{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"C1D7Y5","uniProtkbId":"PHNN_LARHH","entryAudit":{"firstPublicDate":"2011-09-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-05-26","entryVersion":76,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Laribacter hongkongensis (strain HLHK9)","taxonId":557598,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Betaproteobacteria","Neisseriales","Aquaspirillaceae","Laribacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Ribose 1,5-bisphosphate phosphokinase PhnN"},"ecNumbers":[{"value":"2.7.4.23"}]},"alternativeNames":[{"fullName":{"value":"Ribose 1,5-bisphosphokinase"}}]},"genes":[{"geneName":{"value":"phnN"},"orderedLocusNames":[{"value":"LHK_01589"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"alpha-D-ribose 1,5-bisphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20109"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:58017"},{"database":"ChEBI","id":"CHEBI:68688"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.4.23"}},{"texts":[{"value":"Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 3/3"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"In the C-terminal section; belongs to the ribose 1,5-bisphosphokinase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"Ribose 1,5-bisphosphate phosphokinase PhnN","featureId":"PRO_0000412789"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"unknown"},{"type":"Region","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"Ribose 1,5-bisphosphokinase"},{"type":"Binding site","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"19283063","citationType":"journal article","authors":["Woo P.C.Y.","Lau S.K.P.","Tse H.","Teng J.L.L.","Curreem S.O.","Tsang A.K.L.","Fan R.Y.Y.","Wong G.K.M.","Huang Y.","Loman N.J.","Snyder L.A.S.","Cai J.J.","Huang J.-D.","Mak W.","Pallen M.J.","Lok S.","Yuen K.-Y."],"citationCrossReferences":[{"database":"PubMed","id":"19283063"},{"database":"DOI","id":"10.1371/journal.pgen.1000416"}],"title":"The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats.","publicationDate":"2009","journal":"PLoS Genet.","firstPage":"E1000416","lastPage":"E1000416","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"HLHK9","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP001154","properties":[{"key":"ProteinId","value":"ACO74575.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_012697061.1","properties":[{"key":"NucleotideSequenceId","value":"NC_012559.1"}]},{"database":"AlphaFoldDB","id":"C1D7Y5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"C1D7Y5","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"557598.LHK_01589","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"lhk:LHK_01589","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG3709","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_603790_0_0_4","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00087","properties":[{"key":"RectionId","value":"UER00175"}]},{"database":"Proteomes","id":"UP000002010","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0033863","properties":[{"key":"GoTerm","value":"F:ribose 1,5-bisphosphate phosphokinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006015","properties":[{"key":"GoTerm","value":"P:5-phosphoribose 1-diphosphate biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0019634","properties":[{"key":"GoTerm","value":"P:organic phosphonate metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00836","properties":[{"key":"EntryName","value":"PhnN"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR009389","properties":[{"key":"EntryName","value":"DUF1045"}]},{"database":"InterPro","id":"IPR008145","properties":[{"key":"EntryName","value":"GK/Ca_channel_bsu"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR012699","properties":[{"key":"EntryName","value":"PhnN"}]},{"database":"NCBIfam","id":"TIGR02322","properties":[{"key":"EntryName","value":"phosphon_PhnN"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF007485","properties":[{"key":"EntryName","value":"PRK10078.1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06299","properties":[{"key":"EntryName","value":"DUF1045"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00072","properties":[{"key":"EntryName","value":"GuKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRYAVYLAPPPASRFWQLGSAWLGRDAWLNRPVALPSGWSAADADRVAAAARYGWHATLRAPFALAEGASEAAVHATLRTLARRFATFGLTLAPATLNGFAALRPVSGQSQVAELATAALLALDALAAPAPLRTGLSAREAELCRRWGYPYVFECYRCHFTLTSQLDEVDIPSWLARAAAHFDGALYQPVEGLALFVEPEAGAAFRLCRLVWLLMAGSTSMRTETGQLIYVMGPSGAGKDSLLGYARERLAGQPLVFAHRYITRPATAGSENHVALSEAEFALREAHGCFALSWRRNGLAYGLGCEVTDWLAAGLVVVVNGSRAALPQARQCFPGLKPLWITASPAVLAARLAARGRESADDIAARLAASAGFRPPADCRVLCNDGELAVAGDELVAWLSSHCHQPITAL","length":410,"molWeight":43805,"crc64":"BA3CC5A8BEDF28A3","md5":"EC457EBB4BEA045CFEAEFC5C97F2AE99"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Binding site":1},"uniParcId":"UPI00019A9595"}}