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With the RNA-binding protein (RBP) csdA, forms a post-transcriptional control network for secondary metabolites biosynthesis, csdA controlling the expression of laeB at the post-transcriptional level by influencing the alternative splicing of its pre-mRNA (By similarity). Once translated, the laeB protein is able to interact with csdA to form a regulatory complex to regulate the growth, development, and metabolism (By similarity). Plays also an important role in the maintenance of the cell wall and in membrane integrity (PubMed:36909432). Particularly required for the production of secondary metabolites including deoxynivalenol (DON), and subsequent full virulence (PubMed:36909432)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"W3WX91"}],"value":"Interacts with csdA"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"W3WX91"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"W3WX91"}],"value":"The RNA-binding protein csdA mediates laeB expression by binding specific motif GUCGGUAU on laeB pre-mRNA for alternative splicing, regulating the stability of intron 2 splicing, thereby producing normal levels of laeB protein that interacts with csdA to regulate fungal growth, development and secondary metabolism"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36909432"}],"value":"Reduces vegetative growth and formation of conifia (PubMed:36909432). Affects the expression of many genes involved in secondary metabolism (PubMed:36909432). Especially, down-regulates 20 times the expression levels of the TRI5 gene which impairs the generation of deoxynivalenol (DON) and decreases the virulence during infection of wheat stem base or head (PubMed:36909432)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the laeB global regulator family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":738,"modifier":"EXACT"}},"description":"Global regulator 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