{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A5ICM0","uniProtkbId":"GLND_LEGPC","entryAudit":{"firstPublicDate":"2008-01-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-06-26","entryVersion":98,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Legionella pneumophila (strain Corby)","taxonId":400673,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Legionellales","Legionellaceae","Legionella"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00277"}],"value":"Bifunctional uridylyltransferase/uridylyl-removing enzyme"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00277"}],"value":"UTase/UR"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00277"}],"value":"Bifunctional [protein-PII] modification enzyme"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00277"}],"value":"Bifunctional nitrogen sensor protein"}}],"includes":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00277"}],"value":"[Protein-PII] uridylyltransferase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00277"}],"value":"PII uridylyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00277"}],"value":"UTase"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00277"}],"value":"2.7.7.59"}]}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00277"}],"value":"[Protein-PII]-UMP uridylyl-removing enzyme"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00277"}],"value":"UR"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00277"}],"value":"3.1.4.-"}]}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00277"}],"value":"glnD"},"orderedLocusNames":[{"value":"LPC_1154"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00277"}],"value":"Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13673"},{"database":"Rhea","id":"RHEA-COMP:12147"},{"database":"Rhea","id":"RHEA-COMP:12148"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:46398"},{"database":"ChEBI","id":"CHEBI:46858"},{"database":"ChEBI","id":"CHEBI:90602"}],"ecNumber":"2.7.7.59","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00277"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + UMP + 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