{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"C0SP79","secondaryAccessions":["O34547","Q795V6"],"uniProtkbId":"YTAF_BACSU","entryAudit":{"firstPublicDate":"2009-11-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-05-05","entryVersion":73,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Bacillus subtilis (strain 168)","taxonId":224308,"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Bacillaceae","Bacillus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Probable sporulation protein YtaF"}}},"genes":[{"geneName":{"value":"ytaF"},"orderedLocusNames":[{"value":"BSU29070"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23396918"}],"value":"Expressed in the mother cell during sporulation"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23396918"}],"value":"Expression is regulated by the sporulation transcription factor sigma E"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23396918"}],"value":"Disruption of the gene causes a 10-fold reduction in the efficiency of sporulation. Mutants divide asymmetrically but fail to complete engulfment of the forespore by the mother cell"}],"commentType":"DISRUPTION PHENOTYPE"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAC00352.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAC00352.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Probable sporulation protein YtaF","featureId":"PRO_0000389489"},{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0749","category":"Biological process","name":"Sporulation"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"9387221","citationType":"journal article","authors":["Lapidus A.","Galleron N.","Sorokin A.","Ehrlich S.D."],"citationCrossReferences":[{"database":"PubMed","id":"9387221"},{"database":"DOI","id":"10.1099/00221287-143-11-3431"}],"title":"Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region.","publicationDate":"1997","journal":"Microbiology","firstPage":"3431","lastPage":"3441","volume":"143"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"9384377","citationType":"journal article","authors":["Kunst F.","Ogasawara N.","Moszer I.","Albertini A.M.","Alloni G.","Azevedo V.","Bertero M.G.","Bessieres P.","Bolotin A.","Borchert S.","Borriss R.","Boursier L.","Brans A.","Braun M.","Brignell S.C.","Bron S.","Brouillet S.","Bruschi C.V.","Caldwell B.","Capuano V.","Carter N.M.","Choi S.-K.","Codani J.-J.","Connerton I.F.","Cummings N.J.","Daniel R.A.","Denizot F.","Devine K.M.","Duesterhoeft A.","Ehrlich S.D.","Emmerson P.T.","Entian K.-D.","Errington J.","Fabret C.","Ferrari E.","Foulger D.","Fritz C.","Fujita M.","Fujita Y.","Fuma S.","Galizzi A.","Galleron N.","Ghim S.-Y.","Glaser P.","Goffeau A.","Golightly E.J.","Grandi G.","Guiseppi G.","Guy B.J.","Haga K.","Haiech J.","Harwood C.R.","Henaut A.","Hilbert H.","Holsappel S.","Hosono S.","Hullo M.-F.","Itaya M.","Jones L.-M.","Joris B.","Karamata D.","Kasahara Y.","Klaerr-Blanchard M.","Klein C.","Kobayashi Y.","Koetter P.","Koningstein G.","Krogh S.","Kumano M.","Kurita K.","Lapidus A.","Lardinois S.","Lauber J.","Lazarevic V.","Lee S.-M.","Levine A.","Liu H.","Masuda S.","Mauel C.","Medigue C.","Medina N.","Mellado R.P.","Mizuno M.","Moestl D.","Nakai S.","Noback M.","Noone D.","O'Reilly M.","Ogawa K.","Ogiwara A.","Oudega B.","Park S.-H.","Parro V.","Pohl T.M.","Portetelle D.","Porwollik S.","Prescott A.M.","Presecan E.","Pujic P.","Purnelle B.","Rapoport G.","Rey M.","Reynolds S.","Rieger M.","Rivolta C.","Rocha E.","Roche B.","Rose M.","Sadaie Y.","Sato T.","Scanlan E.","Schleich S.","Schroeter R.","Scoffone F.","Sekiguchi J.","Sekowska A.","Seror S.J.","Serror P.","Shin B.-S.","Soldo B.","Sorokin A.","Tacconi E.","Takagi T.","Takahashi H.","Takemaru K.","Takeuchi M.","Tamakoshi A.","Tanaka T.","Terpstra P.","Tognoni A.","Tosato V.","Uchiyama S.","Vandenbol M.","Vannier F.","Vassarotti A.","Viari A.","Wambutt R.","Wedler E.","Wedler H.","Weitzenegger T.","Winters P.","Wipat A.","Yamamoto H.","Yamane K.","Yasumoto K.","Yata K.","Yoshida K.","Yoshikawa H.-F.","Zumstein E.","Yoshikawa H.","Danchin A."],"citationCrossReferences":[{"database":"PubMed","id":"9384377"},{"database":"DOI","id":"10.1038/36786"}],"title":"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.","publicationDate":"1997","journal":"Nature","firstPage":"249","lastPage":"256","volume":"390"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"168","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"19383706","citationType":"journal article","authors":["Barbe V.","Cruveiller S.","Kunst F.","Lenoble P.","Meurice G.","Sekowska A.","Vallenet D.","Wang T.","Moszer I.","Medigue C.","Danchin A."],"citationCrossReferences":[{"database":"PubMed","id":"19383706"},{"database":"DOI","id":"10.1099/mic.0.027839-0"}],"title":"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.","publicationDate":"2009","journal":"Microbiology","firstPage":"1758","lastPage":"1775","volume":"155"},"referencePositions":["SEQUENCE REVISION TO N- AND C-TERMINUS"]},{"referenceNumber":4,"citation":{"id":"23396918","citationType":"journal article","authors":["Abecasis A.B.","Serrano M.","Alves R.","Quintais L.","Pereira-Leal J.B.","Henriques A.O."],"citationCrossReferences":[{"database":"PubMed","id":"23396918"},{"database":"DOI","id":"10.1128/jb.02110-12"}],"title":"A genomic signature and the identification of new sporulation genes.","publicationDate":"2013","journal":"J. Bacteriol.","firstPage":"2101","lastPage":"2115","volume":"195"},"referencePositions":["DEVELOPMENTAL STAGE","INDUCTION","DISRUPTION PHENOTYPE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF008220","properties":[{"key":"ProteinId","value":"AAC00352.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL009126","properties":[{"key":"ProteinId","value":"CAB14867.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_003229449.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000964.3"}]},{"database":"AlphaFoldDB","id":"C0SP79","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"C0SP79","properties":[{"key":"Number of interactors","value":"4"}]},{"database":"STRING","id":"224308.BSU29070","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"224308-BSU29070","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"CAB14867","properties":[{"key":"ProteinId","value":"CAB14867"},{"key":"GeneId","value":"BSU_29070"}]},{"database":"GeneID","id":"86872576","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"937389","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"bsu:BSU29070","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|224308.43.peg.3041","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"eggNOG","id":"COG1971","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"InParanoid","id":"C0SP79","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"1679205at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"C0SP79","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"BSUB:BSU29070-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001570","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"C0SP79","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005384","properties":[{"key":"GoTerm","value":"F:manganese ion transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030026","properties":[{"key":"GoTerm","value":"P:intracellular manganese ion homeostasis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0140048","properties":[{"key":"GoTerm","value":"P:manganese ion export across plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR003810","properties":[{"key":"EntryName","value":"Mntp/YtaF"}]},{"database":"InterPro","id":"IPR014205","properties":[{"key":"EntryName","value":"Spore_YtaF"}]},{"database":"NCBIfam","id":"TIGR02840","properties":[{"key":"EntryName","value":"spore_YtaF"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR35529","properties":[{"key":"EntryName","value":"MANGANESE EFFLUX PUMP MNTP-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR35529:SF2","properties":[{"key":"EntryName","value":"SPORULATION PROTEIN YTAF-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02659","properties":[{"key":"EntryName","value":"Mntp"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSGAVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLLNLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSPIVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL","length":210,"molWeight":22773,"crc64":"0ECAAED023A5AD3D","md5":"B50C254DCE85E6220CC060382C968698"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"INDUCTION":1,"DISRUPTION PHENOTYPE":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Transmembrane":6},"uniParcId":"UPI000195C6AF"}}