{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"B0BNA9","uniProtkbId":"CNO11_RAT","entryAudit":{"firstPublicDate":"2010-01-19","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-02-26","entryVersion":93,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rattus norvegicus","commonName":"Rat","taxonId":10116,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Rattus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"CCR4-NOT transcription complex subunit 11"}}},"genes":[{"geneName":{"value":"Cnot11"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Does not seem to be required for complex deadenylase function (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CNOT11 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":504,"modifier":"EXACT"}},"description":"CCR4-NOT transcription complex subunit 11","featureId":"PRO_0000390655"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UKZ1"}]}],"keywords":[{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0943","category":"Biological process","name":"RNA-mediated gene silencing"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0810","category":"Biological process","name":"Translation regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-70VOB8UOSDVQL","citationType":"submission","authors":["Mural R.J.","Adams M.D.","Myers E.W.","Smith H.O.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Spleen","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CH473965","properties":[{"key":"ProteinId","value":"EDL99194.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC158750","properties":[{"key":"ProteinId","value":"AAI58751.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001102264.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001108794.2"}]},{"database":"AlphaFoldDB","id":"B0BNA9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"B0BNA9","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"B0BNA9","properties":[{"key":"Number of interactors","value":"3637"}]},{"database":"STRING","id":"10116.ENSRNOP00000035943","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"B0BNA9","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"B0BNA9","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"B0BNA9","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"B0BNA9","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10116-ENSRNOP00000035943","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"B0BNA9","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSRNOT00055033945","properties":[{"key":"ProteinId","value":"ENSRNOP00055027569"},{"key":"GeneId","value":"ENSRNOG00055019862"}]},{"database":"Ensembl","id":"ENSRNOT00060044250","properties":[{"key":"ProteinId","value":"ENSRNOP00060036694"},{"key":"GeneId","value":"ENSRNOG00060025569"}]},{"database":"Ensembl","id":"ENSRNOT00065052679","properties":[{"key":"ProteinId","value":"ENSRNOP00065043303"},{"key":"GeneId","value":"ENSRNOG00065030569"}]},{"database":"GeneID","id":"363221","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"rno:363221","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"RGD:1560909","properties":[{"key":"OrganismName","value":"rat"}]},{"database":"AGR","id":"RGD:1560909","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"55571","properties":[{"key":"Description","value":"-"}]},{"database":"RGD","id":"1560909","properties":[{"key":"GeneName","value":"Cnot11"}]},{"database":"eggNOG","id":"KOG4508","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_028648_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"B0BNA9","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PDHSVQW","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10265389at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"B0BNA9","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-RNO-6804115","properties":[{"key":"PathwayName","value":"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"}]},{"database":"PRO","id":"PR:B0BNA9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002494","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"Bgee","id":"ENSRNOG00000023220","properties":[{"key":"ExpressionPatterns","value":"Expressed in thymus and 19 other cell types or tissues"}]},{"database":"GO","id":"GO:0030014","properties":[{"key":"GoTerm","value":"C:CCR4-NOT complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR019312","properties":[{"key":"EntryName","value":"CNOT11_C"}]},{"database":"InterPro","id":"IPR063413","properties":[{"key":"EntryName","value":"CNOT11_N"}]},{"database":"PANTHER","id":"PTHR15975","properties":[{"key":"EntryName","value":"CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15975:SF0","properties":[{"key":"EntryName","value":"CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10155","properties":[{"key":"EntryName","value":"CNOT11"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27642","properties":[{"key":"EntryName","value":"CNOT11_N"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPGGGASTASGRLLSADPRGAREAAAFRSGPAGSSGGRGGAGGPGSGSGGPAGRMSLTPKELSSLLSIISEEAGGGSTFEGLSTAFHHYFSKADHFRLGSVLVMLLQQPDLLPSAAQRLTALYLLWEMYRTEPLAANPFAASFAHLLNPAPPARGGQEPDRPPLSGFLPPITPPEKFFLSQLMLAPPRELFKKTPRQIALMDVGNMGQSVDISGLQLALAERQSELPTQSKASFPSILSDPDPDSSNSAFDSSVASRITESLVSGPKPPIESHFRPEFIRPPPPLHICEDELAWLNPTEPEHAIQWDRSMCVKNSTGVEIKRIMAKAFKSPLSSPQQTQLLGELEKDPKLVYHIGLTPAKLPDLVENNPLVAIEMLLKLMQSSQITEYFSVLVNMDMSLHSMEVVNRLTTAVDLPPEFIHLYISNCISTCEQIKDKYMQNRLVRLVCVFLQSLIRNKIINVQDLFIEVQAFCIEFSRIREAAGLFRLLKTLDTGETPSETKVSK","length":504,"molWeight":54836,"crc64":"3E0BF7825656A901","md5":"680093546762CDB3DA02EA2F0F4B3A39"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Compositional bias":2,"Modified residue":1},"uniParcId":"UPI00002513AE"}}