{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"G5EGA5","uniProtkbId":"FAT2_CAEEL","entryAudit":{"firstPublicDate":"2013-09-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-12-14","entryVersion":96,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Caenorhabditis elegans","taxonId":6239,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Nematoda","Chromadorea","Rhabditida","Rhabditina","Rhabditomorpha","Rhabditoidea","Rhabditidae","Peloderinae","Caenorhabditis"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11972048"}],"value":"Delta(12) fatty acid desaturase fat-2"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11972048"}],"value":"FAT-2"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22041902"}],"value":"1.14.19.-"},{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10775428"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11972048"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22041902"}],"value":"1.14.19.6"}]},"alternativeNames":[{"fullName":{"value":"Fatty acid desaturase 2"}}]},"genes":[{"geneName":{"value":"fat-2"},"orfNames":[{"value":"W02A2.1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10775428"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11972048"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22041902"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26806391"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"10775428"}],"value":"Can function as a Delta(12)/Delta(15) bifunctional desaturase and behaves as a nu +3' desaturase. 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HPO-19 knockdown or mutation alters FAT-2 desaturase activity. Although FAT-2 lacks a cytochrome b5 domain, its N-terminal contains a DUF3474 domain that may possess some oxidoreductase activity for electron transfer, obviating the need for an extra cytochrome b5 enzyme, but still requiring cytochrome b5 reductase HPO-19/T05H4.4 to become activated"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the fatty acid desaturase type 1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"Delta(12) fatty acid desaturase fat-2","featureId":"PRO_0000423384"},{"type":"Transmembrane","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0275","category":"Biological process","name":"Fatty acid biosynthesis"},{"id":"KW-0276","category":"Biological process","name":"Fatty acid metabolism"},{"id":"KW-0444","category":"Biological process","name":"Lipid biosynthesis"},{"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10775428","citationType":"journal article","authors":["Peyou-Ndi M.M.","Watts J.L.","Browse J."],"citationCrossReferences":[{"database":"PubMed","id":"10775428"},{"database":"DOI","id":"10.1006/abbi.2000.1733"}],"title":"Identification and characterization of an animal delta(12) fatty acid desaturase gene by heterologous expression in Saccharomyces cerevisiae.","publicationDate":"2000","journal":"Arch. 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