{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"D3Z5T1","uniProtkbId":"CCD78_MOUSE","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":83,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Coiled-coil domain-containing protein 78"}}},"genes":[{"geneName":{"value":"Ccdc78"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Localizes to centrioles and deuterosome. Found primarily in the perinuclear region as well as along the sarcolemmal membrane and in reticular pattern within the sarcoplasm (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole","id":"SL-0046"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cytoplasm, perinuclear region","id":"SL-0198"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell membrane, sarcolemma","id":"SL-0238"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Sarcoplasmic reticulum","id":"SL-0239"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CCDC78 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":437,"modifier":"EXACT"}},"description":"Coiled-coil domain-containing protein 78","featureId":"PRO_0000415805"},{"type":"Coiled coil","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0970","category":"Biological process","name":"Cilium biogenesis/degradation"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0703","category":"Cellular component","name":"Sarcoplasmic reticulum"}],"references":[{"referenceNumber":1,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC134908","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS50035.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001159401.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001165929.1"}]},{"database":"AlphaFoldDB","id":"D3Z5T1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"D3Z5T1","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"D3Z5T1","properties":[{"key":"Number of interactors","value":"94"}]},{"database":"STRING","id":"10090.ENSMUSP00000093155","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"D3Z5T1","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"PhosphoSitePlus","id":"D3Z5T1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000093155","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"265718","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"22861","properties":[{"key":"antibodies","value":"24 antibodies from 12 providers"}]},{"database":"Ensembl","id":"ENSMUST00000095500.5","properties":[{"key":"ProteinId","value":"ENSMUSP00000093155.5"},{"key":"GeneId","value":"ENSMUSG00000071202.6"}]},{"database":"GeneID","id":"381077","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:381077","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc012ank.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:2685784","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"124093","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2685784","properties":[{"key":"GeneName","value":"Ccdc78"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000071202","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502R5JQ","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000013678","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_032909_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"D3Z5T1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WAGTSKK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2113965at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"D3Z5T1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"381077","properties":[{"key":"hits","value":"0 hits in 79 CRISPR screens"}]},{"database":"PRO","id":"PR:D3Z5T1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"D3Z5T1","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000071202","properties":[{"key":"ExpressionPatterns","value":"Expressed in ovary and 43 other cell types or tissues"}]},{"database":"GO","id":"GO:0005814","properties":[{"key":"GoTerm","value":"C:centriole"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20577004"}]},{"database":"GO","id":"GO:0098536","properties":[{"key":"GoTerm","value":"C:deuterosome"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042383","properties":[{"key":"GoTerm","value":"C:sarcolemma"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0016529","properties":[{"key":"GoTerm","value":"C:sarcoplasmic reticulum"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0098535","properties":[{"key":"GoTerm","value":"P:de novo centriole assembly involved in multi-ciliated epithelial cell differentiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0003009","properties":[{"key":"GoTerm","value":"P:skeletal muscle contraction"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR039873","properties":[{"key":"EntryName","value":"CCDC78"}]},{"database":"InterPro","id":"IPR029329","properties":[{"key":"EntryName","value":"DUF4472"}]},{"database":"PANTHER","id":"PTHR22106","properties":[{"key":"EntryName","value":"COILED-COIL DOMAIN-CONTAINING PROTEIN 78"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22106:SF5","properties":[{"key":"EntryName","value":"COILED-COIL DOMAIN-CONTAINING PROTEIN 78"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14739","properties":[{"key":"EntryName","value":"DUF4472"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDQRPELLSSMEYVASPDPKPGVPLRVAENVAPGAEDWLPSASGHLAWATSLETEHQTHLELSEEQRLQISKELVDLQIATHHLREQHEAEVFELRREILRLESRVLELELHGNGACQGHKVQPMANLGQHQVPPLEPPGGQQKLQEELKWLLEHHRARQQALETQVGVLSQQLQGAREEARTTGQQLASQAMVLASCKGQLRQAEAENTQLQLQLKKMNEEYAVRLQHYARETVENASSTNQAALQAFLESTLQDIRAAHRTREQQLAQAARTYRKRLADLNQRQELLLTTCRATFATAINLEPLPMHWATELSHPRENEYGRHRTLLLYPEKGSGETSKENKSQPLALDTASWAQIQQRLQDFSQDTQAELERERAQLMVRATMAEQQLSELQEYVDQHLGRYKQEILKLRKLVNIGDPQGVEAVSSPGSGGARL","length":437,"molWeight":49472,"crc64":"FAD68A601FFCC216","md5":"93A90BC0827F1504AB47EA1C50D2FA19"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Coiled coil":3},"uniParcId":"UPI0001B83816"}}