{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"E9Q555","secondaryAccessions":["F7A6H4","Q8BVK6"],"uniProtkbId":"RN213_MOUSE","entryAudit":{"firstPublicDate":"2012-03-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-09-29","entryVersion":94,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"E3 ubiquitin-protein ligase RNF213"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}],"value":"2.3.2.27"},{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"}],"value":"3.6.4.-"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"E3 ubiquitin-lipopolysaccharide ligase RNF213"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}],"value":"2.3.2.-"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26126547"}],"value":"Mysterin"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"RING finger protein 213"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1289196"}],"value":"Rnf213"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26126547"}],"value":"Mystr"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34012115"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34599178"}],"value":"Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:32573437). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (By similarity). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (By similarity). Also functions as an intracellular sensor for ISGylated proteins: upon type I interferon stimulation, undergoes ISGylation and oligomerizes on lipid droplets to form a binding platform for ISG15-modified substrate proteins, thereby acting as a broad-spectrum antimicrobial effector. Restricts intracellular bacterial pathogens in an ISG15-dependent manner by decorating the bacterial surface with ubiquitin to promote autophagic clearance (PubMed:34599178). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (By similarity). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (By similarity). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (By similarity). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (By similarity). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:32573437)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.","ecNumber":"2.3.2.27","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}],"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"}],"value":"Monomer (PubMed:32573437). Oligomerates upon ISGylation induced by type I interferon (By similarity). Interacts with UBE2L3/UBCH7; UBE2L3/UBCH7 is the most efficient ubiquitin-conjugating enzyme E2 for the ubiquitin ligase activity (PubMed:32573437). Interacts with UBE2N/UBC13; promoting 'Lys-63'-linked ubiquitination of target proteins (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}],"value":"Lipid droplet","id":"SL-0154"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"}],"value":"Composed of an N-terminal stalk, a dynein-like core comprised of two catalytically active and four inactive ATPase domains, and a C-terminal E3 module (PubMed:32573437). The ATPase regions do not generate movement but rather act like an intricate molecular 'switch' (PubMed:32573437)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}],"value":"The RING-type zinc finger domain is required for the ubiquitin-protein ligase activity"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}],"value":"The RZ-type (RNF213-ZNFX1) zinc-finger is required for the ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34599178"}],"value":"ISGylated. Conjugated to ubiquitin-like protein ISG15 upon IFN-beta stimulation. ISGylation positively regulates oligomerization on lipid droplets"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23410753"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24440776"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25383461"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33420513"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34599178"}],"value":"No visible phenotype (PubMed:23410753, PubMed:24440776). Males and female are fertile and produce normal-sized litters (PubMed:23410753, PubMed:24440776). Mice do not spontaneously develop Moyamoya disease, a chronic occlusive cerebrovascular disease (PubMed:24440776). Mice are however more susceptible to Rift Valley fever virus infection (PubMed:33420513). Mice show elevated expression of MMP9 (PubMed:25383461). Knockouts show a dramatically increased bacterial burden in spleen at 24h, 48h and 72h post-Listeria infection (PubMed:34599178)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the AAA ATPase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"}],"value":"The stoichiometry is unclear: was initially thought to form homohexamers (By similarity). However, the electron microscopy structure showed that it is monomeric and is composed of six ATPase modules within a single polypeptide chain (PubMed:32573437)"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAC37048.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":5148,"modifier":"EXACT"}},"description":"E3 ubiquitin-protein ligase RNF213","featureId":"PRO_0000415918"},{"type":"Zinc finger","location":{"start":{"value":3947,"modifier":"EXACT"},"end":{"value":3986,"modifier":"EXACT"}},"description":"RING-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00175"}]},{"type":"Zinc finger","location":{"start":{"value":4429,"modifier":"EXACT"},"end":{"value":4501,"modifier":"EXACT"}},"description":"RZ-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01325"}]},{"type":"Region","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":3435,"modifier":"EXACT"},"end":{"value":3465,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":4462,"modifier":"EXACT"},"end":{"value":4462,"modifier":"EXACT"}},"description":"Nucleophile; for E3 ubiquitin-lipopolysaccharide ligase activity","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01325"}]},{"type":"Binding site","location":{"start":{"value":1957,"modifier":"EXACT"},"end":{"value":1957,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":1958,"modifier":"EXACT"},"end":{"value":1958,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":1959,"modifier":"EXACT"},"end":{"value":1959,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":1960,"modifier":"EXACT"},"end":{"value":1960,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":1961,"modifier":"EXACT"},"end":{"value":1961,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":1961,"modifier":"EXACT"},"end":{"value":1961,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":1962,"modifier":"EXACT"},"end":{"value":1962,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":2060,"modifier":"EXACT"},"end":{"value":2060,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":2060,"modifier":"EXACT"},"end":{"value":2060,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":2114,"modifier":"EXACT"},"end":{"value":2114,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":2116,"modifier":"EXACT"},"end":{"value":2116,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":2177,"modifier":"EXACT"},"end":{"value":2177,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":2460,"modifier":"EXACT"},"end":{"value":2460,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":2535,"modifier":"EXACT"},"end":{"value":2535,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":3947,"modifier":"EXACT"},"end":{"value":3947,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":3950,"modifier":"EXACT"},"end":{"value":3950,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":3962,"modifier":"EXACT"},"end":{"value":3962,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":3964,"modifier":"EXACT"},"end":{"value":3964,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":3967,"modifier":"EXACT"},"end":{"value":3967,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":3970,"modifier":"EXACT"},"end":{"value":3970,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":3982,"modifier":"EXACT"},"end":{"value":3982,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":3985,"modifier":"EXACT"},"end":{"value":3985,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":4451,"modifier":"EXACT"},"end":{"value":4451,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01325"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":4455,"modifier":"EXACT"},"end":{"value":4455,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01325"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":4471,"modifier":"EXACT"},"end":{"value":4471,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01325"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":4472,"modifier":"EXACT"},"end":{"value":4472,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Modified residue","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}]},{"type":"Modified residue","location":{"start":{"value":2234,"modifier":"EXACT"},"end":{"value":2234,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}]},{"type":"Cross-link","location":{"start":{"value":1128,"modifier":"EXACT"},"end":{"value":1128,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63HN8"}]},{"type":"Mutagenesis","location":{"start":{"value":4753,"modifier":"EXACT"},"end":{"value":4753,"modifier":"EXACT"}},"description":"Knockin mice grow normally and do not show any visible phenotype. Slightly impaired angiogenesis. Does not affect ATPase or E3 ubiquitin ligase activities.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26126547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26315378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Helix","location":{"start":{"value":493,"modifier":"EXACT"},"end":{"value":512,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OIK"}]},{"type":"Helix","location":{"start":{"value":518,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OIK"}]},{"type":"Helix","location":{"start":{"value":556,"modifier":"EXACT"},"end":{"value":575,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OIK"}]},{"type":"Helix","location":{"start":{"value":593,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":604,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":609,"modifier":"EXACT"},"end":{"value":611,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":614,"modifier":"EXACT"},"end":{"value":617,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":618,"modifier":"EXACT"},"end":{"value":621,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":629,"modifier":"EXACT"},"end":{"value":635,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":636,"modifier":"EXACT"},"end":{"value":639,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":644,"modifier":"EXACT"},"end":{"value":655,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":656,"modifier":"EXACT"},"end":{"value":660,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":663,"modifier":"EXACT"},"end":{"value":666,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":668,"modifier":"EXACT"},"end":{"value":671,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":673,"modifier":"EXACT"},"end":{"value":675,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":683,"modifier":"EXACT"},"end":{"value":685,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":689,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":700,"modifier":"EXACT"},"end":{"value":702,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":704,"modifier":"EXACT"},"end":{"value":706,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":712,"modifier":"EXACT"},"end":{"value":719,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":721,"modifier":"EXACT"},"end":{"value":725,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":729,"modifier":"EXACT"},"end":{"value":735,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":740,"modifier":"EXACT"},"end":{"value":742,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":743,"modifier":"EXACT"},"end":{"value":748,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":751,"modifier":"EXACT"},"end":{"value":756,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":760,"modifier":"EXACT"},"end":{"value":771,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":772,"modifier":"EXACT"},"end":{"value":774,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":781,"modifier":"EXACT"},"end":{"value":800,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":803,"modifier":"EXACT"},"end":{"value":810,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":811,"modifier":"EXACT"},"end":{"value":826,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":831,"modifier":"EXACT"},"end":{"value":833,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":836,"modifier":"EXACT"},"end":{"value":849,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":852,"modifier":"EXACT"},"end":{"value":854,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":865,"modifier":"EXACT"},"end":{"value":888,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":893,"modifier":"EXACT"},"end":{"value":895,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Beta strand","location":{"start":{"value":897,"modifier":"EXACT"},"end":{"value":900,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":904,"modifier":"EXACT"},"end":{"value":908,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":909,"modifier":"EXACT"},"end":{"value":917,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":924,"modifier":"EXACT"},"end":{"value":927,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":930,"modifier":"EXACT"},"end":{"value":938,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":943,"modifier":"EXACT"},"end":{"value":950,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":952,"modifier":"EXACT"},"end":{"value":955,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":963,"modifier":"EXACT"},"end":{"value":981,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":995,"modifier":"EXACT"},"end":{"value":1009,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1013,"modifier":"EXACT"},"end":{"value":1015,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1022,"modifier":"EXACT"},"end":{"value":1030,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1032,"modifier":"EXACT"},"end":{"value":1043,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1045,"modifier":"EXACT"},"end":{"value":1048,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1049,"modifier":"EXACT"},"end":{"value":1051,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1054,"modifier":"EXACT"},"end":{"value":1071,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1072,"modifier":"EXACT"},"end":{"value":1076,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1080,"modifier":"EXACT"},"end":{"value":1088,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1090,"modifier":"EXACT"},"end":{"value":1101,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1114,"modifier":"EXACT"},"end":{"value":1142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":1143,"modifier":"EXACT"},"end":{"value":1147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1149,"modifier":"EXACT"},"end":{"value":1151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1155,"modifier":"EXACT"},"end":{"value":1158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1167,"modifier":"EXACT"},"end":{"value":1170,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1191,"modifier":"EXACT"},"end":{"value":1202,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1207,"modifier":"EXACT"},"end":{"value":1217,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1231,"modifier":"EXACT"},"end":{"value":1233,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1234,"modifier":"EXACT"},"end":{"value":1237,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1238,"modifier":"EXACT"},"end":{"value":1242,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1243,"modifier":"EXACT"},"end":{"value":1256,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":1257,"modifier":"EXACT"},"end":{"value":1259,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1263,"modifier":"EXACT"},"end":{"value":1269,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1271,"modifier":"EXACT"},"end":{"value":1273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1277,"modifier":"EXACT"},"end":{"value":1288,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":1289,"modifier":"EXACT"},"end":{"value":1292,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1296,"modifier":"EXACT"},"end":{"value":1298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1299,"modifier":"EXACT"},"end":{"value":1328,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1339,"modifier":"EXACT"},"end":{"value":1345,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1362,"modifier":"EXACT"},"end":{"value":1367,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":1368,"modifier":"EXACT"},"end":{"value":1370,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1375,"modifier":"EXACT"},"end":{"value":1377,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1378,"modifier":"EXACT"},"end":{"value":1386,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1389,"modifier":"EXACT"},"end":{"value":1397,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1401,"modifier":"EXACT"},"end":{"value":1403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1404,"modifier":"EXACT"},"end":{"value":1414,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1419,"modifier":"EXACT"},"end":{"value":1439,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1448,"modifier":"EXACT"},"end":{"value":1463,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1468,"modifier":"EXACT"},"end":{"value":1476,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1479,"modifier":"EXACT"},"end":{"value":1486,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1498,"modifier":"EXACT"},"end":{"value":1506,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1508,"modifier":"EXACT"},"end":{"value":1511,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1516,"modifier":"EXACT"},"end":{"value":1518,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1522,"modifier":"EXACT"},"end":{"value":1525,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1526,"modifier":"EXACT"},"end":{"value":1530,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1541,"modifier":"EXACT"},"end":{"value":1544,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1545,"modifier":"EXACT"},"end":{"value":1556,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1564,"modifier":"EXACT"},"end":{"value":1593,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1596,"modifier":"EXACT"},"end":{"value":1600,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1602,"modifier":"EXACT"},"end":{"value":1606,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1612,"modifier":"EXACT"},"end":{"value":1616,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1620,"modifier":"EXACT"},"end":{"value":1622,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1625,"modifier":"EXACT"},"end":{"value":1627,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1631,"modifier":"EXACT"},"end":{"value":1659,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1662,"modifier":"EXACT"},"end":{"value":1665,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1668,"modifier":"EXACT"},"end":{"value":1678,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1680,"modifier":"EXACT"},"end":{"value":1682,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1687,"modifier":"EXACT"},"end":{"value":1690,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":1691,"modifier":"EXACT"},"end":{"value":1695,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1700,"modifier":"EXACT"},"end":{"value":1708,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1714,"modifier":"EXACT"},"end":{"value":1725,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1727,"modifier":"EXACT"},"end":{"value":1730,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1736,"modifier":"EXACT"},"end":{"value":1749,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1751,"modifier":"EXACT"},"end":{"value":1753,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1761,"modifier":"EXACT"},"end":{"value":1774,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1782,"modifier":"EXACT"},"end":{"value":1784,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1789,"modifier":"EXACT"},"end":{"value":1796,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1799,"modifier":"EXACT"},"end":{"value":1801,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1803,"modifier":"EXACT"},"end":{"value":1809,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":1810,"modifier":"EXACT"},"end":{"value":1812,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":1817,"modifier":"EXACT"},"end":{"value":1819,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1821,"modifier":"EXACT"},"end":{"value":1826,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1833,"modifier":"EXACT"},"end":{"value":1843,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1849,"modifier":"EXACT"},"end":{"value":1851,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1853,"modifier":"EXACT"},"end":{"value":1857,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1859,"modifier":"EXACT"},"end":{"value":1861,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1864,"modifier":"EXACT"},"end":{"value":1880,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1887,"modifier":"EXACT"},"end":{"value":1892,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1894,"modifier":"EXACT"},"end":{"value":1896,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":1901,"modifier":"EXACT"},"end":{"value":1904,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1906,"modifier":"EXACT"},"end":{"value":1908,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1918,"modifier":"EXACT"},"end":{"value":1929,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1933,"modifier":"EXACT"},"end":{"value":1935,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1938,"modifier":"EXACT"},"end":{"value":1941,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1942,"modifier":"EXACT"},"end":{"value":1945,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1947,"modifier":"EXACT"},"end":{"value":1959,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1960,"modifier":"EXACT"},"end":{"value":1973,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1974,"modifier":"EXACT"},"end":{"value":1977,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1982,"modifier":"EXACT"},"end":{"value":1987,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":1989,"modifier":"EXACT"},"end":{"value":1991,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":1994,"modifier":"EXACT"},"end":{"value":2001,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":2002,"modifier":"EXACT"},"end":{"value":2004,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2005,"modifier":"EXACT"},"end":{"value":2010,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2015,"modifier":"EXACT"},"end":{"value":2020,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2028,"modifier":"EXACT"},"end":{"value":2032,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2033,"modifier":"EXACT"},"end":{"value":2037,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2040,"modifier":"EXACT"},"end":{"value":2042,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2048,"modifier":"EXACT"},"end":{"value":2050,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2055,"modifier":"EXACT"},"end":{"value":2062,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2081,"modifier":"EXACT"},"end":{"value":2084,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2085,"modifier":"EXACT"},"end":{"value":2087,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2090,"modifier":"EXACT"},"end":{"value":2092,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":2096,"modifier":"EXACT"},"end":{"value":2100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2117,"modifier":"EXACT"},"end":{"value":2120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2123,"modifier":"EXACT"},"end":{"value":2136,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2155,"modifier":"EXACT"},"end":{"value":2165,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2168,"modifier":"EXACT"},"end":{"value":2170,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OIK"}]},{"type":"Helix","location":{"start":{"value":2173,"modifier":"EXACT"},"end":{"value":2192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2195,"modifier":"EXACT"},"end":{"value":2202,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2203,"modifier":"EXACT"},"end":{"value":2205,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2208,"modifier":"EXACT"},"end":{"value":2223,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":2248,"modifier":"EXACT"},"end":{"value":2250,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2251,"modifier":"EXACT"},"end":{"value":2254,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2260,"modifier":"EXACT"},"end":{"value":2262,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2266,"modifier":"EXACT"},"end":{"value":2269,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2271,"modifier":"EXACT"},"end":{"value":2273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2276,"modifier":"EXACT"},"end":{"value":2280,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2282,"modifier":"EXACT"},"end":{"value":2285,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2289,"modifier":"EXACT"},"end":{"value":2294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2296,"modifier":"EXACT"},"end":{"value":2298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2301,"modifier":"EXACT"},"end":{"value":2304,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":2309,"modifier":"EXACT"},"end":{"value":2317,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2326,"modifier":"EXACT"},"end":{"value":2329,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":2331,"modifier":"EXACT"},"end":{"value":2341,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2352,"modifier":"EXACT"},"end":{"value":2354,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2358,"modifier":"EXACT"},"end":{"value":2373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2377,"modifier":"EXACT"},"end":{"value":2380,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2383,"modifier":"EXACT"},"end":{"value":2387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2388,"modifier":"EXACT"},"end":{"value":2399,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2407,"modifier":"EXACT"},"end":{"value":2411,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2418,"modifier":"EXACT"},"end":{"value":2439,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2443,"modifier":"EXACT"},"end":{"value":2449,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2456,"modifier":"EXACT"},"end":{"value":2463,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2479,"modifier":"EXACT"},"end":{"value":2485,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2493,"modifier":"EXACT"},"end":{"value":2500,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2502,"modifier":"EXACT"},"end":{"value":2504,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2510,"modifier":"EXACT"},"end":{"value":2512,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2516,"modifier":"EXACT"},"end":{"value":2521,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2522,"modifier":"EXACT"},"end":{"value":2524,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2525,"modifier":"EXACT"},"end":{"value":2527,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2530,"modifier":"EXACT"},"end":{"value":2533,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":2537,"modifier":"EXACT"},"end":{"value":2539,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2540,"modifier":"EXACT"},"end":{"value":2542,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Beta strand","location":{"start":{"value":2548,"modifier":"EXACT"},"end":{"value":2550,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OIK"}]},{"type":"Helix","location":{"start":{"value":2551,"modifier":"EXACT"},"end":{"value":2563,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2565,"modifier":"EXACT"},"end":{"value":2567,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OIK"}]},{"type":"Helix","location":{"start":{"value":2572,"modifier":"EXACT"},"end":{"value":2588,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2589,"modifier":"EXACT"},"end":{"value":2591,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":2598,"modifier":"EXACT"},"end":{"value":2600,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2601,"modifier":"EXACT"},"end":{"value":2614,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2618,"modifier":"EXACT"},"end":{"value":2630,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2643,"modifier":"EXACT"},"end":{"value":2650,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2651,"modifier":"EXACT"},"end":{"value":2655,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2661,"modifier":"EXACT"},"end":{"value":2668,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":2669,"modifier":"EXACT"},"end":{"value":2671,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2674,"modifier":"EXACT"},"end":{"value":2676,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2679,"modifier":"EXACT"},"end":{"value":2696,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2707,"modifier":"EXACT"},"end":{"value":2721,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2726,"modifier":"EXACT"},"end":{"value":2729,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2734,"modifier":"EXACT"},"end":{"value":2737,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2738,"modifier":"EXACT"},"end":{"value":2746,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2749,"modifier":"EXACT"},"end":{"value":2751,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2753,"modifier":"EXACT"},"end":{"value":2755,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":2756,"modifier":"EXACT"},"end":{"value":2759,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2762,"modifier":"EXACT"},"end":{"value":2768,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2776,"modifier":"EXACT"},"end":{"value":2790,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2797,"modifier":"EXACT"},"end":{"value":2805,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":2807,"modifier":"EXACT"},"end":{"value":2810,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2818,"modifier":"EXACT"},"end":{"value":2820,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2821,"modifier":"EXACT"},"end":{"value":2824,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":2825,"modifier":"EXACT"},"end":{"value":2827,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2830,"modifier":"EXACT"},"end":{"value":2832,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":2836,"modifier":"EXACT"},"end":{"value":2838,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2841,"modifier":"EXACT"},"end":{"value":2848,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2852,"modifier":"EXACT"},"end":{"value":2855,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2857,"modifier":"EXACT"},"end":{"value":2862,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2868,"modifier":"EXACT"},"end":{"value":2879,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2886,"modifier":"EXACT"},"end":{"value":2889,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2890,"modifier":"EXACT"},"end":{"value":2892,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2893,"modifier":"EXACT"},"end":{"value":2906,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2908,"modifier":"EXACT"},"end":{"value":2910,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":2914,"modifier":"EXACT"},"end":{"value":2931,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2937,"modifier":"EXACT"},"end":{"value":2947,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2956,"modifier":"EXACT"},"end":{"value":2960,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":2975,"modifier":"EXACT"},"end":{"value":2983,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":2992,"modifier":"EXACT"},"end":{"value":2994,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OIK"}]},{"type":"Beta strand","location":{"start":{"value":3002,"modifier":"EXACT"},"end":{"value":3009,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3011,"modifier":"EXACT"},"end":{"value":3014,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3015,"modifier":"EXACT"},"end":{"value":3019,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3026,"modifier":"EXACT"},"end":{"value":3028,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3038,"modifier":"EXACT"},"end":{"value":3055,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3059,"modifier":"EXACT"},"end":{"value":3062,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":3065,"modifier":"EXACT"},"end":{"value":3067,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":3069,"modifier":"EXACT"},"end":{"value":3071,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3072,"modifier":"EXACT"},"end":{"value":3076,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3080,"modifier":"EXACT"},"end":{"value":3082,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3085,"modifier":"EXACT"},"end":{"value":3092,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3095,"modifier":"EXACT"},"end":{"value":3100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3107,"modifier":"EXACT"},"end":{"value":3112,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3113,"modifier":"EXACT"},"end":{"value":3119,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3122,"modifier":"EXACT"},"end":{"value":3124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3125,"modifier":"EXACT"},"end":{"value":3127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3130,"modifier":"EXACT"},"end":{"value":3132,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":3136,"modifier":"EXACT"},"end":{"value":3138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3141,"modifier":"EXACT"},"end":{"value":3158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3164,"modifier":"EXACT"},"end":{"value":3166,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3170,"modifier":"EXACT"},"end":{"value":3172,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3173,"modifier":"EXACT"},"end":{"value":3176,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3184,"modifier":"EXACT"},"end":{"value":3196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3205,"modifier":"EXACT"},"end":{"value":3218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3223,"modifier":"EXACT"},"end":{"value":3228,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3229,"modifier":"EXACT"},"end":{"value":3231,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3232,"modifier":"EXACT"},"end":{"value":3234,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3237,"modifier":"EXACT"},"end":{"value":3244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3245,"modifier":"EXACT"},"end":{"value":3249,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3255,"modifier":"EXACT"},"end":{"value":3262,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3263,"modifier":"EXACT"},"end":{"value":3265,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3271,"modifier":"EXACT"},"end":{"value":3281,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3282,"modifier":"EXACT"},"end":{"value":3284,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3288,"modifier":"EXACT"},"end":{"value":3294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":3295,"modifier":"EXACT"},"end":{"value":3299,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3304,"modifier":"EXACT"},"end":{"value":3307,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3308,"modifier":"EXACT"},"end":{"value":3310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3314,"modifier":"EXACT"},"end":{"value":3325,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3327,"modifier":"EXACT"},"end":{"value":3344,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3349,"modifier":"EXACT"},"end":{"value":3364,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3371,"modifier":"EXACT"},"end":{"value":3378,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":3381,"modifier":"EXACT"},"end":{"value":3386,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3397,"modifier":"EXACT"},"end":{"value":3400,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3408,"modifier":"EXACT"},"end":{"value":3410,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3414,"modifier":"EXACT"},"end":{"value":3419,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3422,"modifier":"EXACT"},"end":{"value":3425,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3477,"modifier":"EXACT"},"end":{"value":3489,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3495,"modifier":"EXACT"},"end":{"value":3498,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3502,"modifier":"EXACT"},"end":{"value":3511,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3512,"modifier":"EXACT"},"end":{"value":3517,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3518,"modifier":"EXACT"},"end":{"value":3538,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3539,"modifier":"EXACT"},"end":{"value":3542,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3544,"modifier":"EXACT"},"end":{"value":3547,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3549,"modifier":"EXACT"},"end":{"value":3554,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3557,"modifier":"EXACT"},"end":{"value":3563,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3566,"modifier":"EXACT"},"end":{"value":3589,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3591,"modifier":"EXACT"},"end":{"value":3593,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3596,"modifier":"EXACT"},"end":{"value":3599,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3600,"modifier":"EXACT"},"end":{"value":3602,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3605,"modifier":"EXACT"},"end":{"value":3614,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":3618,"modifier":"EXACT"},"end":{"value":3620,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3654,"modifier":"EXACT"},"end":{"value":3656,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3658,"modifier":"EXACT"},"end":{"value":3675,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3678,"modifier":"EXACT"},"end":{"value":3680,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3681,"modifier":"EXACT"},"end":{"value":3691,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3693,"modifier":"EXACT"},"end":{"value":3698,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3703,"modifier":"EXACT"},"end":{"value":3721,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3725,"modifier":"EXACT"},"end":{"value":3727,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":3728,"modifier":"EXACT"},"end":{"value":3745,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3748,"modifier":"EXACT"},"end":{"value":3750,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Beta strand","location":{"start":{"value":3753,"modifier":"EXACT"},"end":{"value":3756,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OIK"}]},{"type":"Beta strand","location":{"start":{"value":3758,"modifier":"EXACT"},"end":{"value":3761,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OIK"}]},{"type":"Helix","location":{"start":{"value":3763,"modifier":"EXACT"},"end":{"value":3783,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3788,"modifier":"EXACT"},"end":{"value":3799,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3802,"modifier":"EXACT"},"end":{"value":3805,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3808,"modifier":"EXACT"},"end":{"value":3823,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3824,"modifier":"EXACT"},"end":{"value":3827,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3829,"modifier":"EXACT"},"end":{"value":3838,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3840,"modifier":"EXACT"},"end":{"value":3846,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":3849,"modifier":"EXACT"},"end":{"value":3851,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3857,"modifier":"EXACT"},"end":{"value":3879,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3880,"modifier":"EXACT"},"end":{"value":3884,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3885,"modifier":"EXACT"},"end":{"value":3889,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3895,"modifier":"EXACT"},"end":{"value":3909,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3918,"modifier":"EXACT"},"end":{"value":3940,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":3948,"modifier":"EXACT"},"end":{"value":3950,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":3955,"modifier":"EXACT"},"end":{"value":3959,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Beta strand","location":{"start":{"value":3965,"modifier":"EXACT"},"end":{"value":3967,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":3968,"modifier":"EXACT"},"end":{"value":3975,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":3976,"modifier":"EXACT"},"end":{"value":3978,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":3983,"modifier":"EXACT"},"end":{"value":3985,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":3987,"modifier":"EXACT"},"end":{"value":3989,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4000,"modifier":"EXACT"},"end":{"value":4025,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":4026,"modifier":"EXACT"},"end":{"value":4028,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4030,"modifier":"EXACT"},"end":{"value":4032,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4036,"modifier":"EXACT"},"end":{"value":4044,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4069,"modifier":"EXACT"},"end":{"value":4072,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4075,"modifier":"EXACT"},"end":{"value":4077,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":4083,"modifier":"EXACT"},"end":{"value":4088,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4093,"modifier":"EXACT"},"end":{"value":4095,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4097,"modifier":"EXACT"},"end":{"value":4110,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4113,"modifier":"EXACT"},"end":{"value":4115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4117,"modifier":"EXACT"},"end":{"value":4137,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4143,"modifier":"EXACT"},"end":{"value":4155,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":4161,"modifier":"EXACT"},"end":{"value":4163,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Beta strand","location":{"start":{"value":4166,"modifier":"EXACT"},"end":{"value":4168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4172,"modifier":"EXACT"},"end":{"value":4197,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":4202,"modifier":"EXACT"},"end":{"value":4204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4205,"modifier":"EXACT"},"end":{"value":4218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4223,"modifier":"EXACT"},"end":{"value":4235,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4238,"modifier":"EXACT"},"end":{"value":4244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4246,"modifier":"EXACT"},"end":{"value":4248,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4252,"modifier":"EXACT"},"end":{"value":4254,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4257,"modifier":"EXACT"},"end":{"value":4261,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4272,"modifier":"EXACT"},"end":{"value":4275,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4280,"modifier":"EXACT"},"end":{"value":4292,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4297,"modifier":"EXACT"},"end":{"value":4303,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4310,"modifier":"EXACT"},"end":{"value":4330,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4331,"modifier":"EXACT"},"end":{"value":4334,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":4338,"modifier":"EXACT"},"end":{"value":4342,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4343,"modifier":"EXACT"},"end":{"value":4352,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":4354,"modifier":"EXACT"},"end":{"value":4356,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4359,"modifier":"EXACT"},"end":{"value":4369,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":4374,"modifier":"EXACT"},"end":{"value":4377,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4381,"modifier":"EXACT"},"end":{"value":4384,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":4385,"modifier":"EXACT"},"end":{"value":4402,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4406,"modifier":"EXACT"},"end":{"value":4408,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4409,"modifier":"EXACT"},"end":{"value":4416,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4418,"modifier":"EXACT"},"end":{"value":4421,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4422,"modifier":"EXACT"},"end":{"value":4425,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":4523,"modifier":"EXACT"},"end":{"value":4543,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4545,"modifier":"EXACT"},"end":{"value":4551,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4560,"modifier":"EXACT"},"end":{"value":4577,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4578,"modifier":"EXACT"},"end":{"value":4580,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4582,"modifier":"EXACT"},"end":{"value":4595,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4614,"modifier":"EXACT"},"end":{"value":4632,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":4636,"modifier":"EXACT"},"end":{"value":4638,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4639,"modifier":"EXACT"},"end":{"value":4647,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":4650,"modifier":"EXACT"},"end":{"value":4654,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4656,"modifier":"EXACT"},"end":{"value":4659,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":4660,"modifier":"EXACT"},"end":{"value":4663,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4666,"modifier":"EXACT"},"end":{"value":4668,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4669,"modifier":"EXACT"},"end":{"value":4672,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4677,"modifier":"EXACT"},"end":{"value":4680,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Turn","location":{"start":{"value":4681,"modifier":"EXACT"},"end":{"value":4684,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4692,"modifier":"EXACT"},"end":{"value":4701,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":4702,"modifier":"EXACT"},"end":{"value":4707,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4709,"modifier":"EXACT"},"end":{"value":4716,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4718,"modifier":"EXACT"},"end":{"value":4721,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4724,"modifier":"EXACT"},"end":{"value":4726,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4727,"modifier":"EXACT"},"end":{"value":4740,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4743,"modifier":"EXACT"},"end":{"value":4745,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4752,"modifier":"EXACT"},"end":{"value":4756,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4762,"modifier":"EXACT"},"end":{"value":4782,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":4783,"modifier":"EXACT"},"end":{"value":4785,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4786,"modifier":"EXACT"},"end":{"value":4789,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4798,"modifier":"EXACT"},"end":{"value":4801,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4807,"modifier":"EXACT"},"end":{"value":4809,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4816,"modifier":"EXACT"},"end":{"value":4819,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4821,"modifier":"EXACT"},"end":{"value":4844,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4855,"modifier":"EXACT"},"end":{"value":4857,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":4860,"modifier":"EXACT"},"end":{"value":4862,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4868,"modifier":"EXACT"},"end":{"value":4872,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4873,"modifier":"EXACT"},"end":{"value":4877,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4880,"modifier":"EXACT"},"end":{"value":4884,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4891,"modifier":"EXACT"},"end":{"value":4894,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4896,"modifier":"EXACT"},"end":{"value":4904,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":4905,"modifier":"EXACT"},"end":{"value":4907,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4908,"modifier":"EXACT"},"end":{"value":4910,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4916,"modifier":"EXACT"},"end":{"value":4918,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4931,"modifier":"EXACT"},"end":{"value":4940,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4945,"modifier":"EXACT"},"end":{"value":4947,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":4948,"modifier":"EXACT"},"end":{"value":4956,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4961,"modifier":"EXACT"},"end":{"value":4979,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":4985,"modifier":"EXACT"},"end":{"value":4988,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":4991,"modifier":"EXACT"},"end":{"value":4996,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":5004,"modifier":"EXACT"},"end":{"value":5010,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":5015,"modifier":"EXACT"},"end":{"value":5017,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":5018,"modifier":"EXACT"},"end":{"value":5035,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":5042,"modifier":"EXACT"},"end":{"value":5044,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OIK"}]},{"type":"Helix","location":{"start":{"value":5046,"modifier":"EXACT"},"end":{"value":5048,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":5054,"modifier":"EXACT"},"end":{"value":5065,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":5069,"modifier":"EXACT"},"end":{"value":5083,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Beta strand","location":{"start":{"value":5090,"modifier":"EXACT"},"end":{"value":5092,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":5099,"modifier":"EXACT"},"end":{"value":5106,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Turn","location":{"start":{"value":5109,"modifier":"EXACT"},"end":{"value":5111,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAY"}]},{"type":"Helix","location":{"start":{"value":5115,"modifier":"EXACT"},"end":{"value":5120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]},{"type":"Helix","location":{"start":{"value":5132,"modifier":"EXACT"},"end":{"value":5148,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TAX"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0037","category":"Biological process","name":"Angiogenesis"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0551","category":"Cellular component","name":"Lipid droplet"},{"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4807-5148"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Brown adipose tissue","type":"TISSUE"},{"value":"Heart","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Liver","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Pancreas","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"23410753","citationType":"journal article","authors":["Kobayashi H.","Yamazaki S.","Takashima S.","Liu W.","Okuda H.","Yan J.","Fujii Y.","Hitomi T.","Harada K.H.","Habu T.","Koizumi A."],"citationCrossReferences":[{"database":"PubMed","id":"23410753"},{"database":"DOI","id":"10.1016/j.bbrc.2013.02.015"}],"title":"Ablation of Rnf213 retards progression of diabetes in the Akita mouse.","publicationDate":"2013","journal":"Biochem. Biophys. Res. Commun.","firstPage":"519","lastPage":"525","volume":"432"},"referencePositions":["DISRUPTION PHENOTYPE"]},{"referenceNumber":5,"citation":{"id":"24440776","citationType":"journal article","authors":["Sonobe S.","Fujimura M.","Niizuma K.","Nishijima Y.","Ito A.","Shimizu H.","Kikuchi A.","Arai-Ichinoi N.","Kure S.","Tominaga T."],"citationCrossReferences":[{"database":"PubMed","id":"24440776"},{"database":"DOI","id":"10.1016/j.brainres.2014.01.011"}],"title":"Temporal profile of the vascular anatomy evaluated by 9.4-T magnetic resonance angiography and histopathological analysis in mice lacking RNF213: a susceptibility gene for moyamoya disease.","publicationDate":"2014","journal":"Brain Res.","firstPage":"64","lastPage":"71","volume":"1552"},"referencePositions":["DISRUPTION PHENOTYPE"]},{"referenceNumber":6,"citation":{"id":"25383461","citationType":"journal article","authors":["Sonobe S.","Fujimura M.","Niizuma K.","Fujimura T.","Furudate S.","Nishijima Y.","Kure S.","Tominaga T."],"citationCrossReferences":[{"database":"PubMed","id":"25383461"},{"database":"DOI","id":"10.1097/wnr.0000000000000289"}],"title":"Increased vascular MMP-9 in mice lacking RNF213: moyamoya disease susceptibility gene.","publicationDate":"2014","journal":"NeuroReport","firstPage":"1442","lastPage":"1446","volume":"25"},"referencePositions":["DISRUPTION PHENOTYPE"]},{"referenceNumber":7,"citation":{"id":"26315378","citationType":"journal article","authors":["Kanoke A.","Fujimura M.","Niizuma K.","Ito A.","Sakata H.","Sato-Maeda M.","Morita-Fujimura Y.","Kure S.","Tominaga T."],"citationCrossReferences":[{"database":"PubMed","id":"26315378"},{"database":"DOI","id":"10.1016/j.brainres.2015.07.039"}],"title":"Temporal profile of the vascular anatomy evaluated by 9.4-tesla magnetic resonance angiography and histological analysis in mice with the R4859K mutation of RNF213, the susceptibility gene for moyamoya disease.","publicationDate":"2015","journal":"Brain Res.","firstPage":"497","lastPage":"505","volume":"1624"},"referencePositions":["MUTAGENESIS OF ARG-4753"]},{"referenceNumber":8,"citation":{"id":"26126547","citationType":"journal article","authors":["Kobayashi H.","Matsuda Y.","Hitomi T.","Okuda H.","Shioi H.","Matsuda T.","Imai H.","Sone M.","Taura D.","Harada K.H.","Habu T.","Takagi Y.","Miyamoto S.","Koizumi A."],"citationCrossReferences":[{"database":"PubMed","id":"26126547"},{"database":"DOI","id":"10.1161/jaha.115.002146"}],"title":"Biochemical and functional characterization of RNF213 (Mysterin) R4810K, a susceptibility mutation of Moyamoya disease, in angiogenesis in vitro and in vivo.","publicationDate":"2015","journal":"J. Am. Heart Assoc.","firstPage":"0","lastPage":"0","volume":"4"},"referencePositions":["MUTAGENESIS OF ARG-4753"]},{"referenceNumber":9,"citation":{"id":"33420513","citationType":"journal article","authors":["Houzelstein D.","Simon-Chazottes D.","Batista L.","Tokuda S.","Langa Vives F.","Flamand M.","Montagutelli X.","Panthier J.J."],"citationCrossReferences":[{"database":"PubMed","id":"33420513"},{"database":"DOI","id":"10.1007/s00335-020-09856-y"}],"title":"The ring finger protein 213 gene (Rnf213) contributes to Rift Valley fever resistance in mice.","publicationDate":"2021","journal":"Mamm. Genome","firstPage":"30","lastPage":"37","volume":"32"},"referencePositions":["DISRUPTION PHENOTYPE"]},{"referenceNumber":10,"citation":{"id":"34012115","citationType":"journal article","authors":["Otten E.G.","Werner E.","Crespillo-Casado A.","Boyle K.B.","Dharamdasani V.","Pathe C.","Santhanam B.","Randow F."],"citationCrossReferences":[{"database":"PubMed","id":"34012115"},{"database":"DOI","id":"10.1038/s41586-021-03566-4"}],"title":"Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection.","publicationDate":"2021","journal":"Nature","firstPage":"111","lastPage":"116","volume":"594"},"referencePositions":["FUNCTION"]},{"referenceNumber":11,"citation":{"id":"34599178","citationType":"journal article","authors":["Thery F.","Martina L.","Asselman C.","Zhang Y.","Vessely M.","Repo H.","Sedeyn K.","Moschonas G.D.","Bredow C.","Teo Q.W.","Zhang J.","Leandro K.","Eggermont D.","De Sutter D.","Boucher K.","Hochepied T.","Festjens N.","Callewaert N.","Saelens X.","Dermaut B.","Knobeloch K.P.","Beling A.","Sanyal S.","Radoshevich L.","Eyckerman S.","Impens F."],"citationCrossReferences":[{"database":"PubMed","id":"34599178"},{"database":"DOI","id":"10.1038/s41467-021-26061-w"}],"title":"Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity.","publicationDate":"2021","journal":"Nat. Commun.","firstPage":"5772","lastPage":"5772","volume":"12"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE","ISGYLATION"]},{"referenceNumber":12,"citation":{"id":"32573437","citationType":"journal article","authors":["Ahel J.","Lehner A.","Vogel A.","Schleiffer A.","Meinhart A.","Haselbach D.","Clausen T."],"citationCrossReferences":[{"database":"PubMed","id":"32573437"},{"database":"DOI","id":"10.7554/elife.56185"}],"title":"Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism.","publicationDate":"2020","journal":"Elife","firstPage":"0","lastPage":"0","volume":"9"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) OF 591-5152 IN COMPLEX WITH ZINC AND ATP","FUNCTION","CATALYTIC ACTIVITY","SUBUNIT","INTERACTION WITH UBE2L3","DOMAIN","MUTAGENESIS OF ARG-4753"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TAY"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL645911","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK077880","properties":[{"key":"ProteinId","value":"BAC37048.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001035094.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001040005.3"}]},{"database":"PDB","id":"6TAX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=591-5148"}]},{"database":"PDB","id":"6TAY","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=591-5148"}]},{"database":"PDB","id":"7OIK","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A=1-5148"}]},{"database":"PDB","id":"7OIM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"A=339-5148"}]},{"database":"PDB","id":"9I1I","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.50 A"},{"key":"Chains","value":"A=1-5148"}]},{"database":"PDB","id":"9I1J","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"A=339-5148"}]},{"database":"PDBsum","id":"6TAX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TAY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7OIK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7OIM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9I1I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9I1J","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-10429","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-10430","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12931","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12932","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52570","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52571","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9Q555","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"E9Q555","properties":[{"key":"Number of interactors","value":"1565"}]},{"database":"IntAct","id":"E9Q555","properties":[{"key":"Interactions","value":"1"}]},{"database":"MINT","id":"E9Q555","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"10090.ENSMUSP00000091429","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"E9Q555","properties":[{"key":"glycosylation","value":"4 sites, 1 O-linked glycan (3 sites)"}]},{"database":"iPTMnet","id":"E9Q555","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"E9Q555","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"E9Q555","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"E9Q555","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000091429","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"E9Q555","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"300423","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"E9Q555","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"46314","properties":[{"key":"antibodies","value":"196 antibodies from 29 providers"}]},{"database":"GeneID","id":"672511","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:672511","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"MGI:1289196","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"57674","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1289196","properties":[{"key":"GeneName","value":"Rnf213"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000070327","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QQ65","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_000066_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"E9Q555","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"E9Q555","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-983168","properties":[{"key":"PathwayName","value":"Antigen processing: Ubiquitination & Proteasome degradation"}]},{"database":"UniPathway","id":"UPA00143","properties":[{"key":"RectionId","value":"-"}]},{"database":"PRO","id":"PR:E9Q555","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"E9Q555","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000070327","properties":[{"key":"ExpressionPatterns","value":"Expressed in small intestine Peyer's patch and 218 other cell types or tissues"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005811","properties":[{"key":"GoTerm","value":"C:lipid droplet"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32573437"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0061630","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0004842","properties":[{"key":"GoTerm","value":"F:ubiquitin-protein transferase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001525","properties":[{"key":"GoTerm","value":"P:angiogenesis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26126547"}]},{"database":"GO","id":"GO:0042742","properties":[{"key":"GoTerm","value":"P:defense response to bacterium"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"34012115"}]},{"database":"GO","id":"GO:0140042","properties":[{"key":"GoTerm","value":"P:lipid droplet formation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0120323","properties":[{"key":"GoTerm","value":"P:lipid ubiquitination"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"34012115"}]},{"database":"GO","id":"GO:2000051","properties":[{"key":"GoTerm","value":"P:negative regulation of non-canonical Wnt signaling pathway"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0051865","properties":[{"key":"GoTerm","value":"P:protein autoubiquitination"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070534","properties":[{"key":"GoTerm","value":"P:protein K63-linked ubiquitination"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0016567","properties":[{"key":"GoTerm","value":"P:protein ubiquitination"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0019216","properties":[{"key":"GoTerm","value":"P:regulation of lipid metabolic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0002040","properties":[{"key":"GoTerm","value":"P:sprouting angiogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006511","properties":[{"key":"GoTerm","value":"P:ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0098792","properties":[{"key":"GoTerm","value":"P:xenophagy"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"CDD","id":"cd16561","properties":[{"key":"EntryName","value":"RING-HC_RNF213"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.40.10:FF:000488","properties":[{"key":"EntryName","value":"E3 ubiquitin-protein ligase RNF213"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000491","properties":[{"key":"EntryName","value":"E3 ubiquitin-protein ligase RNF213"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000804","properties":[{"key":"EntryName","value":"E3 ubiquitin-protein ligase RNF213"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.40.10","properties":[{"key":"EntryName","value":"Zinc/RING finger domain, C3HC4 (zinc finger)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003593","properties":[{"key":"EntryName","value":"AAA+_ATPase"}]},{"database":"InterPro","id":"IPR063148","properties":[{"key":"EntryName","value":"AAA_RNF213_1"}]},{"database":"InterPro","id":"IPR063190","properties":[{"key":"EntryName","value":"AAA_RNF213_2"}]},{"database":"InterPro","id":"IPR063558","properties":[{"key":"EntryName","value":"AAA_RNF213_3"}]},{"database":"InterPro","id":"IPR063556","properties":[{"key":"EntryName","value":"AAA_RNF213_4"}]},{"database":"InterPro","id":"IPR063375","properties":[{"key":"EntryName","value":"AAA_RNF213_5"}]},{"database":"InterPro","id":"IPR063172","properties":[{"key":"EntryName","value":"AAA_RNF213_6"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR031248","properties":[{"key":"EntryName","value":"RNF213"}]},{"database":"InterPro","id":"IPR063557","properties":[{"key":"EntryName","value":"RNF213_stalk"}]},{"database":"InterPro","id":"IPR046439","properties":[{"key":"EntryName","value":"ZF_RZ_dom"}]},{"database":"InterPro","id":"IPR018957","properties":[{"key":"EntryName","value":"Znf_C3HC4_RING-type"}]},{"database":"InterPro","id":"IPR001841","properties":[{"key":"EntryName","value":"Znf_RING"}]},{"database":"InterPro","id":"IPR013083","properties":[{"key":"EntryName","value":"Znf_RING/FYVE/PHD"}]},{"database":"InterPro","id":"IPR017907","properties":[{"key":"EntryName","value":"Znf_RING_CS"}]},{"database":"PANTHER","id":"PTHR22605:SF16","properties":[{"key":"EntryName","value":"E3 UBIQUITIN-PROTEIN LIGASE RNF213"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22605","properties":[{"key":"EntryName","value":"RZ-TYPE DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30695","properties":[{"key":"EntryName","value":"AAA_RNF213_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30686","properties":[{"key":"EntryName","value":"AAA_RNF213_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30694","properties":[{"key":"EntryName","value":"AAA_RNF213_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30683","properties":[{"key":"EntryName","value":"AAA_RNF213_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30684","properties":[{"key":"EntryName","value":"AAA_RNF213_5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30685","properties":[{"key":"EntryName","value":"AAA_RNF213_6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30696","properties":[{"key":"EntryName","value":"RNF213_stalk"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00097","properties":[{"key":"EntryName","value":"zf-C3HC4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20173","properties":[{"key":"EntryName","value":"ZnF_RZ-type"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00382","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00184","properties":[{"key":"EntryName","value":"RING"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF57850","properties":[{"key":"EntryName","value":"RING/U-box"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00518","properties":[{"key":"EntryName","value":"ZF_RING_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50089","properties":[{"key":"EntryName","value":"ZF_RING_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51981","properties":[{"key":"EntryName","value":"ZF_RZ"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MECPQCGHVSSEKAPKFCSECGQKLPSAATVQGDLKNDNTLVVSSTPEGKTEQGAVLREEEVLLSSTDPGKELEKPEESDSNASWTTQMSKKEKRRRKRQGTISSSEAPSSGLWSLDMPPSPGSHNSALPQNQAQQGGAASQPGHPLDTENMPMEDGFVHTEGSGSPLQGQAAERTDAQSNLAPSDLAEVKDLNTSKPSVDKGLPLDGGPALSAFKGHPKMTDASQKAPLPESKGETSGQEKKVPPIDAAASPVKTAGKETGEDVRKPKPSPVSPVASKHGDQEAELKGKLATPVRKSNEGGNTQPEDQRKPGEGRNFAAAVKTQQAAAPQQAAAPEPTSAFNPRDTVTVYFHAIVSRHFGFNPEEHKVYVRGGEGLGQKGWTDACEMYCTQDLHDLGSLVEGKMDIPRQSLDKPIPYKYVIHRGGSSKDTVEYEFIYEQAQKKGEHVNRCLRVVSTSLGNGDWHQYDDIICMRSTGFFQQAKNRILDSTRKELLKGKKQAAVVMLDRIFSVLQPWSDINLQSFMTQFLQFYSVVREPMIHDGRARKWTSLQYEEKEVWTNLWEHVKKQMAPFLEGKSGESLPADCPVRSKLTLGLSILFMVEAAEFTVPKKDLDSLCYLLIPSAGSPEALHSDLSPVLRIRQRWRIYLTNLCLRCIDERCDRWLGILPLLHTCMQKSPPKKNSKSQPEDTWAGLEGISFSEFRDKAPTRSQPLQFMQSKMALLRVDEYLFRSWLSVVPLESLSSYLENSIDYLSDVPVRVLDCLQGISYRLPGLRKISNQNMKKDVENVFKMLMHLVDIYQHRIFGENLLQIYLTECLTLHETVCNITANHQFFEIPALSAELICKLLELSPPGHTDEGLPEKSYEDLVTSTLQEALATTRNWLRSLFKSRMLSISSAYVRLTYSEEMAVWRRLVEIGFPEKHGWKGSLLGDMEGRLKQEPPRLQISFFCSSQCRDGGLHDSVSRSFEKCVIEAVSSACQSQTSVLEGLSCQDLQKFGTLLSAVITKSWPVHNGEPVFDVDEIFKYLLKWPDVRQLFELCGTNEKIIDNITEEGRQLMATAESVFQKVAGELENGTIVVGQLELILEHQSQFLDIWNLNRRRLPSQEKACDVRSLLKRRRDDLLFLKQEKRYVESLLRQLGRVKHLVQVDFGNIEIIHSQDLSNKKLNEAVIKLPNSSSYKRETHYCLSPDIREMASKLDSLKDSHIFQDFWQETAESLNTLDKDPRELKVSLPEVLEYLYNPCYDNFYTLYENLKSGKITFAEVDAIFKDFVDKYDELKNDLKFMCTMNPQDQKGWISERVGQIKEYHTLHQAVSSAKVILQVRRALGVTGDFSVLNPLLNFADSFEDFGNEKLDQISPQFIKAKQLLQDISEPRQRCLEELARQTELVAWLHKALEDINELKVFVDLASISAGENDIDVDRVACFHDAVQGYASLLYKMDERTNFSDFMNHLQELWRALDNDQHLPDKLKDSARNLEWLKTVKESHGSVELSSLSLATAINSRGVYVIEAPKDGQKISPDTVLRLLLPDGHGYPEALRTYSTEELKELLNKLMLMSGKKDHNSNTEVEKFSEVFSNMQRLVHVFIKLHCAGNMLFRTWTAKVYCCPDGGIFMNFGLELLSQLTEKGDVIQLLGALCRQMEDFLDNWKTVVAQKRAEHFYLNFYTAEQLVYLSSELRKPRPSEAALMMLSFIKGKCTVQDLVQATSACESKADRYCLREVMKKLPQQLLSEPSLMGKLQVIMMQSLVYMSAFLPHCLDLDALGRCLAHLATMGGTPVERPLPKGLQAGQPNLILCGHSEVLPAALAIYMQAPRQPLPTFDEVLLCTPATTIEEVELLLRRCLTSGSQGHKVYSLLFADQLSYEVGCQAEEFFQSLCTRAHREDYQLVILCDAAREHCYIPSTFSQYKVPLVPQAPLPNIQAYLQSHYQVPKRLLSAATVFRDGLCVGIVTSERAGVGKSLYVNTLHTKLKAKLRDETVPLKIIRLTEPHLDENQVLSALLPFLKEKYQKMPVIFHIDISTSVQTGIPIFLFKLLILQYLMDINGKIWRRSPGHLYLVEIPQGLSVQPKRSSKLNARAPLFKFLDLFPKVTCRPPKEVIDMELTPERSHTDPAMDPVEFCSEAFQRPYQYLKRFHQQQNLDTFQYEKGSVEGSPEECLQHFLIYCGLINPSWSELRNFAWFLNCQLKDCEASIFCKSAFTGDTLRGFKNFVVTFMILMARDFATPTLHTSDQSPGRQSVTIGEVVEEDLAPFSLRKRWESEPHPYVFFNGDHMTMTFIGFHLETNNNGYVDAINPSNGKVIKKDVMTKELFDGLRLQRVPFNIDFDNLPRYEKLERLCLALGIEWPIDPDETYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLKRGSVEAETMKLVKVHGGTTPSMIYSKVKEAERTAFSNKAQHKLDTILFFDEANTTEAVSCIKEILCDRTVDGEHLHEDSGLHIIAACNPYRKHSQEMILRLESAGLGYRVSAEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLNDSAEKLYIQQIVQRLVDSVSVNPSETCVIADVLSASQMFMRKRENECGFVSLRDVERCVKVFRWFHDHSDMLLKELDKFLHESSDSTHTFERDPVLWSLVMAIGVCYHASLEEKASYRTAIARCFPKPYNSSRAILDEVTHVQDLFLRGAPIRTNIARNLALKENVFMMVICIELKIPLFLVGKPGSSKSLAKIIVADAMQGQAAFSELFRCLKQVHLVSFQCSPHSTPQGIISTFKQCARFQQGKDLGQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPYKKVGFVGISNWALDPAKMNRGIFVSRGSPNEKELIESAEGICSSDRLVQDKIRGYFAPFAKAYETVCQKQDKEFFGLRDYYSLIKMVFAKAKASKRGLSPQDITHAVLRNFSGKDNIQALSIFTASLPEARYKEEVSTVELIKQNIYPGPQASSRGLDGAESRYLLVLTRNYVALQILQQTFFEGQQPEIIFGSSFPQDQEYTQICRNINRVKICMETGKMVVLLNLQNLYESLYDALNQYYVYLGGQKYVDLGLGTHRVKCRVHTAFRLIVIEEKDVVYKQFPVPLINRLEKHYLDMNTVLQPWQKSIVQELQQWAHEFADVKADQFIARHKYSPADVFIGYHSDACASVVLQAVERQGCRDLTEELYRKVSEEARSILLDCATPDAVVRLSGSSLGSFTAKQLSQEYYYAQQHNSFVDFLQAHLRMTHHECRAVFTEITTFSRLLTGNDCDVLASELRGLASKPVVLSLQQYDTEYSFLKDVRSWLTNPGKRKVLVIQADFDDGTRSAQLVASAKYTAINEINKTQGTKDFVFVYFVTKLSRMGSGTSYVGFHGGLWRSVHIDDLRRSTIMASDVTKLQNVTISQLFKPEDKPEQEEMEIETSQSKELAEEQMEVEDSEEMKKASDPRSCDCSQFLDTTRLVQSCVQGAVGMLRDQNESCARNMRRVTILLDLLNEDNTRNASFLRESKMRLHVLLNKQEENQVRSLKEWVTREAANQDALQEAGTFRHTLWKRVQDVVTPILASMIAHIDRDGNLELLAQPDSPAWVQDLWMFIYSDIKFLNISLVLNNTRSNSEMSFILVQSHMNLLKDAYNAVPFSWRIRDYLEELWVQAQYITDTEGLSKKFVEIFQKTPLGVFLAQFPVAQQQKLLQSYLKDFLLLTMKVSSREELMFLQMALWSCLRELQEASGTPDETYKFPLSLPWVHLAFQHFRTRLQNFSRILTIHPQVLSSLSQAAEKHSLAGCEMTLDAFAAMACAEMLKGDLLKPSPKAWLQLVKNLSTPLELVCSEGYLCDSGSMTRSVIQEVRALWNRIFSIALFVEHVLLGTESHIPELSPLVTTYVSLLDKCLEEDSNLKTCRPFVAVMTTLCDCKDKASKKFSRFGIQPCFICHGDAQDPVCLPCDHVYCLRCIQTWLIPGQMMCPYCLTDLPDKFSPTVSQDHRKAIEKHAQFRHMCNSFFVDLVSTMCFKDNTPPEKSVIDTLLSLLFVQKELLRDASQKHREHTKSLSPFDDVVDQTPVIRSVLLKLLLKYSFHEVKDYIQNYLTQLEKKAFLTEDKTELYLLFISCLEDSVHQKTSAGCRNLEQVLREEGHFLRTYSPGLQGQEPVRIASVEYLQEVARVRLCLDLAADFLSELQEGSELAEDKRRFLKHVEEFCTRVNNDWHRVYLVRKLSSQRGMEFVQSFSKQGHPCQWVFPRKVIAQQKDHVSLMDRYLVHGNEYKAVRDATAKAVLECKTLDIGNALMACRSPKPQQTAYLLLALYTEVAALYRSPNGSLHPEAKQLEAVNKFIKESKILSDPNIRCFARSLVDNTLPLLKIRSANSILKGTVTEMAVHVATILLCGHNQILKPLRNLAFYPVNMANAFLPTMPEDLLVHARTWRGLENVTWYTCPRGHPCSVGECGRPMQESTCLDCGLPVGGLNHTPHEGFSAIRNNEDRTQTGHVLGSPQSSGVAEVSDRGQSPVVFILTRLLTHLAMLVGATHNPQALTVIIKPWVQDPQGFLQQHIQRDLEQLTKMLGRSADETIHVVHLILSSLLRVQSHGVLNFNAELSTKGCRNNWEKHFETLLLRELKHLDKNLPAINALISQDERISSNPVTKIIYGDPATFLPHLPQKSIIHCSKIWSCRRKITVEYLQHIVEQKNGKETVPVLWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVSRVEYSSIRGFIHSHSSDGLRKLLHDRITIFLSTWNALRRSLETNGEIKLPKDYCCSDLDLDAEFEVILPRRQGLGLCGTALVSYLISLHNNMVYTVQKFSNEDNSYSVDISEVADLHVISYEVERDLNPLILSNCQYQVQQGGETSQEFDLEKIQRQISSRFLQGKPRLTLKGIPTLVYRRDWNYEHLFMDIKNKMAQSSLPNLAISTISGQLQSYSDACEALSIIEITLGFLSTAGGDPGMDLNVYIEEVLRMCDQTAQVLKAFSRCQLRHIIALWQFLSAHKSEQRLRLNKELFREIDVQYKEELSTQHQRLLGTFLNEAGLDAFLLELHEMIVLKLKGPRAANSFNPNWSLKDTLVSYMETKDSDILSEVESQFPEEILMSSCISVWKIAATRKWDRQSR","length":5148,"molWeight":584258,"crc64":"668FFE0AB2C2F8CE","md5":"7283130023BF2E049B9CB2E18B24491E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"PATHWAY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DOMAIN":3,"PTM":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1,"CAUTION":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Zinc finger":2,"Region":1,"Coiled coil":1,"Compositional bias":8,"Active site":1,"Binding site":26,"Modified residue":2,"Cross-link":1,"Mutagenesis":1,"Helix":238,"Turn":45,"Beta strand":134},"uniParcId":"UPI000DCA2F88"}}