{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"E2JF22","uniProtkbId":"PIEZ1_MOUSE","entryAudit":{"firstPublicDate":"2011-01-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-11-30","entryVersion":84,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Piezo-type mechanosensitive ion channel component 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20813920"}],"value":"Protein FAM38A"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:3603204"}],"value":"Piezo1"},"synonyms":[{"value":"Fam38a"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q92508"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20813920"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22343900"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24157948"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24958852"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25119035"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26390154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29261642"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29799007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36515266"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38184690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38228630"}],"value":"Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:20813920, PubMed:22343900, PubMed:38184690, PubMed:26390154, PubMed:29261642, PubMed:35388220, PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:26390154, PubMed:29261642, PubMed:35388220, PubMed:37590348). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (PubMed:20813920, PubMed:22343900, PubMed:38228630). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+) (By similarity). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (By similarity). Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (PubMed:38228630). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing (PubMed:24157948). Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (By similarity). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (PubMed:24958852, PubMed:25119035, PubMed:36515266). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells (PubMed:29799007). In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca(2+) influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"K(+)(in) = K(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29463"},{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20813920"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Na(+)(in) = Na(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34963"},{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20813920"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20813920"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Mg(2+)(in) = Mg(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29827"},{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20813920"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q92508"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29799007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"}],"value":"Regulated by auxillary subunits MDFIC and MDFI (PubMed:37590348). Down-regulated by phosphatidylserines exposed on the cell surface (PubMed:29799007). Divalent ions decrease the single-channel permeability of K(+) (By similarity)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22343900"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24157948"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24662763"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26390154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29261642"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38228630"}],"value":"Homotrimer; the homotrimer forms a propeller-shaped Piezo channel with a cation-ion conducting pore (PubMed:26390154, PubMed:29261642, PubMed:35388220, PubMed:37590348). Heterotrimeric interaction may occur between PIEZO1 and PIEZO2 (PubMed:38228630). Interacts with PKD2 (PubMed:24157948). Interacts with STOMl3 (PubMed:24662763). Interacts with TMC1, TMC2, PCDG15 and CIB2; the interaction may be part of the MET complex (PubMed:38228630). Interacts with MDFIC (via C-terminus); the interaction prolongs Piezo channel inactivation (PubMed:37590348). Interacts with MDFI (via C-terminus); the interaction prolongs Piezo channel inactivation (PubMed:37590348)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"E2JF22","intActId":"EBI-9837938"},"interactantTwo":{"uniProtKBAccession":"O55143","geneName":"Atp2a2","intActId":"EBI-770763"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"E2JF22","intActId":"EBI-9837938"},"interactantTwo":{"uniProtKBAccession":"E2JF22","geneName":"Piezo1","intActId":"EBI-9837938"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"E2JF22","intActId":"EBI-9837938"},"interactantTwo":{"uniProtKBAccession":"O35245","geneName":"Pkd2","intActId":"EBI-9823400"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"E2JF22","intActId":"EBI-9837938"},"interactantTwo":{"uniProtKBAccession":"P16615-1","geneName":"ATP2A2","intActId":"EBI-11613988"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q92508"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23479567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29799007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36515266"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38228630"}],"value":"In erythrocytes, located in the plasma membrane (PubMed:23479567). Accumulates at the leading apical lamellipodia of endothelial cells in response to shear stress (By similarity). Colocalizes with F-actin and MYH9 at the actomyosin cortex in myoblasts. Non-uniform distribution of Piezo1 in the red blood cell membrane with an enrichment at the dimple (PubMed:36515266). Located at the tips and sides of stereocilia and cuticular plate membranes (PubMed:38228630)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q92508"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29261642"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q0KL00"}],"value":"Endoplasmic reticulum-Golgi intermediate compartment membrane","id":"SL-0099"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20813920"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26390154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29261642"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36515266"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38184690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38228630"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26390154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29261642"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q92508"}],"value":"Cell projection, lamellipodium membrane","id":"SL-0292"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20813920"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23479567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24958852"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29799007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36515266"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38228630"}],"value":"Expressed in bladder, colon, kidney and skin. Also expressed in bone marrow, liver, lung, spleen and erythrocytes (at protein level). Expressed in myoblasts (at protein level). Expressed in red blood cells (PubMed:36515266). Expressed in cochlear inner and outer hair cells (IHCs and OHCs) and vestibular organ HCs (PubMed:38228630)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23479567"}],"value":"Expressed at least from 9.5 dpc. Expression levels increase up to 15.5 dpc and remain high at least until birth"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24958852"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25119035"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38228630"}],"value":"Embryo lethality at midgestation with defects in vascular remodeling. Conditional knockout mice in inner ear hair cells show no auditory and vestibular defects (PubMed:38228630)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20813920"}],"value":"Piezo comes from the Greek 'piesi' meaning pressure"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the PIEZO (TC 1.A.75) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":2547,"modifier":"EXACT"}},"description":"Piezo-type mechanosensitive ion channel component 1","featureId":"PRO_0000403959"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"Helical; Name=8","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":424,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":425,"modifier":"EXACT"},"end":{"value":445,"modifier":"EXACT"}},"description":"Helical; Name=9","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":446,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":463,"modifier":"EXACT"}},"description":"Helical; Name=10","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":464,"modifier":"EXACT"},"end":{"value":468,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":469,"modifier":"EXACT"},"end":{"value":491,"modifier":"EXACT"}},"description":"Helical; Name=11","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":492,"modifier":"EXACT"},"end":{"value":518,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":519,"modifier":"EXACT"},"end":{"value":536,"modifier":"EXACT"}},"description":"Helical; Name=12","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":537,"modifier":"EXACT"},"end":{"value":580,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":581,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"Helical; Name=13","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":602,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":603,"modifier":"EXACT"},"end":{"value":623,"modifier":"EXACT"}},"description":"Helical; Name=14","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":624,"modifier":"EXACT"},"end":{"value":633,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":634,"modifier":"EXACT"},"end":{"value":655,"modifier":"EXACT"}},"description":"Helical; Name=15","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":656,"modifier":"EXACT"},"end":{"value":685,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Transmembrane","location":{"start":{"value":686,"modifier":"EXACT"},"end":{"value":702,"modifier":"EXACT"}},"description":"Helical; Name=16","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37590348"}]},{"type":"Topological domain","location":{"start":{"value":703,"modifier":"EXACT"},"end":{"value":811,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":812,"modifier":"EXACT"},"end":{"value":823,"modifier":"EXACT"}},"description":"Helical; Name=17","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":824,"modifier":"EXACT"},"end":{"value":826,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":827,"modifier":"EXACT"},"end":{"value":840,"modifier":"EXACT"}},"description":"Helical; Name=18","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":841,"modifier":"EXACT"},"end":{"value":854,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":855,"modifier":"EXACT"},"end":{"value":869,"modifier":"EXACT"}},"description":"Helical; Name=19","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":870,"modifier":"EXACT"},"end":{"value":921,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":922,"modifier":"EXACT"},"end":{"value":949,"modifier":"EXACT"}},"description":"Helical; Name=20","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":950,"modifier":"EXACT"},"end":{"value":989,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":990,"modifier":"EXACT"},"end":{"value":1005,"modifier":"EXACT"}},"description":"Helical; Name=21","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":1006,"modifier":"EXACT"},"end":{"value":1007,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":1008,"modifier":"EXACT"},"end":{"value":1023,"modifier":"EXACT"}},"description":"Helical; Name=22","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":1024,"modifier":"EXACT"},"end":{"value":1036,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":1037,"modifier":"EXACT"},"end":{"value":1052,"modifier":"EXACT"}},"description":"Helical; Name=23","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":1053,"modifier":"EXACT"},"end":{"value":1091,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":1092,"modifier":"EXACT"},"end":{"value":1113,"modifier":"EXACT"}},"description":"Helical; Name=24","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":1114,"modifier":"EXACT"},"end":{"value":1148,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":1149,"modifier":"EXACT"},"end":{"value":1175,"modifier":"EXACT"}},"description":"Helical; Name=25","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":1176,"modifier":"EXACT"},"end":{"value":1180,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":1181,"modifier":"EXACT"},"end":{"value":1199,"modifier":"EXACT"}},"description":"Helical; Name=26","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":1200,"modifier":"EXACT"},"end":{"value":1212,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":1213,"modifier":"EXACT"},"end":{"value":1231,"modifier":"EXACT"}},"description":"Helical; Name=27","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":1232,"modifier":"EXACT"},"end":{"value":1280,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":1281,"modifier":"EXACT"},"end":{"value":1297,"modifier":"EXACT"}},"description":"Helical; Name=28","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":1298,"modifier":"EXACT"},"end":{"value":1656,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":1657,"modifier":"EXACT"},"end":{"value":1700,"modifier":"EXACT"}},"description":"Helical; Name=29","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":1701,"modifier":"EXACT"},"end":{"value":1704,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":1705,"modifier":"EXACT"},"end":{"value":1720,"modifier":"EXACT"}},"description":"Helical; Name=30","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":1721,"modifier":"EXACT"},"end":{"value":1728,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":1729,"modifier":"EXACT"},"end":{"value":1747,"modifier":"EXACT"}},"description":"Helical; Name=31","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":1748,"modifier":"EXACT"},"end":{"value":1779,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":1780,"modifier":"EXACT"},"end":{"value":1801,"modifier":"EXACT"}},"description":"Helical; Name=32","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":1802,"modifier":"EXACT"},"end":{"value":1976,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":1977,"modifier":"EXACT"},"end":{"value":1996,"modifier":"EXACT"}},"description":"Helical; Name=33","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":1997,"modifier":"EXACT"},"end":{"value":2016,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":2017,"modifier":"EXACT"},"end":{"value":2033,"modifier":"EXACT"}},"description":"Helical; Name=34","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":2034,"modifier":"EXACT"},"end":{"value":2047,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":2048,"modifier":"EXACT"},"end":{"value":2068,"modifier":"EXACT"}},"description":"Helical; Name=35","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":2069,"modifier":"EXACT"},"end":{"value":2076,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":2077,"modifier":"EXACT"},"end":{"value":2092,"modifier":"EXACT"}},"description":"Helical; Name=36","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":2093,"modifier":"EXACT"},"end":{"value":2192,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":2193,"modifier":"EXACT"},"end":{"value":2213,"modifier":"EXACT"}},"description":"Helical; Name=37","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":2214,"modifier":"EXACT"},"end":{"value":2457,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26390154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Transmembrane","location":{"start":{"value":2458,"modifier":"EXACT"},"end":{"value":2478,"modifier":"EXACT"}},"description":"Helical; Name=38","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Topological domain","location":{"start":{"value":2479,"modifier":"EXACT"},"end":{"value":2547,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35388220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37590348"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]},{"type":"Region","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1354,"modifier":"EXACT"},"end":{"value":1396,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1456,"modifier":"EXACT"},"end":{"value":1480,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1567,"modifier":"EXACT"},"end":{"value":1610,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1816,"modifier":"EXACT"},"end":{"value":1931,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":1334,"modifier":"EXACT"},"end":{"value":1365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1361,"modifier":"EXACT"},"end":{"value":1372,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1376,"modifier":"EXACT"},"end":{"value":1392,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1592,"modifier":"EXACT"},"end":{"value":1610,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1816,"modifier":"EXACT"},"end":{"value":1837,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1855,"modifier":"EXACT"},"end":{"value":1880,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1881,"modifier":"EXACT"},"end":{"value":1894,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1912,"modifier":"EXACT"},"end":{"value":1931,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":758,"modifier":"EXACT"},"end":{"value":758,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q0KL00"}]},{"type":"Modified residue","location":{"start":{"value":1385,"modifier":"EXACT"},"end":{"value":1385,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19144319"}]},{"type":"Modified residue","location":{"start":{"value":1390,"modifier":"EXACT"},"end":{"value":1390,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q92508"}]},{"type":"Modified residue","location":{"start":{"value":1627,"modifier":"EXACT"},"end":{"value":1627,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1631,"modifier":"EXACT"},"end":{"value":1631,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1646,"modifier":"EXACT"},"end":{"value":1646,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19144319"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Glycosylation","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":2437,"modifier":"EXACT"},"end":{"value":2441,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26390154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29261642"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3JAC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4RAX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6BPZ"}]},{"type":"Mutagenesis","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Affects channel gating properties resulting in reduced pressure-induced channel opening. No effect on channel conductance. No effect on localization to cell membrane.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38184690"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":2211,"modifier":"EXACT"},"end":{"value":2211,"modifier":"EXACT"}},"description":"Affects channel gating properties resulting in reduced pressure-induced channel opening. No effect on channel conductance. No effect on localization to cell membrane.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38184690"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":2493,"modifier":"EXACT"},"end":{"value":2496,"modifier":"EXACT"}},"description":"Hearing and vestibular impairment in conditional knockin mice in inner ear hair cells.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38228630"}],"alternativeSequence":{"originalSequence":"MFEE","alternativeSequences":["AAAA"]}},{"type":"Mutagenesis","location":{"start":{"value":2493,"modifier":"EXACT"},"end":{"value":2494,"modifier":"EXACT"}},"description":"Non-functional channel. Proper trimeric assembly and subcellular location.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29261642"}],"alternativeSequence":{"originalSequence":"MF","alternativeSequences":["AA"]}},{"type":"Mutagenesis","location":{"start":{"value":2494,"modifier":"EXACT"},"end":{"value":2494,"modifier":"EXACT"}},"description":"Increased channel activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29261642"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Helix","location":{"start":{"value":785,"modifier":"EXACT"},"end":{"value":823,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":827,"modifier":"EXACT"},"end":{"value":839,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":846,"modifier":"EXACT"},"end":{"value":867,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Beta strand","location":{"start":{"value":900,"modifier":"EXACT"},"end":{"value":904,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Beta strand","location":{"start":{"value":918,"modifier":"EXACT"},"end":{"value":921,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":925,"modifier":"EXACT"},"end":{"value":949,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Beta strand","location":{"start":{"value":969,"modifier":"EXACT"},"end":{"value":972,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":974,"modifier":"EXACT"},"end":{"value":984,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Turn","location":{"start":{"value":985,"modifier":"EXACT"},"end":{"value":989,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":990,"modifier":"EXACT"},"end":{"value":1005,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1008,"modifier":"EXACT"},"end":{"value":1022,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1026,"modifier":"EXACT"},"end":{"value":1052,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1074,"modifier":"EXACT"},"end":{"value":1079,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Beta strand","location":{"start":{"value":1085,"modifier":"EXACT"},"end":{"value":1087,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1094,"modifier":"EXACT"},"end":{"value":1113,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Turn","location":{"start":{"value":1114,"modifier":"EXACT"},"end":{"value":1118,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Turn","location":{"start":{"value":1143,"modifier":"EXACT"},"end":{"value":1145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1149,"modifier":"EXACT"},"end":{"value":1159,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1162,"modifier":"EXACT"},"end":{"value":1175,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1181,"modifier":"EXACT"},"end":{"value":1200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1203,"modifier":"EXACT"},"end":{"value":1227,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1228,"modifier":"EXACT"},"end":{"value":1231,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Turn","location":{"start":{"value":1232,"modifier":"EXACT"},"end":{"value":1240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1243,"modifier":"EXACT"},"end":{"value":1249,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Beta strand","location":{"start":{"value":1255,"modifier":"EXACT"},"end":{"value":1259,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Beta strand","location":{"start":{"value":1261,"modifier":"EXACT"},"end":{"value":1263,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1264,"modifier":"EXACT"},"end":{"value":1266,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Beta strand","location":{"start":{"value":1275,"modifier":"EXACT"},"end":{"value":1277,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1281,"modifier":"EXACT"},"end":{"value":1298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1300,"modifier":"EXACT"},"end":{"value":1364,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1403,"modifier":"EXACT"},"end":{"value":1407,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1412,"modifier":"EXACT"},"end":{"value":1415,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1494,"modifier":"EXACT"},"end":{"value":1547,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1553,"modifier":"EXACT"},"end":{"value":1556,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1657,"modifier":"EXACT"},"end":{"value":1668,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1673,"modifier":"EXACT"},"end":{"value":1685,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1687,"modifier":"EXACT"},"end":{"value":1700,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1705,"modifier":"EXACT"},"end":{"value":1713,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1714,"modifier":"EXACT"},"end":{"value":1718,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Beta strand","location":{"start":{"value":1721,"modifier":"EXACT"},"end":{"value":1724,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1727,"modifier":"EXACT"},"end":{"value":1748,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Beta strand","location":{"start":{"value":1756,"modifier":"EXACT"},"end":{"value":1758,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1759,"modifier":"EXACT"},"end":{"value":1762,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1770,"modifier":"EXACT"},"end":{"value":1774,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Beta strand","location":{"start":{"value":1784,"modifier":"EXACT"},"end":{"value":1786,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1787,"modifier":"EXACT"},"end":{"value":1802,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1947,"modifier":"EXACT"},"end":{"value":1967,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":1977,"modifier":"EXACT"},"end":{"value":1996,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2017,"modifier":"EXACT"},"end":{"value":2040,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2043,"modifier":"EXACT"},"end":{"value":2059,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2060,"modifier":"EXACT"},"end":{"value":2064,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2065,"modifier":"EXACT"},"end":{"value":2068,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Turn","location":{"start":{"value":2072,"modifier":"EXACT"},"end":{"value":2074,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2077,"modifier":"EXACT"},"end":{"value":2099,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2109,"modifier":"EXACT"},"end":{"value":2111,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2116,"modifier":"EXACT"},"end":{"value":2127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2131,"modifier":"EXACT"},"end":{"value":2142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2149,"modifier":"EXACT"},"end":{"value":2174,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2182,"modifier":"EXACT"},"end":{"value":2184,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2185,"modifier":"EXACT"},"end":{"value":2213,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Beta strand","location":{"start":{"value":2224,"modifier":"EXACT"},"end":{"value":2232,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Turn","location":{"start":{"value":2233,"modifier":"EXACT"},"end":{"value":2235,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Beta strand","location":{"start":{"value":2238,"modifier":"EXACT"},"end":{"value":2243,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Beta strand","location":{"start":{"value":2247,"modifier":"EXACT"},"end":{"value":2250,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Helix","location":{"start":{"value":2253,"modifier":"EXACT"},"end":{"value":2263,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Helix","location":{"start":{"value":2267,"modifier":"EXACT"},"end":{"value":2273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Helix","location":{"start":{"value":2278,"modifier":"EXACT"},"end":{"value":2280,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Beta strand","location":{"start":{"value":2281,"modifier":"EXACT"},"end":{"value":2289,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Helix","location":{"start":{"value":2298,"modifier":"EXACT"},"end":{"value":2310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Beta strand","location":{"start":{"value":2315,"modifier":"EXACT"},"end":{"value":2324,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Helix","location":{"start":{"value":2327,"modifier":"EXACT"},"end":{"value":2329,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Beta strand","location":{"start":{"value":2334,"modifier":"EXACT"},"end":{"value":2344,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Helix","location":{"start":{"value":2349,"modifier":"EXACT"},"end":{"value":2357,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Beta strand","location":{"start":{"value":2366,"modifier":"EXACT"},"end":{"value":2372,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Beta strand","location":{"start":{"value":2375,"modifier":"EXACT"},"end":{"value":2378,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Beta strand","location":{"start":{"value":2380,"modifier":"EXACT"},"end":{"value":2383,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Turn","location":{"start":{"value":2388,"modifier":"EXACT"},"end":{"value":2390,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Helix","location":{"start":{"value":2394,"modifier":"EXACT"},"end":{"value":2397,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Beta strand","location":{"start":{"value":2398,"modifier":"EXACT"},"end":{"value":2409,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Helix","location":{"start":{"value":2423,"modifier":"EXACT"},"end":{"value":2425,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Beta strand","location":{"start":{"value":2426,"modifier":"EXACT"},"end":{"value":2434,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Beta strand","location":{"start":{"value":2443,"modifier":"EXACT"},"end":{"value":2450,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Helix","location":{"start":{"value":2454,"modifier":"EXACT"},"end":{"value":2456,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RAX"}]},{"type":"Beta strand","location":{"start":{"value":2462,"modifier":"EXACT"},"end":{"value":2466,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2467,"modifier":"EXACT"},"end":{"value":2482,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Turn","location":{"start":{"value":2483,"modifier":"EXACT"},"end":{"value":2485,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2489,"modifier":"EXACT"},"end":{"value":2492,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Turn","location":{"start":{"value":2493,"modifier":"EXACT"},"end":{"value":2495,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2501,"modifier":"EXACT"},"end":{"value":2516,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2519,"modifier":"EXACT"},"end":{"value":2534,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]},{"type":"Helix","location":{"start":{"value":2536,"modifier":"EXACT"},"end":{"value":2542,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WLT"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0407","category":"Molecular function","name":"Ion channel"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"20813920","citationType":"journal article","authors":["Coste B.","Mathur J.","Schmidt M.","Earley T.J.","Ranade S.","Petrus M.J.","Dubin A.E.","Patapoutian A."],"citationCrossReferences":[{"database":"PubMed","id":"20813920"},{"database":"DOI","id":"10.1126/science.1193270"}],"title":"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.","publicationDate":"2010","journal":"Science","firstPage":"55","lastPage":"60","volume":"330"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","FUNCTION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","TRANSPORTER ACTIVITY"]},{"referenceNumber":2,"citation":{"id":"19144319","citationType":"journal article","authors":["Trost M.","English L.","Lemieux S.","Courcelles M.","Desjardins M.","Thibault P."],"citationCrossReferences":[{"database":"PubMed","id":"19144319"},{"database":"DOI","id":"10.1016/j.immuni.2008.11.006"}],"title":"The phagosomal proteome in interferon-gamma-activated macrophages.","publicationDate":"2009","journal":"Immunity","firstPage":"143","lastPage":"154","volume":"30"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1385 AND SER-1646","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":3,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1627; SER-1631 AND SER-1646","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brown adipose tissue","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"22343900","citationType":"journal article","authors":["Coste B.","Xiao B.","Santos J.S.","Syeda R.","Grandl J.","Spencer K.S.","Kim S.E.","Schmidt M.","Mathur J.","Dubin A.E.","Montal M.","Patapoutian A."],"citationCrossReferences":[{"database":"PubMed","id":"22343900"},{"database":"DOI","id":"10.1038/nature10812"}],"title":"Piezo proteins are pore-forming subunits of mechanically activated channels.","publicationDate":"2012","journal":"Nature","firstPage":"176","lastPage":"181","volume":"483"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":5,"citation":{"id":"23479567","citationType":"journal article","authors":["Andolfo I.","Alper S.L.","De Franceschi L.","Auriemma C.","Russo R.","De Falco L.","Vallefuoco F.","Esposito M.R.","Vandorpe D.H.","Shmukler B.E.","Narayan R.","Montanaro D.","D'Armiento M.","Vetro A.","Limongelli I.","Zuffardi O.","Glader B.E.","Schrier S.L.","Brugnara C.","Stewart G.W.","Delaunay J.","Iolascon A."],"citationCrossReferences":[{"database":"PubMed","id":"23479567"},{"database":"DOI","id":"10.1182/blood-2013-02-482489"}],"title":"Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1.","publicationDate":"2013","journal":"Blood","firstPage":"3925","lastPage":"3935","volume":"121"},"referencePositions":["SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"]},{"referenceNumber":6,"citation":{"id":"24157948","citationType":"journal article","authors":["Peyronnet R.","Martins J.R.","Duprat F.","Demolombe S.","Arhatte M.","Jodar M.","Tauc M.","Duranton C.","Paulais M.","Teulon J.","Honore E.","Patel A."],"citationCrossReferences":[{"database":"PubMed","id":"24157948"},{"database":"DOI","id":"10.1038/embor.2013.170"}],"title":"Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells.","publicationDate":"2013","journal":"EMBO Rep.","firstPage":"1143","lastPage":"1148","volume":"14"},"referencePositions":["INTERACTION WITH PKD2","FUNCTION"]},{"referenceNumber":7,"citation":{"id":"24662763","citationType":"journal article","authors":["Poole K.","Herget R.","Lapatsina L.","Ngo H.D.","Lewin G.R."],"citationCrossReferences":[{"database":"PubMed","id":"24662763"},{"database":"DOI","id":"10.1038/ncomms4520"}],"title":"Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"3520","lastPage":"3520","volume":"5"},"referencePositions":["INTERACTION WITH STOML3"]},{"referenceNumber":8,"citation":{"id":"24958852","citationType":"journal article","authors":["Ranade S.S.","Qiu Z.","Woo S.H.","Hur S.S.","Murthy S.E.","Cahalan S.M.","Xu J.","Mathur J.","Bandell M.","Coste B.","Li Y.S.","Chien S.","Patapoutian A."],"citationCrossReferences":[{"database":"PubMed","id":"24958852"},{"database":"DOI","id":"10.1073/pnas.1409233111"}],"title":"Piezo1, a mechanically activated ion channel, is required for vascular development in mice.","publicationDate":"2014","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10347","lastPage":"10352","volume":"111"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY","DISRUPTION PHENOTYPE"]},{"referenceNumber":9,"citation":{"id":"25119035","citationType":"journal article","authors":["Li J.","Hou B.","Tumova S.","Muraki K.","Bruns A.","Ludlow M.J.","Sedo A.","Hyman A.J.","McKeown L.","Young R.S.","Yuldasheva N.Y.","Majeed Y.","Wilson L.A.","Rode B.","Bailey M.A.","Kim H.R.","Fu Z.","Carter D.A.","Bilton J.","Imrie H.","Ajuh P.","Dear T.N.","Cubbon R.M.","Kearney M.T.","Prasad R.K.","Evans P.C.","Ainscough J.F.","Beech D.J."],"citationCrossReferences":[{"database":"PubMed","id":"25119035"},{"database":"DOI","id":"10.1038/nature13701"}],"title":"Piezo1 integration of vascular architecture with physiological force.","publicationDate":"2014","journal":"Nature","firstPage":"279","lastPage":"282","volume":"515"},"referencePositions":["DISRUPTION PHENOTYPE","FUNCTION"]},{"referenceNumber":10,"citation":{"id":"29799007","citationType":"journal article","authors":["Tsuchiya M.","Hara Y.","Okuda M.","Itoh K.","Nishioka R.","Shiomi A.","Nagao K.","Mori M.","Mori Y.","Ikenouchi J.","Suzuki R.","Tanaka M.","Ohwada T.","Aoki J.","Kanagawa M.","Toda T.","Nagata Y.","Matsuda R.","Takayama Y.","Tominaga M.","Umeda M."],"citationCrossReferences":[{"database":"PubMed","id":"29799007"},{"database":"DOI","id":"10.1038/s41467-018-04436-w"}],"title":"Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.","publicationDate":"2018","journal":"Nat. Commun.","firstPage":"2049","lastPage":"2049","volume":"9"},"referencePositions":["FUNCTION","ACTIVITY REGULATION","TISSUE SPECIFICITY","SUBCELLULAR LOCATION"]},{"referenceNumber":11,"citation":{"id":"36515266","citationType":"journal article","authors":["Vaisey G.","Banerjee P.","North A.J.","Haselwandter C.A.","MacKinnon R."],"citationCrossReferences":[{"database":"PubMed","id":"36515266"},{"database":"DOI","id":"10.7554/elife.82621"}],"title":"Piezo1 as a force-through-membrane sensor in red blood cells.","publicationDate":"2022","journal":"Elife","firstPage":"0","lastPage":"0","volume":"11"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY","SUBCELLULAR LOCATION"]},{"referenceNumber":12,"citation":{"id":"38184690","citationType":"journal article","authors":["Amado N.G.","Nosyreva E.D.","Thompson D.","Egeland T.J.","Ogujiofor O.W.","Yang M.","Fusco A.N.","Passoni N.","Mathews J.","Cantarel B.","Baker L.A.","Syeda R."],"citationCrossReferences":[{"database":"PubMed","id":"38184690"},{"database":"DOI","id":"10.1038/s41467-023-44594-0"}],"title":"PIEZO1 loss-of-function compound heterozygous mutations in the rare congenital human disorder Prune Belly Syndrome.","publicationDate":"2024","journal":"Nat. Commun.","firstPage":"339","lastPage":"339","volume":"15"},"referencePositions":["MUTAGENESIS OF SER-260 AND SER-2211","FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":13,"citation":{"id":"38228630","citationType":"journal article","authors":["Lee J.H.","Perez-Flores M.C.","Park S.","Kim H.J.","Chen Y.","Kang M.","Kersigo J.","Choi J.","Thai P.N.","Woltz R.L.","Perez-Flores D.C.","Perkins G.","Sihn C.R.","Trinh P.","Zhang X.D.","Sirish P.","Dong Y.","Feng W.W.","Pessah I.N.","Dixon R.E.","Sokolowski B.","Fritzsch B.","Chiamvimonvat N.","Yamoah E.N."],"citationCrossReferences":[{"database":"PubMed","id":"38228630"},{"database":"DOI","id":"10.1038/s41467-023-44230-x"}],"title":"The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell.","publicationDate":"2024","journal":"Nat. Commun.","firstPage":"526","lastPage":"526","volume":"15"},"referencePositions":["FUNCTION","SUBUNIT","INTERACTION WITH TMC1; TMC2; PCDH15 AND CIB2","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DISRUPTION PHENOTYPE","MUTAGENESIS OF 2493-MET--GLU-2496"]},{"referenceNumber":14,"citation":{"id":"26390154","citationType":"journal article","authors":["Ge J.","Li W.","Zhao Q.","Li N.","Chen M.","Zhi P.","Li R.","Gao N.","Xiao B.","Yang M."],"citationCrossReferences":[{"database":"PubMed","id":"26390154"},{"database":"DOI","id":"10.1038/nature15247"}],"title":"Architecture of the mammalian mechanosensitive Piezo1 channel.","publicationDate":"2015","journal":"Nature","firstPage":"64","lastPage":"69","volume":"527"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (4.80 ANGSTROMS)","X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 2214-2457","FUNCTION","SUBUNIT","SUBCELLULAR LOCATION","TOPOLOGY"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3JAC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4RAX"}]},{"referenceNumber":15,"citation":{"id":"29261642","citationType":"journal article","authors":["Saotome K.","Murthy S.E.","Kefauver J.M.","Whitwam T.","Patapoutian A.","Ward A.B."],"citationCrossReferences":[{"database":"PubMed","id":"29261642"},{"database":"DOI","id":"10.1038/nature25453"}],"title":"Structure of the mechanically activated ion channel Piezo1.","publicationDate":"2018","journal":"Nature","firstPage":"481","lastPage":"486","volume":"554"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.80 ANGSTROMS) OF 1137-2547","DISULFIDE BONDS","MUTAGENESIS OF 2493-MET-PHE-2494 AND PHE-2494","FUNCTION","SUBUNIT","SUBCELLULAR LOCATION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6BPZ"}]},{"referenceNumber":16,"citation":{"id":"35388220","citationType":"journal article","authors":["Yang X.","Lin C.","Chen X.","Li S.","Li X.","Xiao B."],"citationCrossReferences":[{"database":"PubMed","id":"35388220"},{"database":"DOI","id":"10.1038/s41586-022-04574-8"}],"title":"Structure deformation and curvature sensing of PIEZO1 in lipid membranes.","publicationDate":"2022","journal":"Nature","firstPage":"377","lastPage":"383","volume":"604"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.46 ANGSTROMS)","FUNCTION","ACTIVITY REGULATION","SUBUNIT","INTERACTION WITH MDFIC AND MDFI","SUBCELLULAR LOCATION","TOPOLOGY"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WLU"}]},{"referenceNumber":17,"citation":{"id":"37590348","citationType":"journal article","authors":["Zhou Z.","Ma X.","Lin Y.","Cheng D.","Bavi N.","Secker G.A.","Li J.V.","Janbandhu V.","Sutton D.L.","Scott H.S.","Yao M.","Harvey R.P.","Harvey N.L.","Corry B.","Zhang Y.","Cox C.D."],"citationCrossReferences":[{"database":"PubMed","id":"37590348"},{"database":"DOI","id":"10.1126/science.adh8190"}],"title":"MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels.","publicationDate":"2023","journal":"Science","firstPage":"799","lastPage":"804","volume":"381"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.66 ANGSTROMS) IN COMPLEX WITH MDFIC","FUNCTION","ACTIVITY REGULATION","SUBUNIT","SUBCELLULAR LOCATION","INTERACTION WITH MDFIC AND MDFI","TOPOLOGY"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8IMZ"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HQ215520","properties":[{"key":"ProteinId","value":"ADN28064.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS90474.1","properties":[{"key":"Description","value":"-"}]},{"database":"PDB","id":"11YE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"C/D/E=1-2547"}]},{"database":"PDB","id":"11ZC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.00 A"},{"key":"Chains","value":"A/C/E=1-2547"}]},{"database":"PDB","id":"3JAC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.80 A"},{"key":"Chains","value":"A/B/C=1961-2547"}]},{"database":"PDB","id":"4RAX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A=2214-2457"}]},{"database":"PDB","id":"5Z10","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.97 A"},{"key":"Chains","value":"A/B/C=1-2547"}]},{"database":"PDB","id":"6B3R","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"A/C/E=1-2547"}]},{"database":"PDB","id":"6BPZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"A/B/C=1137-2547"}]},{"database":"PDB","id":"6LQI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.50 A"},{"key":"Chains","value":"A/B/C=1-2547"}]},{"database":"PDB","id":"7WLT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.46 A"},{"key":"Chains","value":"A/C/E=1-2547"}]},{"database":"PDB","id":"7WLU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.81 A"},{"key":"Chains","value":"A/C/E=1-2547"}]},{"database":"PDB","id":"8IMZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.66 A"},{"key":"Chains","value":"A/B/C=1-2547"}]},{"database":"PDB","id":"8IXN","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.07 A"},{"key":"Chains","value":"A/C/D=1-2547"}]},{"database":"PDB","id":"8IXO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"A/B/F=1-2547"}]},{"database":"PDBsum","id":"11YE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"11ZC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3JAC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4RAX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5Z10","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6B3R","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6BPZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6LQI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WLT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WLU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8IMZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8IXN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8IXO","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"E2JF22","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-0946","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32592","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32593","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35577","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35799","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35800","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35994","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36004","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36241","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36242","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36243","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36244","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-6343","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-6865","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-7042","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-7128","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-76184","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-76212","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E2JF22","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-59655N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"E2JF22","properties":[{"key":"Number of interactors","value":"478"}]},{"database":"IntAct","id":"E2JF22","properties":[{"key":"Interactions","value":"5"}]},{"database":"MINT","id":"E2JF22","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"10090.ENSMUSP00000089777","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"E2JF22","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL5169095","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"2945","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.A.75.1.14","properties":[{"key":"FamilyName","value":"the mechanical nociceptor, piezo (piezo) family"}]},{"database":"GlyConnect","id":"E2JF22","properties":[{"key":"glycosylation","value":"2 N-Linked glycans (1 site)"}]},{"database":"GlyCosmos","id":"E2JF22","properties":[{"key":"glycosylation","value":"3 sites, 2 glycans"}]},{"database":"GlyGen","id":"E2JF22","properties":[{"key":"glycosylation","value":"5 sites, 5 N-linked glycans (3 sites), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"E2JF22","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"E2JF22","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"E2JF22","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"E2JF22","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000089777","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"E2JF22","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"289571","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"E2JF22","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"MGI:3603204","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:3603204","properties":[{"key":"GeneName","value":"Piezo1"}]},{"database":"eggNOG","id":"KOG1893","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"E2JF22","properties":[{"key":"Description","value":"-"}]},{"database":"EvolutionaryTrace","id":"E2JF22","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:E2JF22","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"RNAct","id":"E2JF22","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0032437","properties":[{"key":"GoTerm","value":"C:cuticular plate"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38228630"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0033116","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum-Golgi intermediate compartment membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031258","properties":[{"key":"GoTerm","value":"C:lamellipodium membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20813920"}]},{"database":"GO","id":"GO:0032420","properties":[{"key":"GoTerm","value":"C:stereocilium"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38228630"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"22343900"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"26390154"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"29176668"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"29261642"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"29469092"}]},{"database":"GO","id":"GO:0140135","properties":[{"key":"GoTerm","value":"F:mechanosensitive monoatomic cation channel activity"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"32142647"}]},{"database":"GO","id":"GO:0008381","properties":[{"key":"GoTerm","value":"F:mechanosensitive monoatomic ion channel activity"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20813920"}]},{"database":"GO","id":"GO:0005261","properties":[{"key":"GoTerm","value":"F:monoatomic cation channel activity"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20813920"}]},{"database":"GO","id":"GO:0071260","properties":[{"key":"GoTerm","value":"P:cellular response to mechanical stimulus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0050982","properties":[{"key":"GoTerm","value":"P:detection of mechanical stimulus"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20813920"}]},{"database":"GO","id":"GO:0006812","properties":[{"key":"GoTerm","value":"P:monoatomic cation transport"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20813920"}]},{"database":"GO","id":"GO:0033634","properties":[{"key":"GoTerm","value":"P:positive regulation of cell-cell adhesion mediated by integrin"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0033625","properties":[{"key":"GoTerm","value":"P:positive regulation of integrin activation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0010831","properties":[{"key":"GoTerm","value":"P:positive regulation of myotube differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29799007"}]},{"database":"GO","id":"GO:0042391","properties":[{"key":"GoTerm","value":"P:regulation of membrane potential"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20813920"}]},{"database":"InterPro","id":"IPR027272","properties":[{"key":"EntryName","value":"Piezo"}]},{"database":"InterPro","id":"IPR031334","properties":[{"key":"EntryName","value":"Piezo_cap_dom"}]},{"database":"InterPro","id":"IPR056770","properties":[{"key":"EntryName","value":"Piezo_THU9_anchor"}]},{"database":"InterPro","id":"IPR056769","properties":[{"key":"EntryName","value":"Piezo_TM1-24"}]},{"database":"InterPro","id":"IPR031805","properties":[{"key":"EntryName","value":"Piezo_TM25-28"}]},{"database":"InterPro","id":"IPR056768","properties":[{"key":"EntryName","value":"THU_Piezo"}]},{"database":"PANTHER","id":"PTHR47049:SF5","properties":[{"key":"EntryName","value":"PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47049","properties":[{"key":"EntryName","value":"PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12166","properties":[{"key":"EntryName","value":"Piezo_cap"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24874","properties":[{"key":"EntryName","value":"Piezo_THU9_anchor"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24871","properties":[{"key":"EntryName","value":"Piezo_TM1-24"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15917","properties":[{"key":"EntryName","value":"Piezo_TM25-28"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23188","properties":[{"key":"EntryName","value":"THU_Piezo1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEPHVLGAGLYWLLLPCTLLAASLLRFNALSLVYLLFLLLLPWLPGPSRHSIPGHTGRLLRALLCLSLLFLVAHLAFQICLHTVPHLDQFLGQNGSLWVKVSQHIGVTRLDLKDIFNTTRLVAPDLGVLLASSLCLGLCGRLTRKAGQSRRTQELQDDDDDDDDDDEDIDAAPAVGLKGAPALATKRRLWLASRFRVTAHWLLMTSGRTLVIVLLALAGIAHPSAFSSIYLVVFLAICTWWSCHFPLSPLGFNTLCVMVSCFGAGHLICLYCYQTPFIQDMLPPGNIWARLFGLKNFVDLPNYSSPNALVLNTKHAWPIYVSPGILLLLYYTATSLLKLHKSCPSELRKETPREDEEHELELDHLEPEPQARDATQGEMPMTTEPDLDNCTVHVLTSQSPVRQRPVRPRLAELKEMSPLHGLGHLIMDQSYVCALIAMMVWSIMYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPCILLYGLTLCCLRYVWAMELPELPTTLGPVSLHQLGLEHTRYPCLDLGAMLLYLLTFWLLLRQFVKEKLLKKQKVPAALLEVTVADTEPTQTQTLLRSLGELVTGIYVKYWIYVCAGMFIVVSFAGRLVVYKIVYMFLFLLCLTLFQVYYTLWRKLLRVFWWLVVAYTMLVLIAVYTFQFQDFPTYWRNLTGFTDEQLGDLGLEQFSVSELFSSILIPGFFLLACILQLHYFHRPFMQLTDLEHVPPPGTRHPRWAHRQDAVSEAPLLEHQEEEEVFREDGQSMDGPHQATQVPEGTASKWGLVADRLLDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFALPYPRFRPMASCLSTVWTCIIIVCKMLYQLKIVNPHEYSSNCTEPFPNNTNLQPLEINQSLLYRGPVDPANWFGVRKGYPNLGYIQNHLQILLLLVFEAVVYRRQEHYRRQHQQAPLPAQAVCADGTRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAILTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMPPALCIDYPWRWSKAIPMNSALIKWLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAGINTDHLEPLRGEPNPIPNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQKDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSNFCWVIQLFSLVCTVKGYYDPKEMMTRDRDCLLPVEEAGIIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGFALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASRGQLQSKDPQDPSQEPGPDSPGGSSPPRRQWWRPWLDHATVIHSGDYFLFESDSEEEEEALPEDPRPAAQSAFQMAYQAWVTNAQTVLRQRRERARQERAEQLASGGDLNPDVEPVDVPEDEMAGRSHMMQRVLSTMQFLWVLGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLRVGEVRRGVLDQLYVGEDEATLSGPVETRDGPSTASSGLGAEEPLSSMTDDTSSPLSTGYNTRSGSEEIVTDAGDLQAGTSLHGSQELLANARTRMRTASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPWNSYVVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLCYGLWDHEEDRYPKDHCRSSVKDREAKEEPEAKLESQSETGTGHPKEPVLAGTPRDHIQGKGSIRSKDVIQDPPEDLKPRHTRHISIRFRRRKETPGPKGTAVMETEHEEGEGKETTERKRPRHTQEKSKFRERMKAAGRRLQSFCVSLAQSFYQPLQRFFHDILHTKYRAATDVYALMFLADIVDIIIIIFGFWAFGKHSAATDIASSLSDDQVPQAFLFMLLVQFGTMVIDRALYLRKTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEKHTLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLGVRIQLRREQVGTGASGEQAGTKASDFLEWWVIELQDCKADCNLLPMVIFSDKVSPPSLGFLAGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTRERE","length":2547,"molWeight":292002,"crc64":"0C24CF18BDF502E3","md5":"6028E2592EF447F8606EEC09D17314FA"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":4,"ACTIVITY REGULATION":1,"SUBUNIT":1,"INTERACTION":4,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"DISRUPTION PHENOTYPE":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":39,"Transmembrane":38,"Region":5,"Coiled coil":1,"Compositional bias":8,"Modified residue":6,"Glycosylation":1,"Disulfide bond":1,"Mutagenesis":5,"Helix":59,"Beta strand":23,"Turn":9},"uniParcId":"UPI0001E43DDC"}}