{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A4FVR1","secondaryAccessions":["Q9LFZ2","Q9LG31"],"uniProtkbId":"GIP1L_ARATH","entryAudit":{"firstPublicDate":"2016-02-17","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-04-17","entryVersion":108,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24484953"}],"value":"GBF-interacting protein 1-like"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24484953"}],"value":"Protein GIP1-like"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24484953"}],"value":"GIP1L"},"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Araport","id":"AT1G55820"}],"value":"At1g55820"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAF79311.1"}],"value":"F14J16.6"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAF79498.1"}],"value":"F20N2.19"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8VZS6"}],"value":"May act as a transcriptional coactivator of LOB domain-containing proteins"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24484953"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24484953"}],"value":"Expressed in roots, leaves, stems and flowers"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"Belongs to the GIP1 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAF79311.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAF79498.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":575,"modifier":"EXACT"}},"description":"GBF-interacting protein 1-like","featureId":"PRO_0000435636"},{"type":"Region","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11130712","citationType":"journal article","authors":["Theologis A.","Ecker J.R.","Palm C.J.","Federspiel N.A.","Kaul S.","White O.","Alonso J.","Altafi H.","Araujo R.","Bowman C.L.","Brooks S.Y.","Buehler E.","Chan A.","Chao Q.","Chen H.","Cheuk R.F.","Chin C.W.","Chung M.K.","Conn L.","Conway A.B.","Conway A.R.","Creasy T.H.","Dewar K.","Dunn P.","Etgu P.","Feldblyum T.V.","Feng J.-D.","Fong B.","Fujii C.Y.","Gill J.E.","Goldsmith A.D.","Haas B.","Hansen N.F.","Hughes B.","Huizar L.","Hunter J.L.","Jenkins J.","Johnson-Hopson C.","Khan S.","Khaykin E.","Kim C.J.","Koo H.L.","Kremenetskaia I.","Kurtz D.B.","Kwan A.","Lam B.","Langin-Hooper S.","Lee A.","Lee J.M.","Lenz C.A.","Li J.H.","Li Y.-P.","Lin X.","Liu S.X.","Liu Z.A.","Luros J.S.","Maiti R.","Marziali A.","Militscher J.","Miranda M.","Nguyen M.","Nierman W.C.","Osborne B.I.","Pai G.","Peterson J.","Pham P.K.","Rizzo M.","Rooney T.","Rowley D.","Sakano H.","Salzberg S.L.","Schwartz J.R.","Shinn P.","Southwick A.M.","Sun H.","Tallon L.J.","Tambunga G.","Toriumi M.J.","Town C.D.","Utterback T.","Van Aken S.","Vaysberg M.","Vysotskaia V.S.","Walker M.","Wu D.","Yu G.","Fraser C.M.","Venter J.C.","Davis R.W."],"citationCrossReferences":[{"database":"PubMed","id":"11130712"},{"database":"DOI","id":"10.1038/35048500"}],"title":"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.","publicationDate":"2000","journal":"Nature","firstPage":"816","lastPage":"820","volume":"408"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"CI-BIJKM3QK9B7GB","citationType":"submission","authors":["Bautista V.R.","Kim C.J.","Chen H.","Wu S.Y.","De Los Reyes C.","Ecker J.R."],"title":"Arabidopsis ORF clones.","publicationDate":"MAR-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"19376835","citationType":"journal article","authors":["Reiland S.","Messerli G.","Baerenfaller K.","Gerrits B.","Endler A.","Grossmann J.","Gruissem W.","Baginsky S."],"citationCrossReferences":[{"database":"PubMed","id":"19376835"},{"database":"DOI","id":"10.1104/pp.109.138677"}],"title":"Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.","publicationDate":"2009","journal":"Plant Physiol.","firstPage":"889","lastPage":"903","volume":"150"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":6,"citation":{"id":"24484953","citationType":"journal article","authors":["Lee H.W.","Park J.H.","Park M.Y.","Kim J."],"citationCrossReferences":[{"database":"PubMed","id":"24484953"},{"database":"DOI","id":"10.1016/j.jplph.2013.11.003"}],"title":"GIP1 may act as a coactivator that enhances transcriptional activity of LBD18 in Arabidopsis.","publicationDate":"2014","journal":"J. Plant Physiol.","firstPage":"14","lastPage":"18","volume":"171"},"referencePositions":["SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002304","properties":[{"key":"ProteinId","value":"AAF79311.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC002328","properties":[{"key":"ProteinId","value":"AAF79498.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002684","properties":[{"key":"ProteinId","value":"AEE33303.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408683","properties":[{"key":"ProteinId","value":"CAO7031163.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BT030359","properties":[{"key":"ProteinId","value":"ABO38772.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PIR","id":"F96599","properties":[{"key":"EntryName","value":"F96599"}]},{"database":"RefSeq","id":"NP_175978.2","properties":[{"key":"NucleotideSequenceId","value":"NM_104459.4"}]},{"database":"AlphaFoldDB","id":"A4FVR1","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"A4FVR1","properties":[{"key":"Number of interactors","value":"63"}]},{"database":"IntAct","id":"A4FVR1","properties":[{"key":"Interactions","value":"1"}]},{"database":"STRING","id":"3702.A4FVR1","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"A4FVR1","properties":[{"key":"glycosylation","value":"3 sites, 1 O-linked glycan (2 sites)"}]},{"database":"iPTMnet","id":"A4FVR1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-A4FVR1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"220765","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"842032","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT1G55820","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT1G55820","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT1G55820","properties":[{"key":"GeneName","value":"-"}]},{"database":"eggNOG","id":"ENOG502RQC4","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_482657_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A4FVR1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PTNFFPY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PhylomeDB","id":"A4FVR1","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:A4FVR1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24484953"}]},{"database":"InterPro","id":"IPR044277","properties":[{"key":"EntryName","value":"GIP1"}]},{"database":"InterPro","id":"IPR009719","properties":[{"key":"EntryName","value":"GIP1_N"}]},{"database":"InterPro","id":"IPR009060","properties":[{"key":"EntryName","value":"UBA-like_sf"}]},{"database":"PANTHER","id":"PTHR46775","properties":[{"key":"EntryName","value":"FLOCCULATION PROTEIN (DUF1296)"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46775:SF2","properties":[{"key":"EntryName","value":"GBF-INTERACTING PROTEIN 1-LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06972","properties":[{"key":"EntryName","value":"GIP1_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46934","properties":[{"key":"EntryName","value":"UBA-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSSSDGGSSRVSIPYHLRKTLQKIREYTGKQHSDEDIFAVYKDSFNDPHETAQKLLFLDTFHEVRSKREKKKEPIVPVTQPSGRGGRRNFASSNSYQGSGRNASFKRENGANHVTRGSRTAQPATNKASNITVPNETKVSGPASIPSEVSNHKAQDDPSLISASRCSSKSDQAIEIETASKQGKNQSLPKPDVSEQSHVTFPFHLQVAKGLQNGLTFGSFDSNFVKEVSSSNGASGGYDSNFESSHGTGDDERESSPTTNGITGVASAREETSTVSEDKDYGISNSATGAEPVVHSDHIVPPVEEVPKEEALSNTETHQIAYGQEAPLSVFGLVPSLSAIGQPVNTEAAETQPGNSNSPPISLVSYPPDQSSIAAATQQTNFLRQQYPPNFFPYGYYSPYYMPPPYIHQFLSPNGIPQQSYFPQGAALTAPSHAKPVDNTENPPTTNPYLHTSPMVASSIPSTTTLNSIHSEEKASHLTESAAAWIGQGFGNLQVNPMYNLAYQGQPLGFPVVQAGHGGLMGMHQPTQPMAAASTTYQTLPPPPHTTTAMGEPIGHPHIAYQQPQAALTNWVNNY","length":575,"molWeight":61877,"crc64":"EA9530C15839548A","md5":"2FCC8EC0C3723C60DD1937638E4420CE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Region":2,"Compositional bias":4},"uniParcId":"UPI0000F581E8"}}