{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A6X8Z9","secondaryAccessions":["A4QMY3","Q8C5T0"],"uniProtkbId":"TEX55_MOUSE","entryAudit":{"firstPublicDate":"2019-04-10","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2007-08-21","entryVersion":105,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96M34"}],"value":"Testis-specific expressed protein 55"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19821082"}],"value":"Testis-specific conserved, cAMP-dependent type II PK-anchoring protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96M34"}],"value":"Tex55"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19821082"}],"value":"Tscpa"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19821082"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19821082"}],"value":"Testis-specific"}],"commentType":"TISSUE SPECIFICITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"Testis-specific expressed protein 55","featureId":"PRO_0000446513"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Sequence conflict","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"in Ref. 3; EDK97996 and 4; AAI15689","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"in Ref. 3; EDK97996 and 4; AAI15689","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}}],"keywords":[{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-70VOHH7BF94TO","citationType":"submission","authors":["Mural R.J.","Adams M.D.","Myers E.W.","Smith H.O.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":5,"citation":{"id":"19821082","citationType":"journal article","authors":["Yu Z.","Wu B.","Tang A.","Chen J.","Guo X.","Qin J.","Gui Y.","Cai Z."],"citationCrossReferences":[{"database":"PubMed","id":"19821082"},{"database":"DOI","id":"10.1007/s11596-009-0502-9"}],"title":"Expression profile of a novel germ cell-specific gene, TSCPA, in mice and human.","publicationDate":"2009","journal":"J. Huazhong Univ. Sci. Technol. Med. Sci.","firstPage":"535","lastPage":"539","volume":"29"},"referencePositions":["SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK077164","properties":[{"key":"ProteinId","value":"BAC36654.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CT009576","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH466521","properties":[{"key":"ProteinId","value":"EDK97996.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC115688","properties":[{"key":"ProteinId","value":"AAI15689.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS49850.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_083318.1","properties":[{"key":"NucleotideSequenceId","value":"NM_029042.2"}]},{"database":"AlphaFoldDB","id":"A6X8Z9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A6X8Z9","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"A6X8Z9","properties":[{"key":"Number of interactors","value":"36"}]},{"database":"STRING","id":"10090.ENSMUSP00000113120","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"A6X8Z9","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"A6X8Z9","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000113120","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"346922","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000122078.3","properties":[{"key":"ProteinId","value":"ENSMUSP00000113120.2"},{"key":"GeneId","value":"ENSMUSG00000022798.9"}]},{"database":"GeneID","id":"74663","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:74663","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007zfn.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1921913","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"152405","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1921913","properties":[{"key":"GeneName","value":"Tex55"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000022798","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SEVH","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000154487","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_034619_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A6X8Z9","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QPCKFEP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"522106at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"74663","properties":[{"key":"hits","value":"0 hits in 77 CRISPR screens"}]},{"database":"PRO","id":"PR:A6X8Z9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"RNAct","id":"A6X8Z9","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000022798","properties":[{"key":"ExpressionPatterns","value":"Expressed in seminiferous tubule of testis and 4 other cell types or tissues"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19821082"}]},{"database":"GO","id":"GO:0036126","properties":[{"key":"GoTerm","value":"C:sperm flagellum"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"CDD","id":"cd22975","properties":[{"key":"EntryName","value":"DD_TEX55"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.890.10","properties":[{"key":"EntryName","value":"cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR040760","properties":[{"key":"EntryName","value":"Tex55"}]},{"database":"InterPro","id":"IPR048377","properties":[{"key":"EntryName","value":"TEX55_DD"}]},{"database":"PANTHER","id":"PTHR47110","properties":[{"key":"EntryName","value":"TESTIS-SPECIFIC EXPRESSED PROTEIN 55"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47110:SF1","properties":[{"key":"EntryName","value":"TESTIS-SPECIFIC EXPRESSED PROTEIN 55"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17819","properties":[{"key":"EntryName","value":"Tex55"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47391","properties":[{"key":"EntryName","value":"Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDEPPDESLNHENTTRAPDNEKNNIEGAGQALHRGSEHAGVGSSEPTGDKVSGQANAGSRQTGRRTSEEAEQRSSQPTEHRLPGHAERRASQQAERRLSERRTSQPPNQQLPSHSERKTSGKIDGQESLLSEQTDQETSEFDDLIPSASTDYLSARSQQQEYNQHGYWTEDSSDPHRLSEDLEKDYTRVKHITEKQAGYRSYYKTLAHIESRTLTDTNDYRETGQRLQPCTFEDSEAELPSKVSTTEETESATTIQAYNTQDTELTTSTSHEKLPSITTKVYYSSSPEKIQTTEYTSDTTPVFDQGRSSQRSSQSSRWRFPPIVFEDPYHVALRYVEKHNILHIFQQITENLVYERPDDPLYFMLDQVQNMIKHRDERQSD","length":381,"molWeight":43579,"crc64":"415E4D7FD8FD2FA4","md5":"CEA1517AD2A30A17F3E70B65921902DB"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Compositional bias":8,"Sequence conflict":2},"uniParcId":"UPI00001C5A58"}}