{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"E9Q793","secondaryAccessions":["E0CX29","Q9CUE4"],"uniProtkbId":"JHY_MOUSE","entryAudit":{"firstPublicDate":"2017-11-22","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2011-04-05","entryVersion":85,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23906841"}],"value":"Jhy protein"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23906841"}],"value":"Juvenile hydrocephalus protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23906841"},{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1918239"}],"value":"Jhy"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23906841"}],"value":"Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23906841"}],"value":"Expressed in the brain, specifically in hypothalamus, pineal gland, and ependymal cells of the aqueduct of Sylvius, as well as in the choroid plexus of the third ventricle. Expressed in the ependymal cells lining the lateral ventricles (at protein level)"}],"commentType":"TISSUE SPECIFICITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":770,"modifier":"EXACT"}},"description":"Jhy protein","featureId":"PRO_0000442261"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":438,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":493,"modifier":"EXACT"},"end":{"value":527,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":595,"modifier":"EXACT"},"end":{"value":647,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":708,"modifier":"EXACT"},"end":{"value":740,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":398,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":410,"modifier":"EXACT"},"end":{"value":438,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":493,"modifier":"EXACT"},"end":{"value":509,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":510,"modifier":"EXACT"},"end":{"value":521,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":642,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0970","category":"Biological process","name":"Cilium biogenesis/degradation"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 358-770"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"23906841","citationType":"journal article","authors":["Appelbe O.K.","Bollman B.","Attarwala A.","Triebes L.A.","Muniz-Talavera H.","Curry D.J.","Schmidt J.V."],"citationCrossReferences":[{"database":"PubMed","id":"23906841"},{"database":"DOI","id":"10.1016/j.ydbio.2013.07.003"}],"title":"Disruption of the mouse Jhy gene causes abnormal ciliary microtubule patterning and juvenile hydrocephalus.","publicationDate":"2013","journal":"Dev. Biol.","firstPage":"172","lastPage":"185","volume":"382"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC159820","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK016487","properties":[{"key":"ProteinId","value":"BAB30266.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS40592.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001074590.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001081121.2"}]},{"database":"RefSeq","id":"NP_001344289.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001357360.1"}]},{"database":"RefSeq","id":"XP_006510663.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006510600.5"}]},{"database":"AlphaFoldDB","id":"E9Q793","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"E9Q793","properties":[{"key":"Number of interactors","value":"2"}]},{"database":"STRING","id":"10090.ENSMUSP00000034521","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"E9Q793","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"E9Q793","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"E9Q793","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000034521","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"269027","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"49546","properties":[{"key":"antibodies","value":"16 antibodies from 6 providers"}]},{"database":"Ensembl","id":"ENSMUST00000034521.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000034521.8"},{"key":"GeneId","value":"ENSMUSG00000032023.8"}]},{"database":"GeneID","id":"70989","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:70989","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009pac.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1918239","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"79864","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1918239","properties":[{"key":"GeneName","value":"Jhy"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000032023","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S6KC","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000002823","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_407472_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"E9Q793","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WKFHPSS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10057281at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"70989","properties":[{"key":"hits","value":"6 hits in 80 CRISPR screens"}]},{"database":"PRO","id":"PR:E9Q793","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"RNAct","id":"E9Q793","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000032023","properties":[{"key":"ExpressionPatterns","value":"Expressed in spermatid and 28 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9Q793","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:GOC"}]},{"database":"GO","id":"GO:0035082","properties":[{"key":"GoTerm","value":"P:axoneme assembly"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23906841"}]},{"database":"GO","id":"GO:0007420","properties":[{"key":"GoTerm","value":"P:brain development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23906841"}]},{"database":"GO","id":"GO:0030154","properties":[{"key":"GoTerm","value":"P:cell differentiation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29211732"}]},{"database":"GO","id":"GO:0090660","properties":[{"key":"GoTerm","value":"P:cerebrospinal fluid circulation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23906841"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29211732"}]},{"database":"GO","id":"GO:0044458","properties":[{"key":"GoTerm","value":"P:motile cilium assembly"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29211732"}]},{"database":"GO","id":"GO:0090175","properties":[{"key":"GoTerm","value":"P:regulation of establishment of planar polarity"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29211732"}]},{"database":"InterPro","id":"IPR027968","properties":[{"key":"EntryName","value":"JHY"}]},{"database":"PANTHER","id":"PTHR14726","properties":[{"key":"EntryName","value":"JHY PROTEIN HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14726:SF1","properties":[{"key":"EntryName","value":"JHY PROTEIN HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15261","properties":[{"key":"EntryName","value":"JHY"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNKYKPVPKLSSQSPVHHTNLRIPPSGRPFKKEDFLNLISKDSLESDSESLPQEAKSWSDIKDQIQDKDMEPDSLEEDSPSETEEAVNRKAAHNTNREDLSAHDAGVNHSQHQVEDKYSDLRYDPNWKNKREEGQPLAGEALPGSADSSSENLPLAPLYPSREPSMGLSAGKGKEKKSPQSEASLLGSEFLSPKYERSTRQNGFFSELSDSDQEEKSSGLSQYLKSSSSHNDVFLPGSRGPRRRKSKQYFVEKNKLTLGLPMPKTDSYLQLHNKKRGETRLEQISYPVRDTDKMTVQNDKEVENTFMDPEDKWHQRAKQLKNYQEHLSQYEDTKSGNVPRGQSSDAANGQQPSRRTAKARVRKQRKHQKGLKSLGTKELVVSQNNQNNPFQQPQNQRQTADASAKHELAAQTNASNPNLQDARTLTHNPKVTSDSFVSPKQALDRALYKNSISGLNANKRRGHRREEERILYQPQPIYVFSDTHLQDFNELPHRHESPSQRAPQSDHHMNTHRSTKTKKPAKQPQAETKYKNIEMLWKFHSSSDMEPASASPDSRLAQIMEQHQQALMQLAEVQPSEGSLASIILPPILSRVESESQLNSERSHRHQVKMARSNSEGYLLQLERGKRHRKRSSTKSSKLKGYQKRDVKLGGLGPDFASVRDKMQMLMQQKEYAQQVKDYNMKALSILSKPQTSKTESKSAISRKKALDYAKTIPKPKPPNLPDQTAKKTKNSRHSEKEGGLPEISLLEILQSRHEREKQAVAAFKVLHIV","length":770,"molWeight":87417,"crc64":"2477A2667C344485","md5":"18D81E88DAE77782D212CF27A12D131D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"TISSUE SPECIFICITY":1},"countByFeatureType":{"Chain":1,"Region":5,"Compositional bias":12},"uniParcId":"UPI0000606043"}}