_TM1-24"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15917","properties":[{"key":"EntryName","value":"Piezo_TM25-28"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23188","properties":[{"key":"EntryName","value":"THU_Piezo1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVFSYACMVLQRIVVPAVLVLAALMRPVGISFVYLLMFFVSPFVPLATRRNFKGSVTAFFIILLTLSTLVLLGHITLQILAVSLTLPIYNCSFSERLLRHIGFVSFIDLQPFAIIEWLVPEVLVFATSLGSYLTVKRVASQPVGAEQLENGEVVDGQAENAQTSSQPSAADANGGDVQQATVTTPLQQQQQQLRKRVSMISQHIHFEGLVKISPLFCLATLFFAAVLRPSVPGGFYFLIFLLSGTYWATCQTLQRGFALLLRCVMVVLVLHSLSIVSYQTPWMQSHLNHTTLTARLIGLEPLIESYCSPDIRVFLYNNKLSLDSYLNPFALFFAYFALALTTKHLIKPRLVRQSTRKARTPQPLESGSSVAPSVTQRGNDMQLESMEQRSEQENTTTSILDQISYGFVSVGGFIYQNSYIFTNILMMAWSIVYHSWLTFVLLLSANVLWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYGMDLNNEELPTSVPTAGINLQQIGFERPIENQMRPCVPLIVKTAFVLMFWVTSRQFFKEKRDRRRDSTLADFIAPLQITVGSAGSSYLINDGKKTSKFLKKAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRICYMALFLFFLLVFQSSSKAWVKIMYGFWLFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQKDIGLKRYQTKDLFLHLVSPTIIVILTVIQVHYFHKRFIASLQQQPLAGGSAQQKPTETTALEPAPSKRRGSAGSLRKSQGPSAEAAPGATTDFETSVRDLVRISFRKIKNKSEYIFKNFKDVFWRFLELHIMKAVYIAAFVCSVSEVCVLHIIFVGFCVLGATSRKAVQVVISRLISFIVTVIVLSKMIYQIEYLSHSQHNVVCSDNRTANNAEWIGLTKADKVTGGLMSLLRTYIIYMVIVTMHAVISLRQLQMRVKIGALNAPPTKLLFPNIIRADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVVYALWLVVLLLLRRSQCAKIWGVFQAFFAISILTQYIVLVGLPPSSCLVFPWDEGPFGEGIQRWAMLPGALHFNHVPKLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTHDFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQLTKDCCWLVHMLGITCTSNVLTEQIMLPEEAELALKPGECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDEHGYPLPAPTVRRRKEIKLHPHATRAGDYYMFEEMDDKFELDLIHDEIDFLEEENITESEMKMQRRKTLYDKSKDAPTGEFPSTSKGISKERDAATASSSASPAPTRDVGDLPVIPPPSTGLGREQTSKETSDSKSKMEVDSGEVTAKDSDEDFDTNPIIRLLEGFLVTLTIRLNRFSRNYRFVNRILAGEKKTLKESSSLNRLGLSSAAAMFHFLKSNLESDESEPPASSSTPRRVVIAPPNATEHSDPTSTTLNTNTTTTPLSPPEPLQPLQPLQPNTTSTPQQQHQHIRAAEEIIELPVDTVDGVAHRKQSINSSPPAKGAGEFNLEEENFAQRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQPLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYKFFFSLVHKSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPIYTTNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPLVIKMHRDNETNGLWWEIRDYCNDTFYNETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTRPKEEYVDDDGDTDSIPSRMSVRRPEQLQPQQPQ","length":2551,"molWeight":289447,"crc64":"CC463BCC881AF6F0","md5":"5F0E50156B49BEADE62BCFEDFEAE1CE5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"DISRUPTION PHENOTYPE":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":40,"Region":6,"Compositional bias":7,"Sequence conflict":2},"uniParcId":"UPI0001F7707B"}}