{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"B0Y6Q5","uniProtkbId":"DSCC_ASPFC","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-04-08","entryVersion":55,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)","commonName":"Neosartorya fumigata","taxonId":451804,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Eurotiomycetes","Eurotiomycetidae","Eurotiales","Aspergillaceae","Aspergillus","Fumigati"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23104569"}],"value":"DSC E3 ubiquitin ligase complex subunit C"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23104569"}],"value":"Defective for SREBP cleavage protein C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23104569"}],"value":"dscC"},"orfNames":[{"value":"AFUB_067780"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23104569"}],"value":"Component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions (PubMed:23104569). Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA) (PubMed:23104569)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23104569"}],"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23104569"}],"value":"Component of the DSC E3 ubiquitin ligase complex composed of dscA, dscB, dscC and dscD"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23104569"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23104569"}],"value":"Impairs growth on solid media under hypoxia and leads to triazole susceptibility (PubMed:23104569). Impairs virulence in a murine model of invasive pulmonary aspergillosis (IPA) (PubMed:23104569)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the dsc3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"DSC E3 ubiquitin ligase complex subunit C","featureId":"PRO_0000460155"},{"type":"Transmembrane","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Glycosylation","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00498"}],"featureId":""}],"keywords":[{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"18404212","citationType":"journal article","authors":["Fedorova N.D.","Khaldi N.","Joardar V.S.","Maiti R.","Amedeo P.","Anderson M.J.","Crabtree J.","Silva J.C.","Badger J.H.","Albarraq A.","Angiuoli S.","Bussey H.","Bowyer P.","Cotty P.J.","Dyer P.S.","Egan A.","Galens K.","Fraser-Liggett C.M.","Haas B.J.","Inman J.M.","Kent R.","Lemieux S.","Malavazi I.","Orvis J.","Roemer T.","Ronning C.M.","Sundaram J.P.","Sutton G.","Turner G.","Venter J.C.","White O.R.","Whitty B.R.","Youngman P.","Wolfe K.H.","Goldman G.H.","Wortman J.R.","Jiang B.","Denning D.W.","Nierman W.C."],"citationCrossReferences":[{"database":"PubMed","id":"18404212"},{"database":"DOI","id":"10.1371/journal.pgen.1000046"}],"title":"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.","publicationDate":"2008","journal":"PLoS Genet.","firstPage":"E1000046","lastPage":"E1000046","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"CBS 144.89 / FGSC A1163 / CEA10","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"23104569","citationType":"journal article","authors":["Willger S.D.","Cornish E.J.","Chung D.","Fleming B.A.","Lehmann M.M.","Puttikamonkul S.","Cramer R.A."],"citationCrossReferences":[{"database":"PubMed","id":"23104569"},{"database":"DOI","id":"10.1128/ec.00252-12"}],"title":"Dsc orthologs are required for hypoxia adaptation, triazole drug responses, and fungal virulence in Aspergillus fumigatus.","publicationDate":"2012","journal":"Eukaryot. Cell","firstPage":"1557","lastPage":"1567","volume":"11"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DS499598","properties":[{"key":"ProteinId","value":"EDP50440.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0Y6Q5","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"EDP50440","properties":[{"key":"ProteinId","value":"EDP50440"},{"key":"GeneId","value":"AFUB_067780"}]},{"database":"VEuPathDB","id":"FungiDB:AFUB_067780","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_035821_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"122381at5052","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"B0Y6Q5","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00143","properties":[{"key":"RectionId","value":"-"}]},{"database":"Proteomes","id":"UP000001699","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0044695","properties":[{"key":"GoTerm","value":"C:Dsc E3 ubiquitin ligase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0016567","properties":[{"key":"GoTerm","value":"P:protein ubiquitination"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd17039","properties":[{"key":"EntryName","value":"Ubl_ubiquitin_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000406","properties":[{"key":"EntryName","value":"Putative conserved membrane protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR045226","properties":[{"key":"EntryName","value":"Dsc3"}]},{"database":"InterPro","id":"IPR025390","properties":[{"key":"EntryName","value":"Dsc3_C"}]},{"database":"InterPro","id":"IPR019413","properties":[{"key":"EntryName","value":"Dsc3_ub-like_dom"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR28049:SF1","properties":[{"key":"EntryName","value":"DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR28049","properties":[{"key":"EntryName","value":"TRANSMEMBRANE PROTEIN YOR223W"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13373","properties":[{"key":"EntryName","value":"Dsc3_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10302","properties":[{"key":"EntryName","value":"Dsc3_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTFPAFLSPDPTWDGDSTGGPLLLTVRFSASIPDFPLDIENPDITTAAGLKQLIRTHLPPNLSSHRLRLIYAGRGLEDATPLSVSLKLPPSPSRTPVVQEDATTVKGKGKAPIREQPRLYIHCSIGDIVLSDADLAAEAAIATTLQQEQADEGYTGRKKQQQPPPSTTSAPRGFDRLLSAGFTPSEVSALRSQFMAIQSVSRTPDTMPTGAELRELEDRWMDEGSSAMAAGVPGGGEGISFADDDGGFGAGSRGAMDDMLWGAVMGFFWPVGCAMWLRREEGVWSWRKGLAVFVGVVINVAFGAMRIMN","length":309,"molWeight":33135,"crc64":"EA82B5810E7A8ACC","md5":"2369BB905D3471892B57F001EBD78867"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"PATHWAY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":2,"Region":2,"Glycosylation":1},"uniParcId":"UPI000170C183"}}