{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"F4I1X0","secondaryAccessions":["A0A2H1ZEE4","F4I1X1","Q9LFZ4","Q9LG34","Q9LG35"],"uniProtkbId":"HIP41_ARATH","entryAudit":{"firstPublicDate":"2016-11-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-06-28","entryVersion":87,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000006548"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"21072340"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23368984"}],"value":"Heavy metal-associated isoprenylated plant protein 41"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"21072340"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23368984"}],"value":"AtHIP41"}]},"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"21072340"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23368984"}],"value":"HIPP41"},"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Araport","id":"AT1G55790"}],"value":"At1g55790"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAF79341.1"}],"value":"F14J16.2"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAF79340.1"}],"value":"F14J16.3"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAF79501.1"}],"value":"F20N2.17"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9LZF1"}],"value":"Heavy-metal-binding protein"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the HIPP family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAF79340.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAF79341.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAF79501.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AEE33296.2","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":512,"modifier":"EXACT"}},"description":"Heavy metal-associated isoprenylated plant protein 41","featureId":"PRO_0000437855"},{"type":"Propeptide","location":{"start":{"value":513,"modifier":"EXACT"},"end":{"value":515,"modifier":"EXACT"}},"description":"Removed in mature form","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"PRO_0000437856"},{"type":"Domain","location":{"start":{"value":376,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"HMA","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00280"}]},{"type":"Modified residue","location":{"start":{"value":512,"modifier":"EXACT"},"end":{"value":512,"modifier":"EXACT"}},"description":"Cysteine methyl ester","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9SZN7"}]},{"type":"Lipidation","location":{"start":{"value":512,"modifier":"EXACT"},"end":{"value":512,"modifier":"EXACT"}},"description":"S-farnesyl cysteine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9SZN7"}]}],"keywords":[{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0636","category":"PTM","name":"Prenylation"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11130712","citationType":"journal article","authors":["Theologis A.","Ecker J.R.","Palm C.J.","Federspiel N.A.","Kaul S.","White O.","Alonso J.","Altafi H.","Araujo R.","Bowman C.L.","Brooks S.Y.","Buehler E.","Chan A.","Chao Q.","Chen H.","Cheuk R.F.","Chin C.W.","Chung M.K.","Conn L.","Conway A.B.","Conway A.R.","Creasy T.H.","Dewar K.","Dunn P.","Etgu P.","Feldblyum T.V.","Feng J.-D.","Fong B.","Fujii C.Y.","Gill J.E.","Goldsmith A.D.","Haas B.","Hansen N.F.","Hughes B.","Huizar L.","Hunter J.L.","Jenkins J.","Johnson-Hopson C.","Khan S.","Khaykin E.","Kim C.J.","Koo H.L.","Kremenetskaia I.","Kurtz D.B.","Kwan A.","Lam B.","Langin-Hooper S.","Lee A.","Lee J.M.","Lenz C.A.","Li J.H.","Li Y.-P.","Lin X.","Liu S.X.","Liu Z.A.","Luros J.S.","Maiti R.","Marziali A.","Militscher J.","Miranda M.","Nguyen M.","Nierman W.C.","Osborne B.I.","Pai G.","Peterson J.","Pham P.K.","Rizzo M.","Rooney T.","Rowley D.","Sakano H.","Salzberg S.L.","Schwartz J.R.","Shinn P.","Southwick A.M.","Sun H.","Tallon L.J.","Tambunga G.","Toriumi M.J.","Town C.D.","Utterback T.","Van Aken S.","Vaysberg M.","Vysotskaia V.S.","Walker M.","Wu D.","Yu G.","Fraser C.M.","Venter J.C.","Davis R.W."],"citationCrossReferences":[{"database":"PubMed","id":"11130712"},{"database":"DOI","id":"10.1038/35048500"}],"title":"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.","publicationDate":"2000","journal":"Nature","firstPage":"816","lastPage":"820","volume":"408"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"21072340","citationType":"journal article","authors":["Tehseen M.","Cairns N.","Sherson S.","Cobbett C.S."],"citationCrossReferences":[{"database":"PubMed","id":"21072340"},{"database":"DOI","id":"10.1039/c003484c"}],"title":"Metallochaperone-like genes in Arabidopsis thaliana.","publicationDate":"2010","journal":"Metallomics","firstPage":"556","lastPage":"564","volume":"2"},"referencePositions":["GENE FAMILY","NOMENCLATURE"]},{"referenceNumber":5,"citation":{"id":"23368984","citationType":"journal article","authors":["de Abreu-Neto J.B.","Turchetto-Zolet A.C.","de Oliveira L.F.","Zanettini M.H.","Margis-Pinheiro M."],"citationCrossReferences":[{"database":"PubMed","id":"23368984"},{"database":"DOI","id":"10.1111/febs.12159"}],"title":"Heavy metal-associated isoprenylated plant protein (HIPP): characterization of a family of proteins exclusive to plants.","publicationDate":"2013","journal":"FEBS J.","firstPage":"1604","lastPage":"1616","volume":"280"},"referencePositions":["GENE FAMILY","NOMENCLATURE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002304","properties":[{"key":"ProteinId","value":"AAF79340.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC002304","properties":[{"key":"ProteinId","value":"AAF79341.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC002328","properties":[{"key":"ProteinId","value":"AAF79501.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002684","properties":[{"key":"ProteinId","value":"AEE33296.2"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408683","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_564700.3","properties":[{"key":"NucleotideSequenceId","value":"NM_104455.4"}]},{"database":"AlphaFoldDB","id":"F4I1X0","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-F4I1X0","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"230241","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"842028","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT1G55790","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT1G55790","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT1G55790","properties":[{"key":"GeneName","value":"-"}]},{"database":"eggNOG","id":"KOG4174","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_529320_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"F4I1X0","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:F4I1X0","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0070042","properties":[{"key":"GoTerm","value":"F:rRNA (uridine-N3-)-methyltransferase activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0070475","properties":[{"key":"GoTerm","value":"P:rRNA base methylation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"FunFam","id":"3.30.70.100:FF:000095","properties":[{"key":"EntryName","value":"Disease resistance protein RGA5"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.150:FF:000440","properties":[{"key":"EntryName","value":"Os09g0479300 protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.100","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.150","properties":[{"key":"EntryName","value":"Vaccinia Virus protein VP39"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR019446","properties":[{"key":"EntryName","value":"BMT5-like"}]},{"database":"InterPro","id":"IPR006121","properties":[{"key":"EntryName","value":"HMA_dom"}]},{"database":"InterPro","id":"IPR029063","properties":[{"key":"EntryName","value":"SAM-dependent_MTases_sf"}]},{"database":"PANTHER","id":"PTHR11538:SF26","properties":[{"key":"EntryName","value":"FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11538","properties":[{"key":"EntryName","value":"PHENYLALANYL-TRNA SYNTHETASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10354","properties":[{"key":"EntryName","value":"BMT5-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53335","properties":[{"key":"EntryName","value":"S-adenosyl-L-methionine-dependent methyltransferases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50846","properties":[{"key":"EntryName","value":"HMA_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAMRELSQLNRDSDGDEEVWVKHYSSNHQILLVGEGDFSFSHSLATLFGSASNICASSLDSYDVVVRKYKKARSNLKTLKRLGALLLHGVDATTLHFHPDLRYRRFDRVIFNFPHAGFHGRESDSSLIRKHRELVFGFFNGASRLLRANGEVHVSHKNKAPFSEWNLEELASRCFLVLIQRVAFEKNNYPGYENKRGDGRRCDQPFLLGECSTFKFRFSRVAKELYAEKVRSREVKERESMYPEAILNKQPVSFDHRYRLQTEFEAIAGTITLGKSKILWLSQEKGHLHWIFVTTKNVDVYSSKIPVFLICTLESRQRDIACFVKTFQFKLVKNHYPNTLTAGVEFLVKFITGKYEECQQVTYLRKNFSGYGDGNKQRIVLKMDMSDEKSMKKAMKIASAKPGVRSVSIQGQNDQLVLLGEGIDLAELTRELKKKVCMTTIITVQAAPPQQPPQPHPMGQYNQMPPARRCTCEIPNSGFCGFCRSMSQPNYQVVPSPYYPPMLYCRDETDGCRIL","length":515,"molWeight":59038,"crc64":"F0D90367D1C3CA46","md5":"5FE41A4B8BFC30B472A86A2FC5802A4C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SIMILARITY":1,"SEQUENCE CAUTION":4},"countByFeatureType":{"Chain":1,"Propeptide":1,"Domain":1,"Modified residue":1,"Lipidation":1},"uniParcId":"UPI0001E92AAB"}}