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Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:16921370, PubMed:17928448, PubMed:27281198). By regulating the excitability of neurons, ensures that they respond appropriately to synaptic inputs, maintaining the balance between excitation and inhibition in brain neural circuits (PubMed:16921370, PubMed:22914087). Nav1.1 plays a role in controlling the excitability and action potential propagation from somatosensory neurons, thereby contributing to the sensory perception of mechanically-induced pain (PubMed:27281198)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Na(+)(in) = Na(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34963"},{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27281198"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16921370"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27281198"}],"value":"Activated by the spider toxins Hm1a and Hm1b (H.maculata, AC P60992 and AC P0DOC5) eliciting acute pain and mechanical allodynia"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P35498"}],"value":"The Nav1.1 voltage-gated sodium channel consists of an ion-conducting alpha subunit SCN1A which is functional on its own regulated by one or more beta-1 (SCN1B), beta-2 (SCN2B), beta-3 (SCN3B) and beta-4 (SCN4B) subunits. SCN1B and SCN3B are non-covalently associated with SCN1A. SCN2B and SCN4B are disulfide-linked to SCN1A. SCN1B regulates both the expression at the plasma membrane and the voltage dependence of Nav1.1 inactivation. SCN3B and SCN4B reduce Nav1.1 conductance. Probably interacts with TMEM233; modulates the gating properties of NaV1.1. 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Heterozygous mice exhibit autistic-like behavior, characterized by hyperactivity, stereotyped behaviors, social interaction deficits and impaired context-dependent spatial memory (PubMed:22914087). Defects are caused by caused by impaired GABAergic neurotransmission (PubMed:22914087). Conditional knockout in forebrain GABAergic neurons leads to premature death caused by generalized tonic-clonic seizures in heterozygous mice (PubMed:22908258)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the sodium channel (TC 1.A.1.10) family. 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