ID   C1T9B_HUMAN             Reviewed;         333 AA.
AC   B2RNN3; A2A3T6; B9EH31; Q0VGC5; Q5VX65; Q5VX66; Q8IUU4;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   27-MAR-2024, entry version 119.
DE   RecName: Full=Complement C1q and tumor necrosis factor-related protein 9B;
DE   AltName: Full=C1q/TNF-related protein 9B;
DE            Short=CTRP9B;
DE   AltName: Full=Complement C1q and tumor necrosis factor-related protein 9-like;
DE   Flags: Precursor;
GN   Name=C1QTNF9B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA   Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA   Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA   Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA   Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA   Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA   Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA   Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA   Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA   Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA   Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA   Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA   Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA   Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION, SUBUNIT, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Hippocampus;
RX   PubMed=19666007; DOI=10.1016/j.bbrc.2009.08.014;
RA   Peterson J.M., Wei Z., Wong G.W.;
RT   "CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF
RT   family members.";
RL   Biochem. Biophys. Res. Commun. 388:360-365(2009).
CC   -!- FUNCTION: Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK
CC       signaling pathways. {ECO:0000250|UniProtKB:Q4ZJN1}.
CC   -!- SUBUNIT: Interacts with CTRP9A and ADIPOQ. Forms heterotrimers and
CC       heterooligomeric complexes with CTRP9A. {ECO:0000269|PubMed:19666007}.
CC   -!- INTERACTION:
CC       B2RNN3; P0C862: C1QTNF9; NbExp=3; IntAct=EBI-10828035, EBI-5654640;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19666007}.
CC       Note=Heteromeric complex formation with CTRP9A or ADIPOQ is required
CC       for secretion, otherwise, it is retained in the endoplasmic reticulum.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=B2RNN3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=B2RNN3-2; Sequence=VSP_035153, VSP_035154;
CC   -!- TISSUE SPECIFICITY: Expressed at low levels. Not expressed in adipose
CC       tissues. {ECO:0000269|PubMed:19666007}.
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DR   EMBL; AL445985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC110413; AAI10414.1; -; mRNA.
DR   EMBL; BC137004; AAI37005.1; -; mRNA.
DR   EMBL; BC137006; AAI37007.1; -; mRNA.
DR   CCDS; CCDS31947.1; -. [B2RNN3-1]
DR   RefSeq; NP_001007538.1; NM_001007537.2. [B2RNN3-1]
DR   RefSeq; XP_011533372.1; XM_011535070.2.
DR   AlphaFoldDB; B2RNN3; -.
DR   SMR; B2RNN3; -.
DR   BioGRID; 132501; 65.
DR   IntAct; B2RNN3; 2.
DR   STRING; 9606.ENSP00000371572; -.
DR   iPTMnet; B2RNN3; -.
DR   PhosphoSitePlus; B2RNN3; -.
DR   BioMuta; C1QTNF9B; -.
DR   jPOST; B2RNN3; -.
DR   MassIVE; B2RNN3; -.
DR   MaxQB; B2RNN3; -.
DR   PaxDb; 9606-ENSP00000371572; -.
DR   PeptideAtlas; B2RNN3; -.
DR   ProteomicsDB; 3442; -. [B2RNN3-1]
DR   Antibodypedia; 78005; 38 antibodies from 9 providers.
DR   DNASU; 387911; -.
DR   Ensembl; ENST00000382137.7; ENSP00000371572.3; ENSG00000205863.11. [B2RNN3-1]
DR   GeneID; 387911; -.
DR   KEGG; hsa:387911; -.
DR   UCSC; uc001uoz.3; human. [B2RNN3-1]
DR   AGR; HGNC:34072; -.
DR   CTD; 387911; -.
DR   DisGeNET; 387911; -.
DR   GeneCards; C1QTNF9B; -.
DR   HGNC; HGNC:34072; C1QTNF9B.
DR   HPA; ENSG00000205863; Tissue enhanced (skin, testis).
DR   MIM; 614148; gene.
DR   neXtProt; NX_B2RNN3; -.
DR   OpenTargets; ENSG00000205863; -.
DR   VEuPathDB; HostDB:ENSG00000205863; -.
DR   eggNOG; ENOG502QVBU; Eukaryota.
DR   GeneTree; ENSGT00940000154936; -.
DR   HOGENOM; CLU_001074_0_0_1; -.
DR   InParanoid; B2RNN3; -.
DR   OMA; DEMWLQV; -.
DR   OrthoDB; 4224143at2759; -.
DR   PhylomeDB; B2RNN3; -.
DR   TreeFam; TF334029; -.
DR   PathwayCommons; B2RNN3; -.
DR   SignaLink; B2RNN3; -.
DR   BioGRID-ORCS; 387911; 14 hits in 1038 CRISPR screens.
DR   ChiTaRS; C1QTNF9B; human.
DR   GenomeRNAi; 387911; -.
DR   Pharos; B2RNN3; Tdark.
DR   PRO; PR:B2RNN3; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   RNAct; B2RNN3; Protein.
DR   Bgee; ENSG00000205863; Expressed in primordial germ cell in gonad and 89 other cell types or tissues.
DR   ExpressionAtlas; B2RNN3; baseline and differential.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR15427:SF21; COMPLEMENT C1Q AND TUMOR NECROSIS FACTOR-RELATED PROTEIN 9A; 1.
DR   PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR   Pfam; PF00386; C1q; 1.
DR   Pfam; PF01391; Collagen; 4.
DR   PRINTS; PR00007; COMPLEMNTC1Q.
DR   SMART; SM00110; C1Q; 1.
DR   SUPFAM; SSF49842; TNF-like; 1.
DR   PROSITE; PS50871; C1Q; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Collagen; Reference proteome; Repeat; Secreted;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..333
FT                   /note="Complement C1q and tumor necrosis factor-related
FT                   protein 9B"
FT                   /id="PRO_0000348424"
FT   DOMAIN          24..82
FT                   /note="Collagen-like 1"
FT   DOMAIN          95..154
FT                   /note="Collagen-like 2"
FT   DOMAIN          155..191
FT                   /note="Collagen-like 3"
FT   DOMAIN          197..333
FT                   /note="C1q"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT   REGION          24..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..88
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         89..99
FT                   /note="GDQGSRGSPGK -> EMFRCLWSKME (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_035153"
FT   VAR_SEQ         100..333
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_035154"
SQ   SEQUENCE   333 AA;  34713 MW;  A15F3F7546938A70 CRC64;
     MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG DKGDAGEPGC
     PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH GPKGLAGPMG EKGLRGETGP
     QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI
     RGWKGDRGEK GKIGETLVLP KSAFTVGLTV LSKFPSSDVP IKFDKILYNE FNHYDTAVGK
     FTCHIAGVYY FTYHITVFSR NVQVSLVKNG VKILHTRDAY VSSEDQASGS IVLQLKLGDE
     MWLQVTGGER FNGLFADEDD DTTFTGFLLF SSQ
//