{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A6NLE4","uniProtkbId":"SIM23_HUMAN","entryAudit":{"firstPublicDate":"2008-06-10","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2016-09-07","entryVersion":104,"sequenceVersion":3},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Small integral membrane protein 23"}}},"genes":[{"geneName":{"value":"SMIM23"},"synonyms":[{"value":"C5orf50"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"Small integral membrane protein 23","featureId":"PRO_0000341237"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Natural variant","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"in dbSNP:rs10037031","featureCrossReferences":[{"database":"dbSNP","id":"rs10037031"}],"featureId":"VAR_057736","alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0735","category":"Domain","name":"Signal-anchor"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.-F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"CI-DE11SLTGRTAJ6","citationType":"submission","authors":["Stevens M.","Wei C.","Gross S.S.","McPherson J.","Brent M.R."],"title":"Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in human.","publicationDate":"OCT-2006","submissionDatabase":"UniProtKB"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-124"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011410","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"DN930602","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EG327839","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS87347.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001276899.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001289970.2"}]},{"database":"AlphaFoldDB","id":"A6NLE4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A6NLE4","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000430818","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SMIM23","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000430818","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"1469","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"64430","properties":[{"key":"antibodies","value":"3 antibodies from 3 providers"}]},{"database":"DNASU","id":"644994","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000523047.4","properties":[{"key":"ProteinId","value":"ENSP00000430818.4"},{"key":"GeneId","value":"ENSG00000185662.11"}]},{"database":"Ensembl","id":"ENST00000639838.1","properties":[{"key":"ProteinId","value":"ENSP00000490990.1"},{"key":"GeneId","value":"ENSG00000185662.11"}]},{"database":"GeneID","id":"644994","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:644994","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000523047.4","properties":[{"key":"ProteinId","value":"ENSP00000430818.4"},{"key":"RefSeqNucleotideId","value":"NM_001289970.2"},{"key":"RefSeqProteinId","value":"NP_001276899.1"}]},{"database":"UCSC","id":"uc063jql.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:34440","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"644994","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SMIM23","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:34440","properties":[{"key":"GeneName","value":"SMIM23"}]},{"database":"HPA","id":"ENSG00000185662","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (testis)"}]},{"database":"OpenTargets","id":"ENSG00000185662","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000185662","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502TDUM","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000017300","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A6NLE4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GSRCEDK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9450349at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"A6NLE4","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PathwayCommons","id":"A6NLE4","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"A6NLE4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"644994","properties":[{"key":"hits","value":"1 hit in 191 CRISPR screens"}]},{"database":"GenomeRNAi","id":"644994","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"A6NLE4","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:A6NLE4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"A6NLE4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000185662","properties":[{"key":"ExpressionPatterns","value":"Expressed in male germ line stem cell (sensu Vertebrata) in testis and 45 other cell types or tissues"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR027880","properties":[{"key":"EntryName","value":"DUF4635"}]},{"database":"PANTHER","id":"PTHR37865","properties":[{"key":"EntryName","value":"SMALL INTEGRAL MEMBRANE PROTEIN 23"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR37865:SF1","properties":[{"key":"EntryName","value":"SMALL INTEGRAL MEMBRANE PROTEIN 23"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15466","properties":[{"key":"EntryName","value":"DUF4635"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MATQQVDSRRQVAAEQVAAQLLERRRGSHCDDEKQTLLALLILVLYLSTEIWGSSWEVSERIRECNYYQNLAVPQGLEYQTNEPSEEPIKTIRNWLKEKLHVFSEKLEEEVQQLEQLAWDLELWLDALLGEPHQEEHCSTYKSHLWEWAWALGREHKGGEGLLEISLSGAEL","length":172,"molWeight":20025,"crc64":"40CB2BCB063CB240","md5":"24A02F2BE1F5C325ED7E46664D3F1D04"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1,"Topological domain":2,"Transmembrane":1,"Coiled coil":1,"Natural variant":1},"uniParcId":"UPI0001608A22"}}