{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A6ND36","secondaryAccessions":["Q3KQZ4","Q6ZW60"],"uniProtkbId":"SCK1G_HUMAN","entryAudit":{"firstPublicDate":"2008-04-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-01-15","entryVersion":132,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Scaffolding CK1 anchoring protein G"}},"alternativeNames":[{"fullName":{"value":"Protein FAM83G"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24554596"}],"value":"Protein associated with SMAD1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:32554"}],"value":"SACK1G"},"synonyms":[{"value":"FAM83G"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24554596"}],"value":"PAWS1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24554596"}],"value":"Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24554596"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29789297"}],"value":"Interacts with SMAD1 (via MH2 domain); in a SMAD4-independent manner (PubMed:24554596, PubMed:29789297). Directly interacts (via SACK1 domain) with casein kinase isoforms CSNK1A1 and CSNK1A1L (PubMed:29789297)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"A6ND36","intActId":"EBI-1047240"},"interactantTwo":{"uniProtKBAccession":"P48729","geneName":"CSNK1A1","intActId":"EBI-1383726"},"numberOfExperiments":17,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24554596"}],"value":"Detected predominantly in the cytosol. Upon BMP stimulation, a small portion localizes the nucleus"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24554596"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29789297"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24554596"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["A6ND36-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["A6ND36-2"],"sequenceIds":["VSP_033120","VSP_033121","VSP_033122","VSP_033123"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"29789297"}],"value":"All members of the SACK1 family of proteins share a conserved N-terminal DUF1669 (domain of unknown function 1669) domain of about 300 amino acids. This domain mediates the interaction with casein kinase 1 (CK1) isoforms. Therefore, it has been proposed to rename DUF1669 the scaffold anchor of CK1 domain (SACK1)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29789297"}],"value":"Phosphorylated in vitro by CSNK1A1"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24554596"}],"value":"BMP signaling induces the phosphorylation by BMPR1A at Ser-610, Ser-614 and Ser-616. Phosphorylation at Ser-610 is necessary for the activation of SMAD4-independent BMP target genes such as NEDD9 and ASNS"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SACK1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":823,"modifier":"EXACT"}},"description":"Scaffolding CK1 anchoring protein G","featureId":"PRO_0000330817"},{"type":"Domain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"SACK1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01440"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"29789297"}]},{"type":"Region","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"3-helix","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01440"}]},{"type":"Region","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Loop","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01440"}]},{"type":"Region","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"PLD-like","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01440"}]},{"type":"Region","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":823,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":452,"modifier":"EXACT"},"end":{"value":465,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":497,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":529,"modifier":"EXACT"},"end":{"value":543,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":578,"modifier":"EXACT"},"end":{"value":587,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":672,"modifier":"EXACT"},"end":{"value":681,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":809,"modifier":"EXACT"},"end":{"value":823,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":610,"modifier":"EXACT"},"end":{"value":610,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24554596"}]},{"type":"Modified residue","location":{"start":{"value":614,"modifier":"EXACT"},"end":{"value":614,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24554596"}]},{"type":"Modified residue","location":{"start":{"value":616,"modifier":"EXACT"},"end":{"value":616,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24554596"}]},{"type":"Modified residue","location":{"start":{"value":650,"modifier":"EXACT"},"end":{"value":650,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":666,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16964243"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18220336"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_033120","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_033121","alternativeSequence":{"originalSequence":"KFKGALAQKFMFVDGDRAVCGSY","alternativeSequences":["MGARGLGGGSRVMCLTSAPSLCC"]}},{"type":"Alternative sequence","location":{"start":{"value":695,"modifier":"EXACT"},"end":{"value":725,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_033122","alternativeSequence":{"originalSequence":"GQQFHHHRVPASGTRDKDGFPGPPRYRSAAD","alternativeSequences":["VGQGPCTPGVTSPSLPATQELELLSSGLPCP"]}},{"type":"Alternative sequence","location":{"start":{"value":726,"modifier":"EXACT"},"end":{"value":823,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_033123","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"found in patient with Joubert syndrome; uncertain significance; dbSNP:rs371100508","featureCrossReferences":[{"database":"dbSNP","id":"rs371100508"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26477546"}],"featureId":"VAR_075713","alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"in dbSNP:rs2074283","featureCrossReferences":[{"database":"dbSNP","id":"rs2074283"}],"featureId":"VAR_053903","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":630,"modifier":"EXACT"},"end":{"value":630,"modifier":"EXACT"}},"description":"found in patient with Joubert syndrome; uncertain significance; dbSNP:rs201046878","featureCrossReferences":[{"database":"dbSNP","id":"rs201046878"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26477546"}],"featureId":"VAR_075714","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Mutagenesis","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Loss of interaction with CSNK1A1. Loss of interaction with CSNK1A1; when associated with A-300.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29789297"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"No effect on interaction with CSNK1A1. Loss of interaction with CSNK1A1; when associated with A-296.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29789297"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":610,"modifier":"EXACT"},"end":{"value":610,"modifier":"EXACT"}},"description":"Completely abolishes phosphorylation by ALK3 in vitro. NEDD9 and ASNS activation in response to BMPs is abolished.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24554596"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Tongue","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.-K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 618-823 (ISOFORM 1)"],"referenceComments":[{"value":"Bone","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"16964243","citationType":"journal article","authors":["Beausoleil S.A.","Villen J.","Gerber S.A.","Rush J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"16964243"},{"database":"DOI","id":"10.1038/nbt1240"}],"title":"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.","publicationDate":"2006","journal":"Nat. Biotechnol.","firstPage":"1285","lastPage":"1292","volume":"24"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-666","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"18220336","citationType":"journal article","authors":["Cantin G.T.","Yi W.","Lu B.","Park S.K.","Xu T.","Lee J.-D.","Yates J.R. III"],"citationCrossReferences":[{"database":"PubMed","id":"18220336"},{"database":"DOI","id":"10.1021/pr0705441"}],"title":"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"1346","lastPage":"1351","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-666","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-666","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-124; SER-127 AND SER-356","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":8,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-650","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-650","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"24554596","citationType":"journal article","authors":["Vogt J.","Dingwell K.S.","Herhaus L.","Gourlay R.","Macartney T.","Campbell D.","Smith J.C.","Sapkota G.P."],"citationCrossReferences":[{"database":"PubMed","id":"24554596"},{"database":"DOI","id":"10.1098/rsob.130210"}],"title":"Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling.","publicationDate":"2014","journal":"Open Biol.","firstPage":"130210","lastPage":"130210","volume":"4"},"referencePositions":["FUNCTION","INTERACTION WITH SMAD1","SUBCELLULAR LOCATION","PHOSPHORYLATION AT SER-610; SER-614 AND SER-616 BY BMPR1A","MUTAGENESIS OF SER-610"]},{"referenceNumber":11,"citation":{"id":"29789297","citationType":"journal article","authors":["Fulcher L.J.","Bozatzi P.","Tachie-Menson T.","Wu K.Z.L.","Cummins T.D.","Bufton J.C.","Pinkas D.M.","Dunbar K.","Shrestha S.","Wood N.T.","Weidlich S.","Macartney T.J.","Varghese J.","Gourlay R.","Campbell D.G.","Dingwell K.S.","Smith J.C.","Bullock A.N.","Sapkota G.P."],"citationCrossReferences":[{"database":"PubMed","id":"29789297"},{"database":"DOI","id":"10.1126/scisignal.aao2341"}],"title":"The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.","publicationDate":"2018","journal":"Sci. Signal.","firstPage":"0","lastPage":"0","volume":"11"},"referencePositions":["INTERACTION WITH CSNK1A1; CSNK1A1L AND SMAD1","SUBCELLULAR LOCATION","PHOSPHORYLATION","MUTAGENESIS OF PHE-296 AND PHE-300"]},{"referenceNumber":12,"citation":{"id":"26477546","citationType":"journal article","authoringGroup":["Care4Rare Canada Consortium"],"authors":["Srour M.","Hamdan F.F.","McKnight D.","Davis E.","Mandel H.","Schwartzentruber J.","Martin B.","Patry L.","Nassif C.","Dionne-Laporte A.","Ospina L.H.","Lemyre E.","Massicotte C.","Laframboise R.","Maranda B.","Labuda D.","Decarie J.C.","Rypens F.","Goldsher D.","Fallet-Bianco C.","Soucy J.F.","Laberge A.M.","Maftei C.","Boycott K.","Brais B.","Boucher R.M.","Rouleau G.A.","Katsanis N.","Majewski J.","Elpeleg O.","Kukolich M.K.","Shalev S.","Michaud J.L."],"citationCrossReferences":[{"database":"PubMed","id":"26477546"},{"database":"DOI","id":"10.1016/j.ajhg.2015.09.009"}],"title":"Joubert Syndrome in French Canadians and Identification of Mutations in CEP104.","publicationDate":"2015","journal":"Am. J. Hum. Genet.","firstPage":"744","lastPage":"753","volume":"97"},"referencePositions":["VARIANTS PHE-64 AND TRP-630"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK123558","properties":[{"key":"ProteinId","value":"BAC85645.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC090286","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC105988","properties":[{"key":"ProteinId","value":"AAI05989.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS42276.1","properties":[{"key":"Description","value":"-"}],"isoformId":"A6ND36-1"},{"database":"RefSeq","id":"NP_001035088.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001039999.3"}],"isoformId":"A6ND36-1"},{"database":"RefSeq","id":"XP_016880442.1","properties":[{"key":"NucleotideSequenceId","value":"XM_017024953.3"}],"isoformId":"A6ND36-1"},{"database":"AlphaFoldDB","id":"A6ND36","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A6ND36","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"569917","properties":[{"key":"Interactions","value":"30"}]},{"database":"FunCoup","id":"A6ND36","properties":[{"key":"Number of interactors","value":"1474"}]},{"database":"IntAct","id":"A6ND36","properties":[{"key":"Interactions","value":"23"}]},{"database":"STRING","id":"9606.ENSP00000373647","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"A6ND36","properties":[{"key":"glycosylation","value":"2 sites"}]},{"database":"iPTMnet","id":"A6ND36","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"A6ND36","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"FAM83G","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"A6ND36","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A6ND36","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000373647","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A6ND36","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"879","properties":[{"key":"Description","value":"-"}],"isoformId":"A6ND36-1"},{"database":"ProteomicsDB","id":"880","properties":[{"key":"Description","value":"-"}],"isoformId":"A6ND36-2"},{"database":"Pumba","id":"A6ND36","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"6816","properties":[{"key":"antibodies","value":"98 antibodies from 19 providers"}]},{"database":"DNASU","id":"644815","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000388995.11","properties":[{"key":"ProteinId","value":"ENSP00000373647.5"},{"key":"GeneId","value":"ENSG00000188522.17"}],"isoformId":"A6ND36-1"},{"database":"Ensembl","id":"ENST00000884590.1","properties":[{"key":"ProteinId","value":"ENSP00000554649.1"},{"key":"GeneId","value":"ENSG00000188522.17"}],"isoformId":"A6ND36-1"},{"database":"Ensembl","id":"ENST00000921602.1","properties":[{"key":"ProteinId","value":"ENSP00000591661.1"},{"key":"GeneId","value":"ENSG00000188522.17"}],"isoformId":"A6ND36-1"},{"database":"GeneID","id":"644815","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:644815","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000388995.11","properties":[{"key":"ProteinId","value":"ENSP00000373647.5"},{"key":"RefSeqNucleotideId","value":"NM_001039999.3"},{"key":"RefSeqProteinId","value":"NP_001035088.2"}]},{"database":"UCSC","id":"uc002guw.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"A6ND36-1"},{"database":"AGR","id":"HGNC:32554","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA144596433","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"644815","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"644815","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"FAM83G","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:32554","properties":[{"key":"GeneName","value":"SACK1G"}]},{"database":"HPA","id":"ENSG00000188522","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (esophagus, skin)"}]},{"database":"MIM","id":"615886","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000188522","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000188522","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QS42","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157932","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_019056_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A6ND36","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PYWQSKA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6103632at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"A6ND36","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"A6ND36","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"A6ND36","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"A6ND36","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"A6ND36","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000188522","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"644815","properties":[{"key":"hits","value":"11 hits in 1160 CRISPR screens"}]},{"database":"ChiTaRS","id":"FAM83G","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"644815","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"A6ND36","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:A6ND36","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"A6ND36","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000188522","properties":[{"key":"ExpressionPatterns","value":"Expressed in upper arm skin and 137 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A6ND36","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24554596"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24554596"}]},{"database":"GO","id":"GO:0019901","properties":[{"key":"GoTerm","value":"F:protein kinase binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030509","properties":[{"key":"GoTerm","value":"P:BMP signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24554596"}]},{"database":"CDD","id":"cd09187","properties":[{"key":"EntryName","value":"PLDc_FAM83G_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.870.10:FF:000004","properties":[{"key":"EntryName","value":"protein FAM83H isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.870.10","properties":[{"key":"EntryName","value":"Endonuclease Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050944","properties":[{"key":"EntryName","value":"FAM83"}]},{"database":"InterPro","id":"IPR012461","properties":[{"key":"EntryName","value":"SACK1"}]},{"database":"PANTHER","id":"PTHR16181","properties":[{"key":"EntryName","value":"PROTEIN FAM83A-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16181:SF29","properties":[{"key":"EntryName","value":"PROTEIN FAM83A-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07894","properties":[{"key":"EntryName","value":"SACK1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56024","properties":[{"key":"EntryName","value":"Phospholipase D/nuclease"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS52096","properties":[{"key":"EntryName","value":"SACK1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVYMQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKNLRVRSSGGTEFFTRSATKFKGALAQKFMFVDGDRAVCGSYSFTWSAARTDRNVISVLSGQVVEMFDRQFQELYLMSHSVSLKGIPMEKEPEPEPIVLPSVVPLVPAGTVAKKLVNPKYALVKAKSVDEIAKISSEKQEAKKPLGLKGPALAEHPGELPELLPPIHPGLLHLERANMFEYLPTWVEPDPEPGSDILGYINIIDPNIWNPQPSQMNRIKIRDTSQASAQHQLWKQSQDSRPRPEPCPPPEPSAPQDGVPAENGLPQGDPEPLPPVPKPRTVPVADVLARDSSDIGWVLELPKEEAPQNGTDHRLPRMAGPGHAPLQRQLSVTQDDPESLGVGLPNGLDGVEEEDDDDYVTLSDQDSHSGSSGRGPGPRRPSVASSVSEEYFEVREHSVPLRRRHSEQVANGPTPPPRRQLSAPHITRGTFVGPQGGSPWAQSRGREEADALKRMQAQRSTDKEAQGQQFHHHRVPASGTRDKDGFPGPPRYRSAADSVQSSTRNAGPAMAGPHHWQAKGGQVPRLLPDPGSPRLAQNARPMTDGRATEEHPSPFGIPYSKLSQSKHLKARTGGSQWASSDSKRRAQAPRDRKDP","length":823,"molWeight":90835,"crc64":"FAAF2B78CB76725F","md5":"7F915746398B1C20D7AB11450B5B63AD"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"DOMAIN":1,"PTM":2,"SIMILARITY":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Domain":1,"Region":5,"Compositional bias":6,"Modified residue":10,"Alternative sequence":4,"Natural variant":3,"Mutagenesis":3},"uniParcId":"UPI0000E03260"}}