{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A3KPW9","uniProtkbId":"BAG6_DANRE","entryAudit":{"firstPublicDate":"2011-01-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-04-03","entryVersion":102,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Danio rerio","commonName":"Zebrafish","synonyms":["Brachydanio rerio"],"taxonId":7955,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Ostariophysi","Cypriniformes","Danionidae","Danioninae","Danio"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Large proline-rich protein BAG6"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P46379"}],"value":"BCL2-associated athanogene 6"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P46379"}],"value":"HLA-B-associated transcript 3"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P46379"}],"value":"Bag6"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P46379"}],"value":"Bat3"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"CAM56392.1"}],"value":"si:ch211-215a10.6"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P46379"}],"value":"ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the bag6/bat3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Similarly, the bag6/bat3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The bag6/bat3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. Also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. May ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress. By stabilizing a large spectrum of proteins, may indirectly affect different biological processes including apoptosis. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P46379"}],"value":"When nuclear, may also act as a component of some chromatin regulator complex"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P46379"}],"value":"Component of the bag6/bat3 complex"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P46379"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P46379"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P46379"}],"value":"Secreted, extracellular exosome","id":"SL-0466"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1160,"modifier":"EXACT"}},"description":"Large proline-rich protein BAG6","featureId":"PRO_0000403752"},{"type":"Domain","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"Ubiquitin-like","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00214"}]},{"type":"Region","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":478,"modifier":"EXACT"},"end":{"value":547,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":563,"modifier":"EXACT"},"end":{"value":628,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":672,"modifier":"EXACT"},"end":{"value":711,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":962,"modifier":"EXACT"},"end":{"value":1038,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1126,"modifier":"EXACT"},"end":{"value":1160,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":417,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":478,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":566,"modifier":"EXACT"},"end":{"value":614,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":677,"modifier":"EXACT"},"end":{"value":698,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":699,"modifier":"EXACT"},"end":{"value":708,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1132,"modifier":"EXACT"},"end":{"value":1146,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"23594743","citationType":"journal article","authors":["Howe K.","Clark M.D.","Torroja C.F.","Torrance J.","Berthelot C.","Muffato M.","Collins J.E.","Humphray S.","McLaren K.","Matthews L.","McLaren S.","Sealy I.","Caccamo M.","Churcher C.","Scott C.","Barrett J.C.","Koch R.","Rauch G.J.","White S.","Chow W.","Kilian B.","Quintais L.T.","Guerra-Assuncao J.A.","Zhou Y.","Gu Y.","Yen J.","Vogel J.H.","Eyre T.","Redmond S.","Banerjee R.","Chi J.","Fu B.","Langley E.","Maguire S.F.","Laird G.K.","Lloyd D.","Kenyon E.","Donaldson S.","Sehra H.","Almeida-King J.","Loveland J.","Trevanion S.","Jones M.","Quail M.","Willey D.","Hunt A.","Burton J.","Sims S.","McLay K.","Plumb B.","Davis J.","Clee C.","Oliver K.","Clark R.","Riddle C.","Elliot D.","Threadgold G.","Harden G.","Ware D.","Begum S.","Mortimore B.","Kerry G.","Heath P.","Phillimore B.","Tracey A.","Corby N.","Dunn M.","Johnson C.","Wood J.","Clark S.","Pelan S.","Griffiths G.","Smith M.","Glithero R.","Howden P.","Barker N.","Lloyd C.","Stevens C.","Harley J.","Holt K.","Panagiotidis G.","Lovell J.","Beasley H.","Henderson C.","Gordon D.","Auger K.","Wright D.","Collins J.","Raisen C.","Dyer L.","Leung K.","Robertson L.","Ambridge K.","Leongamornlert D.","McGuire S.","Gilderthorp R.","Griffiths C.","Manthravadi D.","Nichol S.","Barker G.","Whitehead S.","Kay M.","Brown J.","Murnane C.","Gray E.","Humphries M.","Sycamore N.","Barker D.","Saunders D.","Wallis J.","Babbage A.","Hammond S.","Mashreghi-Mohammadi M.","Barr L.","Martin S.","Wray P.","Ellington A.","Matthews N.","Ellwood M.","Woodmansey R.","Clark G.","Cooper J.","Tromans A.","Grafham D.","Skuce C.","Pandian R.","Andrews R.","Harrison E.","Kimberley A.","Garnett J.","Fosker N.","Hall R.","Garner P.","Kelly D.","Bird C.","Palmer S.","Gehring I.","Berger A.","Dooley C.M.","Ersan-Urun Z.","Eser C.","Geiger H.","Geisler M.","Karotki L.","Kirn A.","Konantz J.","Konantz M.","Oberlander M.","Rudolph-Geiger S.","Teucke M.","Lanz C.","Raddatz G.","Osoegawa K.","Zhu B.","Rapp A.","Widaa S.","Langford C.","Yang F.","Schuster S.C.","Carter N.P.","Harrow J.","Ning Z.","Herrero J.","Searle S.M.","Enright A.","Geisler R.","Plasterk R.H.","Lee C.","Westerfield M.","de Jong P.J.","Zon L.I.","Postlethwait J.H.","Nusslein-Volhard C.","Hubbard T.J.","Roest Crollius H.","Rogers J.","Stemple D.L."],"citationCrossReferences":[{"database":"PubMed","id":"23594743"},{"database":"DOI","id":"10.1038/nature12111"}],"title":"The zebrafish reference genome sequence and its relationship to the human genome.","publicationDate":"2013","journal":"Nature","firstPage":"498","lastPage":"503","volume":"496"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Tuebingen","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BX510301","properties":[{"key":"ProteinId","value":"CAM56392.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001315205.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001328276.1"}]},{"database":"AlphaFoldDB","id":"A3KPW9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A3KPW9","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"A3KPW9","properties":[{"key":"Number of interactors","value":"1545"}]},{"database":"STRING","id":"7955.ENSDARP00000148444","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"A3KPW9","properties":[{"key":"glycosylation","value":"4 sites"}]},{"database":"PaxDb","id":"7955-ENSDARP00000148444","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A3KPW9","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSDART00000088760","properties":[{"key":"ProteinId","value":"ENSDARP00000083193"},{"key":"GeneId","value":"ENSDARG00000077531"}]},{"database":"Ensembl","id":"ENSDART00000135128","properties":[{"key":"ProteinId","value":"ENSDARP00000117226"},{"key":"GeneId","value":"ENSDARG00000077531"}]},{"database":"GeneID","id":"751663","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"dre:751663","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"ZFIN:ZDB-GENE-060307-2","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"751663","properties":[{"key":"Description","value":"-"}]},{"database":"ZFIN","id":"ZDB-GENE-060307-2","properties":[{"key":"GeneName","value":"bag6l"}]},{"database":"eggNOG","id":"KOG4248","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000016199","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_012159_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A3KPW9","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"1885901at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"A3KPW9","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:A3KPW9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000437","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"Bgee","id":"ENSDARG00000077531","properties":[{"key":"ExpressionPatterns","value":"Expressed in blastula and 20 other cell types or tissues"}]},{"database":"GO","id":"GO:0071818","properties":[{"key":"GoTerm","value":"C:BAT3 complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0051787","properties":[{"key":"GoTerm","value":"F:misfolded protein binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0031593","properties":[{"key":"GoTerm","value":"F:polyubiquitin modification-dependent protein binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070628","properties":[{"key":"GoTerm","value":"F:proteasome binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043022","properties":[{"key":"GoTerm","value":"F:ribosome binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007420","properties":[{"key":"GoTerm","value":"P:brain development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0061857","properties":[{"key":"GoTerm","value":"P:endoplasmic reticulum stress-induced pre-emptive quality control"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0036503","properties":[{"key":"GoTerm","value":"P:ERAD pathway"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0018393","properties":[{"key":"GoTerm","value":"P:internal peptidyl-lysine acetylation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042771","properties":[{"key":"GoTerm","value":"P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070059","properties":[{"key":"GoTerm","value":"P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001822","properties":[{"key":"GoTerm","value":"P:kidney development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030324","properties":[{"key":"GoTerm","value":"P:lung development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032435","properties":[{"key":"GoTerm","value":"P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045861","properties":[{"key":"GoTerm","value":"P:negative regulation of proteolysis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0010498","properties":[{"key":"GoTerm","value":"P:proteasomal protein catabolic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0050821","properties":[{"key":"GoTerm","value":"P:protein stabilization"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042981","properties":[{"key":"GoTerm","value":"P:regulation of apoptotic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045995","properties":[{"key":"GoTerm","value":"P:regulation of embryonic development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007283","properties":[{"key":"GoTerm","value":"P:spermatogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007130","properties":[{"key":"GoTerm","value":"P:synaptonemal complex assembly"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0071816","properties":[{"key":"GoTerm","value":"P:tail-anchored membrane protein insertion into ER membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006511","properties":[{"key":"GoTerm","value":"P:ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"CDD","id":"cd01809","properties":[{"key":"EntryName","value":"Ubl_BAG6"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000041","properties":[{"key":"EntryName","value":"large proline-rich protein BAG6 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR021925","properties":[{"key":"EntryName","value":"BAG6"}]},{"database":"InterPro","id":"IPR048926","properties":[{"key":"EntryName","value":"Bag6_BAGS"}]},{"database":"InterPro","id":"IPR000626","properties":[{"key":"EntryName","value":"Ubiquitin-like_dom"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR15204","properties":[{"key":"EntryName","value":"LARGE PROLINE-RICH PROTEIN BAG6"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15204:SF0","properties":[{"key":"EntryName","value":"LARGE PROLINE-RICH PROTEIN BAG6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12057","properties":[{"key":"EntryName","value":"BAG6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20960","properties":[{"key":"EntryName","value":"Bag6_BAGS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00240","properties":[{"key":"EntryName","value":"ubiquitin"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00213","properties":[{"key":"EntryName","value":"UBQ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50053","properties":[{"key":"EntryName","value":"UBIQUITIN_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEESGVIEVTVKTLDSQSRTFTVRGEWTVKQFKEHIAASVEISVDKQRLIYQGKVLQDERTLTEYNVDGKVIHLVERPPPQSSQPGGGGGGVSGSSGAADGGSSSSQSSAYTTSHDRNANNYVMLGTFNLPVNIMDPQQIQMSVQQMLAGVGEMGRNVRVSTSTGSSGSVDVHINVDQSVQSEPRMRLHLAENLLRETQALIHRLEGQSSEPSQQETPPPQPSSSSFSAHPMDSSPPPPSVSSSASQTEGETQSGPNHPSPLELVEVLSEVRRVEERLRPFMERTHSILGAATSADYNNNTQEREEDQRTLNLIGESLHLLGNTLVALSDLRCNLSAQPPRHLHVVRPMSHYTSPVMMQSGLPHIPIPMNLGSTVTMTSNSRQTSDGQPQPPHSSNQSDQQGQAPPTPANESNQQTGHGQGTPRVIRITHQTMEPVVMMQMNLDGTTVPLHVPGLPPEFMQAIMHQISQQAVTMATAASAGHQGQQQGTAGAGAQNGESPVPPPPQARVVITRPTLSPRVPQPMGTRGTTINLRAAVPPPSGQQTNQMVSGLVGQLLLPLHTGDQTSTTSSSHSFSFSTSSSTSSSSSFSSASPPLSSANTSGQTSTHTTSTASVGQAQESGPGDNLAQLLGSLLGGAAGAGGGVSGATPSITVTVPGVPAFIQGLSEFIQSGQPVFPSPNQQPPPSQATPPSAPSGPAPTTAPSGGAETLSPELFTGIVQGVLSTMMGSLGAGQGNTESIAQFIQRLSQTSNLFTPGAGDAVGFFGDLLSLVCQSFSMVDMVLLLHGNPQPLSRIQPQLTAFFTEHYLQGREPTDANIASASEDLINELEEYIAESFSTVTVREGVDIIQTNMSFLRQQFTRMATHILRCTDNTFGQRLLYLCTQGLFECLALNLYCLRGEQRALTTVINHRIRRMSAEVNPSLVNWLTSMMSMRLHVILEHNPVTEDQIQHYVIYTQSESARRTEAGSQSSQQSQNMNVEEGLSPAPATTAEEALRSTGDTDGDEAPGRPSAEETRGAVAMATTEREESTGEAEPWAATVPPEWVPIIRRDMLTQRKMKAQPPLSDAYMHGMPAKRRKTAQGEGPHLSLTEAVSRAARTAGVRPVTAPDSLQGELETPELQEAYAQQVKSDIKKRLSDDPDYNHQRFPNTHRVFSEDA","length":1160,"molWeight":124121,"crc64":"11C550916176775A","md5":"124BE7FBFD3923366B13BB5EA3326805"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":8,"Compositional bias":10},"uniParcId":"UPI0000D77C53"}}