{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"G2WWX2","uniProtkbId":"VP2_VERDV","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":31,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)","commonName":"Verticillium wilt","taxonId":498257,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Sordariomycetes","Hypocreomycetidae","Glomerellales","Plectosphaerellaceae","Verticillium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37883523"}],"value":"Elicotor VP2"}},"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"21829347"}],"value":"VP2"},"orfNames":[{"value":"VDAG_02751"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37883523"}],"value":"Secreted protein that acts as an elicitor that can be recognized by multiple plant species and trigger the immune response (PubMed:37883523). Significantly activates the expression of Nicotiana benthamiana genes involved in hypersensitive response (HR), like HSR203 and HIN1, and PAMP triggered immunity (PTI)-related genes, like Acre31, pia5, CYP71D20, and WRKY7 (PubMed:37883523). Its elicitor activity depends on BAK1 but not on SOBIR1 in Nicotiana benthamiana (PubMed:37883523). In cotton, triggers the immune system and defense response leading to enhanced resistance to Verticillium dahliae without causing abnormal plant growth and development, by activating phytohormone synthesis and phenolic metabolite biosynthesis (PubMed:37883523). Up-regulates the expression of cotton genes involved in the salicylic acid (SA) signaling pathway, including PR1, PR2, and PR5 and jasmonic acid (JA) signaling pathway such as PR4 (PubMed:37883523). Finally, VP2 also induces expression of plant lignin synthesis related genes, including cotton phenylalanine ammonia-lyases (PALs), as well as CCoAOMT, F5H-6, F5H-7, and 4CL-1 (PubMed:37883523)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37883523"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37883523"}],"value":"Expresssion is highly up-regulated at the early stage invasion"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37883523"}],"value":"Attenuates the pathogenicity"}],"commentType":"DISRUPTION PHENOTYPE"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"Elicotor VP2","featureId":"PRO_5003439142"},{"type":"Glycosylation","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00498"}],"featureId":""}],"keywords":[{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0843","category":"Biological process","name":"Virulence"}],"references":[{"referenceNumber":1,"citation":{"id":"21829347","citationType":"journal article","authors":["Klosterman S.J.","Subbarao K.V.","Kang S.","Veronese P.","Gold S.E.","Thomma B.P.H.J.","Chen Z.","Henrissat B.","Lee Y.-H.","Park J.","Garcia-Pedrajas M.D.","Barbara D.J.","Anchieta A.","de Jonge R.","Santhanam P.","Maruthachalam K.","Atallah Z.","Amyotte S.G.","Paz Z.","Inderbitzin P.","Hayes R.J.","Heiman D.I.","Young S.","Zeng Q.","Engels R.","Galagan J.","Cuomo C.A.","Dobinson K.F.","Ma L.-J."],"citationCrossReferences":[{"database":"PubMed","id":"21829347"},{"database":"DOI","id":"10.1371/journal.ppat.1002137"}],"title":"Comparative genomics yields insights into niche adaptation of plant vascular wilt pathogens.","publicationDate":"2011","journal":"PLoS Pathog.","firstPage":"E1002137","lastPage":"E1002137","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"VdLs.17 / ATCC MYA-4575 / FGSC 10137","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"37883523","citationType":"journal article","authors":["Qiu P.","Zheng B.","Yuan H.","Yang Z.","Lindsey K.","Wang Y.","Ming Y.","Zhang L.","Hu Q.","Shaban M.","Kong J.","Zhang X.","Zhu L."],"citationCrossReferences":[{"database":"PubMed","id":"37883523"},{"database":"DOI","id":"10.1111/pbi.14201"}],"title":"The elicitor VP2 from Verticillium dahliae triggers defence response in cotton.","publicationDate":"2024","journal":"Plant Biotechnol. 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