{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A7F519","uniProtkbId":"A7F519_SCLS1","entryAudit":{"firstPublicDate":"2007-09-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-09-11","entryVersion":97,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)","commonName":"White mold","synonyms":["Whetzelinia sclerotiorum"],"taxonId":665079,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EDN97840.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000001312"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Leotiomycetes","Helotiales","Sclerotiniaceae","Sclerotinia"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012438"}],"value":"histidine kinase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012438"}],"value":"2.7.13.3"}]}},"genes":[{"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EDN97840.1"}],"value":"SS1G_12694"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.","ecNumber":"2.7.13.3","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000085"}]}}],"features":[{"type":"Domain","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"HAMP","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50885"}]},{"type":"Domain","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"HAMP","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50885"}]},{"type":"Domain","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"HAMP","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50885"}]},{"type":"Domain","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":527,"modifier":"EXACT"}},"description":"HAMP","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50885"}]},{"type":"Domain","location":{"start":{"value":567,"modifier":"EXACT"},"end":{"value":619,"modifier":"EXACT"}},"description":"HAMP","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50885"}]},{"type":"Domain","location":{"start":{"value":659,"modifier":"EXACT"},"end":{"value":711,"modifier":"EXACT"}},"description":"HAMP","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50885"}]},{"type":"Domain","location":{"start":{"value":733,"modifier":"EXACT"},"end":{"value":957,"modifier":"EXACT"}},"description":"Histidine kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50109"}]},{"type":"Domain","location":{"start":{"value":1108,"modifier":"EXACT"},"end":{"value":1227,"modifier":"EXACT"}},"description":"Response regulatory","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50110"}]},{"type":"Region","location":{"start":{"value":1239,"modifier":"EXACT"},"end":{"value":1309,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":1242,"modifier":"EXACT"},"end":{"value":1266,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1279,"modifier":"EXACT"},"end":{"value":1295,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":736,"modifier":"EXACT"},"end":{"value":736,"modifier":"EXACT"}},"description":"Phosphohistidine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00107"}]},{"type":"Modified residue","location":{"start":{"value":1157,"modifier":"EXACT"},"end":{"value":1157,"modifier":"EXACT"}},"description":"4-aspartylphosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00169"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00107"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00169"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000001312"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00107"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023012"}],"id":"KW-0902","category":"Biological process","name":"Two-component regulatory system"}],"references":[{"referenceNumber":1,"citation":{"id":"21876677","citationType":"journal article","authors":["Amselem J.","Cuomo C.A.","van Kan J.A.","Viaud M.","Benito E.P.","Couloux A.","Coutinho P.M.","de Vries R.P.","Dyer P.S.","Fillinger S.","Fournier E.","Gout L.","Hahn M.","Kohn L.","Lapalu N.","Plummer K.M.","Pradier J.M.","Quevillon E.","Sharon A.","Simon A.","ten Have A.","Tudzynski B.","Tudzynski P.","Wincker P.","Andrew M.","Anthouard V.","Beever R.E.","Beffa R.","Benoit I.","Bouzid O.","Brault B.","Chen Z.","Choquer M.","Collemare J.","Cotton P.","Danchin E.G.","Da Silva C.","Gautier A.","Giraud C.","Giraud T.","Gonzalez C.","Grossetete S.","Guldener U.","Henrissat B.","Howlett B.J.","Kodira C.","Kretschmer M.","Lappartient A.","Leroch M.","Levis C.","Mauceli E.","Neuveglise C.","Oeser B.","Pearson M.","Poulain J.","Poussereau N.","Quesneville H.","Rascle C.","Schumacher J.","Segurens B.","Sexton A.","Silva E.","Sirven C.","Soanes D.M.","Talbot N.J.","Templeton M.","Yandava C.","Yarden O.","Zeng Q.","Rollins J.A.","Lebrun M.H.","Dickman M."],"citationCrossReferences":[{"database":"PubMed","id":"21876677"},{"database":"DOI","id":".1371/journal.pgen.1002230"}],"title":"Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea.","publicationDate":"2011","journal":"PLoS Genet.","firstPage":"E1002230","lastPage":"E1002230","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000001312"}],"value":"ATCC 18683 / 1980 / Ss-1","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000001312"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CH476642","properties":[{"key":"ProteinId","value":"EDN97840.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"XP_001586119.1","properties":[{"key":"NucleotideSequenceId","value":"XM_001586069.1"}]},{"database":"SMR","id":"A7F519","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"665079.A7F519","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"5482414","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ssl:SS1G_12694","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A7F519","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CLAAQMD","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"BRENDA","id":"2.7.13.3","properties":[{"key":"OrganismId","value":"5625"}]},{"database":"PHI-base","id":"PHI:2910","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001312","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000155","properties":[{"key":"GoTerm","value":"F:phosphorelay sensor kinase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004673","properties":[{"key":"GoTerm","value":"F:protein histidine kinase activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0071474","properties":[{"key":"GoTerm","value":"P:cellular hyperosmotic response"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd06225","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"5"}]},{"database":"CDD","id":"cd16922","properties":[{"key":"EntryName","value":"HATPase_EvgS-ArcB-TorS-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00082","properties":[{"key":"EntryName","value":"HisKA"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd17546","properties":[{"key":"EntryName","value":"REC_hyHK_CKI1_RcsC-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.130:FF:000002","properties":[{"key":"EntryName","value":"Two-component osmosensing histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.1530:FF:000001","properties":[{"key":"EntryName","value":"Two-component osmosensing histidine kinase"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"1.20.120.1530:FF:000002","properties":[{"key":"EntryName","value":"Two-component osmosensing histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.565.10:FF:000015","properties":[{"key":"EntryName","value":"Two-component osmosensing histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.2300:FF:000207","properties":[{"key":"EntryName","value":"Two-component osmosensing histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.130","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.1530","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"3"}]},{"database":"Gene3D","id":"3.40.50.2300","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.565.10","properties":[{"key":"EntryName","value":"Histidine kinase-like ATPase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011006","properties":[{"key":"EntryName","value":"CheY-like_superfamily"}]},{"database":"InterPro","id":"IPR003660","properties":[{"key":"EntryName","value":"HAMP_dom"}]},{"database":"InterPro","id":"IPR036890","properties":[{"key":"EntryName","value":"HATPase_C_sf"}]},{"database":"InterPro","id":"IPR003594","properties":[{"key":"EntryName","value":"HATPase_dom"}]},{"database":"InterPro","id":"IPR005467","properties":[{"key":"EntryName","value":"His_kinase_dom"}]},{"database":"InterPro","id":"IPR003661","properties":[{"key":"EntryName","value":"HisK_dim/P_dom"}]},{"database":"InterPro","id":"IPR036097","properties":[{"key":"EntryName","value":"HisK_dim/P_sf"}]},{"database":"InterPro","id":"IPR004358","properties":[{"key":"EntryName","value":"Sig_transdc_His_kin-like_C"}]},{"database":"InterPro","id":"IPR001789","properties":[{"key":"EntryName","value":"Sig_transdc_resp-reg_receiver"}]},{"database":"PANTHER","id":"PTHR45339","properties":[{"key":"EntryName","value":"HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45339:SF1","properties":[{"key":"EntryName","value":"HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00672","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF18947","properties":[{"key":"EntryName","value":"HAMP_2"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF02518","properties":[{"key":"EntryName","value":"HATPase_c"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00512","properties":[{"key":"EntryName","value":"HisKA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00072","properties":[{"key":"EntryName","value":"Response_reg"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00344","properties":[{"key":"EntryName","value":"BCTRLSENSOR"}]},{"database":"SMART","id":"SM00304","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"6"}]},{"database":"SMART","id":"SM00387","properties":[{"key":"EntryName","value":"HATPase_c"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00388","properties":[{"key":"EntryName","value":"HisKA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00448","properties":[{"key":"EntryName","value":"REC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55874","properties":[{"key":"EntryName","value":"ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52172","properties":[{"key":"EntryName","value":"CheY-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47384","properties":[{"key":"EntryName","value":"Homodimeric domain of signal transducing histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF58104","properties":[{"key":"EntryName","value":"Methyl-accepting chemotaxis protein (MCP) signaling domain"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50885","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"6"}]},{"database":"PROSITE","id":"PS50109","properties":[{"key":"EntryName","value":"HIS_KIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50110","properties":[{"key":"EntryName","value":"RESPONSE_REGULATORY"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGDTTIAHTTAILQTLAVLSLDSPQANVYGNKGIRLPGADTAEKLALERELAALVSRVQRLEAKATANNHVLPDTPNEIGAPSAFADVLTGAPSRASKSTTSRQQLVNSLLAAREAPTGGERPPKFTKLSDEELEALREHVDDQSKQLDSQKSELAGVHAQLFEQKQRQEQALNVLEVERVAALERELKKHQQANEAFQKALREIGEIVTAVARGDLSKKVQIHSVEMDPEITTFKRVINTMMDQLQIFSSEVSRVAREVGTEGILGGQAKISGVDGTWKELTDNVNVMAQNLTDQVREIASVTTAVAHGDLTQKIERPAQGEILQLQQTINTMVDQLRTFAAEVTRVARDVGTEGILGGQAEIEGVQGMWNTLIVNVNAMANNLTTQVRDIAIVTTAVAKGDLTQKVQAECKGEIKQLKETINSMVDQLQQFAREVTKIAREVGTEGRLGGQATVHDVEGTWRDLTENVNGMAMNLTTQVREIAKVTTAVARGDLTKKIEVEVQGEIASLKDTINTMVDRLGTFAFEVSKVAREVGTDGTLGGQAQVDNVEGKWKDLTENVNTMARNLTTQVRGISTVTQAIANGDMSQKIEVAAAGEILILKETINNMVDRLSIFSNEVQRVAKDVGVDGKMGGQADVAGIGGRWKEITTDVNTMANNLTTQVRAFGDITNAATDGDFTKLITVEASGEMDELKRKINQMVYNLRDSIQRNTLAREAAEFANRTKSEFLANMSHEIRTPMNGIIGMTQLTLDTDLTQYQREMLNIVHNLANSLLTIIDDILDLSKIEANRMIMEEIPYTLRGTVFNALKTLAVKANEKFLDLTYRVDSSVPDHVVGDSFRLRQIILNLVGNAIKFTEHGEVSLTIQKAEQDHCAPNEYAVEFCVSDTGIGIQADKLNLIFDTFQQADGSMTRKFGGTGLGLSISKRLVNLMRGDVWVKSQYGKGSSFYFTCTVRLATSDISFIQKQLKPYQGHNVLFIDKGQTGHGKEIITMLTQLGLVPVVVDSEQHTILLGNGRTKEKIASTYDVIVVDSIETARKLRSIDEFKYIPIVLLAPVVHVSLKSALDLGITSYMTTPCLTIDLGNGMIPALENRAAPSLADNTKSFDILLAEDNIVNQRLAVKILEKYHHVVTVVGNGQEALDAIKEKRYDVILMDVQMPIMGGFEATAKIREYERSLGTQRTPIIALTAHAMLGDREKCIQAQMDEYLSKPLKQNHLIQTILKCATLGGALLEKGREVRQSANEESPNSQNGTRSNQHPASSPTPAHLRPTIEPRAYTTTGPINHGSVESPSLVTADAEDPLARNLY","length":1309,"molWeight":143318,"crc64":"027CCB57B27C34BF","md5":"3A37B48552D29D066AF15C57B2CF6CC1"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1},"countByFeatureType":{"Domain":8,"Region":1,"Coiled coil":1,"Compositional bias":2,"Modified residue":2},"uniParcId":"UPI00015A068A"}}