{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A6NGS2","uniProtkbId":"ERIC4_HUMAN","entryAudit":{"firstPublicDate":"2008-06-10","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2008-06-10","entryVersion":98,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Glutamate-rich protein 4"}}},"genes":[{"geneName":{"value":"ERICH4"},"synonyms":[{"value":"C19orf69"}]}],"comments":[{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"A6NGS2","intActId":"EBI-18398448"},"interactantTwo":{"uniProtKBAccession":"Q15172","geneName":"PPP2R5A","intActId":"EBI-641666"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"A6NGS2","intActId":"EBI-18398448"},"interactantTwo":{"uniProtKBAccession":"P51687","geneName":"SUOX","intActId":"EBI-3921347"},"numberOfExperiments":3,"organismDiffer":false}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Glutamate-rich protein 4","featureId":"PRO_0000340277"},{"type":"Region","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.S.","Terry A.","Schmutz J.","Lamerdin J.E.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.V.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.-H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.M.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011526","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS46085.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001123986.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001130514.3"}]},{"database":"AlphaFoldDB","id":"A6NGS2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A6NGS2","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"936859","properties":[{"key":"Interactions","value":"2"}]},{"database":"IntAct","id":"A6NGS2","properties":[{"key":"Interactions","value":"2"}]},{"database":"STRING","id":"9606.ENSP00000367429","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ERICH4","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"A6NGS2","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A6NGS2","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000367429","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A6NGS2","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"1148","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"65006","properties":[{"key":"antibodies","value":"9 antibodies from 5 providers"}]},{"database":"DNASU","id":"100170765","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000378187.3","properties":[{"key":"ProteinId","value":"ENSP00000367429.2"},{"key":"GeneId","value":"ENSG00000204978.3"}]},{"database":"GeneID","id":"100170765","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:100170765","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000378187.3","properties":[{"key":"ProteinId","value":"ENSP00000367429.2"},{"key":"RefSeqNucleotideId","value":"NM_001130514.3"},{"key":"RefSeqProteinId","value":"NP_001123986.1"}]},{"database":"UCSC","id":"uc010xwc.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:34497","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162378862","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"100170765","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ERICH4","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:34497","properties":[{"key":"GeneName","value":"ERICH4"}]},{"database":"HPA","id":"ENSG00000204978","properties":[{"key":"ExpressionPatterns","value":"Group enriched (intestine, kidney)"}]},{"database":"OpenTargets","id":"ENSG00000204978","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000204978","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502RWFY","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000006319","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_152287_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A6NGS2","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"LWIWQEL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9838132at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"A6NGS2","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"A6NGS2","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"A6NGS2","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"A6NGS2","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"100170765","properties":[{"key":"hits","value":"5 hits in 246 CRISPR screens"}]},{"database":"GenomeRNAi","id":"100170765","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"A6NGS2","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:A6NGS2","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"RNAct","id":"A6NGS2","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000204978","properties":[{"key":"ExpressionPatterns","value":"Expressed in jejunal mucosa and 94 other cell types or tissues"}]},{"database":"InterPro","id":"IPR029202","properties":[{"key":"EntryName","value":"DUF4530"}]},{"database":"PANTHER","id":"PTHR36879","properties":[{"key":"EntryName","value":"GLUTAMATE-RICH PROTEIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR36879:SF1","properties":[{"key":"EntryName","value":"GLUTAMATE-RICH PROTEIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15039","properties":[{"key":"EntryName","value":"DUF4530"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MELWRQLNQAGLVPPGLGPPPQALREVSPVEIPGQTLRTAGADTGGACDSLLWIREELGNLRRVDVQLLGQLCSLGLEMGALREELVTILEEEEESSKEEEEDQEPQRKQEEEHLEACPAPHPPDFEMMI","length":130,"molWeight":14477,"crc64":"5DC372C000DB8040","md5":"172BAF30B1440E4498635AB966276D86"},"extraAttributes":{"countByCommentType":{"INTERACTION":2},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":2},"uniParcId":"UPI00017503B7"}}