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Absence of pantothenate from the growth medium of the mutant cells results in a slow-growing phenotype (PubMed:19478918)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01527"}],"value":"Belongs to the GTP cyclohydrolase IV family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"GTP cyclohydrolase MptA","featureId":"PRO_0000454760"},{"type":"Region","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"May be catalytically important","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01527"}]}],"keywords":[{"id":"KW-0289","category":"Biological process","name":"Folate biosynthesis"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0408","category":"Ligand","name":"Iron"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"20333302","citationType":"journal article","authors":["Hartman A.L.","Norais C.","Badger J.H.","Delmas S.","Haldenby S.","Madupu R.","Robinson J.","Khouri H.","Ren Q.","Lowe T.M.","Maupin-Furlow J.","Pohlschroder M.","Daniels C.","Pfeiffer F.","Allers T.","Eisen J.A."],"citationCrossReferences":[{"database":"PubMed","id":"20333302"},{"database":"DOI","id":"10.1371/journal.pone.0009605"}],"title":"The complete genome sequence of Haloferax volcanii DS2, a model archaeon.","publicationDate":"2010","journal":"PLoS ONE","firstPage":"E9605","lastPage":"E9605","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000008243"}],"value":"ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"ADE05034.1"},{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000008243"}]},{"referenceNumber":2,"citation":{"id":"25393412","citationType":"journal article","authors":["Becker E.A.","Seitzer P.M.","Tritt A.","Larsen D.","Krusor M.","Yao A.I.","Wu D.","Madern D.","Eisen J.A.","Darling A.E.","Facciotti M.T."],"citationCrossReferences":[{"database":"PubMed","id":"25393412"},{"database":"DOI","id":"10.1371/journal.pgen.1004784"}],"title":"Phylogenetically driven sequencing of extremely halophilic archaea reveals strategies for static and dynamic osmo-response.","publicationDate":"2014","journal":"PLoS Genet.","firstPage":"E1004784","lastPage":"E1004784","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"ELY32791.1"}]},{"referenceNumber":3,"citation":{"id":"18931107","citationType":"journal article","authors":["Phillips G.","El Yacoubi B.","Lyons B.","Alvarez S.","Iwata-Reuyl D.","de Crecy-Lagard V."],"citationCrossReferences":[{"database":"PubMed","id":"18931107"},{"database":"DOI","id":"10.1128/jb.00874-08"}],"title":"Biosynthesis of 7-deazaguanosine-modified tRNA nucleosides: a new role for GTP cyclohydrolase I.","publicationDate":"2008","journal":"J. 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