{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A9US33","uniProtkbId":"GHL3_MONBE","entryAudit":{"firstPublicDate":"2011-05-31","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-02-05","entryVersion":39,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Monosiga brevicollis","commonName":"Choanoflagellate","taxonId":81824,"lineage":["Eukaryota","Choanoflagellata","Craspedida","Salpingoecidae","Monosiga"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Putative glycoside hydrolase 22789"},"ecNumbers":[{"value":"3.2.1.-"}]}},"genes":[{"orfNames":[{"value":"22789"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the glycoside hydrolase-like 3 (GHL3) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1191,"modifier":"EXACT"}},"description":"Putative glycoside hydrolase 22789","featureId":"PRO_0000408873"},{"type":"Region","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0326","category":"Molecular function","name":"Glycosidase"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"18273011","citationType":"journal article","authoringGroup":["JGI Sequencing"],"authors":["King N.","Westbrook M.J.","Young S.L.","Kuo A.","Abedin M.","Chapman J.","Fairclough S.","Hellsten U.","Isogai Y.","Letunic I.","Marr M.","Pincus D.","Putnam N.","Rokas A.","Wright K.J.","Zuzow R.","Dirks W.","Good M.","Goodstein D.","Lemons D.","Li W.","Lyons J.B.","Morris A.","Nichols S.","Richter D.J.","Salamov A.","Bork P.","Lim W.A.","Manning G.","Miller W.T.","McGinnis W.","Shapiro H.","Tjian R.","Grigoriev I.V.","Rokhsar D."],"citationCrossReferences":[{"database":"PubMed","id":"18273011"},{"database":"DOI","id":"10.1038/nature06617"}],"title":"The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.","publicationDate":"2008","journal":"Nature","firstPage":"783","lastPage":"788","volume":"451"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"MX1 / ATCC 50154","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"20556855","citationType":"journal article","authors":["Naumoff D.G."],"citationCrossReferences":[{"database":"PubMed","id":"20556855"},{"database":"DOI","id":"10.1142/s0219720010004628"}],"title":"GH101 family of glycoside hydrolases: subfamily structure and evolutionary connections with other families.","publicationDate":"2010","journal":"J. Bioinform. Comput. Biol.","firstPage":"437","lastPage":"451","volume":"8"},"referencePositions":["PUTATIVE FUNCTION","FAMILY ASSIGNMENT"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CH991544","properties":[{"key":"ProteinId","value":"EDQ92033.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"XP_001743319.1","properties":[{"key":"NucleotideSequenceId","value":"XM_001743267.1"}]},{"database":"AlphaFoldDB","id":"A9US33","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblProtists","id":"EDQ92033","properties":[{"key":"ProteinId","value":"EDQ92033"},{"key":"GeneId","value":"MONBRDRAFT_22789"}]},{"database":"KEGG","id":"mbr:MONBRDRAFT_22789","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SHKS","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"A9US33","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001357","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"InterPro","id":"IPR046226","properties":[{"key":"EntryName","value":"DUF6259"}]},{"database":"Pfam","id":"PF19773","properties":[{"key":"EntryName","value":"DUF6259"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDPNNAAASSAHDLSSLDLSCLNEAERIVINSFMRGPHAHFEHLGVGPNVKWDENLSKRAFYHLVAINHATLKLLVAQARLCSMQQMNAPNLTNGASATALGSLHPFSLGNPATSVTMASNPLANGPGLRTQLMAPDFALALLGNGTTPHASAGLGALNPGLYNPSASILGGPSSSGASSVLPSPSAHTPDAATDANHLPNPDPASGRQELTRAGRPARKKMKATALDAALRTEMPNWPSVQDDFVRWTRLAWFEAGFASTISDGAIGVQTRRPFSPFLTTTFAQVGVHLPSMSPNLLRAFNSWVDMHLRSLRDHFKGRIDKPHAGKASLAARSLEDTTFVSLTEFINNMCNSYNLINSELSVAAVRALCKLYLNVRNMATAKDSEGVLRVHIRDASNRQPPNILRGTLPQDREDDDLLTLITECGAIDFDLPTDTSDTMALAVLMVMSTSATTLTLDQAGCFSSLSGAASAQVNLLTNVTCEWFSVTMVTESGTSTISLPSSTRPSAHISAHGKDFALSWPKITEGLEIDIGLTLELQHNVTLDAYELRAKVVNHRPKAKASLWQLELNLRNVRQPEDGSAFFPAGYGVRYQGAFAASGSYPSSGATMQWMAAGGGAANEGQGLYLAAHDGYGYIKFLNAAAVEDVASLSIVYLVEDAGLPFAESTMPFPLTLAVVGGGDDLWYQAAQMYRTFALGEAQWMQAGRLHQRQDIPGWYVNNSIWINSGWQCHDIFNETQGDPHTVLNVTRRIRERFNTNMALHWYEWQQGPDANASARYRFDTHYPDYLPPRGGDYFGTVVRELEKEGVHIFPYINGRIFDVASTSYAQHNGSDHCCRKANPSFGAADQSFYVESYGSGSTFHTADPTDIYWQTTLADTVDALVNTYGVEGVYIDQLAAAAPTPDWTSWHNHTKGGGFYWRTGIVDIIKAMRQRVGPTVPLVTESNSEPYMDAISGFLTLVAFEPAFVGTKALVPAFPAIYGGYFVGFGDIFNAEDLADQDPLMARVVAQFVYGAQLGWFSLGGVTSGPDVDTSCGKMGEYDLWMSESSDAIVAAVEYYGNLRVCLLEYLAHGRILAPPSLSPAPAEFMAVETAVQNAGPFPSAMSAVWLHEDEASAVIIVAGVLDAGQTYNVSVDLTFSLPSLHDRQVTVQEMSCDGLSQQLDVMPANDIQIYDVTLSDRNARVYRVHFGA","length":1191,"molWeight":129012,"crc64":"DF6215087F6259A9","md5":"B047768BA87B34E9738DA134F343E86F"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI000163AEA7"}}