{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"C0SP89","secondaryAccessions":["O34576","Q796F8"],"uniProtkbId":"YOAH_BACSU","entryAudit":{"firstPublicDate":"2009-11-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-05-05","entryVersion":80,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Bacillus subtilis (strain 168)","taxonId":224308,"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Bacillaceae","Bacillus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Putative methyl-accepting chemotaxis protein YoaH"}}},"genes":[{"geneName":{"value":"yoaH"},"orderedLocusNames":[{"value":"BSU18610"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15033535"}],"value":"Transcriptionally regulated by sigma-D factor"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the methyl-accepting chemotaxis (MCP) protein family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAB84447.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":561,"modifier":"EXACT"}},"description":"Putative methyl-accepting chemotaxis protein YoaH","featureId":"PRO_0000387464"},{"type":"Transmembrane","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"HAMP","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00102"}]},{"type":"Domain","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"Methyl-accepting transducer","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00284"}]},{"type":"Region","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"Glutamate methyl ester (Glu)","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Modified residue","location":{"start":{"value":494,"modifier":"EXACT"},"end":{"value":494,"modifier":"EXACT"}},"description":"Glutamate methyl ester (Gln)","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Modified residue","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"Glutamate methyl ester (Gln)","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Modified residue","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"Glutamate methyl ester (Glu)","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Modified residue","location":{"start":{"value":537,"modifier":"EXACT"},"end":{"value":537,"modifier":"EXACT"}},"description":"Glutamate methyl ester (Glu)","evidences":[{"evidenceCode":"ECO:0000250"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9F96KTPCQ0QK3","citationType":"submission","authors":["Lapidus A.","Galleron N.","Sorokin A.","Ehrlich S.D."],"title":"Sequence analysis of the Bacillus subtilis chromosome region between the terC and odhAB loci cloned in a yeast artificial chromosome.","publicationDate":"OCT-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"9384377","citationType":"journal article","authors":["Kunst F.","Ogasawara N.","Moszer I.","Albertini A.M.","Alloni G.","Azevedo V.","Bertero M.G.","Bessieres P.","Bolotin A.","Borchert S.","Borriss R.","Boursier L.","Brans A.","Braun M.","Brignell S.C.","Bron S.","Brouillet S.","Bruschi C.V.","Caldwell B.","Capuano V.","Carter N.M.","Choi S.-K.","Codani J.-J.","Connerton I.F.","Cummings N.J.","Daniel R.A.","Denizot F.","Devine K.M.","Duesterhoeft A.","Ehrlich S.D.","Emmerson P.T.","Entian K.-D.","Errington J.","Fabret C.","Ferrari E.","Foulger D.","Fritz C.","Fujita M.","Fujita Y.","Fuma S.","Galizzi A.","Galleron N.","Ghim S.-Y.","Glaser P.","Goffeau A.","Golightly E.J.","Grandi G.","Guiseppi G.","Guy B.J.","Haga K.","Haiech J.","Harwood C.R.","Henaut A.","Hilbert H.","Holsappel S.","Hosono S.","Hullo M.-F.","Itaya M.","Jones L.-M.","Joris B.","Karamata D.","Kasahara Y.","Klaerr-Blanchard M.","Klein C.","Kobayashi Y.","Koetter P.","Koningstein G.","Krogh S.","Kumano M.","Kurita K.","Lapidus A.","Lardinois S.","Lauber J.","Lazarevic V.","Lee S.-M.","Levine A.","Liu H.","Masuda S.","Mauel C.","Medigue C.","Medina N.","Mellado R.P.","Mizuno M.","Moestl D.","Nakai S.","Noback M.","Noone D.","O'Reilly M.","Ogawa K.","Ogiwara A.","Oudega B.","Park S.-H.","Parro V.","Pohl T.M.","Portetelle D.","Porwollik S.","Prescott A.M.","Presecan E.","Pujic P.","Purnelle B.","Rapoport G.","Rey M.","Reynolds S.","Rieger M.","Rivolta C.","Rocha E.","Roche B.","Rose M.","Sadaie Y.","Sato T.","Scanlan E.","Schleich S.","Schroeter R.","Scoffone F.","Sekiguchi J.","Sekowska A.","Seror S.J.","Serror P.","Shin B.-S.","Soldo B.","Sorokin A.","Tacconi E.","Takagi T.","Takahashi H.","Takemaru K.","Takeuchi M.","Tamakoshi A.","Tanaka T.","Terpstra P.","Tognoni A.","Tosato V.","Uchiyama S.","Vandenbol M.","Vannier F.","Vassarotti A.","Viari A.","Wambutt R.","Wedler E.","Wedler H.","Weitzenegger T.","Winters P.","Wipat A.","Yamamoto H.","Yamane K.","Yasumoto K.","Yata K.","Yoshida K.","Yoshikawa H.-F.","Zumstein E.","Yoshikawa H.","Danchin A."],"citationCrossReferences":[{"database":"PubMed","id":"9384377"},{"database":"DOI","id":"10.1038/36786"}],"title":"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.","publicationDate":"1997","journal":"Nature","firstPage":"249","lastPage":"256","volume":"390"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"168","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"15033535","citationType":"journal article","authors":["Serizawa M.","Yamamoto H.","Yamaguchi H.","Fujita Y.","Kobayashi K.","Ogasawara N.","Sekiguchi J."],"citationCrossReferences":[{"database":"PubMed","id":"15033535"},{"database":"DOI","id":"10.1016/j.gene.2003.12.024"}],"title":"Systematic analysis of SigD-regulated genes in Bacillus subtilis by DNA microarray and Northern blotting analyses.","publicationDate":"2004","journal":"Gene","firstPage":"125","lastPage":"136","volume":"329"},"referencePositions":["INDUCTION BY SIGMA-D"],"referenceComments":[{"value":"168","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF027868","properties":[{"key":"ProteinId","value":"AAB84447.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL009126","properties":[{"key":"ProteinId","value":"CAB13753.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"B69896","properties":[{"key":"EntryName","value":"B69896"}]},{"database":"RefSeq","id":"NP_389742.2","properties":[{"key":"NucleotideSequenceId","value":"NC_000964.3"}]},{"database":"RefSeq","id":"WP_003231425.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000964.3"}]},{"database":"AlphaFoldDB","id":"C0SP89","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"C0SP89","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"C0SP89","properties":[{"key":"Number of interactors","value":"55"}]},{"database":"STRING","id":"224308.BSU18610","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"224308-BSU18610","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"CAB13753","properties":[{"key":"ProteinId","value":"CAB13753"},{"key":"GeneId","value":"BSU_18610"}]},{"database":"GeneID","id":"940110","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"bsu:BSU18610","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|224308.179.peg.2029","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"eggNOG","id":"COG0840","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"eggNOG","id":"COG5278","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"InParanoid","id":"C0SP89","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"107771at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"C0SP89","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"BSUB:BSU18610-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001570","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"C0SP89","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004888","properties":[{"key":"GoTerm","value":"F:transmembrane signaling receptor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006935","properties":[{"key":"GoTerm","value":"P:chemotaxis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd06225","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd11386","properties":[{"key":"EntryName","value":"MCP_signal"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.340.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.950","properties":[{"key":"EntryName","value":"Methyl-accepting chemotaxis protein"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007891","properties":[{"key":"EntryName","value":"CHASE3"}]},{"database":"InterPro","id":"IPR004090","properties":[{"key":"EntryName","value":"Chemotax_Me-accpt_rcpt"}]},{"database":"InterPro","id":"IPR003660","properties":[{"key":"EntryName","value":"HAMP_dom"}]},{"database":"InterPro","id":"IPR004089","properties":[{"key":"EntryName","value":"MCPsignal_dom"}]},{"database":"PANTHER","id":"PTHR32089","properties":[{"key":"EntryName","value":"METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR32089:SF114","properties":[{"key":"EntryName","value":"METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05227","properties":[{"key":"EntryName","value":"CHASE3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00672","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00015","properties":[{"key":"EntryName","value":"MCPsignal"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00260","properties":[{"key":"EntryName","value":"CHEMTRNSDUCR"}]},{"database":"SMART","id":"SM00304","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00283","properties":[{"key":"EntryName","value":"MA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF58104","properties":[{"key":"EntryName","value":"Methyl-accepting chemotaxis protein (MCP) signaling domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50111","properties":[{"key":"EntryName","value":"CHEMOTAXIS_TRANSDUC_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50885","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKMEFQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQSNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRLDQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEIAHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASAEESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSSMRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTNLLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNNIKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVHTLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY","length":561,"molWeight":61004,"crc64":"DBAF969970871179","md5":"967923EFFEBF477452F81C36C4F1621E"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"INDUCTION":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Transmembrane":2,"Domain":2,"Region":1,"Compositional bias":1,"Modified residue":5},"uniParcId":"UPI000195C689"}}