{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"I3LGZ3","uniProtkbId":"GL15L_PIG","entryAudit":{"firstPublicDate":"2017-12-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-07-11","entryVersion":57,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Sus scrofa","commonName":"Pig","taxonId":9823,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Laurasiatheria","Artiodactyla","Suina","Suidae","Sus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein GPR15LG"}},"alternativeNames":[{"fullName":{"value":"Protein GPR15 ligand"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28900043"}],"value":"Protein GPR15L"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"GPR15LG"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28900043"}],"value":"GPR15L"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6UWK7"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28900043"}],"value":"Highly cationic protein that has multiple functions. 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In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6UWK7"}],"value":"Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6UWK7"}],"value":"Interacts with SUSD2; the interaction is direct"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28900043"}],"value":"Secreted","id":"SL-0243"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28900043"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Protein GPR15LG","featureId":"PRO_5003675598"},{"type":"Disulfide bond","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28900043"}]},{"type":"Disulfide bond","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28900043"}]}],"keywords":[{"id":"KW-0044","category":"Molecular function","name":"Antibiotic"},{"id":"KW-0929","category":"Molecular function","name":"Antimicrobial"},{"id":"KW-0145","category":"Biological process","name":"Chemotaxis"},{"id":"KW-0202","category":"Molecular function","name":"Cytokine"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-64I80C5JJIVVB","citationType":"submission","authoringGroup":["Porcine genome sequencing project"],"publicationDate":"NOV-2009","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Duroc","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"28900043","citationType":"journal article","authors":["Suply T.","Hannedouche S.","Carte N.","Li J.","Grosshans B.","Schaefer M.","Raad L.","Beck V.","Vidal S.","Hiou-Feige A.","Beluch N.","Barbieri S.","Wirsching J.","Lageyre N.","Hillger F.","Debon C.","Dawson J.","Smith P.","Lannoy V.","Detheux M.","Bitsch F.","Falchetto R.","Bouwmeester T.","Porter J.","Baumgarten B.","Mansfield K.","Carballido J.M.","Seuwen K.","Bassilana F."],"citationCrossReferences":[{"database":"PubMed","id":"28900043"},{"database":"DOI","id":"10.1126/scisignal.aal0180"}],"title":"A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia.","publicationDate":"2017","journal":"Sci. 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