{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A4QH19","uniProtkbId":"SHIR_CORGB","entryAudit":{"firstPublicDate":"2022-10-12","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-05-15","entryVersion":99,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Corynebacterium glutamicum (strain R)","taxonId":340322,"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Mycobacteriales","Corynebacteriaceae","Corynebacterium"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"HTH-type transcriptional regulator ShiR"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25406451"}],"value":"shiR"},"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAF55535.1"}],"value":"cgR_2524"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25406451"}],"value":"Activates expression of the shikimate transporter ShiA in the presence of shikimate (PubMed:25406451). Binds to the shiA promoter region (PubMed:25406451)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the LysR transcriptional regulatory family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"HTH-type transcriptional regulator ShiR","featureId":"PRO_0000456461"},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"HTH lysR-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00253"}]},{"type":"DNA binding","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"H-T-H motif","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00253"}]}],"keywords":[{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"17379713","citationType":"journal article","authors":["Yukawa H.","Omumasaba C.A.","Nonaka H.","Kos P.","Okai N.","Suzuki N.","Suda M.","Tsuge Y.","Watanabe J.","Ikeda Y.","Vertes A.A.","Inui M."],"citationCrossReferences":[{"database":"PubMed","id":"17379713"},{"database":"DOI","id":"10.1099/mic.0.2006/003657-0"}],"title":"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R.","publicationDate":"2007","journal":"Microbiology","firstPage":"1042","lastPage":"1058","volume":"153"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"R","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"25406451","citationType":"journal article","authors":["Kubota T.","Tanaka Y.","Takemoto N.","Hiraga K.","Yukawa H.","Inui M."],"citationCrossReferences":[{"database":"PubMed","id":"25406451"},{"database":"DOI","id":"10.1099/mic.0.083733-0"}],"title":"Identification and expression analysis of a gene encoding a shikimate transporter of Corynebacterium glutamicum.","publicationDate":"2015","journal":"Microbiology","firstPage":"254","lastPage":"263","volume":"161"},"referencePositions":["FUNCTION","DNA-BINDING"],"referenceComments":[{"value":"R","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP009044","properties":[{"key":"ProteinId","value":"BAF55535.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_003863076.1","properties":[{"key":"NucleotideSequenceId","value":"NC_009342.1"}]},{"database":"AlphaFoldDB","id":"A4QH19","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A4QH19","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"cgt:cgR_2524","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_039613_6_4_11","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"A4QH19","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0032993","properties":[{"key":"GoTerm","value":"C:protein-DNA complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd08414","properties":[{"key":"EntryName","value":"PBP2_LTTR_aromatics_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.10:FF:000001","properties":[{"key":"EntryName","value":"LysR family transcriptional regulator"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.190.10","properties":[{"key":"EntryName","value":"Periplasmic binding protein-like II"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000847","properties":[{"key":"EntryName","value":"LysR_HTH_N"}]},{"database":"InterPro","id":"IPR005119","properties":[{"key":"EntryName","value":"LysR_subst-bd"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR036390","properties":[{"key":"EntryName","value":"WH_DNA-bd_sf"}]},{"database":"PANTHER","id":"PTHR30346:SF0","properties":[{"key":"EntryName","value":"HCA OPERON TRANSCRIPTIONAL ACTIVATOR HCAR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30346","properties":[{"key":"EntryName","value":"TRANSCRIPTIONAL DUAL REGULATOR HCAR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00126","properties":[{"key":"EntryName","value":"HTH_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03466","properties":[{"key":"EntryName","value":"LysR_substrate"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00039","properties":[{"key":"EntryName","value":"HTHLYSR"}]},{"database":"SUPFAM","id":"SSF53850","properties":[{"key":"EntryName","value":"Periplasmic binding protein-like II"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46785","properties":[{"key":"EntryName","value":"Winged helix' DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50931","properties":[{"key":"EntryName","value":"HTH_LYSR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEIRWLEGFIAVAEELHFSNAAIRLGMPQSPLSQLIRRLESELGQKLFDRSTRSVELTAAGRAFLPHARGIVASAAVAREAVNAAEGEIVGVVRIGFSGVLNYSTLPLLTSEVHKRLPNVELELVGQKLTREAVSLLRLGALDITLMGLPIEDPEIETRLISLEEFCVVLPKDHRLAGEDVVDLVDLAEDGFVTTPEFAGSVFRNSTFQLCAEAGFVPRISQQVNDPYMALLLVGAGVGVAITTHGTGLLAPPNTVHLPIKQHSVELRHGIAWMKGSGRVARDAVIDIALDIFKP","length":295,"molWeight":31946,"crc64":"5DD3E0A04B6833D3","md5":"C852D1865078E1EF418455764735E04A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"DNA binding":1},"uniParcId":"UPI0001335567"}}