{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A6NCI8","uniProtkbId":"CB078_HUMAN","entryAudit":{"firstPublicDate":"2008-02-26","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2011-04-05","entryVersion":97,"sequenceVersion":3},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein C2orf78"}}},"genes":[{"geneName":{"value":"C2orf78"}}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":922,"modifier":"EXACT"}},"description":"Uncharacterized protein C2orf78","featureId":"PRO_0000319422"},{"type":"Region","location":{"start":{"value":459,"modifier":"EXACT"},"end":{"value":522,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":627,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":649,"modifier":"EXACT"},"end":{"value":668,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":692,"modifier":"EXACT"},"end":{"value":835,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":856,"modifier":"EXACT"},"end":{"value":879,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":872,"modifier":"EXACT"},"end":{"value":899,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":546,"modifier":"EXACT"},"end":{"value":567,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":582,"modifier":"EXACT"},"end":{"value":600,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":651,"modifier":"EXACT"},"end":{"value":660,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":692,"modifier":"EXACT"},"end":{"value":702,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":755,"modifier":"EXACT"},"end":{"value":779,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":790,"modifier":"EXACT"},"end":{"value":824,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":2,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK125975","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC092653","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS46338.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001073943.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001080474.3"}]},{"database":"RefSeq","id":"NP_001340273.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001353344.3"}]},{"database":"AlphaFoldDB","id":"A6NCI8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"132921","properties":[{"key":"Interactions","value":"7"}]},{"database":"IntAct","id":"A6NCI8","properties":[{"key":"Interactions","value":"3"}]},{"database":"STRING","id":"9606.ENSP00000387124","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"A6NCI8","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"A6NCI8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"A6NCI8","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"C2orf78","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A6NCI8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000387124","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A6NCI8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"838","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"81892","properties":[{"key":"antibodies","value":"2 antibodies from 2 providers"}]},{"database":"DNASU","id":"388960","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000409561.2","properties":[{"key":"ProteinId","value":"ENSP00000387124.1"},{"key":"GeneId","value":"ENSG00000187833.8"}]},{"database":"Ensembl","id":"ENST00000707660.1","properties":[{"key":"ProteinId","value":"ENSP00000516952.1"},{"key":"GeneId","value":"ENSG00000291484.1"}]},{"database":"GeneID","id":"388960","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:388960","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000409561.2","properties":[{"key":"ProteinId","value":"ENSP00000387124.1"},{"key":"RefSeqNucleotideId","value":"NM_001080474.3"},{"key":"RefSeqProteinId","value":"NP_001073943.1"}]},{"database":"UCSC","id":"uc002sjr.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:34349","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"388960","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"C2orf78","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:34349","properties":[{"key":"GeneName","value":"C2orf78"}]},{"database":"HPA","id":"ENSG00000187833","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (testis)"}]},{"database":"OpenTargets","id":"ENSG00000187833","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000187833","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SEP6","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000014208","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_016596_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A6NCI8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QDFCFQP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9808992at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"A6NCI8","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"A6NCI8","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"A6NCI8","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"A6NCI8","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000187833","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"388960","properties":[{"key":"hits","value":"10 hits in 1133 CRISPR screens"}]},{"database":"GenomeRNAi","id":"388960","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"A6NCI8","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:A6NCI8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"A6NCI8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000187833","properties":[{"key":"ExpressionPatterns","value":"Expressed in male germ line stem cell (sensu Vertebrata) in testis and 6 other cell types or tissues"}]},{"database":"InterPro","id":"IPR040292","properties":[{"key":"EntryName","value":"C2orf78-like"}]},{"database":"InterPro","id":"IPR027898","properties":[{"key":"EntryName","value":"DUF4629"}]},{"database":"PANTHER","id":"PTHR31466","properties":[{"key":"EntryName","value":"GENE 5591-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31466:SF1","properties":[{"key":"EntryName","value":"RIKEN CDNA 4930433I11 GENE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15442","properties":[{"key":"EntryName","value":"DUF4629"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MHWLASATQTSASIVSSSLLSAVDVSSSLTMSEYFQNTSLPGTANSRQFSLPVVSNAAFLTGSISNFSRASAPAISSAWLQPSASGTSFQPLMGSAYLYQHSSTTMLSGVTGQSHICTSAASYPGVFEWDSTASTVKKSSSLRDFTVTVIDQNTAVSSMSMTAQYYKTSDTNTMVPLYPSLSASLVQGTLTQIPNQQGHNLSLPCQIGSQVYYYNQGTLGPQLSCLQSYGSVSYTGYRASAHQPEMVMVLKEVQPTNVLPPVSTSGMYYSVSSQPITETSVQVMETSLGMDTSLGLQSPSQTFCLPQTPEFSKSFSSRNTQTLESNPSPELGDISITPVQSPTNLLTLSPAPSQEKNENENLDEIKTNLSKPLDVHQILIGNQDPPLLPVEIPDIHPLLACIDPLGQEEQPGSENANLRNKSLSLEDQGIFENGIESSSDLADITTWVEDTYLPPIFSSLQDLDQPESPSAKKAKDTSAIKVNQVQEKSCVIKGHSDQVRKNKHKASEPIQGAPKAKIQPKNPECLLEREVVVGSATVSNSASVNKAKHSSNKPHKAASSRISKTKSHGQEKTKGNRKNSSKKSEESKQSGKKVKVEEKQTIPNMKRKKNQPELSQKTLKKPRSSLGMHMLESVQVFHALGKKIDMKTGFSSSRTLGSSSNTQNRQPFPALKPWLDIQHEGKGPEKIQVKAQKLDGSAEKECTSPSHSELPPPGKVKLIPLPFLTLDQPQARHVSRRPNPLASRRPAVAYPARPDSTNSAQSNAVNPSRPAPTNTSLTGPATPAQPISAKATQPSSANPTQPTVPQSAASRPSAYKTSSCSSLQREPVSTAVTSLRSLPKPQNQFLIQDFSLQPRPWRKPTVPEPVMSTPITEEQRPEREAMKRKAQQERENAAKYTSLGKVQFFIERERDMEIAEYYGYTI","length":922,"molWeight":100170,"crc64":"866A70E766774B03","md5":"6065DB78DE07AC145E5DAAA033D353A2"},"extraAttributes":{"countByFeatureType":{"Chain":1,"Region":5,"Coiled coil":1,"Compositional bias":6},"uniParcId":"UPI000015FD87"}}