{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"B1ARD6","secondaryAccessions":["A0A0A0MQG6","Q7TME8","Q7TME9","Q80VG8","Q8C7F7","Q8CB82"],"uniProtkbId":"SLFN9_MOUSE","entryAudit":{"firstPublicDate":"2018-06-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-04-08","entryVersion":121,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Schlafen family member 9"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5U311"}],"value":"3.1.-.-"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15351786"}],"value":"Schlafen-9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15351786"},{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:2445121"}],"value":"Slfn9"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5U311"}],"value":"Endoribonuclease that cleaves tRNAs and rRNAs"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5U311"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5U311"}],"value":"Can also use Mn(2+)."}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q68D06"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15351786"}],"value":"In T-cells, expressed at relatively constant levels during development: expressed in immature CD3(-)CD4(-)CD8(-) T-cells (DN stage), in CD4(+)CD8(+) double-positive stage (DP) and mature CD4(+) or CD8(+) thymocytes. Expression is slightly reduced at the DP stage"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15351786"}],"value":"Induced following infection. Induced in response to LPS and interferon"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5U311"}],"value":"Shows a pseudo-dimeric U-pillow-shaped architecture of the SLFN13 N'-domain that may clamp base-paired RNAs"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Schlafen family. Subgroup III subfamily"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AL603745","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":910,"modifier":"EXACT"}},"description":"Schlafen family member 9","featureId":"PRO_0000444608"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"N'-domain region","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5U311"}]},{"type":"Active site","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5U311"}]},{"type":"Active site","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5U311"}]},{"type":"Binding site","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5U311"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5U311"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5U311"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":599,"modifier":"EXACT"},"end":{"value":606,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Sequence conflict","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"in Ref. 2; BAC34206","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"in Ref. 2; BAC29489","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"in Ref. 2; BAC34206","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":407,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":428,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Sequence conflict","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":528,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"NKTSGG","alternativeSequences":["IETSGS"]}},{"type":"Sequence conflict","location":{"start":{"value":549,"modifier":"EXACT"},"end":{"value":549,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":558,"modifier":"EXACT"},"end":{"value":558,"modifier":"EXACT"}},"description":"in Ref. 2; BAC29489","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":573,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"VL","alternativeSequences":["IV"]}},{"type":"Sequence conflict","location":{"start":{"value":674,"modifier":"EXACT"},"end":{"value":674,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":796,"modifier":"EXACT"},"end":{"value":796,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":843,"modifier":"EXACT"},"end":{"value":843,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30070/AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":904,"modifier":"EXACT"},"end":{"value":904,"modifier":"EXACT"}},"description":"in Ref. 1; AAP30070/AAP30071","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}}],"keywords":[{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0540","category":"Molecular function","name":"Nuclease"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"15351786","citationType":"journal article","authors":["Geserick P.","Kaiser F.","Klemm U.","Kaufmann S.H.E.","Zerrahn J."],"citationCrossReferences":[{"database":"PubMed","id":"15351786"},{"database":"DOI","id":"10.1093/intimm/dxh155"}],"title":"Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.","publicationDate":"2004","journal":"Int. Immunol.","firstPage":"1535","lastPage":"1548","volume":"16"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","TISSUE SPECIFICITY","INDUCTION"],"referenceComments":[{"value":"129/SvJ","type":"STRAIN"},{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Bone","type":"TISSUE"},{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"CI-7F06VE8U0EBCV","citationType":"submission","authors":["Tiong J.D.R.","Byars-Baker C.","Wray S."],"title":"Mouse embryonic cDNA isolated from nasal region after differential screen of nose, tail and limb.","publicationDate":"JAN-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 95-910"],"referenceComments":[{"value":"Swiss Webster","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY261800","properties":[{"key":"ProteinId","value":"AAP30070.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY261801","properties":[{"key":"ProteinId","value":"AAP30071.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK036579","properties":[{"key":"ProteinId","value":"BAC29489.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK050355","properties":[{"key":"ProteinId","value":"BAC34206.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL603745","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY217035","properties":[{"key":"ProteinId","value":"AAO60168.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS25154.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001427064.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001440135.1"}]},{"database":"RefSeq","id":"NP_766384.2","properties":[{"key":"NucleotideSequenceId","value":"NM_172796.3"}]},{"database":"AlphaFoldDB","id":"B1ARD6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"B1ARD6","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"B1ARD6","properties":[{"key":"Number of interactors","value":"761"}]},{"database":"IntAct","id":"B1ARD6","properties":[{"key":"Interactions","value":"1"}]},{"database":"STRING","id":"10090.ENSMUSP00000044435","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"B1ARD6","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"B1ARD6","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000044435","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"B1ARD6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"331264","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"355173","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"B1ARD6","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"237886","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000038211.13","properties":[{"key":"ProteinId","value":"ENSMUSP00000044435.6"},{"key":"GeneId","value":"ENSMUSG00000069793.13"}]},{"database":"Ensembl","id":"ENSMUST00000092840.11","properties":[{"key":"ProteinId","value":"ENSMUSP00000090515.5"},{"key":"GeneId","value":"ENSMUSG00000069793.13"}]},{"database":"GeneID","id":"237886","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:237886","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007kob.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"UCSC","id":"uc007koc.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:2445121","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"237886","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2445121","properties":[{"key":"GeneName","value":"Slfn9"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000069793","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QWKG","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00410000025651","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_007071_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"B1ARD6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"TKQQGSC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6052143at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"B1ARD6","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"237886","properties":[{"key":"hits","value":"3 hits in 76 CRISPR screens"}]},{"database":"PRO","id":"PR:B1ARD6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"B1ARD6","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000069793","properties":[{"key":"ExpressionPatterns","value":"Expressed in dorsal pancreas and 144 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"B1ARD6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18355440"}]},{"database":"GO","id":"GO:0090734","properties":[{"key":"GoTerm","value":"C:site of DNA damage"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0004521","properties":[{"key":"GoTerm","value":"F:RNA endonuclease activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000049","properties":[{"key":"GoTerm","value":"F:tRNA binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0051607","properties":[{"key":"GoTerm","value":"P:defense response to virus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016075","properties":[{"key":"GoTerm","value":"P:rRNA catabolic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0016078","properties":[{"key":"GoTerm","value":"P:tRNA decay"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"FunFam","id":"3.40.50.300:FF:001322","properties":[{"key":"EntryName","value":"Schlafen family member 11"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.950.30:FF:000003","properties":[{"key":"EntryName","value":"Schlafen family member 9"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.950.30","properties":[{"key":"EntryName","value":"Schlafen, AAA domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR031450","properties":[{"key":"EntryName","value":"Poxin-SLFN/SLFN_N"}]},{"database":"InterPro","id":"IPR029684","properties":[{"key":"EntryName","value":"Schlafen"}]},{"database":"InterPro","id":"IPR007421","properties":[{"key":"EntryName","value":"Schlafen_AlbA_2_dom"}]},{"database":"InterPro","id":"IPR038461","properties":[{"key":"EntryName","value":"Schlafen_AlbA_2_dom_sf"}]},{"database":"InterPro","id":"IPR018647","properties":[{"key":"EntryName","value":"SLFN_3-like_DNA/RNA_helicase"}]},{"database":"InterPro","id":"IPR048729","properties":[{"key":"EntryName","value":"SLFN_GTPase-like"}]},{"database":"InterPro","id":"IPR027785","properties":[{"key":"EntryName","value":"UvrD-like_helicase_C"}]},{"database":"PANTHER","id":"PTHR12155","properties":[{"key":"EntryName","value":"SCHLAFEN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12155:SF43","properties":[{"key":"EntryName","value":"SCHLAFEN FAMILY MEMBER 13"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17057","properties":[{"key":"EntryName","value":"B3R"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09848","properties":[{"key":"EntryName","value":"SLFN-g3_helicase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04326","properties":[{"key":"EntryName","value":"SLFN_AlbA_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21026","properties":[{"key":"EntryName","value":"SLFN_GTPase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13538","properties":[{"key":"EntryName","value":"UvrD_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"METYLSLVVKRSYPDLIIYAGEVTLGEKVRNKKDSKKRKLEKTRITQAACALLNSGGGVIVIQMANQSEQPERMGQDLETSLRNLIPSLDLQAFFETKQQEDKFYIFVKSWSSSPEDDSTKPRICSLGTSLYCRSLTSKVAMDSRDAFYFLKKKKAYIKCSPTDDRAPPAKIPRTMSQKSLESNPAFEIFQSKKLEYGQRLLFSESTSIEFKQFDTENAQKYMKDIIPEYISAFANTQGGYLFIGVDDKSIILGCPKDNVDPDSLKIVANEAISKLPVFHFCSSKDKNKVSYETRVIDVFQEGNLYGYLCVIKVEPFCCAVFSEAPISWMVDKEKGVYTLNTEEWVRMMVDVGPEAASNDLSRDFECQLSLSDSPPHCRPVYSKKGLEHKVDLQQRLFQVSPDCLKYTPESLWSELCSQHERLEDLVKQQIRSFSCGLLILSRSWAVDLNLEEKQEVICDALLIAQNSPPILYTILGEQDEQGQDYCTRTAFTLKQKLVNTGGYTGRVCVMTKVLCLSSQNNNKTSGGSVSPIDYPSSYNLANIQEMQGLLQALVIVLLNFRSFLSDQLGCEVLNLLTAQQYEILSKSLRKTRELFVHGLPGSGKTIIAMKIMEKIRNTFHCETDRILYICENQPLRDFIQAKNICQAVTRKTFMNYKFKTERFQHIIIDEAQNFRTEDGNWYEKAKGITRGMKNCPGILWIFLDYFQTSHLQESGLPDFSLQYPKEELTQVVRNADKIAEFLQQELQKIRDNPPCSIPQESLNILHEFKWSQGVSGTYEITYLTLEKMVSYITDKCDVFLSKGYSPQDIAVLFSTDREKKAYEHMFLREMRKRRRASHMNDESVCHSNMFDSIRRFSGLERSIVFGINPIATEQPISHNLLLCLASRAMKHLYILYLSTPEGQSSMVAC","length":910,"molWeight":103992,"crc64":"F05ECEFD4763FD92","md5":"42D78BCD144744DAC73107C01F08B3A3"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Region":1,"Active site":2,"Binding site":4,"Sequence conflict":20},"uniParcId":"UPI0000193610"}}