{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A6T5D6","uniProtkbId":"ACPH_KLEP7","entryAudit":{"firstPublicDate":"2008-02-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-08-21","entryVersion":71,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)","taxonId":272620,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Klebsiella","Klebsiella pneumoniae complex"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01950"}],"value":"Acyl carrier protein phosphodiesterase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01950"}],"value":"ACP phosphodiesterase"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01950"}],"value":"3.1.4.14"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01950"}],"value":"acpH"},"orderedLocusNames":[{"value":"KPN78578_03460"}],"orfNames":[{"value":"KPN_00355"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01950"}],"value":"Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"holo-[ACP] + H2O = apo-[ACP] + (R)-4'-phosphopantetheine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20537"},{"database":"Rhea","id":"RHEA-COMP:9685"},{"database":"Rhea","id":"RHEA-COMP:9690"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:61723"},{"database":"ChEBI","id":"CHEBI:64479"}],"ecNumber":"3.1.4.14","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01950"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01950"}],"value":"Belongs to the AcpH family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"Acyl carrier protein phosphodiesterase","featureId":"PRO_1000070626"}],"keywords":[{"id":"KW-0275","category":"Biological process","name":"Fatty acid biosynthesis"},{"id":"KW-0276","category":"Biological process","name":"Fatty acid metabolism"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0444","category":"Biological process","name":"Lipid biosynthesis"},{"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-EPFHBDUCG65T9","citationType":"submission","authoringGroup":["The Klebsiella pneumonia Genome Sequencing Project"],"authors":["McClelland M.","Sanderson E.K.","Spieth J.","Clifton W.S.","Latreille P.","Sabo A.","Pepin K.","Bhonagiri V.","Porwollik S.","Ali J.","Wilson R.K."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 700721 / MGH 78578","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP000647","properties":[{"key":"ProteinId","value":"ABR75807.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_009307908.1","properties":[{"key":"NucleotideSequenceId","value":"NC_009648.1"}]},{"database":"AlphaFoldDB","id":"A6T5D6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A6T5D6","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"272620.KPN_00355","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"272620-KPN_00355","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"ABR75807","properties":[{"key":"ProteinId","value":"ABR75807"},{"key":"GeneId","value":"KPN_00355"}]},{"database":"KEGG","id":"kpn:KPN_00355","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_099370_1_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000265","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0008770","properties":[{"key":"GoTerm","value":"F:[acyl-carrier-protein] phosphodiesterase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006633","properties":[{"key":"GoTerm","value":"P:fatty acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"HAMAP","id":"MF_01950","properties":[{"key":"EntryName","value":"AcpH"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007431","properties":[{"key":"EntryName","value":"ACP_PD"}]},{"database":"InterPro","id":"IPR023491","properties":[{"key":"EntryName","value":"ACP_phosphodiesterase_gpbac"}]},{"database":"NCBIfam","id":"NF007466","properties":[{"key":"EntryName","value":"PRK10045.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR38764","properties":[{"key":"EntryName","value":"ACYL CARRIER PROTEIN PHOSPHODIESTERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR38764:SF1","properties":[{"key":"EntryName","value":"ACYL CARRIER PROTEIN PHOSPHODIESTERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04336","properties":[{"key":"EntryName","value":"ACP_PD"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF011489","properties":[{"key":"EntryName","value":"DUF479"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNFLAHLHLAHLADSSLPGNLMADFVRGNPQGDYPAEIIDGIYMHRRIDVMTDNLAEVKEAREWFRPQTRRVAPITLDVMWDHFLSQHWAQLSPDLPLDEFVRYAERQIVPILPDSPPRFVNLNQYLWSERWLERYREMDFIQRVLNGMASRRPRLEALRDSWQDLDTHYDRLETQFWRFYPQMMRLAENKQL","length":193,"molWeight":23252,"crc64":"4675929B569BD221","md5":"0476A7DCC1D66E39672E0B6551B07471"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1},"uniParcId":"UPI000157610B"}}