{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"E0CX11","uniProtkbId":"STMP1_HUMAN","entryAudit":{"firstPublicDate":"2011-10-19","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-10-05","entryVersion":85,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23073385"}],"value":"Short transmembrane mitochondrial protein 1"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23073385"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:41909"}],"value":"STMP1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:41909"}],"value":"C7orf73"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0DP99"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35450818"}],"value":"Microprotein involved in mitochondrial respiratory chain complex III (ubiquinol-cytochrome c oxidoreductase) and complex IV (mitochondrial cytochrome c oxidase complex) assembly (PubMed:35450818). Required for the formation of mitochondrial supercomplexes (SCs) (PubMed:35450818). Also required for the activation of the NLRP3 inflammasome (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0DP99"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35450818"}],"value":"Interacts with components of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), such as UQCRC1/QCR1, UQCRC2/QCR2 and UQCR10/QCR9 (By similarity). Interacts with components of the cytochrome c oxidase (mitochondrial respiratory chain complex IV) complex, such as MT-CO2 (PubMed:35450818)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"E0CX11","intActId":"EBI-18397783"},"interactantTwo":{"uniProtKBAccession":"O43765","geneName":"SGTA","intActId":"EBI-347996"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35450818"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0DP99"}],"value":"Mitochondrion outer membrane","id":"SL-0172"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0DP99"}],"value":"Mitochondrion intermembrane space","id":"SL-0169"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31836654"}],"value":"Expressed in monocytes and dendritic cells"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31836654"}],"value":"Down-regulated by bacterial lipopolysaccharide (LPS) in monocytes and dendritic cells"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the STMP1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"Short transmembrane mitochondrial protein 1","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000413534"},{"type":"Transmembrane","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"id":"KW-1000","category":"Cellular component","name":"Mitochondrion outer membrane"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"12853948","citationType":"journal article","authors":["Hillier L.W.","Fulton R.S.","Fulton L.A.","Graves T.A.","Pepin K.H.","Wagner-McPherson C.","Layman D.","Maas J.","Jaeger S.","Walker R.","Wylie K.","Sekhon M.","Becker M.C.","O'Laughlin M.D.","Schaller M.E.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Cordes M.","Du H.","Sun H.","Edwards J.","Bradshaw-Cordum H.","Ali J.","Andrews S.","Isak A.","Vanbrunt A.","Nguyen C.","Du F.","Lamar B.","Courtney L.","Kalicki J.","Ozersky P.","Bielicki L.","Scott K.","Holmes A.","Harkins R.","Harris A.","Strong C.M.","Hou S.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Leonard S.","Rohlfing T.","Rock S.M.","Tin-Wollam A.-M.","Abbott A.","Minx P.","Maupin R.","Strowmatt C.","Latreille P.","Miller N.","Johnson D.","Murray J.","Woessner J.P.","Wendl M.C.","Yang S.-P.","Schultz B.R.","Wallis J.W.","Spieth J.","Bieri T.A.","Nelson J.O.","Berkowicz N.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Bedell J.A.","Mardis E.R.","Clifton S.W.","Chissoe S.L.","Marra M.A.","Raymond C.","Haugen E.","Gillett W.","Zhou Y.","James R.","Phelps K.","Iadanoto S.","Bubb K.","Simms E.","Levy R.","Clendenning J.","Kaul R.","Kent W.J.","Furey T.S.","Baertsch R.A.","Brent M.R.","Keibler E.","Flicek P.","Bork P.","Suyama M.","Bailey J.A.","Portnoy M.E.","Torrents D.","Chinwalla A.T.","Gish W.R.","Eddy S.R.","McPherson J.D.","Olson M.V.","Eichler E.E.","Green E.D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"12853948"},{"database":"DOI","id":"10.1038/nature01782"}],"title":"The DNA sequence of human chromosome 7.","publicationDate":"2003","journal":"Nature","firstPage":"157","lastPage":"164","volume":"424"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"23073385","citationType":"journal article","authors":["Zhang D.","Xi Y.","Coccimiglio M.L.","Mennigen J.A.","Jonz M.G.","Ekker M.","Trudeau V.L."],"citationCrossReferences":[{"database":"PubMed","id":"23073385"},{"database":"DOI","id":"10.1152/physiolgenomics.00079.2012"}],"title":"Functional prediction and physiological characterization of a novel short trans-membrane protein 1 as a subunit of mitochondrial respiratory complexes.","publicationDate":"2012","journal":"Physiol. Genomics","firstPage":"1133","lastPage":"1140","volume":"44"},"referencePositions":["IDENTIFICATION"]},{"referenceNumber":3,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":4,"citation":{"id":"31836654","citationType":"journal article","authors":["Bhatta A.","Atianand M.","Jiang Z.","Crabtree J.","Blin J.","Fitzgerald K.A."],"citationCrossReferences":[{"database":"PubMed","id":"31836654"},{"database":"DOI","id":"10.4049/jimmunol.1900791"}],"title":"A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome.","publicationDate":"2020","journal":"J. Immunol.","firstPage":"428","lastPage":"437","volume":"204"},"referencePositions":["TISSUE SPECIFICITY","INDUCTION BY TLR LIGANDS"]},{"referenceNumber":5,"citation":{"id":"35450818","citationType":"journal article","authors":["Sang Y.","Liu J.Y.","Wang F.Y.","Luo X.Y.","Chen Z.Q.","Zhuang S.M.","Zhu Y."],"citationCrossReferences":[{"database":"PubMed","id":"35450818"},{"database":"DOI","id":"10.1016/j.ymthe.2022.04.012"}],"title":"Mitochondrial micropeptide STMP1 promotes G1/S transition by enhancing mitochondrial complex IV activity.","publicationDate":"2022","journal":"Mol. Ther.","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC091736","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC093107","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS55168.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001124401.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001130929.2"}]},{"database":"AlphaFoldDB","id":"E0CX11","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E0CX11","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"571873","properties":[{"key":"Interactions","value":"2"}]},{"database":"FunCoup","id":"E0CX11","properties":[{"key":"Number of interactors","value":"150"}]},{"database":"IntAct","id":"E0CX11","properties":[{"key":"Interactions","value":"2"}]},{"database":"STRING","id":"9606.ENSP00000425996","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"E0CX11","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"STMP1","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"E0CX11","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E0CX11","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000425996","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"E0CX11","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"15190","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"E0CX11","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"77172","properties":[{"key":"antibodies","value":"4 antibodies from 4 providers"}]},{"database":"DNASU","id":"647087","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000507606.3","properties":[{"key":"ProteinId","value":"ENSP00000425996.1"},{"key":"GeneId","value":"ENSG00000243317.9"}]},{"database":"GeneID","id":"647087","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:647087","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000507606.3","properties":[{"key":"ProteinId","value":"ENSP00000425996.1"},{"key":"RefSeqNucleotideId","value":"NM_001130929.2"},{"key":"RefSeqProteinId","value":"NP_001124401.1"}]},{"database":"UCSC","id":"uc003vsy.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:41909","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"647087","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"647087","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"STMP1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:41909","properties":[{"key":"GeneName","value":"STMP1"}]},{"database":"HPA","id":"ENSG00000243317","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"618755","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000243317","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000243317","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S7PN","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00550000076278","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3177783_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"E0CX11","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"2012160at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"E0CX11","properties":[{"key":"Number of GO annotations","value":"1 GO annotation based on evolutionary models"}]},{"database":"PhylomeDB","id":"E0CX11","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"E0CX11","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"E0CX11","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000243317","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"647087","properties":[{"key":"hits","value":"9 hits in 775 CRISPR screens"}]},{"database":"ChiTaRS","id":"C7orf73","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"647087","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"E0CX11","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:E0CX11","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 7"}]},{"database":"Bgee","id":"ENSG00000243317","properties":[{"key":"ExpressionPatterns","value":"Expressed in pancreatic ductal cell and 192 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E0CX11","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35450818"}]},{"database":"GO","id":"GO:0005758","properties":[{"key":"GoTerm","value":"C:mitochondrial intermembrane space"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005741","properties":[{"key":"GoTerm","value":"C:mitochondrial outer membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"HTP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0006056","source":"PubMed","id":"34800366"}]},{"database":"GO","id":"GO:0098803","properties":[{"key":"GoTerm","value":"C:respiratory chain complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0097250","properties":[{"key":"GoTerm","value":"P:mitochondrial respirasome assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"35450818"}]},{"database":"GO","id":"GO:0034551","properties":[{"key":"GoTerm","value":"P:mitochondrial respiratory chain complex III assembly"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0033617","properties":[{"key":"GoTerm","value":"P:mitochondrial respiratory chain complex IV assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"35450818"}]},{"database":"GO","id":"GO:0032731","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-1 beta production"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1900227","properties":[{"key":"GoTerm","value":"P:positive regulation of NLRP3 inflammasome complex assembly"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR027854","properties":[{"key":"EntryName","value":"STMP1"}]},{"database":"PANTHER","id":"PTHR47709","properties":[{"key":"EntryName","value":"SHORT TRANSMEMBRANE MITOCHONDRIAL PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47709:SF2","properties":[{"key":"EntryName","value":"SHORT TRANSMEMBRANE MITOCHONDRIAL PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15054","properties":[{"key":"EntryName","value":"DUF4535"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLQFLLGFTLGNVVGMYLAQNYDIPNLAKKLEEIKKDLDAKKKPPSA","length":47,"molWeight":5265,"crc64":"A2B4B037CBED539F","md5":"2E29C3D22764BAF4D8EC2AB10DE70FE1"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":1},"uniParcId":"UPI000020FB70"}}