{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A4GZ95","secondaryAccessions":["A4GZ94","A4GZ96"],"uniProtkbId":"ORF3_TTVG1","entryAudit":{"firstPublicDate":"2011-02-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-05-01","entryVersion":30,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Torque teno midi virus 1 (isolate MD1-073)","taxonId":766184,"lineage":["Viruses","Floreoviria","Shotokuvirae","Commensaviricota","Cardeaviricetes","Sanitavirales","Anelloviridae","Gammatorquevirus","Gammatorquevirus homidi1"]},"organismHosts":[{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606}],"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized ORF3 protein"}}},"genes":[{"orfNames":[{"value":"ORF3"}]}],"comments":[{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"ORF3"}],"isoformIds":["A4GZ95-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"ORF2"}],"isoformIds":["A4GZ95-2"],"sequenceIds":["VSP_040550"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"ORF4"}],"isoformIds":["A4GZ95-3"],"sequenceIds":["VSP_040551"],"isoformSequenceStatus":"Described"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Uncharacterized ORF3 protein","featureId":"PRO_0000404291"},{"type":"Region","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Alternative sequence","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_040550","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_040551","alternativeSequence":{"originalSequence":"YQTNQLKTQETKTNMMCPIQSKKHYKLLTQQKTLLPRCSMTGTTDGVALHQQLLKECNKTSQLIHLSNLIQTQNQHPRKKDYYQSSTTHKRKRKRSTNVSSLSAKKVHARSRKRRKTSSSSSSSSSSSSRNSSTTS","alternativeSequences":["TSTQEKKTTTSPPRPTKENGKDQPMSPLSLRRKYMPGAGNGGKHPQAHPAAAAAAAETQAQPLSTNQGLKSETKIITTTNGGTRITLTRFKPGFEQETEKELAQAFNRPPRLFKEDKPFYPWLPRFTPLVNFHLNFKG"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"17554026","citationType":"journal article","authors":["Ninomiya M.","Nishizawa T.","Takahashi M.","Lorenzo F.R.","Shimosegawa T.","Okamoto H."],"citationCrossReferences":[{"database":"PubMed","id":"17554026"},{"database":"DOI","id":"10.1099/vir.0.82895-0"}],"title":"Identification and genomic characterization of a novel human torque teno virus of 3.2 kb.","publicationDate":"2007","journal":"J. Gen. Virol.","firstPage":"1939","lastPage":"1944","volume":"88"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3)"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB290918","properties":[{"key":"ProteinId","value":"BAF49424.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB290918","properties":[{"key":"ProteinId","value":"BAF49425.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB290918","properties":[{"key":"ProteinId","value":"BAF49426.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Proteomes","id":"UP000007078","properties":[{"key":"Component","value":"Genome"}]},{"database":"InterPro","id":"IPR008474","properties":[{"key":"EntryName","value":"DUF755"}]},{"database":"InterPro","id":"IPR004118","properties":[{"key":"EntryName","value":"HEV_TT_vir_Orf2/Gyrovir_Vp2_N"}]},{"database":"Pfam","id":"PF05501","properties":[{"key":"EntryName","value":"DUF755"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02957","properties":[{"key":"EntryName","value":"TT_ORF2-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQNLSAKDFYKPCRYNCETKNQMWMSGIADSHDSWCDCDTPFAHLLASIFPPGHTDRTRTIQEILTRDFRKTCLSGGADATNSGMAETIEEKREDFQKEEKEDFTEEQNIEDLLAAVADAEGRYQTNQLKTQETKTNMMCPIQSKKHYKLLTQQKTLLPRCSMTGTTDGVALHQQLLKECNKTSQLIHLSNLIQTQNQHPRKKDYYQSSTTHKRKRKRSTNVSSLSAKKVHARSRKRRKTSSSSSSSSSSSSRNSSTTS","length":259,"molWeight":29485,"crc64":"066F1ADE8AAA6527","md5":"6C5530410C42B2F787289008369FB12F"},"extraAttributes":{"countByCommentType":{"ALTERNATIVE PRODUCTS":3},"countByFeatureType":{"Chain":1,"Region":1,"Coiled coil":1,"Compositional bias":2,"Alternative sequence":2},"uniParcId":"UPI0000F67B49"}}