{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"E9Q414","secondaryAccessions":["Q3UH74","Q497D8","Q61314","Q61318","Q8CGG8"],"uniProtkbId":"APOB_MOUSE","entryAudit":{"firstPublicDate":"2013-02-06","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":107,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Apolipoprotein B-100"},"shortNames":[{"value":"Apo B-100"}]},"contains":[{"recommendedName":{"fullName":{"value":"Apolipoprotein B-48"},"shortNames":[{"value":"Apo B-48"}]}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"Apob"}}],"comments":[{"texts":[{"value":"Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04114"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19187774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23297397"}],"value":"Interacts with PCSK9 (By similarity). Interacts with MTTP (By similarity). Interacts with AUP1 (By similarity). Interacts with CIDEB (PubMed:19187774, PubMed:23297397)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04114"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04114"}],"value":"Secreted","id":"SL-0243"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04114"}],"value":"Lipid droplet","id":"SL-0154"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle"}],"commentType":"PTM"},{"commentType":"RNA EDITING","locationType":"Known","positions":[{"position":"2179","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TMA5"}]}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TMA5"}],"value":"The stop codon (UAA) at position 2179 is created by an APOBEC1-containing mRNA editing complex. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL (By similarity)"}]}},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAI41358.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAI41361.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAE27983.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":4505,"modifier":"EXACT"}},"description":"Apolipoprotein B-100","featureId":"PRO_0000420969"},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":2178,"modifier":"EXACT"}},"description":"Apolipoprotein B-48","featureId":"PRO_0000420970"},{"type":"Domain","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":672,"modifier":"EXACT"}},"description":"Vitellogenin","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00557"}]},{"type":"Region","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"Heparin-binding","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"Heparin-binding","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":902,"modifier":"EXACT"},"end":{"value":959,"modifier":"EXACT"}},"description":"Heparin-binding","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":2042,"modifier":"EXACT"},"end":{"value":2177,"modifier":"EXACT"}},"description":"Heparin-binding","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":3155,"modifier":"EXACT"},"end":{"value":3230,"modifier":"EXACT"}},"description":"Heparin-binding","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":3168,"modifier":"EXACT"},"end":{"value":3178,"modifier":"EXACT"}},"description":"Basic (possible receptor binding region)","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":3368,"modifier":"EXACT"},"end":{"value":3388,"modifier":"EXACT"}},"description":"LDL receptor binding","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":3378,"modifier":"EXACT"},"end":{"value":3511,"modifier":"EXACT"}},"description":"Heparin-binding","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":3381,"modifier":"EXACT"},"end":{"value":3389,"modifier":"EXACT"}},"description":"Basic (possible receptor binding region)","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Modified residue","location":{"start":{"value":2005,"modifier":"EXACT"},"end":{"value":2005,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04114"}]},{"type":"Modified residue","location":{"start":{"value":3273,"modifier":"EXACT"},"end":{"value":3273,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04114"}]},{"type":"Modified residue","location":{"start":{"value":4013,"modifier":"EXACT"},"end":{"value":4013,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04114"}]},{"type":"Glycosylation","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":983,"modifier":"EXACT"},"end":{"value":983,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1368,"modifier":"EXACT"},"end":{"value":1368,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1377,"modifier":"EXACT"},"end":{"value":1377,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1523,"modifier":"EXACT"},"end":{"value":1523,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":2554,"modifier":"EXACT"},"end":{"value":2554,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":2773,"modifier":"EXACT"},"end":{"value":2773,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16944957"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":2976,"modifier":"EXACT"},"end":{"value":2976,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16944957"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":3095,"modifier":"EXACT"},"end":{"value":3095,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":3331,"modifier":"EXACT"},"end":{"value":3331,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":3353,"modifier":"EXACT"},"end":{"value":3353,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":3460,"modifier":"EXACT"},"end":{"value":3460,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":3860,"modifier":"EXACT"},"end":{"value":3860,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00557"}]},{"type":"Disulfide bond","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00557"}]},{"type":"Disulfide bond","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00557"}]},{"type":"Disulfide bond","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00557"}]},{"type":"Disulfide bond","location":{"start":{"value":385,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00557"}]},{"type":"Disulfide bond","location":{"start":{"value":478,"modifier":"EXACT"},"end":{"value":513,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00557"}]},{"type":"Disulfide bond","location":{"start":{"value":966,"modifier":"EXACT"},"end":{"value":976,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00557"}]},{"type":"Sequence conflict","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"in Ref. 2; AAI00608","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"KD","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"in Ref. 2; AAI00608","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"EL","alternativeSequences":["KK"]}},{"type":"Sequence conflict","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"in Ref. 2; AAI00608","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":1477,"modifier":"EXACT"},"end":{"value":1477,"modifier":"EXACT"}},"description":"in Ref. 2; AAH38263","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":3265,"modifier":"EXACT"},"end":{"value":3265,"modifier":"EXACT"}},"description":"in Ref. 3; AAA37246","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0153","category":"Biological process","name":"Cholesterol metabolism"},{"id":"KW-0162","category":"Cellular component","name":"Chylomicron"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0358","category":"Molecular function","name":"Heparin-binding"},{"id":"KW-0427","category":"Cellular component","name":"LDL"},{"id":"KW-0551","category":"Cellular component","name":"Lipid droplet"},{"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"id":"KW-0445","category":"Biological process","name":"Lipid transport"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0564","category":"PTM","name":"Palmitate"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0691","category":"Coding sequence diversity","name":"RNA editing"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0753","category":"Biological process","name":"Steroid metabolism"},{"id":"KW-1207","category":"Biological process","name":"Sterol metabolism"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0850","category":"Cellular component","name":"VLDL"}],"references":[{"referenceNumber":1,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1477 AND 3004-4505"],"referenceComments":[{"value":"FVB/N","type":"STRAIN"},{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"2332175","citationType":"journal article","authors":["Smith T.J.","Hautamaa D.","Maeda N."],"citationCrossReferences":[{"database":"PubMed","id":"2332175"},{"database":"DOI","id":"10.1016/0378-1119(90)90319-m"}],"title":"Sequence of the putative low-density lipoprotein receptor-binding regions of apolipoprotein B in mouse and hamster.","publicationDate":"1990","journal":"Gene","firstPage":"309","lastPage":"310","volume":"87"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2734-3518"]},{"referenceNumber":4,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2962-4505"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"16944957","citationType":"journal article","authors":["Ghesquiere B.","Van Damme J.","Martens L.","Vandekerckhove J.","Gevaert K."],"citationCrossReferences":[{"database":"PubMed","id":"16944957"},{"database":"DOI","id":"10.1021/pr060186m"}],"title":"Proteome-wide characterization of N-glycosylation events by diagonal chromatography.","publicationDate":"2006","journal":"J. Proteome Res.","firstPage":"2438","lastPage":"2447","volume":"5"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2773 AND ASN-2976"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Plasma","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Brown adipose tissue","type":"TISSUE"},{"value":"Heart","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Liver","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Pancreas","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"19187774","citationType":"journal article","authors":["Ye J.","Li J.Z.","Liu Y.","Li X.","Yang T.","Ma X.","Li Q.","Yao Z.","Li P."],"citationCrossReferences":[{"database":"PubMed","id":"19187774"},{"database":"DOI","id":"10.1016/j.cmet.2008.12.013"}],"title":"Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B.","publicationDate":"2009","journal":"Cell Metab.","firstPage":"177","lastPage":"190","volume":"9"},"referencePositions":["INTERACTION WITH CIDEB"]},{"referenceNumber":8,"citation":{"id":"23297397","citationType":"journal article","authors":["Tiwari S.","Siddiqi S.","Siddiqi S.A."],"citationCrossReferences":[{"database":"PubMed","id":"23297397"},{"database":"DOI","id":"10.1074/jbc.m112.434258"}],"title":"CideB protein is required for the biogenesis of very low density lipoprotein (VLDL) transport vesicle.","publicationDate":"2013","journal":"J. Biol. Chem.","firstPage":"5157","lastPage":"5165","volume":"288"},"referencePositions":["INTERACTION WITH CIDEB"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC163900","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC038263","properties":[{"key":"ProteinId","value":"AAH38263.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC100607","properties":[{"key":"ProteinId","value":"AAI00608.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC141357","properties":[{"key":"ProteinId","value":"AAI41358.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC141360","properties":[{"key":"ProteinId","value":"AAI41361.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M35186","properties":[{"key":"ProteinId","value":"AAA37246.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X15191","properties":[{"key":"ProteinId","value":"CAA33265.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK147540","properties":[{"key":"ProteinId","value":"BAE27983.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS49022.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_033823.2","properties":[{"key":"NucleotideSequenceId","value":"NM_009693.2"}]},{"database":"SMR","id":"E9Q414","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"231944","properties":[{"key":"Interactions","value":"14"}]},{"database":"FunCoup","id":"E9Q414","properties":[{"key":"Number of interactors","value":"162"}]},{"database":"STRING","id":"10090.ENSMUSP00000036044","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"E9Q414","properties":[{"key":"glycosylation","value":"14 sites, No reported glycans"}]},{"database":"GlyGen","id":"E9Q414","properties":[{"key":"glycosylation","value":"18 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (2 sites)"}]},{"database":"iPTMnet","id":"E9Q414","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"E9Q414","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"E9Q414","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-5577","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"E9Q414","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000036044","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"E9Q414","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"296268","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"E9Q414","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"4232","properties":[{"key":"antibodies","value":"1156 antibodies from 47 providers"}]},{"database":"Ensembl","id":"ENSMUST00000037811.13","properties":[{"key":"ProteinId","value":"ENSMUSP00000036044.7"},{"key":"GeneId","value":"ENSMUSG00000020609.15"}]},{"database":"GeneID","id":"238055","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:238055","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007mzf.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:88052","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"338","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:88052","properties":[{"key":"GeneName","value":"Apob"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000020609","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4338","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00590000083139","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"E9Q414","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FTCAYEN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6484170at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-202733","properties":[{"key":"PathwayName","value":"Cell surface interactions at the vascular wall"}]},{"database":"Reactome","id":"R-MMU-3000471","properties":[{"key":"PathwayName","value":"Scavenging by Class B Receptors"}]},{"database":"Reactome","id":"R-MMU-3000480","properties":[{"key":"PathwayName","value":"Scavenging by Class A Receptors"}]},{"database":"Reactome","id":"R-MMU-3000497","properties":[{"key":"PathwayName","value":"Scavenging by Class H Receptors"}]},{"database":"Reactome","id":"R-MMU-381426","properties":[{"key":"PathwayName","value":"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"}]},{"database":"Reactome","id":"R-MMU-432142","properties":[{"key":"PathwayName","value":"Platelet sensitization by LDL"}]},{"database":"Reactome","id":"R-MMU-5686938","properties":[{"key":"PathwayName","value":"Regulation of TLR by endogenous ligand"}]},{"database":"Reactome","id":"R-MMU-8856825","properties":[{"key":"PathwayName","value":"Cargo recognition for clathrin-mediated endocytosis"}]},{"database":"Reactome","id":"R-MMU-8856828","properties":[{"key":"PathwayName","value":"Clathrin-mediated endocytosis"}]},{"database":"Reactome","id":"R-MMU-8866423","properties":[{"key":"PathwayName","value":"VLDL assembly"}]},{"database":"Reactome","id":"R-MMU-8957275","properties":[{"key":"PathwayName","value":"Post-translational protein phosphorylation"}]},{"database":"Reactome","id":"R-MMU-8963888","properties":[{"key":"PathwayName","value":"Chylomicron assembly"}]},{"database":"Reactome","id":"R-MMU-8963901","properties":[{"key":"PathwayName","value":"Chylomicron remodeling"}]},{"database":"Reactome","id":"R-MMU-8964026","properties":[{"key":"PathwayName","value":"Chylomicron clearance"}]},{"database":"Reactome","id":"R-MMU-8964038","properties":[{"key":"PathwayName","value":"LDL clearance"}]},{"database":"Reactome","id":"R-MMU-8964046","properties":[{"key":"PathwayName","value":"VLDL clearance"}]},{"database":"Reactome","id":"R-MMU-9707616","properties":[{"key":"PathwayName","value":"Heme signaling"}]},{"database":"Reactome","id":"R-MMU-975634","properties":[{"key":"PathwayName","value":"Retinoid metabolism and transport"}]},{"database":"BioGRID-ORCS","id":"238055","properties":[{"key":"hits","value":"4 hits in 80 CRISPR screens"}]},{"database":"PRO","id":"PR:E9Q414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"RNAct","id":"E9Q414","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000020609","properties":[{"key":"ExpressionPatterns","value":"Expressed in small intestine Peyer's patch and 70 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9Q414","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0042627","properties":[{"key":"GoTerm","value":"C:chylomicron"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12072432"}]},{"database":"GO","id":"GO:0070971","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum exit site"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0034364","properties":[{"key":"GoTerm","value":"C:high-density lipoprotein particle"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0034363","properties":[{"key":"GoTerm","value":"C:intermediate-density lipoprotein particle"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005811","properties":[{"key":"GoTerm","value":"C:lipid droplet"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0034362","properties":[{"key":"GoTerm","value":"C:low-density lipoprotein particle"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0034359","properties":[{"key":"GoTerm","value":"C:mature chylomicron"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043025","properties":[{"key":"GoTerm","value":"C:neuronal cell body"},{"key":"GoEvidenceType","value":"ISO:MGI"}],"evidences":[{"evidenceCode":"ECO:0000266","source":"PubMed","id":"22897442"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"ISS:MGI"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"20237389"}]},{"database":"GO","id":"GO:0034361","properties":[{"key":"GoTerm","value":"C:very-low-density lipoprotein particle"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0031983","properties":[{"key":"GoTerm","value":"C:vesicle lumen"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0120020","properties":[{"key":"GoTerm","value":"F:cholesterol transfer activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0008201","properties":[{"key":"GoTerm","value":"F:heparin binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0035473","properties":[{"key":"GoTerm","value":"F:lipase binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0050750","properties":[{"key":"GoTerm","value":"F:low-density lipoprotein particle receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005543","properties":[{"key":"GoTerm","value":"F:phospholipid binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0048018","properties":[{"key":"GoTerm","value":"F:receptor ligand activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0048844","properties":[{"key":"GoTerm","value":"P:artery morphogenesis"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"16230502"}]},{"database":"GO","id":"GO:1904646","properties":[{"key":"GoTerm","value":"P:cellular response to amyloid-beta"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0071402","properties":[{"key":"GoTerm","value":"P:cellular response to lipoprotein particle stimulus"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0033344","properties":[{"key":"GoTerm","value":"P:cholesterol efflux"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"22363685"}]},{"database":"GO","id":"GO:0042632","properties":[{"key":"GoTerm","value":"P:cholesterol homeostasis"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7878058"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8921909"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9202070"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9502790"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9852051"}]},{"database":"GO","id":"GO:0008203","properties":[{"key":"GoTerm","value":"P:cholesterol metabolic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0030301","properties":[{"key":"GoTerm","value":"P:cholesterol transport"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7593600"}]},{"database":"GO","id":"GO:0034378","properties":[{"key":"GoTerm","value":"P:chylomicron assembly"},{"key":"GoEvidenceType","value":"ISS:MGI"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"17449472"},{"evidenceCode":"ECO:0000250","source":"PubMed","id":"20237389"}]},{"database":"GO","id":"GO:0009566","properties":[{"key":"GoTerm","value":"P:fertilization"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8855280"}]},{"database":"GO","id":"GO:0030317","properties":[{"key":"GoTerm","value":"P:flagellated sperm motility"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8855280"}]},{"database":"GO","id":"GO:0090077","properties":[{"key":"GoTerm","value":"P:foam cell differentiation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0001701","properties":[{"key":"GoTerm","value":"P:in utero embryonic development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7878058"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9502790"}]},{"database":"GO","id":"GO:0016042","properties":[{"key":"GoTerm","value":"P:lipid catabolic process"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16455790"}]},{"database":"GO","id":"GO:0006629","properties":[{"key":"GoTerm","value":"P:lipid metabolic process"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12072432"}]},{"database":"GO","id":"GO:0042158","properties":[{"key":"GoTerm","value":"P:lipoprotein biosynthetic process"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"13130124"}]},{"database":"GO","id":"GO:0042159","properties":[{"key":"GoTerm","value":"P:lipoprotein catabolic process"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"15863839"}]},{"database":"GO","id":"GO:0042157","properties":[{"key":"GoTerm","value":"P:lipoprotein metabolic process"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10705993"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10713055"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7878058"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9852051"}]},{"database":"GO","id":"GO:0042953","properties":[{"key":"GoTerm","value":"P:lipoprotein transport"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"13130124"}]},{"database":"GO","id":"GO:0034383","properties":[{"key":"GoTerm","value":"P:low-density lipoprotein particle clearance"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0034374","properties":[{"key":"GoTerm","value":"P:low-density lipoprotein particle remodeling"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7878058"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8921909"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9502790"}]},{"database":"GO","id":"GO:0010886","properties":[{"key":"GoTerm","value":"P:positive regulation of cholesterol storage"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22897442"}]},{"database":"GO","id":"GO:0010884","properties":[{"key":"GoTerm","value":"P:positive regulation of lipid storage"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0010744","properties":[{"key":"GoTerm","value":"P:positive regulation of macrophage derived foam cell differentiation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0009791","properties":[{"key":"GoTerm","value":"P:post-embryonic development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9852051"}]},{"database":"GO","id":"GO:0045540","properties":[{"key":"GoTerm","value":"P:regulation of cholesterol biosynthetic process"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16455790"}]},{"database":"GO","id":"GO:0009743","properties":[{"key":"GoTerm","value":"P:response to carbohydrate"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0009615","properties":[{"key":"GoTerm","value":"P:response to virus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007283","properties":[{"key":"GoTerm","value":"P:spermatogenesis"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8855280"}]},{"database":"GO","id":"GO:0019433","properties":[{"key":"GoTerm","value":"P:triglyceride catabolic process"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16455790"}]},{"database":"GO","id":"GO:0006642","properties":[{"key":"GoTerm","value":"P:triglyceride mobilization"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10893242"}]},{"database":"GO","id":"GO:0034379","properties":[{"key":"GoTerm","value":"P:very-low-density lipoprotein particle assembly"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"FunFam","id":"1.25.10.20:FF:000004","properties":[{"key":"EntryName","value":"Apolipoprotein B"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.230.10:FF:000003","properties":[{"key":"EntryName","value":"Apolipoprotein B"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.230.10","properties":[{"key":"EntryName","value":"Lipovitellin, beta-sheet shell regions, chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.80.10","properties":[{"key":"EntryName","value":"Lipovitellin-phosvitin complex, chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.10.20","properties":[{"key":"EntryName","value":"Vitellinogen, superhelical"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR063421","properties":[{"key":"EntryName","value":"ApoB100_4ins"}]},{"database":"InterPro","id":"IPR062040","properties":[{"key":"EntryName","value":"ApoB100_6ins"}]},{"database":"InterPro","id":"IPR062041","properties":[{"key":"EntryName","value":"ApoB100_8ins"}]},{"database":"InterPro","id":"IPR063504","properties":[{"key":"EntryName","value":"ApoB100_arm_9ins"}]},{"database":"InterPro","id":"IPR063333","properties":[{"key":"EntryName","value":"ApoB100_beta_belt1_3"}]},{"database":"InterPro","id":"IPR063258","properties":[{"key":"EntryName","value":"ApoB100_beta_belt2_2"}]},{"database":"InterPro","id":"IPR063254","properties":[{"key":"EntryName","value":"ApoB100_beta_belt3"}]},{"database":"InterPro","id":"IPR022176","properties":[{"key":"EntryName","value":"ApoB100_C"}]},{"database":"InterPro","id":"IPR052418","properties":[{"key":"EntryName","value":"Apolipoprotein_B"}]},{"database":"InterPro","id":"IPR015819","properties":[{"key":"EntryName","value":"Lipid_transp_b-sht_shell"}]},{"database":"InterPro","id":"IPR009454","properties":[{"key":"EntryName","value":"Lipid_transpt_open_b-sht"}]},{"database":"InterPro","id":"IPR011030","properties":[{"key":"EntryName","value":"Lipovitellin_superhlx_dom"}]},{"database":"InterPro","id":"IPR015816","properties":[{"key":"EntryName","value":"Vitellinogen_b-sht_N"}]},{"database":"InterPro","id":"IPR015255","properties":[{"key":"EntryName","value":"Vitellinogen_open_b-sht"}]},{"database":"InterPro","id":"IPR001747","properties":[{"key":"EntryName","value":"Vitellogenin_M"}]},{"database":"InterPro","id":"IPR063611","properties":[{"key":"EntryName","value":"Vitellogenin_N"}]},{"database":"PANTHER","id":"PTHR13769","properties":[{"key":"EntryName","value":"APOLIPOPROTEIN B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13769:SF1","properties":[{"key":"EntryName","value":"APOLIPOPROTEIN B-100"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30436","properties":[{"key":"EntryName","value":"ApoB100_4ins"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30435","properties":[{"key":"EntryName","value":"ApoB100_6ins"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30433","properties":[{"key":"EntryName","value":"ApoB100_8ins"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30406","properties":[{"key":"EntryName","value":"ApoB100_arm_9ins"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30444","properties":[{"key":"EntryName","value":"ApoB100_beta_belt1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30454","properties":[{"key":"EntryName","value":"ApoB100_beta_belt2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30460","properties":[{"key":"EntryName","value":"ApoB100_beta_belt3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12491","properties":[{"key":"EntryName","value":"ApoB100_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06448","properties":[{"key":"EntryName","value":"DUF1081"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01347","properties":[{"key":"EntryName","value":"TPR_Vitellogenin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09172","properties":[{"key":"EntryName","value":"Vit_open_b-sht"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF29934","properties":[{"key":"EntryName","value":"Vitellogenin_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01169","properties":[{"key":"EntryName","value":"DUF1943"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00638","properties":[{"key":"EntryName","value":"LPD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56968","properties":[{"key":"EntryName","value":"Lipovitellin-phosvitin complex, beta-sheet shell regions"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48431","properties":[{"key":"EntryName","value":"Lipovitellin-phosvitin complex, superhelical domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51211","properties":[{"key":"EntryName","value":"VITELLOGENIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGPRKPALRTPLLLLFLLLFLDTSVWAQDEVLENLSFSCPKDATRFKHLRKYVYNYEAESSSGVQGTADSRSATKINCKVELEVPQICGFIMRTNQCTLKEVYGFNPEGKALMKKTKNSEEFAAAMSRYELKLAIPEGKQIVLYPDKDEPKYILNIKRGIISALLVPPETEEDQQELFLDTVYGNCSTQVTVNSRKGTVPTEMSTERNLQQCDGFQPISTSVSPLALIKGLVHPLSTLISSSQTCQYTLDPKRKHVSEAVCDEQHLFLPFSYKNKYGIMTRVTQKLSLEDTPKINSRFFSEGTNRMGLAFESTKSTSSPKQADAVLKTLQELKKLSISEQNAQRANLFNKLVTELRGLTGEAITSLLPQLIEVSSPITLQALVQCGQPQCYTHILQWLKTEKAHPLLVDIVTYLMALIPNPSTQRLQEIFNTAKEQQSRATLYALSHAVNSYFDVDHSRSPVLQDIAGYLLKQIDNECTGNEDHTFLILRVIGNMGRTMEQVMPALKSSVLSCVRSTKPSLLIQKAALQALRKMELEDEVRTILFDTFVNGVAPVEKRLAAYLLLMKNPSSSDINKIAQLLQWEQSEQVKNFVASHIANILNSEELYVQDLKVLIKNALENSQFPTIMDFRKFSRNYQISKSASLPMFDPVSVKIEGNLIFDPSSYLPRESLLKTTLTVFGLASLDLFEIGLEGKGFEPTLEALFGKQGFFPDSVNKALYWVNGRVPDGVSKVLVDHFGYTTDGKHEQDMVNGIMPIVDKLIKDLKSKEIPEARAYLRILGKELSFVRLQDLQVLGKLLLSGAQTLQGIPQMVVQAIREGSKNDLFLHYIFMDNAFELPTGAGLQLQVSSSGVFTPGIKAGVRLELANIQAELVAKPSVSLEFVTNMGIIIPDFAKSSVQMNTNFFHESGLEARVALKAGQLKVIIPSPKRPVKLFSGSNTLHLVSTTKTEVIPPLVENRQSWSTCKPLFTGMNYCTTGAYSNASSTESASYYPLTGDTRYELELRPTGEVEQYSATATYELLKEDKSLVDTLKFLVQAEGVQQSEATVLFKYNRRSRTLSSEVLIPGFDVNFGTILRVNDESAKDKNTYKLILDIQNKKITEVSLVGHLSYDKKGDGKIKGVVSIPRLQAEARSEVHTHWSSTKLLFQMDSSATAYGSTISKRVTWRYDNEIIEFDWNTGTNVDTKKVASNFPVDLSHYPRMLHEYANGLLDHRVPQTDVTFRDMGSKLIVATNTWLQMATRGLPYPQTLQDHLNSLSELNLLKMGLSDFHIPDNLFLKTDGRVKYTMNRNKINIDIPLPLGGKSSKDLKMPESVRTPALNFKSVGFHLPSREVQVPTFTIPKTHQLQVPLLGVLDLSTNVYSNLYNWSASYTGGNTSRDHFSLQAQYRMKTDSVVDLFSYSVQGSGETTYDSKNTFTLSCDGSLHHKFLDSKFKVSHVEKFGNSPVSKGLLTFETSSALGPQMSATVHLDSKKKQHLYVKDIKVDGQFRASSFYAQGKYGLSCERDVTTGQLSGESNMRFNSTYFQGTNQIVGMYQDGALSITSTSDLQDGIFKNTASLKYENYELTLKSDSSGQYENFAASNKLDVTFSTQSALLRSEHQANYKSLRLVTLLSGSLTSQGVELNADILGTDKINTGAHKATLKIARDGLSTSATTNLKYSPLLLENELNAELGLSGASMKLSTNGRFKEHHAKFSLDGRAALTEVSLGSIYQAMILGADSKNIFNFKLSREGLRLSNDLMGSYAEMKLDHTHSLNIAGLSLDFFSKMDNIYSGDKFYKQNFNLQLQPYSFITTLSNDLRYGALDLTNNGRFRLEPLKLNVGGNFKGTYQNNELKHIYTISYTDLVVASYRADTVAKVQGVEFSHRLNADIEGLTSSVDVTTSYNSDPLHFNNVFHFSLAPFTLGIDTHTSGDGKLSFWGEHTGQLYSKFLLKAEPLALIVSHDYKGSTSHSLPYESSISTALEHTVSALLTPAEQTSTWKFKTKLNDKVYSQDFEAYNTKDKIGVELSGRADLSGLYSPIKLPFFYSEPVNVLNGLEVNDAVDKPQEFTIIAVVKYDKNQDVHTINLPFFKSLPDYLERNRRGMISLLEAMRGELQRLSVDQFVRKYRAALSRLPQQIHHYLNASDWERQVAGAKEKITSFMENYRITDNDVLIAIDSAKINFNEKLSQLETYAIQFDQYIKDNYDPHDLKRTIAEIIDRIIEKLKILDEQYHIRVNLAKSIHNLYLFVENVDLNQVSSSNTSWIQNVDSNYQVRIQIQEKLQQLRTQIQNIDIQQLAAEVKRQMDAIDVTMHLDQLRTAILFQRISDIIDRVKYFVMNLIEDFKVTEKINTFRVIVRELIEKYEVDQHIQVLMDKSVELAHRYSLSEPLQKLSNVLQRIEIKDYYEKLVGFIDDTVEWLKALSFKNTIEELNRLTDMLVKKLKAFDYHQFVDKTNSKIREMTQRINAEIQALKLPQKMEALKLLVEDFKTTVSNSLERLKDTKVTVVIDWLQDILTQMKDHFQDTLEDVRDRIYQMDIQRELEHFLSLVNQVYSTLVTYMSDWWTLTAKNITDFAEQYSIQNWAESIKVLVEQGFIVPEMQTFLWTMPAFEVSLRALQEGNFQTPVFIVPLTDLRIPSIRINFKMLKNIKIPLRFSTPEFTLLNTFHVHSFTIDLLEIKAKIIRTIDQILSSELQWPLPEMYLRDLDVVNIPLARLTLPDFHVPEITIPEFTIPNVNLKDLHVPDLHIPEFQLPHLSHTIEIPAFGKLHSILKIQSPLFILDANANIQNVTTSGNKAEIVASVTAKGESQFEALNFDFQAQAQFLELNPHPPVLKESMNFSSKHVRMEHEGEIVFDGKAIEGKSDTVASLHTEKNEVEFNNGMTVKVNNQLTLDSHTKYFHKLSVPRLDFSSKASLNNEIKTLLEAGHVALTSSGTGSWNWACPNFSDEGIHSSQISFTVDGPIAFVGLSNNINGKHLRVIQKLTYESGFLNYSKFEVESKVESQHVGSSILTANGRALLKDAKAEMTGEHNANLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVGFPLKLTGKIDFLNNYALFLSPRAQQASWQASTRFNQYKYNQNFSAINNEHNIEASIGMNGDANLDFLNIPLTIPEINLPYTEFKTPLLKDFSIWEETGLKEFLKTTKQSFDLSVKAQYKKNSDKHSIVVPLGMFYEFILNNVNSWDRKFEKVRNNALHFLTTSYNEAKIKVDKYKTENSLNQPSGTFQNHGYTIPVVNIEVSPFAVETLASSHVIPTAISTPSVTIPGPNIMVPSYKLVLPPLELPVFHGPGNLFKFFLPDFKGFNTIDNIYIPAMGNFTYDFSFKSSVITLNTNAGLYNQSDIVAHFLSSSSFVTDALQYKLEGTSRLMRKRGLKLATAVSLTNKFVKGSHDSTISLTKKNMEASVRTTANLHAPIFSMNFKQELNGNTKSKPTVSSSIELNYDFNSSKLHSTATGGIDHKFSLESLTSYFSIESFTKGNIKSSFLSQEYSGSVANEANVYLNSKGTRSSVRLQGASKVDGIWNVEVGENFAGEATLQRIYTTWEHNMKNHLQVYSYFFTKGKQTCRATLELSPWTMSTLLQVHVSQLSSLLDLHHFDQEVILKANTKNQKISWKGGVQVESRVLQHNAQFSNDQEEIRLDLAGSLDGQLWDLEAIFLPVYGKSLQELLQMDGKRQYLQASTSLLYTKNPNGYLLSLPVQELADRFIIPGIKLNDFSGVKIYKKLSTSPFALNLTMLPKVKFPGIDLLTQYSTPEGSSVPIFEATIPEIHLTVSQFTLPKSLPVGNTVFDLNKLANMIADVDLPSVTLPEQTIVIPPLEFSVPAGIFIPFFGELTARAGMASPLYNVTWSAGWKTKADHVETFLDSMCTSTLQFLEYALKVVETHKIEEDLLTYNIKGTLQHCDFNVEYNEDGLFKGLWDWQGEAHLDITSPALTDFHLYYKEDKTSLSASAASSTIGTVGLDSSTDDQSVELNVYFHPQSPPEKKLSIFKTEWRYKESDGERYIKINWEEEAASRLLGSLKSNVPKASKAIYDYANKYHLEYVSSELRKSLQVNAEHARRMVDEMNMSFQRVARDTYQNLYEEMLAQKSLSIPENLKKRVLDSIVHVTQKYHMAVMWLMDSFIHFLKFNRVQFPGYAGTYTVDELYTIVMKETKKSLSQLFNGLGNLLSYVQNQVEKSRLINDITFKCPFFSKPCKLKDLILIFREELNILSNIGQQDIKFTTILSSLQGFLERVLDIIEEQIKCLKDNESTCVADHINMVFKIQVPYAFKSLREDIYFVLGEFNDFLQSILQEGSYKLQQVHQYMKALREEYFDPSMVGWTVKYYEIEENMVELIKTLLVSFRDVYSEYSVTAADFASKMSTQVEQFVSRDIREYLSMLTDINGKWMEKIAELSIVAKETMKSWVTAVAKIMSDYPQQFHSNLQDFSDQLSSYYEKFVGESTRLIDLSIQNYHVFLRYITELLRKLQVATANNVSPYIKLAQGELMITF","length":4505,"molWeight":509432,"crc64":"09EADB2D499E7A82","md5":"080AF54ACB49A258DBA0BFBF348329A5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"PTM":1,"RNA EDITING":1,"SEQUENCE CAUTION":3},"countByFeatureType":{"Signal":1,"Chain":2,"Domain":1,"Region":9,"Modified residue":3,"Glycosylation":14,"Disulfide bond":7,"Sequence conflict":5},"uniParcId":"UPI000058C5A5"}}