{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"F4I8W1","secondaryAccessions":["Q9LPZ2"],"uniProtkbId":"DUF2_ARATH","entryAudit":{"firstPublicDate":"2016-06-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-06-28","entryVersion":75,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"DUF724 domain-containing protein 2"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19795213"}],"value":"AtDUF2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19795213"}],"value":"DUF2"},"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Araport","id":"AT1G11420"}],"value":"At1g11420"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAF16647.1"}],"value":"T23J18.9"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19795213"}],"value":"May be involved in the polar growth of plant cells via transportation of RNAs"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19795213"}],"value":"Expressed in flowers and siliques, and at lower levels in leaves and stems"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAF16647.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":604,"modifier":"EXACT"}},"description":"DUF724 domain-containing protein 2","featureId":"PRO_0000436420"},{"type":"Domain","location":{"start":{"value":405,"modifier":"EXACT"},"end":{"value":603,"modifier":"EXACT"}},"description":"DUF724","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":520,"modifier":"EXACT"},"end":{"value":575,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0341","category":"Biological process","name":"Growth regulation"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11130712","citationType":"journal article","authors":["Theologis A.","Ecker J.R.","Palm C.J.","Federspiel N.A.","Kaul S.","White O.","Alonso J.","Altafi H.","Araujo R.","Bowman C.L.","Brooks S.Y.","Buehler E.","Chan A.","Chao Q.","Chen H.","Cheuk R.F.","Chin C.W.","Chung M.K.","Conn L.","Conway A.B.","Conway A.R.","Creasy T.H.","Dewar K.","Dunn P.","Etgu P.","Feldblyum T.V.","Feng J.-D.","Fong B.","Fujii C.Y.","Gill J.E.","Goldsmith A.D.","Haas B.","Hansen N.F.","Hughes B.","Huizar L.","Hunter J.L.","Jenkins J.","Johnson-Hopson C.","Khan S.","Khaykin E.","Kim C.J.","Koo H.L.","Kremenetskaia I.","Kurtz D.B.","Kwan A.","Lam B.","Langin-Hooper S.","Lee A.","Lee J.M.","Lenz C.A.","Li J.H.","Li Y.-P.","Lin X.","Liu S.X.","Liu Z.A.","Luros J.S.","Maiti R.","Marziali A.","Militscher J.","Miranda M.","Nguyen M.","Nierman W.C.","Osborne B.I.","Pai G.","Peterson J.","Pham P.K.","Rizzo M.","Rooney T.","Rowley D.","Sakano H.","Salzberg S.L.","Schwartz J.R.","Shinn P.","Southwick A.M.","Sun H.","Tallon L.J.","Tambunga G.","Toriumi M.J.","Town C.D.","Utterback T.","Van Aken S.","Vaysberg M.","Vysotskaia V.S.","Walker M.","Wu D.","Yu G.","Fraser C.M.","Venter J.C.","Davis R.W."],"citationCrossReferences":[{"database":"PubMed","id":"11130712"},{"database":"DOI","id":"10.1038/35048500"}],"title":"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.","publicationDate":"2000","journal":"Nature","firstPage":"816","lastPage":"820","volume":"408"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"19795213","citationType":"journal article","authors":["Cao X.","Yang K.Z.","Xia C.","Zhang X.Q.","Chen L.Q.","Ye D."],"citationCrossReferences":[{"database":"PubMed","id":"19795213"},{"database":"DOI","id":"10.1007/s11103-009-9551-5"}],"title":"Characterization of DUF724 gene family in Arabidopsis thaliana.","publicationDate":"2010","journal":"Plant Mol. Biol.","firstPage":"61","lastPage":"73","volume":"72"},"referencePositions":["FUNCTION","GENE FAMILY","NOMENCLATURE","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011661","properties":[{"key":"ProteinId","value":"AAF16647.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002684","properties":[{"key":"ProteinId","value":"AEE28734.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408683","properties":[{"key":"ProteinId","value":"CAO7026978.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"A86248","properties":[{"key":"EntryName","value":"A86248"}]},{"database":"RefSeq","id":"NP_172609.1","properties":[{"key":"NucleotideSequenceId","value":"NM_101015.2"}]},{"database":"AlphaFoldDB","id":"F4I8W1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"F4I8W1","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"F4I8W1","properties":[{"key":"Number of interactors","value":"300"}]},{"database":"STRING","id":"3702.F4I8W1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-F4I8W1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"837684","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT1G11420","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT1G11420","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT1G11420","properties":[{"key":"GeneName","value":"DUF2"}]},{"database":"eggNOG","id":"ENOG502QTQX","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_007138_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"F4I8W1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NICQMES","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PRO","id":"PR:F4I8W1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"ExpressionAtlas","id":"F4I8W1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"CDD","id":"cd20405","properties":[{"key":"EntryName","value":"Tudor_Agenet_AtDUF_rpt1_3"},{"key":"MatchStatus","value":"2"}]},{"database":"CDD","id":"cd20406","properties":[{"key":"EntryName","value":"Tudor_Agenet_AtDUF_rpt2_4"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR008395","properties":[{"key":"EntryName","value":"Agenet-like_dom"}]},{"database":"InterPro","id":"IPR014002","properties":[{"key":"EntryName","value":"Agenet_dom_plant"}]},{"database":"InterPro","id":"IPR007930","properties":[{"key":"EntryName","value":"DUF724"}]},{"database":"PANTHER","id":"PTHR31917","properties":[{"key":"EntryName","value":"AGENET DOMAIN-CONTAINING PROTEIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31917:SF77","properties":[{"key":"EntryName","value":"DUF724 DOMAIN-CONTAINING PROTEIN 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05641","properties":[{"key":"EntryName","value":"Agenet"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF05266","properties":[{"key":"EntryName","value":"DUF724"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00743","properties":[{"key":"EntryName","value":"Agenet"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MEQMIFIRKDDKVEVFSEEEELKGSYYRAILEDNPTKSGHNKLKVRYLTQLNEHRLAPLTEFVDQRFIRPVPSEDVNDGVVFVEGLMVDAYLKDGWWTGVVVKTMEDEKFLVYFDCPPDIIQFEKKKLRVHLDWTGFKWIRPDNKELVKSVFSCGTMVELRFDCAWIPVIVIKELEKDKRFLVKYWNKSYSCRESKNLIVDSLRLRPMQPPLSVGKYELLDHVEAFSGFEWRQGVVRGIVFEGRYMVSFGATKEASQFNHSDIRPPMEWEDGVWHKRTKPKRQKETSLDGNRNVQTKEPPGNEMADDVKKESGLPITLGVTATKNKTQGKVSPVPMKNGFGNESTREKMPEEPKIKYYTRKRKRGGLKLNSYINKTVLSSDRTPNVVKNSASNAEENHAKHTIMVLPFAKKSPVWKTYESLEVFKSVSHSLHFSPLFETKQDFREGYAIGMMVTYFGLLEKFKDLEADVPVSQLNSLKDSFSELEKHGFNVTTPLSRIDKLLALKDRQLYIMEELKGFDKEMTNEFSKAKQEFDDMEQKILEVKHKIIELQRQEAALKEQKEAEKEQKDAAWKKICQMESCAKDLNVELEDVEFEFETILSAPW","length":604,"molWeight":70272,"crc64":"92F960368DD7662C","md5":"009A9D89EB177EBA9608132A9650B98C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"TISSUE SPECIFICITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":2,"Coiled coil":1},"uniParcId":"UPI0000162D1C"}}