{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A6NKL6","uniProtkbId":"T200C_HUMAN","entryAudit":{"firstPublicDate":"2008-09-02","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2008-09-02","entryVersion":111,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Transmembrane protein 200C"}},"alternativeNames":[{"fullName":{"value":"Transmembrane protein TTMA"}},{"fullName":{"value":"Two transmembrane domain-containing family member A"}}]},"genes":[{"geneName":{"value":"TMEM200C"},"synonyms":[{"value":"TTMA"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TMEM200 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":621,"modifier":"EXACT"}},"description":"Transmembrane protein 200C","featureId":"PRO_0000348944"},{"type":"Transmembrane","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":598,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":405,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":479,"modifier":"EXACT"},"end":{"value":490,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":491,"modifier":"EXACT"},"end":{"value":505,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":586,"modifier":"EXACT"},"end":{"value":595,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"16177791","citationType":"journal article","authors":["Nusbaum C.","Zody M.C.","Borowsky M.L.","Kamal M.","Kodira C.D.","Taylor T.D.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Abouelleil A.","Allen N.R.","Anderson S.","Bloom T.","Bugalter B.","Butler J.","Cook A.","DeCaprio D.","Engels R.","Garber M.","Gnirke A.","Hafez N.","Hall J.L.","Norman C.H.","Itoh T.","Jaffe D.B.","Kuroki Y.","Lehoczky J.","Lui A.","Macdonald P.","Mauceli E.","Mikkelsen T.S.","Naylor J.W.","Nicol R.","Nguyen C.","Noguchi H.","O'Leary S.B.","Piqani B.","Smith C.L.","Talamas J.A.","Topham K.","Totoki Y.","Toyoda A.","Wain H.M.","Young S.K.","Zeng Q.","Zimmer A.R.","Fujiyama A.","Hattori M.","Birren B.W.","Sakaki Y.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16177791"},{"database":"DOI","id":"10.1038/nature03983"}],"title":"DNA sequence and analysis of human chromosome 18.","publicationDate":"2005","journal":"Nature","firstPage":"551","lastPage":"555","volume":"437"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"15722956","citationType":"journal article","authors":["Pickard B.S.","Malloy M.P.","Clark L.","Lehellard S.","Ewald H.L.","Mors O.","Porteous D.J.","Blackwood D.H.","Muir W.J."],"citationCrossReferences":[{"database":"PubMed","id":"15722956"},{"database":"DOI","id":"10.1097/00041444-200503000-00007"}],"title":"Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18.","publicationDate":"2005","journal":"Psychiatr. Genet.","firstPage":"37","lastPage":"44","volume":"15"},"referencePositions":["IDENTIFICATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP005433","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK005124","properties":[{"key":"ProteinId","value":"DAA05326.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS45825.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001073678.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001080209.3"}]},{"database":"RefSeq","id":"NP_001382329.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001395400.1"}]},{"database":"RefSeq","id":"XP_054174952.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054318977.1"}]},{"database":"AlphaFoldDB","id":"A6NKL6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A6NKL6","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"570397","properties":[{"key":"Interactions","value":"5"}]},{"database":"FunCoup","id":"A6NKL6","properties":[{"key":"Number of interactors","value":"15"}]},{"database":"IntAct","id":"A6NKL6","properties":[{"key":"Interactions","value":"1"}]},{"database":"MINT","id":"A6NKL6","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-TMEM200C","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000463375","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"A6NKL6","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"A6NKL6","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"A6NKL6","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"TMEM200C","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A6NKL6","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000463375","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A6NKL6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"1420","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"66113","properties":[{"key":"antibodies","value":"9 antibodies from 5 providers"}]},{"database":"DNASU","id":"645369","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000383490.3","properties":[{"key":"ProteinId","value":"ENSP00000372982.2"},{"key":"GeneId","value":"ENSG00000206432.5"}]},{"database":"Ensembl","id":"ENST00000581347.2","properties":[{"key":"ProteinId","value":"ENSP00000463375.1"},{"key":"GeneId","value":"ENSG00000206432.5"}]},{"database":"Ensembl","id":"ENST00000930047.1","properties":[{"key":"ProteinId","value":"ENSP00000600106.1"},{"key":"GeneId","value":"ENSG00000206432.5"}]},{"database":"Ensembl","id":"ENST00000957277.1","properties":[{"key":"ProteinId","value":"ENSP00000627336.1"},{"key":"GeneId","value":"ENSG00000206432.5"}]},{"database":"GeneID","id":"645369","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:645369","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000383490.3","properties":[{"key":"ProteinId","value":"ENSP00000372982.2"},{"key":"RefSeqNucleotideId","value":"NM_001395400.1"},{"key":"RefSeqProteinId","value":"NP_001382329.1"}]},{"database":"UCSC","id":"uc002kmx.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:37208","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA165429148","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"645369","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"645369","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"TMEM200C","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:37208","properties":[{"key":"GeneName","value":"TMEM200C"}]},{"database":"HPA","id":"ENSG00000206432","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (adrenal gland, brain, salivary gland)"}]},{"database":"OpenTargets","id":"ENSG00000206432","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000206432","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4823","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00530000063698","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_030031_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A6NKL6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QVYRESS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9994280at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"A6NKL6","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"A6NKL6","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"A6NKL6","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"A6NKL6","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000206432","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"645369","properties":[{"key":"hits","value":"6 hits in 1140 CRISPR screens"}]},{"database":"GenomeRNAi","id":"645369","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"A6NKL6","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:A6NKL6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 18"}]},{"database":"RNAct","id":"A6NKL6","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000206432","properties":[{"key":"ExpressionPatterns","value":"Expressed in endothelial cell and 118 other cell types or tissues"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR018787","properties":[{"key":"EntryName","value":"DUF2371_TMEM200"}]},{"database":"PANTHER","id":"PTHR31815","properties":[{"key":"EntryName","value":"AGAP005329-PA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31815:SF2","properties":[{"key":"EntryName","value":"TRANSMEMBRANE PROTEIN 200C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10177","properties":[{"key":"EntryName","value":"DUF2371"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIATGGLLRISARKQDPLRPPSQIPKRKRKAKKRRKNDVVVVKGKLKLCSISGLIALCGILVLLVGIAMAVVGYWPKATGTNREGGKQLPPAGSSHRVPTTANSSSSGSKNRSRSHPRAPGGVNSSSAGAPRSTPPARAASPSSSSTSVGFFFRIFSGYLHSDKLKVFGPLIMGIGIFLFICANAVLHENRDKKTKIINLRDLYSTVIDVHSLRAKDLAAAAAAAAAAAASSSSSAPAAAPPGAIPLNGFLSYVQSRGLELKPGGCGGSGDAFGAAAMLAKGSWPPHPAAPSGGRPRGAASPPDLASSPRCPREPPSLAEAVYSVYRERSGVAGSRRAAAATAAAAASSCSSPAPCSPPESWGRQSTASSFVDSSLSAFALLPLQGGRDRGGDAEGASCSWQRPPGERGSQEIPRGELDLSMTNLRGAEGSMRGARREPEEPEGAVAARAARGQGGRLPRTGRYAALRRRSTSGLPDYRAPPSPEPPPSPGSADPDSSPLAKAASPSPPLRLEGSPPTRRDSGSSQSDDPSSSNKGYTPLREAGTSTESVLDAVAGQTRDSAVAAPVLGAEQSSPEGASQEPPTAEQPQPVQRQFTNKEKLIMISRSHAIGVEEELESTGI","length":621,"molWeight":63928,"crc64":"5192A3FA727CAFB7","md5":"D46881F371719D243F04E53385B57190"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":2,"Region":5,"Compositional bias":8},"uniParcId":"UPI000020198E"}}