{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A4WG70","uniProtkbId":"ZAPB_ENT38","entryAudit":{"firstPublicDate":"2008-05-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-05-20","entryVersion":95,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Enterobacter sp. (strain 638)","taxonId":399742,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Enterobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}],"value":"Cell division protein ZapB"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}],"value":"zapB"},"orderedLocusNames":[{"value":"Ent638_4045"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}],"value":"Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}],"value":"Homodimer. The ends of the coiled-coil dimer bind to each other, forming polymers. Interacts with FtsZ"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}],"value":"Localizes to the septum at mid-cell, in a FtsZ-like pattern"}]},"subcellularLocations":[{"location":{"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}],"value":"Belongs to the ZapB family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"ABP62700.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Cell division protein ZapB","featureId":"PRO_0000333897"},{"type":"Region","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}]},{"type":"Compositional bias","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0132","category":"Biological process","name":"Cell division"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0717","category":"Biological process","name":"Septation"}],"references":[{"referenceNumber":1,"citation":{"id":"20485560","citationType":"journal article","authors":["Taghavi S.","van der Lelie D.","Hoffman A.","Zhang Y.B.","Walla M.D.","Vangronsveld J.","Newman L.","Monchy S."],"citationCrossReferences":[{"database":"PubMed","id":"20485560"},{"database":"DOI","id":"10.1371/journal.pgen.1000943"}],"title":"Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638.","publicationDate":"2010","journal":"PLoS Genet.","firstPage":"E1000943","lastPage":"E1000943","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"638","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP000653","properties":[{"key":"ProteinId","value":"ABP62700.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_190275359.1","properties":[{"key":"NucleotideSequenceId","value":"NC_009436.1"}]},{"database":"AlphaFoldDB","id":"A4WG70","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A4WG70","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"399742.Ent638_4045","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ent:Ent638_4045","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG3074","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_171174_2_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000230","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0090529","properties":[{"key":"GoTerm","value":"P:cell septum assembly"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0043093","properties":[{"key":"GoTerm","value":"P:FtsZ-dependent cytokinesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0016192","properties":[{"key":"GoTerm","value":"P:vesicle-mediated transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01196","properties":[{"key":"EntryName","value":"ZapB"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR009252","properties":[{"key":"EntryName","value":"Cell_div_ZapB"}]},{"database":"InterPro","id":"IPR010989","properties":[{"key":"EntryName","value":"SNARE"}]},{"database":"NCBIfam","id":"NF011951","properties":[{"key":"EntryName","value":"PRK15422.1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06005","properties":[{"key":"EntryName","value":"ZapB"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47661","properties":[{"key":"EntryName","value":"t-snare proteins"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTMSLEVFEKLESKVQQAIDTITLLQMEIEELKEKNNALAQEVHSAQNGREELERENQQLREQQNGWQDRLQALLGRMEEV","length":81,"molWeight":9526,"crc64":"0671799744086436","md5":"633B31DFC44889563529BA68E5704764"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI000173ABDF"}}